Enhanced bioavailability of a poorly soluble VR1 antagonist using an amorphous solid dispersion approach: A case study

Molecular Pharmaceutics

Volumn 5, Issue 6, 2008, Pages 981-993

  Kennedy, Michael ^a   Hu, Jack ^a   Gao, Ping ^a   Li, Lan ^a   Ali Reynolds, Alana ^a   Chal, Ben ^a   Gupta, Vicki ^a   Chandra, Ma ^a   Mahajan, Nidhi ^a   Akrami, Anna ^a   Surapaneni, Sekhar ^a  

^a AMGEN INC   (United States)

Author keywords

Amorphous stability; HPMC AS; Improved bioavail ability; Solid dispersion; Spray drying

Indexed keywords

AMG 517; HYDROXYPROPYLMETHYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; METHYLCELLULOSE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1 ANTAGONIST;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG BIOAVAILABILITY; DRUG CAPSULE; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; GLASS TRANSITION TEMPERATURE; LIGHT SCATTERING; MALE; MONKEY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; THERMOGRAVIMETRY; X RAY DIFFRACTION;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BENZOTHIAZOLES; BIOLOGICAL AVAILABILITY; BUFFERS; CAPSULES; CHEMISTRY, PHARMACEUTICAL; CROSS-OVER STUDIES; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; MACACA MULATTA; MALE; METABOLIC CLEARANCE RATE; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PHOSPHATES; PYRIMIDINES; SOLUBILITY; TRANSITION TEMPERATURE; TRPV CATION CHANNELS; WATER;

EID: 64649094850     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp800061r     Document Type: Article

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