Exendin-4, a glucagon-like peptide-1 receptor agonist, inhibits cell apoptosis induced by lipotoxicity in pancreatic β-cell line

Peptides

Volumn 37, Issue 1, 2012, Pages 18-24

  Wei, Qian ^a   Sun, Yu Qiang ^a   Zhang, Jin ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Diabetes; Exendin 4; Glucagon like peptide 1; Lipotoxicity; Pancreatic cells

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; EXENDIN 4; INSULIN; PALMITIC ACID; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; DRUG EXPOSURE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; INSULIN RELEASE; LIPOTOXICITY; MITOCHONDRION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL SURVIVAL; CELLS, CULTURED; CYTOPROTECTION; INSULIN; INSULIN-SECRETING CELLS; MICE; MITOCHONDRIA; PALMITATES; PEPTIDES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, GLUCAGON; SIGNAL TRANSDUCTION; VENOMS;

MURINAE;

EID: 84865224952     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2012.06.018     Document Type: Article

References (32)

1. A. Bulotta, L. Farilla, H. Hui, and R. Perfetti The role of GLP-1 in the regulation of islet cell mass Cell Biochem Biophys 40 2004 65 78
2. J. Buteau, W. El-Assaad, C.J. Rhodes, L. Rosenberg, E. Joly, and M. Prentki Glucagon-like peptide-1 prevents beta cell lipotoxicity Diabetologia 47 2004 806 815 (Pubitemid 38756992)
3. M. Cnop Fatty acids and glucolipotoxicity in the pathogenesis of type 2 diabetes Biochem Soc Trans 36 2008 348 352 (Pubitemid 351839329)
4. M. Cnop, J. Vidal, R.L. Hull, K.M. Utzschneider, D.B. Carr, and T. Schraw Progressive loss of β-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes Diabetes Care 30 2007 677 682 (Pubitemid 46354352)
5. M.E. Doyle, and J.M. Egan Mechanisms of action of glucagon-like peptide 1 in the pancreas Pharmacol Ther 113 2007 546 593 (Pubitemid 46365961)
6. D.J. Drucker, and M.A. Nauck The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes Lancet 368 2006 1696 1705 (Pubitemid 46048557)
7. K. Eitel, H. Staiger, J. Rieger, H. Mischak, H. Brandhorst, and M.D. Brendel Protein kinase C δ activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells Diabetes 52 2003 991 997 (Pubitemid 36384269)
8. L. Elghazi, N. Balcazar, and E. Bernal-Mizrachi Emerging role of protein kinase B/Akt signaling in pancreatic β-cell mass and function Int J Biochem Cell Biol 38 2006 157 163 (Pubitemid 41619445)
9. M.L. Elks Chronic perfusion of rat islets with palmitate suppresses glucose stimulated insulin release Endocrinology 133 1993 208 214 (Pubitemid 23206395)
10. R. Granata, F. Settanni, L. Biancone, L. Trovato, R. Nano, and F. Bertuzzi Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 30,50-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling Endocrinology 148 2007 512 529 (Pubitemid 46143157)
11. J.J. Holst, and C. Orskov The incretin approach for diabetes treatment: modulation of islet hormone release by GLP-1 agonism Diabetes 53 Suppl. 3 2004 S197 S204
12. J.J. Holst The physiology of glucagon-like peptide 1 Physiol Rev 87 2007 1409 1439 (Pubitemid 350041474)
13. S.E. Kahn The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes Diabetologia 46 2003 3 19 (Pubitemid 36237741)
14. I. Kharroubi, L. Ladriere, A.K. Cardozo, Z. Dogusan, M. Cnop, and D.L. Eizirik Free fatty acids and cytokines induce pancreatic β-cell apoptosis by different mechanisms: role of nuclear factor-B and endoplasmic reticulum stress Endocrinology 145 2004 5087 5096 (Pubitemid 39551129)
15. S.J. Kim, K. Winter, C. Nian, M. Tsuneoka, Y. Koda, and C.H. McIntosh Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and downregulation of bax expression J Biol Chem 280 2005 22297 22307 (Pubitemid 40827886)
16. K. Kitani, S. Oguma, T. Nishiki, I. Ohmori, H. Galons, and H. Matsui A Cdk5 inhibitor enhances the induction of insulin secretion by exendin-4 both in vitro and in vivo J Physiol Sci 57 2007 235 239 (Pubitemid 350133539)
17. L. Li, W. El-Kholy, C.J. Rhodes, and P.L. Brubaker Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B Diabetologia 48 2005 1339 1349 (Pubitemid 41186100)
18. Y. Li, T. Hansotia, B. Yusta, F. Ris, P.A. Halban, and D.J. Drucker Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis J Biol Chem 278 2003 471 478 (Pubitemid 36043598)
19. R. Lupi, F. Dotta, L. Marselli, S.D. Guerra, M. Masini, and C. Santangelo Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated Diabetes 51 2002 1437 1442 (Pubitemid 34826609)
20. B.D. Manning, and L.C. Cantley AKT/PKB signaling: navigating downstream Cell 129 2007 1261 1274 (Pubitemid 46962095)
21. S.C. Martinez, K. Tanabe, C. Cras-Méneur, N.A. Abumrad, E. Bernal-Mizrachi, and M.A. Permutt Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis Diabetes 57 2008 846 859
22. J.D. McGarry, and R.L. Dobbins Fatty acid, lipotoxicity and insulin secretion Diabetologia 42 1999 128 138 (Pubitemid 29064233)
23. 2+ signaling in apoptosis of pancreatic cells and the impairment of glucose-induced insulin secretion Endocrinology 139 1998 1429 1439 (Pubitemid 28510165)
24. V. Poitout, and R.P. Robertson Glucolipotoxicity: fuel excess and beta-cell dysfunction Endocr Rev 29 2008 351 366 (Pubitemid 351679704)
25. M. Prentki, and C.J. Nolan Islet beta cell failure in type 2 diabetes J Clin Invest 116 2006 1802 1812 (Pubitemid 44033300)
26. M. Shigeto, M. Katsura, M. Matsuda, S. Ohkuma, and K. Kaku Low, but physiological, concentration of GLP-1 stimulates insulin secretion independent of the cAMP-dependent protein kinase pathway J Pharmacol Sci 108 2008 274 279
27. D. Tews, S. Lehr, S. Hartwig, A. Osmers, W. Paslack, and J. Ecke Anti-apoptotic action of exendin-4 in INS-1 beta cells: comparative protein pattern analysis of isolated mitochondria Horm Metab Res 41 2009 294 301
28. Q. Wang, and P.L. Brubaker Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice Diabetologia 45 2002 1263 1273
29. Q. Wang, L. Li, E. Xu, V. Wong, C. Rhodes, and P.L. Brubaker Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells Diabetologia 47 2004 478 487 (Pubitemid 38491244)
30. S.B. Widenmaier, A.V. Sampaio, T. Michael, and C. Mclntosh Noncanonical activation of Akt/protein kinase B in β-cells by the incretin hormone glucose-dependent insulinotropic polypeptide J Biol Chem 284 2009 10764 10773
31. C.E. Wrede, L.M. Dickson, M.K. Lingohr, I. Briaud, and C.J. Rhodes Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1) J Biol Chem 277 2002 49676 49684 (Pubitemid 36014411)
32. Y.P. Zhou, and V.E. Grill Long-term exposure of rat pancreatic islets to fatty acid inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle J Clin Invest 93 1994 870 876 (Pubitemid 24072831)