Cyclosporin A-loaded poly(ethylene glycol)- b -poly(d, l -lactic acid) micelles: Preparation, in vitro and in vivo characterization and transport mechanism across the intestinal barrier

Molecular Pharmaceutics

Volumn 7, Issue 4, 2010, Pages 1169-1182

  Zhang, Yanhui ^a   Li, Xinru ^a   Zhou, Yanxia ^a   Fan, Yating ^a   Wang, Xiaoning ^a   Huang, Yanqing ^a   Liu, Yan ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Caco 2 cells; Cyclosporin A; monomethoxy poly(ethylene glycol) b poly(D,L lactic acid); oral administration; P glycoprotein; polymeric micelles; transport mechanism

Indexed keywords

COPOLYMER; CYCLOSPORIN A; MACROGOL; POLY(ETHYLENE GLYCOL) B POLY(DEXTRO,LEVO LACTIC ACID); UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG TRANSPORT; ELECTRIC RESISTANCE; ENDOCYTOSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CELL; INTESTINE MUCOSA PERMEABILITY; MALE; MAXIMUM PLASMA CONCENTRATION; MICELLE; NONHUMAN; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CACO-2 CELLS; CELL SURVIVAL; CYCLOSPORINE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTESTINES; MALE; MICELLES; MICROSCOPY, CONFOCAL; POLYESTERS; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; RHODAMINES;

EID: 77955239415     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100033k     Document Type: Article

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