The influence of bile acids on the oral bioavailability of vitamin K encapsulated in polymeric micelles

Journal of Controlled Release

Volumn 133, Issue 2, 2009, Pages 161-168

  van Hasselt, P M ^a   Janssens, G E P J ^b   Slot, T K ^b   van der Ham, M ^c   Minderhoud, T C ^a   Talelli, M ^b   Akkermans, L M ^c   Rijcken, C J F ^b   van Nostrum, C F ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Bile acids; Block copolymers; Jaundice; Micelles; Oral administration; Vitamin K

Indexed keywords

ABSORPTION; ACIDS; AGGLOMERATION; BIOCHEMISTRY; BLOCK COPOLYMERS; BODY FLUIDS; COPOLYMERIZATION; DUCTS; HYDROPHOBICITY; MICELLES; MOTION PICTURE EXPERTS GROUP STANDARDS; POLYMERS; RATS;

BILE ACIDS; BILE DUCTS; DEOXYCHOLIC ACIDS; DOSE DEPENDENTS; HYDROPHOBIC COMPOUNDS; IN VITRO; JAUNDICE; MICELLAR SIZES; MIXED MICELLES; ORAL ADMINISTRATION; ORAL BIOAVAILABILITIES; PLASMA LEVELS; POLYMERIC MICELLES; VITAMIN K;

COLLOIDS;

BILE ACID; COPOLYMER; DEOXYCHOLIC ACID; POLYETHYLENE GLYCOL BLOCK N (2 HYDROXYPROPYL)METHACRYLAMIDE DILACTATE COPOLYMER; POLYMER; TAUROCHOLIC ACID; UNCLASSIFIED DRUG; VITAMIN K GROUP;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BILE DUCT LIGATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG STABILITY; ENCAPSULATION; GASTROINTESTINAL ABSORPTION; IN VITRO STUDY; LIGHT SCATTERING; MALE; MICELLE; MICELLIZATION; NONHUMAN; PINOCYTOSIS; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BILE ACIDS AND SALTS; BILE DUCTS; BIOLOGICAL AVAILABILITY; DRUG CARRIERS; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; LIGATION; LIGHT; MALE; MICELLES; MICROSCOPY, ELECTRON, TRANSMISSION; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYMERS; POLYMETHACRYLIC ACIDS; RATS; RATS, WISTAR; SCATTERING, RADIATION; ULTRAFILTRATION; VITAMIN K; VITAMINS;

EID: 57349157027     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.09.089     Document Type: Article

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