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Volumn , Issue , 2009, Pages 519-547

MMP Inhibitors Based on Earlier Succinimide Strategies: From Early to New Approaches

Author keywords

Matrix metalloproteinases (MMPs, matrixins) promoting hydrolysis and peptide bond cleavage; MMP inhibitors based on earlier succinimide strategies early to new approaches; Peptidomimetic hydroxamate inhibitors

Indexed keywords


EID: 84889323514     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470508169.ch24     Document Type: Chapter
Times cited : (2)

References (95)
  • 1
    • 0003472468 scopus 로고    scopus 로고
    • Matrix Metalloproteinases and TIMPs
    • Oxford University Press: Oxford
    • Woessner, J. F.; Nagase, H. Matrix Metalloproteinases and TIMPs. Oxford University Press: Oxford, 2000; pp 1-223.
    • (2000) , pp. 1-223
    • Woessner, J.F.1    Nagase, H.2
  • 2
    • 0001794971 scopus 로고    scopus 로고
    • Matrix metalloproteinases (MMPs)
    • In Proteinase and Peptidase Inhibition: Recent Potential Targets for Drug Development, Smith, H.J.; Simons, C., Eds.; Taylors & Francis: London, New York
    • Supuran, C. T.; Scozzafava, A. Matrix metalloproteinases (MMPs). In Proteinase and Peptidase Inhibition: Recent Potential Targets for Drug Development, Smith, H.J.; Simons, C., Eds.; Taylors & Francis: London, New York, 2002; pp 35-61.
    • (2002) , pp. 35-61
    • Supuran, C.T.1    Scozzafava, A.2
  • 3
    • 0033999308 scopus 로고    scopus 로고
    • Matrix metalloproteinases: clinical implications
    • Nelson, A.R.; Fingleton, B.; Matrisian, L. M. Matrix metalloproteinases: clinical implications. J. Clin. Oncol. 2000, 18, 1135-1149.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 1135-1149
    • Nelson, A.R.1    Fingleton, B.2    Matrisian, L.M.3
  • 4
    • 0030339578 scopus 로고    scopus 로고
    • Involvement of tissue inhibitors of metalloproteinases (TIMPs) during matrix metalloproteinase activation
    • Nagase, H.; Suzuki, K.; Itoh, Y.; Kan, C. C.; Gehring, M. R.; Huang, W.; Brew, K. Involvement of tissue inhibitors of metalloproteinases (TIMPs) during matrix metalloproteinase activation. Adv. Exp. Med. Biol. 1996, 389, 23-31.
    • (1996) Adv. Exp. Med. Biol. , vol.389 , pp. 23-31
    • Nagase, H.1    Suzuki, K.2    Itoh, Y.3    Kan, C.C.4    Gehring, M.R.5    Huang, W.6    Brew, K.7
  • 5
    • 0031671855 scopus 로고    scopus 로고
    • Matrix metalloproteinase degradation of extracellular matrix: biological consequences
    • Shapiro, S. H. Matrix metalloproteinase degradation of extracellular matrix: biological consequences. Curr. Opin. Cell Biol. 1998, 10, 602-608.
    • (1998) Curr. Opin. Cell Biol. , vol.10 , pp. 602-608
    • Shapiro, S.H.1
  • 6
    • 0035188727 scopus 로고    scopus 로고
    • Howmatrix metalloproteinases regulate cell behaviour
    • Sternlicht, M.;Werb, Z. Howmatrix metalloproteinases regulate cell behaviour. Annu. Rev. Cell Dev. Biol. 2001, 17, 463-516.
    • (2001) Annu. Rev. Cell Dev. Biol. , vol.17 , pp. 463-516
    • Sternlicht, M.1    Werb, Z.2
  • 7
    • 33846120591 scopus 로고    scopus 로고
    • Matrix metalloproteinase as valid clinical targets
    • Fingleton, B.; Matrix metalloproteinase as valid clinical targets. Curr. Pharm. Des. 2007, 13, 333-346.
    • (2007) Curr. Pharm. Des. , vol.13 , pp. 333-346
    • Fingleton, B.1
  • 8
    • 0035376862 scopus 로고    scopus 로고
    • The inhibition of metalloproteinases as a therapeutic target in rheumatoid arthritis and osteoarthritis
    • Bigg, H. F.; Rowan, A. D. The inhibition of metalloproteinases as a therapeutic target in rheumatoid arthritis and osteoarthritis. Curr. Opin. Pharmacol. 2001, 1, 314-320.
    • (2001) Curr. Opin. Pharmacol. , vol.1 , pp. 314-320
    • Bigg, H.F.1    Rowan, A.D.2
  • 9
    • 0032837039 scopus 로고    scopus 로고
    • Clinical trials of a matrix metalloproteinase inhibitor in human periodontal disease
    • Ashley, R. A. Clinical trials of a matrix metalloproteinase inhibitor in human periodontal disease. Ann. NY Acad. Sci. 1999, 878, 335-346.
    • (1999) Ann. NY Acad. Sci. , vol.878 , pp. 335-346
    • Ashley, R.A.1
  • 10
    • 14044274265 scopus 로고    scopus 로고
    • Recent developments in the design of specific matrix metalloproteinase inhibitors aided by structural and computational studies
    • Rao, B. G. Recent developments in the design of specific matrix metalloproteinase inhibitors aided by structural and computational studies. Curr. Pharmaceut. Des. 2005, 11, 295-322.
    • (2005) Curr. Pharmaceut. Des. , vol.11 , pp. 295-322
    • Rao, B.G.1
  • 11
    • 0001651169 scopus 로고    scopus 로고
    • Design and therapeutic application of matrix metalloproteinase inhibitors
    • Whittaker, M.; Floyd, C. D.; Brown, P.; Gearing, A. J. Design and therapeutic application of matrix metalloproteinase inhibitors. Chem. Rev. 1999, 99, 2735-2776.
    • (1999) Chem. Rev. , vol.99 , pp. 2735-2776
    • Whittaker, M.1    Floyd, C.D.2    Brown, P.3    Gearing, A.J.4
  • 12
    • 0031189711 scopus 로고    scopus 로고
    • Molecular recognition of protein-ligand complexes: applications to drug design
    • Babine, R. E.; Bender, S. L. Molecular recognition of protein-ligand complexes: applications to drug design. Chem. Rev. 1997, 97, 1359-1472.
    • (1997) Chem. Rev. , vol.97 , pp. 1359-1472
    • Babine, R.E.1    Bender, S.L.2
  • 13
    • 0032864538 scopus 로고    scopus 로고
    • Matrix metalloproteinases inhibition. From the Jurassic to the third millennium
    • Woessner, J. F., Jr. Matrix metalloproteinases inhibition. From the Jurassic to the third millennium. Ann. NY. Acad. Sci. 1999, 878, 388-403.
    • (1999) Ann. NY. Acad. Sci. , vol.878 , pp. 388-403
    • Woessner Jr, J.F.1
  • 14
    • 0030806173 scopus 로고    scopus 로고
    • Changing views of the role of matrix metalloproteinases in metastasis
    • Chambers, A. F.; Matrisian, L. M. Changing views of the role of matrix metalloproteinases in metastasis. J. Nac. Cancer Inst. 1997, 89, 1260-1270.
    • (1997) J. Nac. Cancer Inst. , vol.89 , pp. 1260-1270
    • Chambers, A.F.1    Matrisian, L.M.2
  • 15
    • 0037192458 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors and cancer: trials and tribulations
    • Coussens, L. M.; Fingleton, B.; Matrisian, L. M. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 2002, 295, 2387-2392.
    • (2002) Science , vol.295 , pp. 2387-2392
    • Coussens, L.M.1    Fingleton, B.2    Matrisian, L.M.3
  • 16
    • 5744249740 scopus 로고    scopus 로고
    • The design, structure and clinical update of small molecular weight matrix metalloproteinase inhibitors
    • Skiles, J.W.; Gonnella, N. C.; Jeng, A. The design, structure and clinical update of small molecular weight matrix metalloproteinase inhibitors. Curr. Med. Chem. 2004, 11, 2911-2977.
    • (2004) Curr. Med. Chem. , vol.11 , pp. 2911-2977
    • Skiles, J.W.1    Gonnella, N.C.2    Jeng, A.3
  • 17
    • 15544373919 scopus 로고    scopus 로고
    • Recent non-hydroxamate matrix metalloproteinase inhibitor
    • Breuer, E.; Frant, J.; Reich, R. Recent non-hydroxamate matrix metalloproteinase inhibitor. Exp. Opin. Ther. Pat. 2005, 15, 253-269.
    • (2005) Exp. Opin. Ther. Pat. , vol.15 , pp. 253-269
    • Breuer, E.1    Frant, J.2    Reich, R.3
  • 18
    • 0036716282 scopus 로고    scopus 로고
    • Strategies forMMPinhibition in cancer innovations for the post-trial era
    • Overall, C. M.; Lopez-Otin, C. Strategies forMMPinhibition in cancer innovations for the post-trial era. Nat. Rev. Cancer 2002, 2, 657-652.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 657-652
    • Overall, C.M.1    Lopez-Otin, C.2
  • 19
    • 21344466344 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors as targets of anticancer therapeutics
    • Mannello, F.; Tonti, G.; Papa, S. Matrix metalloproteinase inhibitors as targets of anticancer therapeutics. Curr. Cancer Drug Targets 2005, 5, 285-298.
    • (2005) Curr. Cancer Drug Targets , vol.5 , pp. 285-298
    • Mannello, F.1    Tonti, G.2    Papa, S.3
  • 20
    • 4644248792 scopus 로고    scopus 로고
    • Recent advances in the design of matrix metalloproteinase inhibitors
    • Matter, H.; Schudok, M. Recent advances in the design of matrix metalloproteinase inhibitors. Curr. Opin. Drug Discov. Devel. 2004, 7, 513-535.
    • (2004) Curr. Opin. Drug Discov. Devel. , vol.7 , pp. 513-535
    • Matter, H.1    Schudok, M.2
  • 21
    • 34047168930 scopus 로고    scopus 로고
    • The design of inhibitors for medicinally relevant metalloproteins
    • Jacobsen, F. E.; Lewis, J. A.; Cohen, S. M. The design of inhibitors for medicinally relevant metalloproteins. Chem. Med. Chem. 2007, 2, 152-171.
    • (2007) Chem. Med. Chem. , vol.2 , pp. 152-171
    • Jacobsen, F.E.1    Lewis, J.A.2    Cohen, S.M.3
  • 22
    • 34447269445 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors: new challenges in the era of post broad-spectrum inhibitors
    • Nuti, E.; Tuccinardi, T.; Rossello, A. Matrix metalloproteinase inhibitors: new challenges in the era of post broad-spectrum inhibitors. Curr. Pharm. Des. 2007, 13, 2087-2100.
    • (2007) Curr. Pharm. Des. , vol.13 , pp. 2087-2100
    • Nuti, E.1    Tuccinardi, T.2    Rossello, A.3
  • 23
    • 4444341426 scopus 로고    scopus 로고
    • The evolution of matrix metalloproteinase inhibitors. drug discovery program at Abbott laboratories
    • Wada, C. K. The evolution of matrix metalloproteinase inhibitors. drug discovery program at Abbott laboratories. Curr. Top. Med. Chem. 2004, 4, 1255-1267.
    • (2004) Curr. Top. Med. Chem. , vol.4 , pp. 1255-1267
    • Wada, C.K.1
  • 24
    • 33646584823 scopus 로고    scopus 로고
    • Recent advances inMMPinhibitor design
    • Fisher, J. F.; Mobashery, S. Recent advances inMMPinhibitor design. Cancer Metast. Rev. 2006, 25, 115-136.
    • (2006) Cancer Metast. Rev. , vol.25 , pp. 115-136
    • Fisher, J.F.1    Mobashery, S.2
  • 25
    • 34547838174 scopus 로고    scopus 로고
    • Insight into the structural determinants for selective inhibition of matrix metalloproteinases
    • Pirard, B. Insight into the structural determinants for selective inhibition of matrix metalloproteinases. Drug Discov. Today 2007, 12, 640-646.
    • (2007) Drug Discov. Today , vol.12 , pp. 640-646
    • Pirard, B.1
  • 26
    • 0037693895 scopus 로고    scopus 로고
    • Matrix metallopronases and tissue inhibitor of metalloproteases:structure, function and biochemistry
    • Visse, R.; Nagase, H. Matrix metallopronases and tissue inhibitor of metalloproteases:structure, function and biochemistry. Ciac. Res. 2003, 92, 827-839.
    • (2003) Ciac. Res. , vol.92 , pp. 827-839
    • Visse, R.1    Nagase, H.2
  • 27
    • 0041919643 scopus 로고    scopus 로고
    • Protease inhibitors of sulphonamide type:anticancer, antiinflammatory and antiviral agents
    • 1-33
    • Supuran, C. T.; Casini, A.; Scozzafava, A. Protease inhibitors of sulphonamide type:anticancer, antiinflammatory and antiviral agents. Med. Res. Rev. 2003, 23, 535-558. 1-33.
    • (2003) Med. Res. Rev. , vol.23 , pp. 535-558
    • Supuran, C.T.1    Casini, A.2    Scozzafava, A.3
  • 28
    • 0031671630 scopus 로고    scopus 로고
    • Matrix metalloproteases: variations on a theme
    • Borkakoti, N. Matrix metalloproteases: variations on a theme. Progr. Biophys. Mol. Biol. 1998, 70, 73-94.
    • (1998) Progr. Biophys. Mol. Biol. , vol.70 , pp. 73-94
    • Borkakoti, N.1
  • 29
    • 0037142342 scopus 로고    scopus 로고
    • Structural differences of matrix metalloproteinases-by the GRID/CPCA approach
    • Terp, G. E.; Cruciani, G.; Christensen, I. T.; Jorgensen, F. S. Structural differences of matrix metalloproteinases-by the GRID/CPCA approach. J. Med. Chem. 2002, 45, 2675-2684.
    • (2002) J. Med. Chem. , vol.45 , pp. 2675-2684
    • Terp, G.E.1    Cruciani, G.2    Christensen, I.T.3    Jorgensen, F.S.4
  • 30
    • 30444435765 scopus 로고    scopus 로고
    • Matrix metalloproteinase target family landscape: a chemomatrix approach to ligand selectivity based on protein binding site analysis
    • Pirard, B.; Matter, H. Matrix metalloproteinase target family landscape: a chemomatrix approach to ligand selectivity based on protein binding site analysis. J. Med. Chem. 2006, 49, 51-69.
    • (2006) J. Med. Chem. , vol.49 , pp. 51-69
    • Pirard, B.1    Matter, H.2
  • 32
    • 4444347179 scopus 로고    scopus 로고
    • Quest for selectivity in inhibition of matrix metalloproteinase inhibitors
    • Brown, S.; Meroueh, S. O.; Fridman, R.; Mobashery, S. Quest for selectivity in inhibition of matrix metalloproteinase inhibitors. Curr. Top. Med. Chem. 2004, 4, 1227-1238.
    • (2004) Curr. Top. Med. Chem. , vol.4 , pp. 1227-1238
    • Brown, S.1    Meroueh, S.O.2    Fridman, R.3    Mobashery, S.4
  • 35
    • 0028651852 scopus 로고
    • Clinical trials of a low molecular weight matrix metalloproteinase inhibitor in cancer
    • Brown, P. D. Clinical trials of a low molecular weight matrix metalloproteinase inhibitor in cancer. Ann NY. Acad. Sci. 1994, 732, 217-221;
    • (1994) Ann NY. Acad. Sci. , vol.732 , pp. 217-221
    • Brown, P.D.1
  • 36
    • 0025237534 scopus 로고
    • Thiol-based inhibitors of mammalian collagenase. Substituted amide and peptide derivatives of the leucine analogue, 2-[R,S)-mercaptomethyl]-4-methylpentanoic acid
    • Darlak, K.; Miller, R. B.; Stack, M. S.; Spatola, A. F.; Gray, R.D. Thiol-based inhibitors of mammalian collagenase. Substituted amide and peptide derivatives of the leucine analogue, 2-[R,S)-mercaptomethyl]-4-methylpentanoic acid. J. Biol. Chem. 1990, 265, 5199-5205.
    • (1990) J. Biol. Chem. , vol.265 , pp. 5199-5205
    • Darlak, K.1    Miller, R.B.2    Stack, M.S.3    Spatola, A.F.4    Gray, R.D.5
  • 37
    • 84889296534 scopus 로고
    • Peptides with collagenase inhibiting activity
    • European Patent EP0320118
    • Markwell, R. E.; Hunter, D. J.; Ward, R. W. Peptides with collagenase inhibiting activity. European Patent EP0320118, 1989.
    • (1989)
    • Markwell, R.E.1    Hunter, D.J.2    Ward, R.W.3
  • 38
    • 84889296534 scopus 로고
    • Peptides with collagenase inhibiting activity
    • World Patent WO9309136
    • Markwell, R. E.; Hunter, D. J.;Ward, R.W. Peptides with collagenase inhibiting activity. World Patent WO9309136, 1989.
    • (1989)
    • Markwell, R.E.1    Hunter, D.J.2    Ward, R.W.3
  • 40
    • 4644248792 scopus 로고    scopus 로고
    • Recent advances in the design of matrix metalloproteinase inhibitors
    • Matter, H.; Schudok, M. Recent advances in the design of matrix metalloproteinase inhibitors. Curr. Opin. Drug Discov. Devel. 2004, 7, 513-535.
    • (2004) Curr. Opin. Drug Discov. Devel. , vol.7 , pp. 513-535
    • Matter, H.1    Schudok, M.2
  • 42
    • 0037192860 scopus 로고    scopus 로고
    • Design, synthesis and characterization of potent. Slow-binding inhibitors that are selective for gelatinases
    • Bernardo, M. M.; Brown, S.; Li, Z. H.; Fridman, R.; Mobashery, S. Design, synthesis and characterization of potent. Slow-binding inhibitors that are selective for gelatinases. J. Biol. Chem. 2002, 277, 11201-11207.
    • (2002) J. Biol. Chem. , vol.277 , pp. 11201-11207
    • Bernardo, M.M.1    Brown, S.2    Li, Z.H.3    Fridman, R.4    Mobashery, S.5
  • 43
    • 0346333073 scopus 로고    scopus 로고
    • Evaluation of P10-diversified phosphinic peptides leads to the development of highly selective inhibitors of MMP-11
    • Matziari, M.; Beau, F.; Cuniasse, P.; Dive, V.; Yiotakis, A. Evaluation of P10-diversified phosphinic peptides leads to the development of highly selective inhibitors of MMP-11. J. Med. Chem. 2004, 47, 325-336.
    • (2004) J. Med. Chem. , vol.47 , pp. 325-336
    • Matziari, M.1    Beau, F.2    Cuniasse, P.3    Dive, V.4    Yiotakis, A.5
  • 46
    • 33749818519 scopus 로고    scopus 로고
    • New hydroxypyrimidinone chelators as potential matrix metalloproteinase inhibitors
    • In Metal Ions in Biology and Medicine, Alpoim M. C.; Morais P. V.; Santos, M. A.; Cristovaó, A. J.; Centeno, J.; Collery, Ph., Eds; John Libbey Eurotext: Paris
    • Esteves, M. A.; Cachudo, A.; Ribeiro, C.; Chaves, S.; Santos, M. A., New hydroxypyrimidinone chelators as potential matrix metalloproteinase inhibitors. In Metal Ions in Biology and Medicine, Alpoim M. C.; Morais P. V.; Santos, M. A.; Cristovaó, A. J.; Centeno, J.; Collery, Ph., Eds; John Libbey Eurotext: Paris, 2006; Vol. 9, pp 35-39.
    • (2006) , vol.9 , pp. 35-39
    • Esteves, M.A.1    Cachudo, A.2    Ribeiro, C.3    Chaves, S.4    Santos, M.A.5
  • 48
    • 0023619941 scopus 로고
    • Collagenase inhibitors: their design and potential therapeutic use
    • Johnson, W. H.; Roberts, N. A.; Borkakoti, N. Collagenase inhibitors: their design and potential therapeutic use. J. Enzyme Inhib. 1987, 2, 1-22.
    • (1987) J. Enzyme Inhib. , vol.2 , pp. 1-22
    • Johnson, W.H.1    Roberts, N.A.2    Borkakoti, N.3
  • 49
    • 0032612382 scopus 로고    scopus 로고
    • New drugs on the horizon: matrix metalloproteinase inhibitors
    • Rothenberg, M. L.; Nelson, A. R.; Hande, K. R. New drugs on the horizon: matrix metalloproteinase inhibitors. Stem Cells 1999, 1, 237-240.
    • (1999) Stem Cells , vol.1 , pp. 237-240
    • Rothenberg, M.L.1    Nelson, A.R.2    Hande, K.R.3
  • 50
    • 0031716672 scopus 로고    scopus 로고
    • Dupuytren's disease and frosen shoulder induced by treatment with a matrix metalloproteinase inhibitor
    • Hutchinson, J.W.; Tierney, G. M.; Parsons, S. L.; Davis, T. R. C. Dupuytren's disease and frosen shoulder induced by treatment with a matrix metalloproteinase inhibitor. J. Bone Joint Surg. Br. 1998, 80-B, 907-908.
    • (1998) J. Bone Joint Surg. Br. , vol.80 B , pp. 907-908
    • Hutchinson, J.W.1    Tierney, G.M.2    Parsons, S.L.3    Davis, T.R.C.4
  • 51
    • 0030839472 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on Batimastat and Marimastat
    • Rasmussen, H. S.; McCann, P. P. Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on Batimastat and Marimastat. Pharmacol. Ther. 1997, 75, 69-75.
    • (1997) Pharmacol. Ther. , vol.75 , pp. 69-75
    • Rasmussen, H.S.1    McCann, P.P.2
  • 52
    • 0034751435 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors: current developments and future perspectives
    • Hoekstra, R.; Skens, F. A. L. M.; Verwej, J. Matrix metalloproteinase inhibitors: current developments and future perspectives. Oncologist 2001, 6, 415-427.
    • (2001) Oncologist , vol.6 , pp. 415-427
    • Hoekstra, R.1    Skens, F.A.L.M.2    Verwej, J.3
  • 53
    • 0031657033 scopus 로고    scopus 로고
    • New drugs on the horizon: matrix metalloproteinase inhibitors
    • Rothemberg, M. L.; Nelson, A. R.; Hande, K. N. New drugs on the horizon: matrix metalloproteinase inhibitors. Oncologist 1998, 3, 271-274.
    • (1998) Oncologist , vol.3 , pp. 271-274
    • Rothemberg, M.L.1    Nelson, A.R.2    Hande, K.N.3
  • 54
    • 5444219883 scopus 로고    scopus 로고
    • Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies
    • Folgueras, A. R.; Pendas, A. M.; Sanchez, L. M.; Lopez-Otin, C. Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies. Int. J. Dev. Biol. 2004, 48, 411-424.
    • (2004) Int. J. Dev. Biol. , vol.48 , pp. 411-424
    • Folgueras, A.R.1    Pendas, A.M.2    Sanchez, L.M.3    Lopez-Otin, C.4
  • 55
    • 18244427699 scopus 로고    scopus 로고
    • Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1)
    • Dahlberg, L.; Billinghhurs, R. C.; Manner, P.; Nelson, S.; Webb, G.; Ionescu, M.; Reiner, A.; Tanzer, M.; Zukor, D.; Chen, J.; Van Wart, H. E.; Poole, A. R. Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1). Arthritis Rheum. 2000, 43, 673-682.
    • (2000) Arthritis Rheum. , vol.43 , pp. 673-682
    • Dahlberg, L.1    Billinghhurs, R.C.2    Manner, P.3    Nelson, S.4    Webb, G.5    Ionescu, M.6    Reiner, A.7    Tanzer, M.8    Zukor, D.9    Chen, J.10    Van Wart, H.E.11    Poole, A.R.12
  • 56
    • 0033864065 scopus 로고    scopus 로고
    • Prinomastat, a hydroxamate-based matrix metalloproteinase inhibitor. a novel pharmaceutical approach for tissue remodelling-related diseases
    • Scatena, R. Prinomastat, a hydroxamate-based matrix metalloproteinase inhibitor. a novel pharmaceutical approach for tissue remodelling-related diseases. Exp. Opin. Invest. Drugs 2000, 9, 2159.
    • (2000) Exp. Opin. Invest. Drugs , vol.9 , pp. 2159
    • Scatena, R.1
  • 57
    • 0028838862 scopus 로고
    • Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor
    • Grams, F.; Crimmin, M.; Hinnes, L.; Huxley, P.; Pieper, M.; Teschesche, H.; Bode, W. Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor. Biochemistry 1995, 34, 14012-14120.
    • (1995) Biochemistry , vol.34 , pp. 14012-14120
    • Grams, F.1    Crimmin, M.2    Hinnes, L.3    Huxley, P.4    Pieper, M.5    Teschesche, H.6    Bode, W.7
  • 62
    • 0346239860 scopus 로고
    • PCT Patent Application
    • WO9421625, 1994; Chem, Abstr
    • Crimmin, M. J.; Beckett, P. R.; Davis, M. H. PCT Patent Application WO9421625, 1994; Chem. Abstr. 1995, 122, 188173.
    • (1995) , vol.122 , pp. 188173
    • Crimmin, M.J.1    Beckett, P.R.2    Davis, M.H.3
  • 63
    • 84889315959 scopus 로고
    • PCT Patent Application
    • WO9424140, 1994; Chem, Abstr
    • Crimmin, M. J.; Ayscough, A. P.; Beckett, R. P. PCT Patent Application WO9424140, 1994; Chem. Abstr. 1995, 123, 144644.
    • (1995) , vol.123 , pp. 144644
    • Crimmin, M.J.1    Ayscough, A.P.2    Beckett, R.P.3
  • 64
    • 0037161592 scopus 로고    scopus 로고
    • b-Aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme
    • Kottirsch, G.; Koch, G.; Feifel, R.; Neumann, U. b-Aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme. J. Med. Chem. 45, 2002, 2289-2293.
    • (2002) J. Med. Chem. , vol.45 , pp. 2289-2293
    • Kottirsch, G.1    Koch, G.2    Feifel, R.3    Neumann, U.4
  • 67
  • 68
    • 33645892563 scopus 로고    scopus 로고
    • A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors
    • Janser, P.; Neumann, U.; Miltz, W.; Feifel, R.; Buhl, T. A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors. Bioorg. Med. Chem. Lett. 16, 2006, 2632-2636.
    • (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 2632-2636
    • Janser, P.1    Neumann, U.2    Miltz, W.3    Feifel, R.4    Buhl, T.5
  • 69
    • 0242493934 scopus 로고    scopus 로고
    • MMPs inhibitors: new succinyl hydroxamates with selective inhibition of MMP-2 over MMP-3
    • Marcq,V.; Mirand, C.; Decarme, M.; Emonard, H.; Hornebeck,W.MMPs inhibitors: new succinyl hydroxamates with selective inhibition of MMP-2 over MMP-3. Bioorg. Med. Chem. 13, 2003, 2843-2846.
    • (2003) Bioorg. Med. Chem. , vol.13 , pp. 2843-2846
    • Marcq, V.1    Mirand, C.2    Decarme, M.3    Emonard, H.4    Hornebeck, W.5
  • 71
    • 0035952220 scopus 로고    scopus 로고
    • Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1)
    • Fray, M. J.; Dickinson, R. P. Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1). Bioorg. Med. Chem. Lett. 11, 2001, 571-574.
    • (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 571-574
    • Fray, M.J.1    Dickinson, R.P.2
  • 72
    • 0035952287 scopus 로고    scopus 로고
    • Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P30 group chirality
    • Fray, M. J.; Burslem, M. F.; Dickinson, R. P. Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P30 group chirality. Bioorg. Med. Chem. Lett. 11, 2001, 567-570.
    • (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 567-570
    • Fray, M.J.1    Burslem, M.F.2    Dickinson, R.P.3
  • 77
    • 0342699963 scopus 로고    scopus 로고
    • Bissubstituted malonic acid hydroxamate derivatives as inhibitors of human neutrophil collagenase (MMP8)
    • Von Roedern, E. G.; Brandstetter, H.; Engh, R. A.; Bode, W.; Grams, F.; Moroder, L. Bissubstituted malonic acid hydroxamate derivatives as inhibitors of human neutrophil collagenase (MMP8). J. Med. Chem. 1998, 41, 3041-3047.
    • (1998) J. Med. Chem. , vol.41 , pp. 3041-3047
    • Von Roedern, E.G.1    Brandstetter, H.2    Engh, R.A.3    Bode, W.4    Grams, F.5    Moroder, L.6
  • 78
    • 0028915695 scopus 로고
    • X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors
    • Grams, F.; Reinemer, P.; Powers, J.C.; Kleine, T.; Pieper, M.; Tschesche, H.; Huber, R.; Bode, W. X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Eur. J. Biochem. 1995, 228, 830-841.
    • (1995) Eur. J. Biochem. , vol.228 , pp. 830-841
    • Grams, F.1    Reinemer, P.2    Powers, J.C.3    Kleine, T.4    Pieper, M.5    Tschesche, H.6    Huber, R.7    Bode, W.8
  • 79
    • 0032576767 scopus 로고    scopus 로고
    • Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8)
    • Von Roedern, E. G.; Grams, F.; Brandstetter, H.; Moroder, L. Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8). J. Med. Chem. 1998, 41, 339-345.
    • (1998) J. Med. Chem. , vol.41 , pp. 339-345
    • Von Roedern, E.G.1    Grams, F.2    Brandstetter, H.3    Moroder, L.4
  • 80
    • 0031798691 scopus 로고    scopus 로고
    • Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. a new binding mode explains apparently anomalous data
    • Brandstetter, H.; Engh, R. A.; Von Roedern, E. G.; Moroder, L.; Huber, R.; Bode, W.; Grams, F. Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. a new binding mode explains apparently anomalous data. Protein Sci. 1998, 7, 1303-1309.
    • (1998) Protein Sci. , vol.7 , pp. 1303-1309
    • Brandstetter, H.1    Engh, R.A.2    Von Roedern, E.G.3    Moroder, L.4    Huber, R.5    Bode, W.6    Grams, F.7
  • 81
    • 33646584823 scopus 로고    scopus 로고
    • Recent advances in MMP inhibitor Design
    • Fisher, J. F.; Mobashery, S. Recent advances in MMP inhibitor Design. Cancer Metastasis Rev. 2006, 25, 115-136.
    • (2006) Cancer Metastasis Rev. , vol.25 , pp. 115-136
    • Fisher, J.F.1    Mobashery, S.2
  • 82
  • 84
    • 84889340197 scopus 로고    scopus 로고
    • GB Patent Application
    • GB 2326881A, 1999; Chem, Abstr
    • Broadhurst, M. J.; Johnson, W. H.; Walter, D. S. GB Patent Application GB 2326881A, 1999; Chem. Abstr. 1999, 130, 110060.
    • (1999) , vol.130 , pp. 110060
    • Broadhurst, M.J.1    Johnson, W.H.2    Walter, D.S.3
  • 85
    • 84889453052 scopus 로고    scopus 로고
    • New metalloenzyme inhibitors with potential clinic application
    • Santos, M. A.; Marques, S. M.; Gil, M.; Tegoni, M.; Chaves, S. New metalloenzyme inhibitors with potential clinic application. PT Patente 103003; 2003.
    • (2003) PT Patente , pp. 103003
    • Santos, M.A.1    Marques, S.M.2    Gil, M.3    Tegoni, M.4    Chaves, S.5
  • 86
    • 58149104406 scopus 로고    scopus 로고
    • Iminodiacetyl-monohydroxamate derivatives as potent and selective MMP inhibitors
    • In MetalIons in Biologyand Medicine, Alpoim, M. C.;Morais,P.V.; SantosM.A., Cristovaó A. J., Centeno J., Collery Ph., Eds; John Libbey Eurotext: Paris
    • Santos, M. A. Iminodiacetyl-monohydroxamate derivatives as potent and selective MMP inhibitors. In MetalIons in Biologyand Medicine, Alpoim, M. C.;Morais,P.V.; SantosM.A., Cristovaó A. J., Centeno J., Collery Ph., Eds; John Libbey Eurotext: Paris, 2006; Vol. 9, pp 117-121.
    • (2006) , vol.9 , pp. 117-121
    • Santos, M.A.1
  • 87
    • 84889388229 scopus 로고    scopus 로고
    • Metalloenzyme inhibitors with potential medical application: 1-hydroxy-piperazine-2,6-dione as a new zinc binding group
    • PT Patente 103897
    • Marques, S. M.; Rossello, A.; Santos, M. A. Metalloenzyme inhibitors with potential medical application: 1-hydroxy-piperazine-2,6-dione as a new zinc binding group. PT Patente 103897, 2007.
    • (2007)
    • Marques, S.M.1    Rossello, A.2    Santos, M.A.3
  • 89
    • 14544300624 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors: a review on pharmacophore mapping and (Q)SARs results
    • Kontogiorgis, C. A.; Papaioannou, P.; Hadjipavlou-Litina, D. J. Matrix metalloproteinase inhibitors: a review on pharmacophore mapping and (Q)SARs results. Curr. Med. Chem. 2005, 12, 339-355.
    • (2005) Curr. Med. Chem. , vol.12 , pp. 339-355
    • Kontogiorgis, C.A.1    Papaioannou, P.2    Hadjipavlou-Litina, D.J.3
  • 90
    • 33749265325 scopus 로고    scopus 로고
    • Design, synthesis and molecular modelling study of iminodiacetyl monohydroxamic acid derivatives as MMP inhibitors
    • Santos, M. A.; Marques, S. M.; Tuccinardi, T.; Carelli, P.; Panelli, L.; Rossello, A. Design, synthesis and molecular modelling study of iminodiacetyl monohydroxamic acid derivatives as MMP inhibitors. Bioorg. Med. Chem. 2006, 14, 7539-7550.
    • (2006) Bioorg. Med. Chem. , vol.14 , pp. 7539-7550
    • Santos, M.A.1    Marques, S.M.2    Tuccinardi, T.3    Carelli, P.4    Panelli, L.5    Rossello, A.6
  • 91
    • 4444274979 scopus 로고    scopus 로고
    • Structure-based design, synthesis, and hemopsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics
    • Hanessian, S.; Moitessier, N. Structure-based design, synthesis, and hemopsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics. Curr. Top. Med. Chem. 2004, 4, 1269-1287.
    • (2004) Curr. Top. Med. Chem. , vol.4 , pp. 1269-1287
    • Hanessian, S.1    Moitessier, N.2
  • 92
    • 33644545381 scopus 로고    scopus 로고
    • Validating matrix metalloproteinases as drug targets and antitargets for cancer therapy
    • Overall, C. M.; Kleifeld, O. Validating matrix metalloproteinases as drug targets and antitargets for cancer therapy. Nat. Rev. Cancer 2006, 6, 227-239.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 227-239
    • Overall, C.M.1    Kleifeld, O.2
  • 93
    • 58149086406 scopus 로고    scopus 로고
    • Dual Inhibitors of Matrix Metalloproteinases and Carbonic Anhydrases: Iminodiacetyl-Based Hydroxamate Benzenesulfonamide Conjugates
    • Marques, S. M.; Nuti, E.; Rossello, A.; Supuran, C. T.; Tuccinardi, T.; Adriano Martinelli, A.; and Santos, M. A. Dual Inhibitors of Matrix Metalloproteinases and Carbonic Anhydrases: Iminodiacetyl-Based Hydroxamate Benzenesulfonamide Conjugates. J. Med. Chem. 2008, 51, 7968-7979.
    • (2008) J. Med. Chem. , vol.51 , pp. 7968-7979
    • Marques, S.M.1    Nuti, E.2    Rossello, A.3    Supuran, C.T.4    Tuccinardi, T.5    Adriano Martinelli, A.6    Santos, M.A.7


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