Peptidyl 3-substituted 1-hydroxyureas as isosteric analogues of succinylhydroxamate MMP inhibitors

European Journal of Medicinal Chemistry

Volumn 43, Issue 5, 2008, Pages 1008-1014

  Campestre, Cristina ^a   Tortorella, Paolo ^b   Agamennone, Mariangela ^a   Preziuso, Serena ^a   Biasone, Alessandro ^a   Nuti, Elisa ^c   Rossello, Armando ^c   Gallina, Carlo ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF BARI   (Italy)

^c UNIVERSITY OF PISA   (Italy)

Author keywords

MMP inhibition; Peptidyl N hydroxyureas; Succinyl hydroxamates

Indexed keywords

AMINO ACID; DIPEPTIDE; GELATINASE A; GELATINASE B; HDYROXYLEUCYLPHENYLALANINE METHYLAMIDE; HYDROXY DEXTRO LEUCYLPHENYLALANINE METHYLAMIDE; HYDROXYUREA; IMIDAZOLINE DERIVATIVE; INTERSTITIAL COLLAGENASE; MATRILYSIN; MATRIX METALLOPROTEINASE INHIBITOR; METHYLIMIDAZOLIDINE 2,4 DIONE; N [(HYDROXYAMINO)CARBONYL] DEXTRO LEUCYLPHENYLALANINE METHYLAMIDE; N [(HYDROXYAMINO)CARBONYL]LEUCYLPHENYLALANINE METHYLAMIDE; NEUTROPHIL COLLAGENASE; PEPTIDYL 1 HYDROXYUREA; STROMELYSIN; SUCCINYLHYDROXAMATE DERIVATIVE; ZINC BINDING PROTEIN;

ARTICLE; CARBAMOYLATION; CARBON NUCLEAR MAGNETIC RESONANCE; CHELATION; CHEMICAL BOND; DIASTEREOISOMER; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANIMALS; DIPEPTIDES; HUMANS; HYDROXAMIC ACIDS; HYDROXYUREA; MATRIX METALLOPROTEINASES; MICE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUCCINATES;

EID: 42949167324     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.07.002     Document Type: Article

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