Bis-substituted malonic acid hydroxamate derivatives as inhibitors of human neutrophil collagenase (MMP8)

Journal of Medicinal Chemistry

Volumn 41, Issue 16, 1998, Pages 3041-3047

  Graf Von Roedern, Erich ^a,c   Brandstetter, Hans ^b,c   Engh, Richard A ^c,d   Bode, Wolfram ^c   Grams, Frank ^d   Moroder, Luis ^c  

^a SANOFI   (France)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; MALONIC ACID DERIVATIVE; NEUTROPHIL COLLAGENASE;

ARTICLE; DRUG ACTIVITY; DRUG BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; NEUTROPHIL; X RAY CRYSTALLOGRAPHY;

BINDING SITES; COLLAGENASES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; HYDROXAMIC ACIDS; MALONATES; MATRIX METALLOPROTEINASE 8; MODELS, MOLECULAR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0342699963     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980112p     Document Type: Article

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