Design, synthesis and molecular modeling study of iminodiacetyl monohydroxamic acid derivatives as MMP inhibitors

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 22, 2006, Pages 7539-7550

  Amelia Santos M ^a   Marques, Sérgio M ^a   Tuccinardi, Tiziano ^b   Carelli, Paolo ^b   Panelli, Laura ^b   Rossello, Armando ^b  

^a INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Enzyme inhibitors; Hydroxamate; Matrix metalloproteinases; MMP inhibitors

Indexed keywords

DIGLYCINE; GELATINASE A; HYDROXAMIC ACID DERIVATIVE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; N [(HYDROXYCARBAMOYL)METHYL] N (4 BIPHENYLSULFONYL)AMINOACETIC ACID; N [(HYDROXYCARBAMOYL)METHYL] N (4 METHOXYBENZENESULFONYL)AMINOACETIC ACID; N [(HYDROXYCARBAMOYL)METHYL] N (4 PHENOXYBENZENESULFONYL)AMINOACETIC ACID; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; DEGENERATIVE DISEASE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; MOLECULAR MODEL;

ACETYLATION; COMPUTER SIMULATION; DRUG DESIGN; HUMANS; HYDROXAMIC ACIDS; IMINES; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33749265325     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.07.011     Document Type: Article

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