메뉴 건너뛰기




Volumn 30, Issue 2, 2013, Pages 584-595

Drug loading of polymeric micelles

Author keywords

cyclodextrins; cosolvent evaporation; dexamethasone; direct dialysis; drug load; freeze drying; HP CD; lyophilization; O W emulsion; polymeric micelles; polypseudorotaxane; SBE CD

Indexed keywords

ACETONE; BETA CYCLODEXTRIN; DEXAMETHASONE; MALTOSE; POLYGLACTIN; POLYLACTIC ACID; POLYMER; SUCROSE; TREHALOSE;

EID: 84873424418     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0903-5     Document Type: Article
Times cited : (60)

References (43)
  • 1
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • 10.1016/S0169-409X(96)00423-1 1:CAS:528:DyaK2sXktlKlsQ%3D%3D
    • Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev. 1997;23:3-25.
    • (1997) Adv Drug Deliv Rev , vol.23 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 2
    • 0034461768 scopus 로고    scopus 로고
    • Drug-like properties and the causes of poor solubility and poor permeability
    • 10.1016/S1056-8719(00)00107-6 1:CAS:528:DC%2BD3MXitF2ksrc%3D
    • Lipinski CA. Drug-like properties and the causes of poor solubility and poor permeability. J Pharmacol Toxicol Meth. 2000;44:235-49.
    • (2000) J Pharmacol Toxicol Meth , vol.44 , pp. 235-249
    • Lipinski, C.A.1
  • 3
    • 0036742053 scopus 로고    scopus 로고
    • Poor aqueous solubility - An industry wide problem in drug discovery
    • Lipinski C. Poor aqueous solubility - an industry wide problem in drug discovery. Am Pharm Rev. 2002;5:82-5.
    • (2002) Am Pharm Rev. , vol.5 , pp. 82-85
    • Lipinski, C.1
  • 4
    • 69249149274 scopus 로고    scopus 로고
    • Drug-like property concepts in pharmaceutical design
    • 19601822 10.2174/138161209788682479 1:CAS:528:DC%2BD1MXotFKhs7k%3D
    • Di L, Kerns EH, Carter GT. Drug-like property concepts in pharmaceutical design. Curr Pharm Des. 2009;15:2184-94.
    • (2009) Curr Pharm des , vol.15 , pp. 2184-2194
    • Di, L.1    Kerns, E.H.2    Carter, G.T.3
  • 5
    • 84857004575 scopus 로고    scopus 로고
    • Bridging solubility between drug discovery and development
    • Di L, Fish PV, Mano T. Bridging solubility between drug discovery and development. Drug Discov Today. 2011.
    • (2011) Drug Discov Today
    • Di, L.1    Fish, P.V.2    Mano, T.3
  • 6
    • 35348949634 scopus 로고    scopus 로고
    • Paclitaxel: A review of adverse toxicities and novel delivery strategies
    • 17877447 10.1517/14740338.6.5.609 1:CAS:528:DC%2BD2sXhtVCrtLvP
    • Marupudi NI, Han JE, Li KW, Renard VM, Tyler BM, Brem H. Paclitaxel: a review of adverse toxicities and novel delivery strategies. Expert Opin Drug Saf. 2007;6:609-21.
    • (2007) Expert Opin Drug Saf , vol.6 , pp. 609-621
    • Marupudi, N.I.1    Han, J.E.2    Li, K.W.3    Renard, V.M.4    Tyler, B.M.5    Brem, H.6
  • 7
    • 77956156055 scopus 로고    scopus 로고
    • Fabrication of micellar nanoparticles for drug delivery through the self-assembly of block copolymers
    • 10.1016/j.progpolymsci.2010.06.003 1:CAS:528:DC%2BC3cXhtV2isbjN
    • Tyrrell ZL, Shen YQ, Radosz M. Fabrication of micellar nanoparticles for drug delivery through the self-assembly of block copolymers. Prog Polym Sci. 2010;35:1128-43.
    • (2010) Prog Polym Sci , vol.35 , pp. 1128-1143
    • Tyrrell, Z.L.1    Shen, Y.Q.2    Radosz, M.3
  • 8
    • 73649133678 scopus 로고    scopus 로고
    • Overcoming the barriers in micellar drug delivery: Loading efficiency, in vivo stability, and micelle-cell interaction
    • 20017660 10.1517/17425240903380446 1:CAS:528:DC%2BD1MXhsFOnsLzK
    • Kim S, Shi Y, Kim JY, Park K, Cheng JX. Overcoming the barriers in micellar drug delivery: loading efficiency, in vivo stability, and micelle-cell interaction. Expert Opin Drug Deliv. 2010;7:49-62.
    • (2010) Expert Opin Drug Deliv. , vol.7 , pp. 49-62
    • Kim, S.1    Shi, Y.2    Kim, J.Y.3    Park, K.4    Cheng, J.X.5
  • 9
    • 0032778659 scopus 로고    scopus 로고
    • Polymeric micelles - A new generation of colloidal drug carriers
    • 10469928 10.1016/S0939-6411(99)00039-9 1:CAS:528:DyaK1MXmtVymurk%3D
    • Jones M, Leroux J. Polymeric micelles - a new generation of colloidal drug carriers. Eur J Pharm Biopharm. 1999;48:101-11.
    • (1999) Eur J Pharm Biopharm , vol.48 , pp. 101-111
    • Jones, M.1    Leroux, J.2
  • 10
    • 19444375996 scopus 로고    scopus 로고
    • Enhancement of oral bioavailability of poorly water-soluble drugs by poly(ethylene glycol)-block-poly(alkyl acrylate-co-methacrylic acid) self-assemblies
    • 15907580 10.1016/j.jconrel.2005.02.010 1:CAS:528:DC%2BD2MXkt1ahu7c%3D
    • Sant VP, Smith D, Leroux JC. Enhancement of oral bioavailability of poorly water-soluble drugs by poly(ethylene glycol)-block-poly(alkyl acrylate-co-methacrylic acid) self-assemblies. J Control Release. 2005;104:289-300.
    • (2005) J Control Release. , vol.104 , pp. 289-300
    • Sant, V.P.1    Smith, D.2    Leroux, J.C.3
  • 11
    • 0037133087 scopus 로고    scopus 로고
    • PLGA-mPEG nanoparticles of cisplatin: In vitro nanoparticle degradation, in vitro drug release and in vivo drug residence in blood properties
    • 11853924 10.1016/S0168-3659(01)00530-2 1:CAS:528:DC%2BD38XhtlSlsL4%3D
    • Avgoustakis K, Beletsi A, Panagi Z, Klepetsanis P, Karydas AG, Ithakissios DS. PLGA-mPEG nanoparticles of cisplatin: in vitro nanoparticle degradation, in vitro drug release and in vivo drug residence in blood properties. J Control Release. 2002;79:123-35.
    • (2002) J Control Release. , vol.79 , pp. 123-135
    • Avgoustakis, K.1    Beletsi, A.2    Panagi, Z.3    Klepetsanis, P.4    Karydas, A.G.5    Ithakissios, D.S.6
  • 12
    • 0031060457 scopus 로고    scopus 로고
    • Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery
    • 10.1016/S0168-3659(96)01484-8
    • Song CX, Labhasetwar V, Murphy H, Qu X, Humphrey WR, Shebuski RJ, Levy RJ. Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery. J Control Release. 1997;43:197-212.
    • (1997) J Control Release. , vol.43 , pp. 197-212
    • Song, C.X.1    Labhasetwar, V.2    Murphy, H.3    Qu, X.4    Humphrey, W.R.5    Shebuski, R.J.6    Levy, R.J.7
  • 13
    • 0034633965 scopus 로고    scopus 로고
    • Effect of solvent on the preparation of surfactant-free poly(DL-lactide-co-glycolide) nanoparticles and norfloxacin release characteristics
    • 11036235 10.1016/S0378-5173(00)00537-8 1:CAS:528:DC%2BD3cXosVGls7c%3D
    • Jeon HJ, Jeong JI, Jang MK, Park YH, Nah JW. Effect of solvent on the preparation of surfactant-free poly(DL-lactide-co-glycolide) nanoparticles and norfloxacin release characteristics. Int J Pharm. 2000;207:99-108.
    • (2000) Int J Pharm , vol.207 , pp. 99-108
    • Jeon, H.J.1    Jeong, J.I.2    Jang, M.K.3    Park, Y.H.4    Nah, J.W.5
  • 14
    • 33845562111 scopus 로고    scopus 로고
    • Encapsulation of hydrophobic drugs in polymeric micelles through co-solvent evaporation: The effect of solvent composition on micellar properties and drug loading
    • 17008034 10.1016/j.ijpharm.2006.08.018 1:CAS:528:DC%2BD28XhtlCmtLjM
    • Aliabadi HM, Elhasi S, Mahmud A, Gulamhusein R, Mahdipoor P, Lavasanifar A. Encapsulation of hydrophobic drugs in polymeric micelles through co-solvent evaporation: the effect of solvent composition on micellar properties and drug loading. Int J Pharm. 2007;329:158-65.
    • (2007) Int J Pharm , vol.329 , pp. 158-165
    • Aliabadi, H.M.1    Elhasi, S.2    Mahmud, A.3    Gulamhusein, R.4    Mahdipoor, P.5    Lavasanifar, A.6
  • 15
    • 3042761142 scopus 로고    scopus 로고
    • A novel one-step drug-loading procedure for water-soluble amphiphilic nanocarriers
    • 15212160 10.1023/B:PHAM.0000029284.40637.69 1:CAS:528: DC%2BD2cXktlykur4%3D
    • Fournier E, Dufresne MH, Smith DC, Ranger M, Leroux JC. A novel one-step drug-loading procedure for water-soluble amphiphilic nanocarriers. Pharm Res. 2004;21:962-8.
    • (2004) Pharm Res , vol.21 , pp. 962-968
    • Fournier, E.1    Dufresne, M.H.2    Smith, D.C.3    Ranger, M.4    Leroux, J.C.5
  • 16
    • 51649088096 scopus 로고    scopus 로고
    • Gamma CD/HP gamma CD: Synergistic solubilization
    • 18691643 10.1016/j.ijpharm.2008.07.011 1:CAS:528:DC%2BD1cXhtFensr7P
    • Jansook P, Loftsson T. gamma CD/HP gamma CD: synergistic solubilization. Int J Pharm. 2008;363:217-9.
    • (2008) Int J Pharm , vol.363 , pp. 217-219
    • Jansook, P.1    Loftsson, T.2
  • 17
    • 84860867672 scopus 로고    scopus 로고
    • Comparative investigations on in vitro serum stability of polymeric micelle formulations
    • 21879388 10.1007/s11095-011-0555-x 1:CAS:528:DC%2BC3MXhtV2gtLvE
    • Miller T, Rachel R, Besheer A, Uezguen S, Weigandt M, Goepferich A. Comparative investigations on in vitro serum stability of polymeric micelle formulations. Pharm Res. 2012;29:448-59.
    • (2012) Pharm Res , vol.29 , pp. 448-459
    • Miller, T.1    Rachel, R.2    Besheer, A.3    Uezguen, S.4    Weigandt, M.5    Goepferich, A.6
  • 18
    • 84873457049 scopus 로고    scopus 로고
    • Cryoprotection-lyophilization and physical stabilization of rifampicin-loaded flower-like polymeric micelles
    • Moretton MA, Chiappetta DA, Sosnik A. Cryoprotection-lyophilization and physical stabilization of rifampicin-loaded flower-like polymeric micelles. J R Soc Interface 2011.
    • (2011) J R Soc Interface
    • Ma, M.1    Chiappetta, D.A.2    Sosnik, A.3
  • 19
    • 77952958086 scopus 로고    scopus 로고
    • Polymeric micelles for parenteral delivery of Sagopilone: Physicochemical characterization, novel formulation approaches and their toxicity assessment in vitro as well as in vivo
    • 20188169 10.1016/j.ejpb.2010.02.010 1:CAS:528:DC%2BC3cXmsVejs7o%3D
    • Richter A, Olbrich C, Krause M, Hoffmann J, Kissel T. Polymeric micelles for parenteral delivery of Sagopilone: physicochemical characterization, novel formulation approaches and their toxicity assessment in vitro as well as in vivo. Eur J Pharm Biopharm. 2010;75:80-9.
    • (2010) Eur J Pharm Biopharm , vol.75 , pp. 80-89
    • Richter, A.1    Olbrich, C.2    Krause, M.3    Hoffmann, J.4    Kissel, T.5
  • 20
    • 34547800192 scopus 로고    scopus 로고
    • Freeze-drying of nanoparticles: Formulation, process and storage considerations
    • 17118485 10.1016/j.addr.2006.09.017 1:CAS:528:DC%2BD28Xht1Kmtb7E
    • Abdelwahed W, Degobert G, Stainmesse S, Fessi H. Freeze-drying of nanoparticles: formulation, process and storage considerations. Adv Drug Deliv Rev. 2006;58:1688-713.
    • (2006) Adv Drug Deliv Rev. , vol.58 , pp. 1688-1713
    • Abdelwahed, W.1    Degobert, G.2    Stainmesse, S.3    Fessi, H.4
  • 21
    • 0142187117 scopus 로고    scopus 로고
    • Corrim-based alignment for improved speed in single-particle image processing
    • 14572477 10.1016/j.jsb.2003.08.001 1:CAS:528:DC%2BD3sXot1GktbY%3D
    • Sander B, Golas MM, Stark H. Corrim-based alignment for improved speed in single-particle image processing. J Struct Biol. 2003;143:219-28.
    • (2003) J Struct Biol , vol.143 , pp. 219-228
    • Sander, B.1    Golas, M.M.2    Stark, H.3
  • 24
    • 0034255393 scopus 로고    scopus 로고
    • Lyophilization and development of solid protein pharmaceuticals
    • 10967427 10.1016/S0378-5173(00)00423-3 1:CAS:528:DC%2BD3cXmtVals7w%3D
    • Wang W. Lyophilization and development of solid protein pharmaceuticals. Int J Pharm. 2000;203:1-60.
    • (2000) Int J Pharm , vol.203 , pp. 1-60
    • Wang, W.1
  • 25
    • 76149096848 scopus 로고    scopus 로고
    • Janus micelle formation induced by protonation/deprotonation of poly(2-vinylpyridine)-block-poly(ethylene oxide) diblock copolymers
    • 10.1002/macp.200900366 1:CAS:528:DC%2BC3cXhslWmu7k%3D
    • Li X, Yang H, Xu LM, Fu XN, Guo HW, Zhang XK. Janus micelle formation induced by protonation/deprotonation of poly(2-vinylpyridine)-block- poly(ethylene oxide) diblock copolymers. Macromol Chem Phys. 2010;211:297-302.
    • (2010) Macromol Chem Phys , vol.211 , pp. 297-302
    • Li, X.1    Yang, H.2    Xu, L.M.3    Fu, X.N.4    Guo, H.W.5    Zhang, X.K.6
  • 26
    • 34250313630 scopus 로고    scopus 로고
    • Molecular exchange through membranes of poly(2-vinylpyridine-block- ethylene oxide) vesicles
    • 17464955 10.1002/smll.200600540 1:CAS:528:DC%2BD2sXmsl2hsbY%3D
    • Leson A, Hauschild S, Rank A, Neub A, Schubert R, Forster S, Mayer C. Molecular exchange through membranes of poly(2-vinylpyridine-block-ethylene oxide) vesicles. Small. 2007;3:1074-83.
    • (2007) Small , vol.3 , pp. 1074-1083
    • Leson, A.1    Hauschild, S.2    Rank, A.3    Neub, A.4    Schubert, R.5    Forster, S.6    Mayer, C.7
  • 27
    • 3242776157 scopus 로고    scopus 로고
    • About the methods of preparation of poly(ethylene oxide)-b-poly(epsilon- caprolactone) nanoparticles in water analysis by dynamic light scattering
    • 10.1016/j.colsurfa.2004.04.070 1:CAS:528:DC%2BD2cXlvFGkur8%3D
    • Vangeyte P, Gautier S, Jerome R. About the methods of preparation of poly(ethylene oxide)-b-poly(epsilon-caprolactone) nanoparticles in water analysis by dynamic light scattering. Colloids Surf, A Physicochem Eng Asp. 2004;242:203-11.
    • (2004) Colloids Surf, A Physicochem Eng Asp , vol.242 , pp. 203-211
    • Vangeyte, P.1    Gautier, S.2    Jerome, R.3
  • 28
    • 3242667191 scopus 로고    scopus 로고
    • Preparation and drug loading of poly(ethylene glycol)-block-poly(epsilon- caprolactone) micelles through the evaporation of a cosolvent azeotrope
    • 15290858 10.1023/B:PHAM.0000033005.25698.9c 1:CAS:528: DC%2BD2cXltF2gtrw%3D
    • Jette KK, Law D, Schmitt EA, Kwon GS. Preparation and drug loading of poly(ethylene glycol)-block-poly(epsilon-caprolactone) micelles through the evaporation of a cosolvent azeotrope. Pharm Res. 2004;21:1184-91.
    • (2004) Pharm Res , vol.21 , pp. 1184-1191
    • Jette, K.K.1    Law, D.2    Schmitt, E.A.3    Kwon, G.S.4
  • 29
    • 71649096560 scopus 로고    scopus 로고
    • Cryoprotectants for freeze drying of drug nano-suspensions: Effect of freezing rate
    • 19475555 10.1002/jps.21786 1:CAS:528:DC%2BD1MXhtlCjsLzK
    • Lee MK, Kim MY, Kim S, Lee J. Cryoprotectants for freeze drying of drug nano-suspensions: effect of freezing rate. J Pharm Sci. 2009;98:4808-17.
    • (2009) J Pharm Sci , vol.98 , pp. 4808-4817
    • Lee, M.K.1    Kim, M.Y.2    Kim, S.3    Lee, J.4
  • 30
    • 0342617569 scopus 로고    scopus 로고
    • Role of saccharides for the freeze-thawing and freeze drying of liposome
    • 10.1016/S0169-409X(96)00454-1 1:CAS:528:DyaK2sXhvFans78%3D
    • Miyajima K. Role of saccharides for the freeze-thawing and freeze drying of liposome. Adv Drug Deliv Rev. 1997;24:151-9.
    • (1997) Adv Drug Deliv Rev , vol.24 , pp. 151-159
    • Miyajima, K.1
  • 31
    • 0026597446 scopus 로고
    • Cryoprotective mechanism of saccharides on freeze-drying of liposome
    • 10.1248/cpb.40.1 1:CAS:528:DyaK38XhvVWjsLo%3D
    • Tanaka K, Takeda T, Fujii K, Miyajima K. Cryoprotective mechanism of saccharides on freeze-drying of liposome. Chem Pharm Bull. 1992;40:1-5.
    • (1992) Chem Pharm Bull , vol.40 , pp. 1-5
    • Tanaka, K.1    Takeda, T.2    Fujii, K.3    Miyajima, K.4
  • 32
    • 33646830139 scopus 로고    scopus 로고
    • Investigation of nanocapsules stabilization by amorphous excipients during freeze-drying and storage
    • 16621490 10.1016/j.ejpb.2006.01.015 1:CAS:528:DC%2BD28XltFCgsLc%3D
    • Abdelwahed W, Degobert G, Fessi H. Investigation of nanocapsules stabilization by amorphous excipients during freeze-drying and storage. Eur J Pharm Biopharm. 2006;63:87-94.
    • (2006) Eur J Pharm Biopharm , vol.63 , pp. 87-94
    • Abdelwahed, W.1    Degobert, G.2    Fessi, H.3
  • 33
    • 0034730570 scopus 로고    scopus 로고
    • Stabilization of lipid/DNA complexes during the freezing step of the lyophilization process: The particle isolation hypothesis
    • 11018658 10.1016/S0005-2736(00)00251-0 1:CAS:528:DC%2BD3cXmvFyqsL4%3D
    • Allison SD, Molina MC, Anchordoquy TJ. Stabilization of lipid/DNA complexes during the freezing step of the lyophilization process: the particle isolation hypothesis. Biochim Biophys Acta. 2000;1468:127-38.
    • (2000) Biochim Biophys Acta , vol.1468 , pp. 127-138
    • Allison, S.D.1    Molina, M.C.2    Anchordoquy, T.J.3
  • 34
    • 42449092410 scopus 로고    scopus 로고
    • Macromolecular self-assembly based on inclusion complexation of cyclodextrins
    • 1:CAS:528:DC%2BD2sXlsVSksLk%3D
    • Guo MY, Jiang M. Macromolecular self-assembly based on inclusion complexation of cyclodextrins. Prog Chem. 2007;19:557-66.
    • (2007) Prog Chem , vol.19 , pp. 557-566
    • Guo, M.Y.1    Jiang, M.2
  • 35
    • 65349182946 scopus 로고    scopus 로고
    • Assembling and de-assembling micelles: Competitive interactions of cyclodextrins and drugs with Pluronics
    • 10.1039/b812805g 1:CAS:528:DC%2BD1MXkvVagtbk%3D
    • Dreiss CA, Nwabunwanne E, Liu R, Brooks NJ. Assembling and de-assembling micelles: competitive interactions of cyclodextrins and drugs with Pluronics. Soft Matter. 2009;5:1888-96.
    • (2009) Soft Matter , vol.5 , pp. 1888-1896
    • Dreiss, C.A.1    Nwabunwanne, E.2    Liu, R.3    Brooks, N.J.4
  • 36
    • 33846880687 scopus 로고    scopus 로고
    • Rupturing polymeric micelles with cyclodextrins rupturing polymeric micelles with cyclodextrins
    • 17209594 10.1021/la061850g 1:CAS:528:DC%2BD28Xht1Cnsr%2FO
    • Joseph J, Dreiss CA, Cosgrove T, Pedersen JS. Rupturing polymeric micelles with cyclodextrins rupturing polymeric micelles with cyclodextrins. Langmuir. 2007;23:460-6.
    • (2007) Langmuir , vol.23 , pp. 460-466
    • Joseph, J.1    Dreiss, C.A.2    Cosgrove, T.3    Pedersen, J.S.4
  • 37
    • 77955769890 scopus 로고    scopus 로고
    • Self-assembly of beta-cyclodextrin and pluronic into hollow nanospheres in aqueous solution
    • 20674928 10.1016/j.jcis.2010.07.019 1:CAS:528:DC%2BC3cXhtVGitr7N
    • Qin J, Meng XW, Li BJ, Ha W, Yu XQ, Zhang S. Self-assembly of beta-cyclodextrin and pluronic into hollow nanospheres in aqueous solution. J Colloid Interface Sci. 2010;350:447-52.
    • (2010) J Colloid Interface Sci , vol.350 , pp. 447-452
    • Qin, J.1    Meng, X.W.2    Li, B.J.3    Ha, W.4    Yu, X.Q.5    Zhang, S.6
  • 38
    • 0347550905 scopus 로고    scopus 로고
    • The curious world of polypseudorotaxanes:GÇë cyclodextrins as probes of water structure
    • 10.1021/jp027023f 1:CAS:528:DC%2BD3sXisVOqu7k%3D
    • Becheri A, Lo Nostro P, Ninham BW, Baglioni P. The curious world of polypseudorotaxanes:GÇë cyclodextrins as probes of water structure. J Phys Chem B. 2003;107:3979-87.
    • (2003) J Phys Chem B. , vol.107 , pp. 3979-3987
    • Becheri, A.1    Lo Nostro, P.2    Ninham, B.W.3    Baglioni, P.4
  • 39
    • 18744417270 scopus 로고    scopus 로고
    • Inclusion interaction of highly densely PEO grafted polymer brush and a-cyclodextrin
    • 10.1021/ma0475333 1:CAS:528:DC%2BD2MXislWltL0%3D
    • He L, Huang J, Chen Y, Xu X, Liu L. Inclusion interaction of highly densely PEO grafted polymer brush and a-cyclodextrin. Macromolecules. 2005;38:3845-51.
    • (2005) Macromolecules , vol.38 , pp. 3845-3851
    • He, L.1    Huang, J.2    Chen, Y.3    Xu, X.4    Liu, L.5
  • 40
    • 0036732518 scopus 로고    scopus 로고
    • Water structure theory and some implications for drug design
    • 12356270 10.1211/002235702320402008 1:CAS:528:DC%2BD38XotVGgsrs%3D
    • Plumridge TH, Waigh RD. Water structure theory and some implications for drug design. J Pharm Pharmacol. 2002;54:1155-79.
    • (2002) J Pharm Pharmacol , vol.54 , pp. 1155-1179
    • Plumridge, T.H.1    Waigh, R.D.2
  • 41
    • 20544474519 scopus 로고    scopus 로고
    • How homogeneous are the trehalose, maltose, and sucrose water solutions? An insight from molecular dynamics simulations
    • 16852346 10.1021/jp0468657 1:CAS:528:DC%2BD2MXjvFykurg%3D
    • Lerbret A, Bordat P, Affouard F, Descamps M, Migliardo F. How homogeneous are the trehalose, maltose, and sucrose water solutions? An insight from molecular dynamics simulations. J Phys Chem B. 2005;109:11046-57.
    • (2005) J Phys Chem B. , vol.109 , pp. 11046-11057
    • Lerbret, A.1    Bordat, P.2    Affouard, F.3    Descamps, M.4    Migliardo, F.5
  • 42
    • 0037437477 scopus 로고    scopus 로고
    • Raman scattering study of water clusters around polyrotaxane and pseudopolyrotaxane supramolecular assemblies
    • 12685902 10.1016/S1386-1425(02)00144-0 1:STN:280:DC%2BD3s7mslyrsg%3D%3D
    • Sano H, Ichi T, Kumashiro Y, Kontani K, Kuze T, Mizutani G, Ooya T, Yui N. Raman scattering study of water clusters around polyrotaxane and pseudopolyrotaxane supramolecular assemblies. Spectrochim Acta A Mol Biomol Spectrosc. 2003;59:285-9.
    • (2003) Spectrochim Acta A Mol Biomol Spectrosc , vol.59 , pp. 285-289
    • Sano, H.1    Ichi, T.2    Kumashiro, Y.3    Kontani, K.4    Kuze, T.5    Mizutani, G.6    Ooya, T.7    Yui, N.8
  • 43
    • 51549089810 scopus 로고    scopus 로고
    • Threading a-cyclodextrin through poly[(R, S)-3-hydroxybutyrate] in poly[(R, S)-3-hydroxybutyrate]-poly(ethylene glycol)-poly[(R, S)-3-hydroxybutyrate] triblock copolymers: Formation of block-selected polypseudorotaxanes
    • 10.1021/ma800366v 1:CAS:528:DC%2BD1cXptVOmu74%3D
    • Liu KL, Goh SH, Li J. Threading a-cyclodextrin through poly[(R, S)-3-hydroxybutyrate] in poly[(R, S)-3-hydroxybutyrate]-poly(ethylene glycol)-poly[(R, S)-3-hydroxybutyrate] triblock copolymers: formation of block-selected polypseudorotaxanes. Macromolecules. 2008;41:6027-34.
    • (2008) Macromolecules , vol.41 , pp. 6027-6034
    • Liu, K.L.1    Goh, S.H.2    Li, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.