Quantitative analysis of the effect of supersaturation on in vivo drug absorption

Molecular Pharmaceutics

Volumn 7, Issue 5, 2010, Pages 1431-1440

  Takano, Ryusuke ^a   Takata, Noriyuki ^a   Saito, Ryoichi ^a   Furumoto, Kentaro ^a   Higo, Shoichi ^a   Hayashi, Yoshiki ^a   MacHida, Minoru ^a   Aso, Yoshinori ^a   Yamashita, Shinji ^b  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b SETSUNAN UNIVERSITY   (Japan)

Author keywords

crystalline salt; in vivo in vitro correlation (IVIVC); Oral absorption; solubility; solubility limited absorption; supersaturation

Indexed keywords

FTI 2600; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COMPUTER SIMULATION; DOG; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; EQUILIBRIUM CONSTANT; IN VITRO STUDY; IN VIVO STUDY; INTESTINE FLUID; MALE; NONHUMAN; NONLINEAR SYSTEM; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIMULATION; TECHNOLOGY; X RAY POWDER DIFFRACTION;

ADMINISTRATION, ORAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; INTESTINAL ABSORPTION; MALE; MODELS, BIOLOGICAL; PHARMACOKINETICS; POWDER DIFFRACTION; SOLUBILITY; SOLUTIONS;

EID: 77957729822     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100109a     Document Type: Article

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