Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data

Protein Science

Volumn 7, Issue 6, 1998, Pages 1303-1309

  Brandstetter, Hans ^a,c   Engh, Richard A ^a,b   Von Roedern, Erich Graf ^a   Moroder, Luis ^a   Huber, Robert ^a   Bode, Wolfram ^a   Grams, Frank ^b  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Binding mode; Drug design; Inhibitor; Malonic acid; Matrix metalloproteinase; MMP 8

Indexed keywords

COLLAGENASE INHIBITOR; HYDROXAMIC ACID; MALONIC ACID DERIVATIVE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; NEUTROPHIL COLLAGENASE; PHOSPHINIC ACID DERIVATIVE; THIOL DERIVATIVE;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; HUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

EID: 0031798691     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560070605     Document Type: Article

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