Self-assembling PEG-p(CL-co-TMC) copolymers for oral delivery of poorly water-soluble drugs: A case study with risperidone

Journal of Controlled Release

Volumn 102, Issue 3, 2005, Pages 657-668

  Ould Ouali, Louisa ^a   Noppe, Marc ^b   Langlois, Xavier ^b   Willems, Bart ^b   Te Riele, Paula ^b   Timmerman, Philip ^b   Brewster, Marcus E ^b   Ariën, Albertina ^b   Préat, Véronique ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

Caco 2 cells; Oral delivery; PEG p(CL co TMC); Risperidone; Self assembling polymeric micelles

Indexed keywords

BLOCK COPOLYMERS; CELLS; MATHEMATICAL MODELS; MICELLES; ORGANIC ACIDS; PHARMACOKINETICS; POLYETHYLENE GLYCOLS; SELF ASSEMBLY; WATER;

AREAS UNDER THE CURVE (AUC); DRUG DELIVERY; ORAL ADMINISTRATION; WATER-SOLUBLE DRUGS;

DRUG PRODUCTS;

COPOLYMER; DRUG CARRIER; METHOXYPOLY(ETHYLENE GLYCOL)POLY(EPSILON CAPROLACTONE CO TRIMETHYLENE CARBONATE); RISPERIDONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELL LINE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG FORMULATION; DRUG PENETRATION; DRUG RECEPTOR BINDING; DRUG SOLUBILITY; DRUG TRANSPORT; IN VITRO STUDY; IN VIVO STUDY; MALE; MICELLE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; CACO-2 CELLS; DRUG DELIVERY SYSTEMS; HUMANS; LACTONES; MALE; POLYETHYLENE GLYCOLS; POLYMERS; RATS; RATS, WISTAR; RISPERIDONE; SOLUBILITY; WATER;

EID: 12844273736     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.10.022     Document Type: Article

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