메뉴 건너뛰기




Volumn 14, Issue 13, 2013, Pages 1579-1590

A review on the use of statins and tocotrienols, individually or in combination for the treatment of osteoporosis

Author keywords

Combination; HMGCoA reductase; Individaul; Mevlonate; Osteoporosis; Statins; Tocotrienols

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; AMINO TERMINAL TELOPEPTIDE; BISPHOSPHONIC ACID DERIVATIVE; BONE MORPHOGENETIC PROTEIN 2; CALCIUM; CARBOXY TERMINAL TELOPEPTIDE; CERIVASTATIN; DELTA TOCOTRIENOL; DENOSUMAB; ESTROGEN; GAMMA TOCOTRIENOL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; NITRILOTRIACETATE IRON; PARATHYROID HORMONE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; SIMVASTATIN; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; VITAMIN D;

EID: 84889030592     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/13894501113149990193     Document Type: Article
Times cited : (15)

References (158)
  • 1
    • 84887114206 scopus 로고    scopus 로고
    • Statins: Candidates forpromoting bone formation via BMP-2
    • Mori M, Nishikawa T, Masuno K, et al. Statins: candidates forpromoting bone formation via BMP-2. Oral Med Patho 2009; 14: 81-7.
    • (2009) Oral Med Patho , vol.14 , pp. 81-87
    • Mori, M.1    Nishikawa, T.2    Masuno, K.3
  • 2
    • 33644863971 scopus 로고    scopus 로고
    • Nutritional modulators of bone remodeling duringaging
    • Mundy GR. Nutritional modulators of bone remodeling duringaging. Am J Clin Nutr 2006; 83: 427S-430S.
    • (2006) Am J Clin Nutr , vol.83
    • Mundy, G.R.1
  • 4
    • 33847292822 scopus 로고    scopus 로고
    • Anabolic agents and the bone morphogenetic proteinpathway
    • Garrett IR. Anabolic agents and the bone morphogenetic proteinpathway. Curr Top Dev Biol 2007; 78: 127-71
    • (2007) Curr Top Dev Biol , vol.78 , pp. 127-171
    • Garrett, I.R.1
  • 5
    • 3242799093 scopus 로고    scopus 로고
    • Effects of simvastatinon bone turnover and BMD: A 1-year randomized controlled trial in postmenopausal osteopenic women
    • Rejnmark L, Buus NH, Vestergaard P, et al. Effects of simvastatinon bone turnover and BMD: a 1-year randomized controlled trial in postmenopausal osteopenic women. J Bone Miner Res 2004; 19: 737-44.
    • (2004) J Bone Miner Res , vol.19 , pp. 737-744
    • Rejnmark, L.1    Buus, N.H.2    Vestergaard, P.3
  • 6
    • 36849040566 scopus 로고    scopus 로고
    • Effects of atorvastatin onbone in postmenopausal women with dyslipidemia: A double-blind, placebo-controlled, dose-ranging trial
    • Bone HG, Kiel DP, Lindsay RS, et al. Effects of atorvastatin onbone in postmenopausal women with dyslipidemia: a double-blind, placebo-controlled, dose-ranging trial. J Clin Endocrinol Metab 2007; 92: 4671-7.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4671-4677
    • Bone, H.G.1    Kiel, D.P.2    Lindsay, R.S.3
  • 7
    • 62249223586 scopus 로고    scopus 로고
    • Prospective, double blind, randomized, controlled trial of simvastatin in human fracture healing
    • Patil S, Holt G, Raby N, et al, Prospective, double blind, randomized, controlled trial of simvastatin in human fracture healing. J Orthop Res 2009; 27: 281-5.
    • (2009) J Orthop Res , vol.27 , pp. 281-285
    • Patil, S.1    Holt, G.2    Raby, N.3
  • 8
    • 13544250565 scopus 로고    scopus 로고
    • Statins and osteoporosis: A clinical review
    • Gonyeau MJ. Statins and osteoporosis: a clinical review. Pharmacotherapy 2005; 25: 228-43.
    • (2005) Pharmacotherapy , vol.25 , pp. 228-243
    • Gonyeau, M.J.1
  • 9
    • 79957830927 scopus 로고    scopus 로고
    • A systematic review on the relationbetween use of statins and osteoporosis
    • Sharif PS, Abdollahi M, A systematic review on the relationbetween use of statins and osteoporosis. Int J of Pharmacol 2011; 7: 180-8.
    • (2011) Int J of Pharmacol , vol.7 , pp. 180-188
    • Sharif, P.S.1    Abdollahi, M.2
  • 10
    • 0036224272 scopus 로고    scopus 로고
    • Statins and osteoporosis: Can these lipid-lowering drugs also bolster bones?
    • Cruz AC, Gruber BL. Statins and osteoporosis: can these lipid-lowering drugs also bolster bones?. Cleve Clin J Med 2002; 69: 277-88
    • (2002) Cleve Clin J Med , vol.69 , pp. 277-288
    • Cruz, A.C.1    Gruber, B.L.2
  • 11
    • 0000128416 scopus 로고    scopus 로고
    • Does statin use reducerisk of fracture in postmenopausal women? Results from the Women's Health Initiative Observational Study
    • Lacroix AZ, Cauley JA, Jackson R, et al. Does statin use reducerisk of fracture in postmenopausal women? Results from the Women's Health Initiative Observational Study. J Bone Min Res 2000; 15: S155.
    • (2000) J Bone Min Res , vol.15
    • Lacroix, A.Z.1    Cauley, J.A.2    Jackson, R.3
  • 12
    • 4344674934 scopus 로고    scopus 로고
    • Theeffect of atorvastatin on markers of bone turnover in patients with type 2 diabetes
    • Braatvedt GD, Bagg W, Gamble G, Davidson J, Reid IR. Theeffect of atorvastatin on markers of bone turnover in patients with type 2 diabetes. Bone 2004; 35: 766-70.
    • (2004) Bone , vol.35 , pp. 766-770
    • Braatvedt, G.D.1    Bagg, W.2    Gamble, G.3    Davidson, J.4    Reid, I.R.5
  • 14
    • 0031908051 scopus 로고    scopus 로고
    • Osteoporoses: A Rationale for Further Definitions?
    • Frost HM. Osteoporoses: A Rationale for Further Definitions? Calcif Tissue Int 1998; 62: 89-94.
    • (1998) Calcif Tissue Int , vol.62 , pp. 89-94
    • Frost, H.M.1
  • 15
    • 0033978735 scopus 로고    scopus 로고
    • Apoptosis and osteoporosis
    • Weinstein RS, Manolagas, SC. Apoptosis and osteoporosis. Am JMed 2000; 108: 153-64.
    • (2000) Am JMed , vol.108 , pp. 153-164
    • Weinstein, R.S.1    Manolagas, S.C.2
  • 17
    • 0007720082 scopus 로고    scopus 로고
    • Histodinamics of endosseous woundhealing
    • In Davies, J.E. (ed.), Toronto: Em Squared Inc
    • Davies JE, Hosseini, MM. Histodinamics of endosseous woundhealing. In Davies, J.E. (ed.). Bone Engineering. 1-14. Toronto: Em Squared Inc 2000.
    • (2000) Bone Engineering , pp. 1-14
    • Davies, J.E.1    Hosseini, M.M.2
  • 18
    • 34247209572 scopus 로고    scopus 로고
    • Androulakis II. Bone remodeling
    • Hadjidakis DJ, Androulakis II. Bone remodeling. Ann N Y AcadSci 2006; 1092: 385-96.
    • (2006) Ann N Y AcadSci , vol.1092 , pp. 385-396
    • Hadjidakis, D.J.1
  • 19
    • 0002575155 scopus 로고    scopus 로고
    • Radiology of osteoporosis
    • In:Marcus E (ed), Academic, San Diego
    • Steiner E, Jergas M, Genant HK. Radiology of osteoporosis. In:Marcus E (ed) Osteoporosis. Academic, San Diego 1996.
    • (1996) Osteoporosis
    • Steiner, E.1    Jergas, M.2    Genant, H.K.3
  • 20
    • 0036273042 scopus 로고    scopus 로고
    • Misconceptions (2): Turnover is always higher in can-cellous than in cortical bone
    • Parfitt AM. Misconceptions (2): turnover is always higher in can-cellous than in cortical bone. Bone 2002; 30: 807-9.
    • (2002) Bone , vol.30 , pp. 807-809
    • Parfitt, A.M.1
  • 21
    • 58149387662 scopus 로고    scopus 로고
    • Normal bone anatomy and physiology
    • Clarke B. Normal bone anatomy and physiology. Clin J Am SocNephrol 2008, 3: S131-9.
    • (2008) Clin J Am SocNephrol , vol.3
    • Clarke, B.1
  • 22
    • 31044432767 scopus 로고    scopus 로고
    • Pathogenesis of osteoporosis: Concepts, conflicts, andprospects
    • Raisz LG. Pathogenesis of osteoporosis: concepts, conflicts, andprospects. J Clin Invest 2005; 115: 3318-25.
    • (2005) J Clin Invest , vol.115 , pp. 3318-3325
    • Raisz, L.G.1
  • 23
    • 1342268230 scopus 로고    scopus 로고
    • Mortality after osteoporoticfractures
    • Johnell O, Kanis JA, Oden A, et al. Mortality after osteoporoticfractures. Osteoporos Int 2004; 15: 38-42.
    • (2004) Osteoporos Int , vol.15 , pp. 38-42
    • Johnell, O.1    Kanis, J.A.2    Oden, A.3
  • 24
    • 84864819754 scopus 로고    scopus 로고
    • Pathophysiology of osteoporosis: Newmechanistic insights
    • Armas LA, Recker RR. Pathophysiology of osteoporosis: newmechanistic insights. Endocrinol Metab Clin North Am 2012; 41: 475-86.
    • (2012) Endocrinol Metab Clin North Am , vol.41 , pp. 475-486
    • Armas, L.A.1    Recker, R.R.2
  • 25
    • 75949164155 scopus 로고    scopus 로고
    • Perspective on post-menopausal osteoporosis:Establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures
    • McNamara LM. Perspective on post-menopausal osteoporosis:establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures. J R Soc Interface 2010; 7: 353-72.
    • (2010) J R Soc Interface , vol.7 , pp. 353-372
    • McNamara, L.M.1
  • 26
    • 80053304304 scopus 로고    scopus 로고
    • Bone his-tomorphometric study of young rats following oestrogen deficiency
    • Estai MA, Suhaimi F, Soelaiman IN, Shuid AN, Das S. Bone his-tomorphometric study of young rats following oestrogen deficiency. AJB 2011; 10: 12064-70
    • (2011) AJB , vol.10 , pp. 12064-12070
    • Estai, M.A.1    Suhaimi, F.2    Soelaiman, I.N.3    Shuid, A.N.4    Das, S.5
  • 27
    • 33646396235 scopus 로고    scopus 로고
    • Estrogen deficiency and bone loss: Aninflammatory tale
    • Weitzmann MN, Pacifici R. Estrogen deficiency and bone loss: aninflammatory tale. J Clin Invest 2006; 116: 1186-94.
    • (2006) J Clin Invest , vol.116 , pp. 1186-1194
    • Weitzmann, M.N.1    Pacifici, R.2
  • 28
    • 84967614664 scopus 로고    scopus 로고
    • Sex steroids and the construc-tion and conservation of the adult skeleton
    • Riggs BL, Khosla S, Melton LJ 3rd. Sex steroids and the construc-tion and conservation of the adult skeleton. Endocr Rev 2002; 23: 279-302.
    • (2002) Endocr Rev , vol.23 , pp. 279-302
    • Riggs, B.L.1    Khosla, S.2    Melton III, L.J.3
  • 29
    • 0030884639 scopus 로고    scopus 로고
    • The death of osteo-cytes via apoptosis accompanies estrogen withdrawal in human bone
    • Tomkinson A, Reeve J, Shaw RW, Noble BS. The death of osteo-cytes via apoptosis accompanies estrogen withdrawal in human bone. J. Clin. Endocrinol. Metab. 1997; 82: 3128-35.
    • (1997) J. Clin. Endocrinol. Metab , vol.82 , pp. 3128-3135
    • Tomkinson, A.1    Reeve, J.2    Shaw, R.W.3    Noble, B.S.4
  • 30
    • 0035831020 scopus 로고    scopus 로고
    • Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: Dissociation from transcriptional activity
    • Kousteni S, Bellido T, Plotkin LI, et al. Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 2001; 104: 719-30.
    • (2001) Cell , vol.104 , pp. 719-730
    • Kousteni, S.1    Bellido, T.2    Plotkin, L.I.3
  • 32
    • 31944443249 scopus 로고    scopus 로고
    • Osteoporosis: A still increasing prevalence
    • Reginster JY, Burlet N. Osteoporosis: a still increasing prevalence. Bone 2006; 38: S4-9.
    • (2006) Bone , vol.38
    • Reginster, J.Y.1    Burlet, N.2
  • 33
  • 34
    • 79960432551 scopus 로고    scopus 로고
    • Adverse reactions anddrug-drug interactions in the management of women with postmenopausal osteoporosis
    • Rizzoli R, Reginster JY, Boonen S, et al. Adverse reactions anddrug-drug interactions in the management of women with postmenopausal osteoporosis. Calcif Tissue Int 2011; 89:91-104.
    • (2011) Calcif Tissue Int , vol.89 , pp. 91-104
    • Rizzoli, R.1    Reginster, J.Y.2    Boonen, S.3
  • 35
    • 84855738844 scopus 로고    scopus 로고
    • Osteoporosis and the burden of osteoporosis-relatedfractures
    • Dempster DW. Osteoporosis and the burden of osteoporosis-relatedfractures. Am J Manag Care 2011; 17: S164-S169.
    • (2011) Am J Manag Care , vol.17
    • Dempster, D.W.1
  • 36
    • 29944433223 scopus 로고    scopus 로고
    • Bone health of immigrantChinese women living in New York City
    • Babbar RK, Handa AB, Lo CM, et al. Bone health of immigrantChinese women living in New York City. J Community Health.2006; 31: 7-23.
    • (2006) J Community Health , vol.31 , pp. 7-23
    • Babbar, R.K.1    Handa, A.B.2    Lo, C.M.3
  • 37
    • 12544259907 scopus 로고    scopus 로고
    • Osteoporosis andfracture risk in women of different ethnic groups
    • Barrett-Connor E, Siris ES, Wehren LE et al. Osteoporosis andfracture risk in women of different ethnic groups. J Bone Miner Res 2005; 20: 185-94.
    • (2005) J Bone Miner Res , vol.20 , pp. 185-194
    • Barrett-Connor, E.1    Siris, E.S.2    Wehren, L.E.3
  • 38
    • 0036312968 scopus 로고    scopus 로고
    • Ethnic variation inbone density in premenopausal and early perimenopausal women: Effects of anthropometric and lifestyle factors
    • Finkelstein JS, Lee M-LT, Sowers M, et al. Ethnic variation inbone density in premenopausal and early perimenopausal women: effects of anthropometric and lifestyle factors. J Clin Endocrinol Metab 2002; 87: 3057-67.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3057-3067
    • Finkelstein, J.S.1    Lee, M.-L.T.2    Sowers, M.3
  • 39
    • 0037318465 scopus 로고    scopus 로고
    • Bonemineral density in postmenopausal Caucasian, Filipina, and Hispanic women
    • Morton DJ, Barrett-Connor E, Kritz-Silverstein D, et al. Bonemineral density in postmenopausal Caucasian, Filipina, and Hispanic women. Int J Epidemiol 2003; 32: 150-6.
    • (2003) Int J Epidemiol , vol.32 , pp. 150-156
    • Morton, D.J.1    Barrett-Connor, E.2    Kritz-Silverstein, D.3
  • 40
    • 29044443630 scopus 로고    scopus 로고
    • Bone health in urban midlifeMalaysian women: Risk factors and prevention
    • Lim PS, Ong FB, Adeeb N, et al. Bone health in urban midlifeMalaysian women: risk factors and prevention. Osteoporos Int 2005; 16: 2069-79.
    • (2005) Osteoporos Int , vol.16 , pp. 2069-2079
    • Lim, P.S.1    Ong, F.B.2    Adeeb, N.3
  • 41
    • 84856324432 scopus 로고    scopus 로고
    • Calcaneal quantita-tive ultrasound value for middle-aged and elderly Malaysian Chinese men and its association with age and body anthropometry
    • Chin KY, Ima-Nirwana S, Isa Naina M, et al. Calcaneal quantita-tive ultrasound value for middle-aged and elderly Malaysian Chinese men and its association with age and body anthropometry. J Clin Densitom 2012; 15: 86-91.
    • (2012) J Clin Densitom , vol.15 , pp. 86-91
    • Chin, K.Y.1    Ima-Nirwana, S.2    Isa, N.M.3
  • 42
    • 84869797749 scopus 로고    scopus 로고
    • Testosterone is asso-ciated with age-related changes in bone health status, muscle strength and body composition in men
    • Chin KY, Soelaiman IN, Mohamed IN, et al. Testosterone is asso-ciated with age-related changes in bone health status, muscle strength and body composition in men. Aging Male 2012; 15: 240-5.
    • (2012) Aging Male , vol.15 , pp. 240-245
    • Chin, K.Y.1    Soelaiman, I.N.2    Mohamed, I.N.3
  • 46
    • 33750209491 scopus 로고    scopus 로고
    • An estimate of the worldwide prevalence anddisability associated with osteoporotic fractures
    • Johnell O, Kanis. An estimate of the worldwide prevalence anddisability associated with osteoporotic fractures. Osteoporos Int 2006; 17: 1726-33.
    • (2006) Osteoporos Int , vol.17 , pp. 1726-1733
    • Johnell, O.1    Kanis2
  • 47
    • 0030023788 scopus 로고    scopus 로고
    • The epidemiology of osteoporosis: The ori-ental perspective in a world context
    • Lau EMC, Cooper C. The epidemiology of osteoporosis: The ori-ental perspective in a world context. Clin Orthop Relat Res 1999; 323: 65-74.
    • (1999) Clin Orthop Relat Res , vol.323 , pp. 65-74
    • Lau, E.M.C.1    Cooper, C.2
  • 49
  • 50
    • 0030964587 scopus 로고    scopus 로고
    • The socioeconomic burden of fractures: Today and in the21st century
    • Johnell O. The socioeconomic burden of fractures: today and in the21st century. Am J Med 1997; 103: S25-S26.
    • (1997) Am J Med , vol.103
    • Johnell, O.1
  • 51
    • 34247194211 scopus 로고    scopus 로고
    • Incidence andeconomic burden of osteoporotic fractures in the United States, 2005-2025
    • Burge RT, Dawson-Hughes B, Solomon D, et al. Incidence andeconomic burden of osteoporotic fractures in the United States, 2005-2025. J Bone Min Res 2007; 22: 465-75.
    • (2007) J Bone Min Res , vol.22 , pp. 465-475
    • Burge, R.T.1    Dawson-Hughes, B.2    Solomon, D.3
  • 52
    • 36749090663 scopus 로고    scopus 로고
    • The incidence of hip fracture in Malaysiansabove 50 years of age: Variation in different ethnic groups
    • Lee JK and Khir ASM. The incidence of hip fracture in Malaysiansabove 50 years of age: variation in different ethnic groups. J Rheumatol 2007; 10: 300-5.
    • (2007) J Rheumatol , vol.10 , pp. 300-305
    • Lee, J.K.1    Khir, A.S.M.2
  • 54
    • 0037129560 scopus 로고    scopus 로고
    • Epidemiology and outcomes of osteo-porotic fractures
    • Cummings SR, Melton JR. Epidemiology and outcomes of osteo-porotic fractures. Lancet 2002; 359: 1761-7.
    • (2002) Lancet , vol.359 , pp. 1761-1767
    • Cummings, S.R.1    Melton, J.R.2
  • 55
    • 18844467137 scopus 로고    scopus 로고
    • The contributionof hip fracture to risk of subsequent fractures: Data from two longitudinal studies
    • Colon-Emeric C, Kuchibhatla M, Pieper C, et al. The contributionof hip fracture to risk of subsequent fractures: data from two longitudinal studies. Osteoporos Int 2003; 14: 879-83.
    • (2003) Osteoporos Int , vol.14 , pp. 879-883
    • Colon-Emeric, C.1    Kuchibhatla, M.2    Pieper, C.3
  • 56
    • 50949105327 scopus 로고    scopus 로고
    • An overview of bone sonometry
    • Laugier P. An overview of bone sonometry. Int Congr 2004; 1274:23-32.
    • (2004) Int Congr , vol.1274 , pp. 23-32
    • Laugier, P.1
  • 57
    • 84876282174 scopus 로고    scopus 로고
    • The effects of age, physical activity level, and body anthropometry on calcaneal speed of sound value in men
    • Chin KY, Soelaiman IN, Mohamed IN, Ibrahim S, Wan Ngah WZ.The effects of age, physical activity level, and body anthropometry on calcaneal speed of sound value in men. Arch Osteoporos 2012; 7: 135-45.
    • (2012) Arch Osteoporos , vol.7 , pp. 135-145
    • Chin, K.Y.1    Soelaiman, I.N.2    Mohamed, I.N.3    Ibrahim, S.4    Wan, N.W.Z.5
  • 58
    • 84877066896 scopus 로고    scopus 로고
    • Discrepancy betweenthe quantitative ultrasound value of malaysian men and the manufacturer's reference and the impact on classification of bone health status
    • Chin KY, Soelaiman IN, Mohamed IN, et al. Discrepancy betweenthe quantitative ultrasound value of malaysian men and the manufacturer's reference and the impact on classification of bone health status. J Clin Densitom 2013; 16: 189-95.
    • (2013) J Clin Densitom , vol.16 , pp. 189-195
    • Chin, K.Y.1    Soelaiman, I.N.2    Mohamed, I.N.3
  • 59
    • 0036793740 scopus 로고    scopus 로고
    • Bone mineraldensity, ultrasound velocity, and broadband attenuation predict mechanical properties of trabecular bone differently
    • Töyräs J, Nieminen MT, Kröger H, Jurvelin JS. Bone mineraldensity, ultrasound velocity, and broadband attenuation predict mechanical properties of trabecular bone differently. Bone 2002; 31: 503-7.
    • (2002) Bone , vol.31 , pp. 503-507
    • Töyräs, J.1    Nieminen, M.T.2    Kröger, H.3    Jurvelin, J.S.4
  • 60
    • 84863465694 scopus 로고    scopus 로고
    • Statins, bone formationand osteoporosis: Hope or hype?
    • Tsartsalis AN, Dokos C, Kaiafa GD, et al. Statins, bone formationand osteoporosis: hope or hype? Hormones (Athens) 2012; 11: 126-39.
    • (2012) Hormones (Athens) , vol.11 , pp. 126-139
    • Tsartsalis, A.N.1    Dokos, C.2    Kaiafa, G.D.3
  • 62
    • 79551518845 scopus 로고    scopus 로고
    • Use of biphosphonates in the management ofpostmenopausal osteoporosis
    • Papapoulos SE. Use of biphosphonates in the management ofpostmenopausal osteoporosis. Ann N Y Acad Sci 2011; 1218: 15-32.
    • (2011) Ann N Y Acad Sci , vol.1218 , pp. 15-32
    • Papapoulos, S.E.1
  • 63
    • 77649183118 scopus 로고    scopus 로고
    • Molecular biology of bone remodeling: Im-plications for new therapeutic targets for osteoporosis
    • Gallagher JC, Sai AJ. Molecular biology of bone remodeling: im-plications for new therapeutic targets for osteoporosis. Maturitas 2010; 65: 301-7.
    • (2010) Maturitas , vol.65 , pp. 301-307
    • Gallagher, J.C.1    Sai, A.J.2
  • 65
    • 66649092722 scopus 로고    scopus 로고
    • Effects of alendronateon the proliferation and osteogenic differentiation of MG-63 cells
    • Xiong Y, Yang HJ, Feng J, Shi ZL, Wu LD. Effects of alendronateon the proliferation and osteogenic differentiation of MG-63 cells. J Int Med Res 2009; 37: 407-16.
    • (2009) J Int Med Res , vol.37 , pp. 407-416
    • Xiong, Y.1    Yang, H.J.2    Feng, J.3    Shi, Z.L.4    Wu, L.D.5
  • 66
    • 80055049165 scopus 로고    scopus 로고
    • Zoledronate, ibandronateand clodronate enhance osteoblast differentiation in a dose dependent manner-a quantitative in vitro gene expression analysis of Dlx5, Runx2, OCN, MSX1 and MSX2
    • Koch FP, Merkel C, Al-Nawas B, et al. Zoledronate, ibandronateand clodronate enhance osteoblast differentiation in a dose dependent manner-a quantitative in vitro gene expression analysis of Dlx5, Runx2, OCN, MSX1 and MSX2. J Craniomaxillofac Surg. 2011; 39: 562-9.
    • (2011) J Craniomaxillofac Surg , vol.39 , pp. 562-569
    • Koch, F.P.1    Merkel, C.2    Al-Nawas, B.3
  • 67
    • 38449103233 scopus 로고    scopus 로고
    • The differential effects ofbisphosphonates, SERMS (selective estrogen receptor modulators), and parathyroid hormone on bone remodeling in osteoporosis
    • Migliaccio S, Brama M, and Spera G. The differential effects ofbisphosphonates, SERMS (selective estrogen receptor modulators), and parathyroid hormone on bone remodeling in osteoporosis. Clin Interv Aging 2007; 2: 55-64.
    • (2007) Clin Interv Aging , vol.2 , pp. 55-64
    • Migliaccio, S.1    Brama, M.2    Spera, G.3
  • 68
    • 78349263788 scopus 로고    scopus 로고
    • Continuous Elevation of PTH Increases the Number of Osteoblasts via Both Osteoclast-Dependent and-Independent Mechanisms
    • Jilka RL, O'Brien CA, Bartell SM, Weinstein RS, Manolagas SC. Continuous Elevation of PTH Increases the Number of Osteoblasts via Both Osteoclast-Dependent and-Independent Mechanisms. J Bone Miner Res 2010; 25: 2427-37.
    • (2010) J Bone Miner Res , vol.25 , pp. 2427-2437
    • Jilka, R.L.1    O'Brien, C.A.2    Bartell, S.M.3    Weinstein, R.S.4    Manolagas, S.C.5
  • 70
    • 0035212177 scopus 로고    scopus 로고
    • Statins and their potential for osteoporosis
    • Mundy GR. Statins and their potential for osteoporosis. Bone 2001;29: 495-7.
    • (2001) Bone , vol.29 , pp. 495-497
    • Mundy, G.R.1
  • 71
    • 0037007254 scopus 로고    scopus 로고
    • Statins: Powerful drugs for lowering cholesterol
    • Gotto AM. Statins: Powerful drugs for lowering cholesterol. Circu-lation 2002; 105: 1514-6.
    • (2002) Circu-lation , vol.105 , pp. 1514-1516
    • Gotto, A.M.1
  • 73
    • 33645160437 scopus 로고    scopus 로고
    • Statins and bone metabolism
    • Horiuchi N, Maeda T. Statins and bone metabolism. Oral Dis 2006;12: 85-10.
    • (2006) Oral Dis , vol.12 , pp. 85-110
    • Horiuchi, N.1    Maeda, T.2
  • 75
    • 84860792378 scopus 로고    scopus 로고
    • Pleiotropic effects of the HMG-CoA reduc-tase inhibitors
    • Mihos CG, Santana O. Pleiotropic effects of the HMG-CoA reduc-tase inhibitors. Int J Gen Med 2011; 4: 261-71.
    • (2011) Int J Gen Med , vol.4 , pp. 261-271
    • Mihos, C.G.1    Santana, O.2
  • 78
    • 79751531393 scopus 로고    scopus 로고
    • Heart disease and strokestatistics-2011 update: A report from the american heart association
    • Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and strokestatistics-2011 update: A report from the american heart association. Circulation 2011; 123: e18-e209.
    • (2011) Circulation , vol.123
    • Roger, V.L.1    Go, A.S.2    Lloyd-Jones, D.M.3
  • 79
    • 71849095929 scopus 로고    scopus 로고
    • Effect of lovastatin onprimary prevention of cardiovascular events in mild CKD and kidney function loss: A post hoc analysis of the Air Force/Texas Coronary Atherosclerosis Prevention Study
    • Kendrick J, Shlipak MG, Targher G, et al. Effect of lovastatin onprimary prevention of cardiovascular events in mild CKD and kidney function loss: a post hoc analysis of the Air Force/Texas Coronary Atherosclerosis Prevention Study. Am J Kidney Dis 2010; 55: 42-49.
    • (2010) Am J Kidney Dis , vol.55 , pp. 42-49
    • Kendrick, J.1    Shlipak, M.G.2    Targher, G.3
  • 80
    • 79952052016 scopus 로고    scopus 로고
    • Statins for the primary preven-tion of cardiovascular disease
    • Taylor F, Ward K, Moore TH, et al. Statins for the primary preven-tion of cardiovascular disease. Cochrane Database Syst Rev 2011; 1: CD004816.
    • (2011) Cochrane Database Syst Rev , vol.1
    • Taylor, F.1    Ward, K.2    Moore, T.H.3
  • 81
    • 27444436456 scopus 로고    scopus 로고
    • Relationship betweenosteoporosis and cardiovascular disease in postmenopausal women
    • Tanko LB, Christiansen C, Cox DA, et al. Relationship betweenosteoporosis and cardiovascular disease in postmenopausal women. J Bone Miner Res 2005; 20: 1912-20.
    • (2005) J Bone Miner Res , vol.20 , pp. 1912-1920
    • Tanko, L.B.1    Christiansen, C.2    Cox, D.A.3
  • 82
    • 84872375027 scopus 로고    scopus 로고
    • Mechanisms of bone anabolism regu-lated by statins
    • Ruan F, Zheng Q, Wang J. Mechanisms of bone anabolism regu-lated by statins. Biosci Rep 2012; 32: 511-9.
    • (2012) Biosci Rep , vol.32 , pp. 511-519
    • Ruan, F.1    Zheng, Q.2    Wang, J.3
  • 83
    • 0036485685 scopus 로고    scopus 로고
    • Nitric oxide as the mediator of the antiosteoporotic ac-tions of estrogen, statins, and essential fatty acids
    • Das UN. Nitric oxide as the mediator of the antiosteoporotic ac-tions of estrogen, statins, and essential fatty acids. Exp Biol Med (Maywood) 2002; 227: 88-93.
    • (2002) Exp Biol Med (Maywood) , vol.227 , pp. 88-93
    • Das, U.N.1
  • 84
    • 0035985804 scopus 로고    scopus 로고
    • The role of statins as potential targets forbone formation
    • Garrett IR, Mundy GR. The role of statins as potential targets forbone formation. Arthritis Res 2002; 4: 237-40.
    • (2002) Arthritis Res , vol.4 , pp. 237-240
    • Garrett, I.R.1    Mundy, G.R.2
  • 85
    • 84993740371 scopus 로고    scopus 로고
    • The role of 3-hydroxy-3-methylglutaryl coenzyme areductase inhibitors (statins) in modern rheumatology
    • Kotyla P. The role of 3-hydroxy-3-methylglutaryl coenzyme areductase inhibitors (statins) in modern rheumatology. Ther Adv Musculoskelet Dis 2010; 2: 257-69.
    • (2010) Ther Adv Musculoskelet Dis , vol.2 , pp. 257-269
    • Kotyla, P.1
  • 87
    • 0037214223 scopus 로고    scopus 로고
    • The ability of statins to inhibitbone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity
    • Staal A, Frith JC, French MH, et al. The ability of statins to inhibitbone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity. J Bone Miner Res 2003; 18: 88-96.
    • (2003) J Bone Miner Res , vol.18 , pp. 88-96
    • Staal, A.1    Frith, J.C.2    French, M.H.3
  • 88
    • 0033521078 scopus 로고    scopus 로고
    • Stimulation of bone formationin vitro and in rodents by statins
    • Mundy G, Garrett R, Harris S, et al. Stimulation of bone formationin vitro and in rodents by statins. Science 1999; 286: 1946-9.
    • (1999) Science , vol.286 , pp. 1946-1949
    • Mundy, G.1    Garrett, R.2    Harris, S.3
  • 89
    • 0035724388 scopus 로고    scopus 로고
    • Effect of statins onbone mineral density and bone histomorphometry in rodents
    • Maritz FJ, Conradie MM, Hulley PA, et al. Effect of statins onbone mineral density and bone histomorphometry in rodents. Arterioscler Thromb Vasc Biol 2001; 21: 1636-41.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1636-1641
    • Maritz, F.J.1    Conradie, M.M.2    Hulley, P.A.3
  • 90
    • 0035211808 scopus 로고    scopus 로고
    • Statin given perorally toadult rats increases cancellous bone mass and compressive strength
    • Oxlund H, Dalstra M, Andreassen TT. Statin given perorally toadult rats increases cancellous bone mass and compressive strength. Calcif Tissue Int 2001; 69: 299-304.
    • (2001) Calcif Tissue Int , vol.69 , pp. 299-304
    • Oxlund, H.1    Dalstra, M.2    Andreassen, T.T.3
  • 93
    • 33750466154 scopus 로고    scopus 로고
    • Simvastatin did not preventnor restore ovariectomy-induced bone loss in adult rats
    • Yao W., Farmer R., Cooper R., et al. Simvastatin did not preventnor restore ovariectomy-induced bone loss in adult rats, J Musculoskelet Neuronal Interact 2006; 6: 277-83.
    • (2006) J Musculoskelet Neuronal Interact , vol.6 , pp. 277-283
    • Yao, W.1    Farmer, R.2    Cooper, R.3
  • 94
    • 84866146318 scopus 로고    scopus 로고
    • Effects oftocotrienol and lovastatin combination on osteoblast and osteoclast activity in estrogen-deficient osteoporosis
    • Abdul-Majeed S, Mohamed N, and Soelaiman IN. Effects oftocotrienol and lovastatin combination on osteoblast and osteoclast activity in estrogen-deficient osteoporosis. Evid Based Complement Alternat Med 2012; 2012: 960742.
    • (2012) Evid Based Complement Alternat Med , vol.2012 , pp. 960742
    • Abdul-Majeed, S.1    Mohamed, N.2    Soelaiman, I.N.3
  • 95
    • 54249137180 scopus 로고    scopus 로고
    • Transdermal lovas-tatin enhances fracture repair in rats
    • Gutierrez GE, Edwards JR, Garrett IR, et al. Transdermal lovas-tatin enhances fracture repair in rats. J Bone Miner Res 2008; 23: 1722-30.
    • (2008) J Bone Miner Res , vol.23 , pp. 1722-1730
    • Gutierrez, G.E.1    Edwards, J.R.2    Garrett, I.R.3
  • 96
    • 33751256268 scopus 로고    scopus 로고
    • Distribu-tion of lovastatin to bone and its effect on bone turnover in rats
    • Jadhav SB, Narayana Murthy PS, Singh MM, Jain GK. Distribu-tion of lovastatin to bone and its effect on bone turnover in rats. J Pharm Pharmacol 2006; 58: 1451-8.
    • (2006) J Pharm Pharmacol , vol.58 , pp. 1451-1458
    • Jadhav, S.B.1    Narayana, M.P.S.2    Singh, M.M.3    Jain, G.K.4
  • 97
    • 0942276470 scopus 로고    scopus 로고
    • Use of statins and fracture:Results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trials
    • Bauer DC, Mundy GR, Jamal SA, et al. Use of statins and fracture:results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trials. Arch Intern Med 2004; 164:146-52.
    • (2004) Arch Intern Med , vol.164 , pp. 146-152
    • Bauer, D.C.1    Mundy, G.R.2    Jamal, S.A.3
  • 98
    • 34249105908 scopus 로고    scopus 로고
    • Effects of statins on bonemineral density: A meta-analysis of clinical studies
    • Uzzan B, Cohen R, Nicolas P, et al. Effects of statins on bonemineral density: a meta-analysis of clinical studies. Bone 2007; 40: 1581-7.
    • (2007) Bone , vol.40 , pp. 1581-1587
    • Uzzan, B.1    Cohen, R.2    Nicolas, P.3
  • 99
    • 77957722872 scopus 로고    scopus 로고
    • Statins and bone health inpostmenopausal women: A systematic review of randomized controlled trials
    • Yue J, Zhang X, Dong B, Yang M. Statins and bone health inpostmenopausal women: a systematic review of randomized controlled trials. Menopause 2010; 17: 1071-9.
    • (2010) Menopause , vol.17 , pp. 1071-1079
    • Yue, J.1    Zhang, X.2    Dong, B.3    Yang, M.4
  • 101
    • 23744495979 scopus 로고    scopus 로고
    • Hydroxymethylglutaryl-coenzyme Areductase inhibitors and osteoporosis: A meta-analysis
    • Hatzigeorgiou C, Jackson JL. Hydroxymethylglutaryl-coenzyme Areductase inhibitors and osteoporosis: a meta-analysis. Osteoporos Int 2005; 16: 990-8.
    • (2005) Osteoporos Int , vol.16 , pp. 990-998
    • Hatzigeorgiou, C.1    Jackson, J.L.2
  • 102
    • 0031881755 scopus 로고    scopus 로고
    • Hydrophilicity/lipophilicity: Relevance forthe pharmacology and clinical effects of HMG-CoA reductase inhibitors
    • Hamelin BA, Turgeon J. Hydrophilicity/lipophilicity: relevance forthe pharmacology and clinical effects of HMG-CoA reductase inhibitors. Trends Pharmacol Sci 1998; 19: 26-37.
    • (1998) Trends Pharmacol Sci , vol.19 , pp. 26-37
    • Hamelin, B.A.1    Turgeon, J.2
  • 103
    • 59549089180 scopus 로고    scopus 로고
    • Statin adverse effects: A review of theliterature and evidence for a mitochondrial mechanism
    • Golomb BA, Evans MA. Statin adverse effects: a review of theliterature and evidence for a mitochondrial mechanism. Am J Cardiovasc Drugs 2008; 8: 373-418.
    • (2008) Am J Cardiovasc Drugs , vol.8 , pp. 373-418
    • Golomb, B.A.1    Evans, M.A.2
  • 104
    • 47849096593 scopus 로고    scopus 로고
    • Relative safety profiles of highdose statin regimens
    • Escobar C, Echarri R, Barrios V. Relative safety profiles of highdose statin regimens. Vasc Health Risk Manag. 2008; 4: 525-533.
    • (2008) Vasc Health Risk Manag , vol.4 , pp. 525-533
    • Escobar, C.1    Echarri, R.2    Barrios, V.3
  • 105
    • 79955961513 scopus 로고    scopus 로고
    • Considerations for safe use of statins: Liverenzyme abnormalities and muscle toxicity
    • Gillett RG, Norrell A. Considerations for safe use of statins: liverenzyme abnormalities and muscle toxicity. Am Fam Physician 2011; 83: 711-6.
    • (2011) Am Fam Physician , vol.83 , pp. 711-716
    • Gillett, R.G.1    Norrell, A.2
  • 106
    • 33645881669 scopus 로고    scopus 로고
    • Statin safety: A systematic review
    • Law M, Rudnicka AR. Statin safety: a systematic review. Am JCardiol 2006; 97: 52C-60C.
    • (2006) Am JCardiol , vol.97
    • Law, M.1    Rudnicka, A.R.2
  • 107
    • 35748962429 scopus 로고    scopus 로고
    • The safety of statins in clinical practice
    • Armitage J. The safety of statins in clinical practice. Lancet 2007;370(9601): 1781-90.
    • (2007) Lancet , vol.370 , Issue.9601 , pp. 1781-1790
    • Armitage, J.1
  • 108
    • 0037075262 scopus 로고    scopus 로고
    • Cerivastatin and reports of fatal rhab-domyolysis
    • Staffa JA, Chang J, Green L. Cerivastatin and reports of fatal rhab-domyolysis. N Engl J Med 2002; 346: 539-40.
    • (2002) N Engl J Med , vol.346 , pp. 539-540
    • Staffa, J.A.1    Chang, J.2    Green, L.3
  • 109
    • 0035528772 scopus 로고    scopus 로고
    • Statins: Mechanism of action and effects
    • Stancu C, Sima A. Statins: mechanism of action and effects. J CellMol Med. 2001; 5: 378-87.
    • (2001) J CellMol Med , vol.5 , pp. 378-387
    • Stancu, C.1    Sima, A.2
  • 111
    • 35448977648 scopus 로고    scopus 로고
    • Vitamin E: An overview of major research directions
    • Zingg, J.M. Vitamin E: An overview of major research directions. Mol. Aspects Med 2007; 28: 400-22.
    • (2007) Mol. Aspects Med , vol.28 , pp. 400-422
    • Zingg, J.M.1
  • 112
    • 33644891347 scopus 로고    scopus 로고
    • Tocotrienols: Vitamin E beyond toco-pherols
    • Sen CK, Khanna S, Roy S. Tocotrienols: Vitamin E beyond toco-pherols. Life Sci. 2006; 78: 2088-98.
    • (2006) Life Sci , vol.78 , pp. 2088-2098
    • Sen, C.K.1    Khanna, S.2    Roy, S.3
  • 113
    • 35448976819 scopus 로고    scopus 로고
    • Tocotrienols in health and disease: Theother half of the natural vitamin
    • Sen CK, Khanna S, Roy S. Tocotrienols in health and disease: theother half of the natural vitamin E family. Mol Aspects Med 2007; 28: 692-728.
    • (2007) E Family. Mol Aspects Med , vol.28 , pp. 692-728
    • Sen, C.K.1    Khanna, S.2    Roy, S.3
  • 114
    • 77957909450 scopus 로고    scopus 로고
    • Tocotrienols,the vitamin E of the 21st century: Its potential against cancer and other chronic diseases
    • Aggarwal BB, Sundaram C, Prasad S, Kannappan R. Tocotrienols,the vitamin E of the 21st century: its potential against cancer and other chronic diseases. Biochem Pharmacol 2010; 80(11): 1613-31.
    • (2010) Biochem Pharmacol , vol.80 , Issue.11 , pp. 1613-1631
    • Aggarwal, B.B.1    Sundaram, C.2    Prasad, S.3    Kannappan, R.4
  • 115
    • 0032318592 scopus 로고    scopus 로고
    • Identification and estimation oftocotrienols in the annatto lipid fraction by gas chromatographymass spectrometry
    • Frega N, Mozzon M, Bocci F. Identification and estimation oftocotrienols in the annatto lipid fraction by gas chromatographymass spectrometry. J Am Oil Chem Soc 1998; 75: 1723-7.
    • (1998) J Am Oil Chem Soc , vol.75 , pp. 1723-1727
    • Frega, N.1    Mozzon, M.2    Bocci, F.3
  • 116
    • 33748744385 scopus 로고    scopus 로고
    • Insig-dependent ubiquitination anddegradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by-and-tocotrienols
    • Song BL, DeBose-Boyd RA. Insig-dependent ubiquitination anddegradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by-and-tocotrienols. J Biol Chem 2006; 281: 25054-61.
    • (2006) J Biol Chem , vol.281 , pp. 25054-25061
    • Song, B.L.1    Debose-Boyd, R.A.2
  • 117
    • 0035146939 scopus 로고    scopus 로고
    • Noveltocotrienols of rice bran suppress cholesterogenesis in hereditary hypercholesterolemic swine
    • Qureshi AA, Peterson DM, Hasler-Rapacz JO, Rapacz J. Noveltocotrienols of rice bran suppress cholesterogenesis in hereditary hypercholesterolemic swine. J Nutr 2001; 131: 223-30.
    • (2001) J Nutr , vol.131 , pp. 223-230
    • Qureshi, A.A.1    Peterson, D.M.2    Hasler-Rapacz, J.O.3    Rapacz, J.4
  • 118
    • 33646790544 scopus 로고    scopus 로고
    • A rice bran oil diet increases LDL-receptorand HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes
    • Chen CW, Cheng HH. A rice bran oil diet increases LDL-receptorand HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. J Nutr 2006; 136: 1472-6.
    • (2006) J Nutr , vol.136 , pp. 1472-1476
    • Chen, C.W.1    Cheng, H.H.2
  • 119
    • 22344435450 scopus 로고    scopus 로고
    • Effects of vegetal oil supple-mentation on the lipid profile of Wistar rats
    • Poveda E, Ayala P, Milena R, et al. Effects of vegetal oil supple-mentation on the lipid profile of Wistar rats. Biomedica 2005; 25: 101-9.
    • (2005) Biomedica , vol.25 , pp. 101-109
    • Poveda, E.1    Ayala, P.2    Milena, R.3
  • 120
    • 68749121983 scopus 로고    scopus 로고
    • The effects of palm oil tocotrienolrich fraction supplementation on biochemical parameters, oxidative stress and the vascular wall of streptozotocin-induced diabetic rats
    • Budin SB, Othman F, Louis SR, Bakar MA, Das S, Mohamed J. The effects of palm oil tocotrienolrich fraction supplementation on biochemical parameters, oxidative stress and the vascular wall of streptozotocin-induced diabetic rats. Clinics (Sao Paulo) 2009; 64: 235-44.
    • (2009) Clinics (Sao Paulo) , vol.64 , pp. 235-244
    • Budin, S.B.1    Othman, F.2    Louis, S.R.3    Bakar, M.A.4    Das, S.5    Mohamed, J.6
  • 121
    • 0036188413 scopus 로고    scopus 로고
    • Dose-dependentsuppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans
    • Qureshi AA, Sami SA, Salser WA, Khan FA. Dose-dependentsuppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans. Atherosclerosis 2002;161: 199-207.
    • (2002) Atherosclerosis , vol.161 , pp. 199-207
    • Qureshi, A.A.1    Sami, S.A.2    Salser, W.A.3    Khan, F.A.4
  • 122
    • 0034975893 scopus 로고    scopus 로고
    • Synergistic effect oftocotrienol-rich fraction (TRF(25)) of rice bran and lovastatin on lipid parameters in hypercholesterolemic humans
    • Qureshi AA, Sami SA, Salser WA, Khan FA. Synergistic effect oftocotrienol-rich fraction (TRF(25)) of rice bran and lovastatin on lipid parameters in hypercholesterolemic humans. J Nutr Biochem 2001; 12: 318-29.
    • (2001) J Nutr Biochem , vol.12 , pp. 318-329
    • Qureshi, A.A.1    Sami, S.A.2    Salser, W.A.3    Khan, F.A.4
  • 123
    • 16244371588 scopus 로고    scopus 로고
    • Effects of palm vita-min E, vitamin D and calcium supplementation on bone metabolism in vitamin E deficient rats
    • Norazlina M, Ima Nirwana S, Khalid BAK. Effects of palm vita-min E, vitamin D and calcium supplementation on bone metabolism in vitamin E deficient rats. Medical Journal of Islamic Academy of Science 1999; 12: 89-96.
    • (1999) Medical Journal of Islamic Academy of Science , vol.12 , pp. 89-96
    • Norazlina, M.1    Ima, N.S.2    Khalid, B.A.K.3
  • 125
    • 0036378262 scopus 로고    scopus 로고
    • Tocotrienols are needed for normal bone calcification in growing female rats
    • Norazlina M, Ima-Nirwana S, Abul Gapor MT, Abdul Kadir Khalid B. Tocotrienols are needed for normal bone calcification in growing female rats. Asia Pac J Clin Nutr 2002; 11: 194-9.
    • (2002) Asia Pac J Clin Nutr , vol.11 , pp. 194-199
    • Norazlina, M.1    Ima-Nirwana, S.2    Abul, G.M.T.3    Abdul, K.K.B.4
  • 126
    • 20544431805 scopus 로고    scopus 로고
    • Vitamin E deficiencyreduced lumbar bone calcium content in female rats
    • Norazlina M, Chua CW, Ima-Nirwana S. Vitamin E deficiencyreduced lumbar bone calcium content in female rats. Med J Malaysia 2004; 59: 623-30.
    • (2004) Med J Malaysia , vol.59 , pp. 623-630
    • Norazlina, M.1    Chua, C.W.2    Ima-Nirwana, S.3
  • 127
    • 84979834397 scopus 로고    scopus 로고
    • Palm vitamin E protects boneagainst dexamethasone-induced osteoporosis in male rats
    • Ima-Nirwana S, Fakhrurazi H. Palm vitamin E protects boneagainst dexamethasone-induced osteoporosis in male rats. Med J Malaysia 2002; 57: 136-44.
    • (2002) Med J Malaysia , vol.57 , pp. 136-144
    • Ima-Nirwana, S.1    Fakhrurazi, H.2
  • 128
    • 0034464445 scopus 로고    scopus 로고
    • Palm vitamin E pre-vents osteoporosis in orchidectomized growing male rats
    • Ima-Nirwana S, Kiftiah A, Zainal AG, et al. Palm vitamin E pre-vents osteoporosis in orchidectomized growing male rats. Nat Prod Sci 2000; 6: 155-60.
    • (2000) Nat Prod Sci , vol.6 , pp. 155-160
    • Ima-Nirwana, S.1    Kiftiah, A.2    Zainal, A.G.3
  • 129
    • 0033924636 scopus 로고    scopus 로고
    • Palm vitamin E is comparable to alpha-tocopherol in maintaining bone mineral density in ovariectomised female rats
    • Norazlina M, Ima-Nirwana S, Gapor MT, Khalid BA. Palm vitamin E is comparable to alpha-tocopherol in maintaining bone mineral density in ovariectomised female rats. Exp Clin Endocrinol Diabetes 2000; 108: 305-10.
    • (2000) Exp Clin Endocrinol Diabetes , vol.108 , pp. 305-310
    • Norazlina, M.1    Ima-Nirwana, S.2    Gapor, M.T.3    Khalid, B.A.4
  • 130
    • 26444503640 scopus 로고    scopus 로고
    • Tocotrienol is required fornormal vitamin D metabolism in female rats
    • Norazlina M, Ng FW, Ima-Nirwana S.-Tocotrienol is required fornormal vitamin D metabolism in female rats. Indian J Pharmacol 2005; 37: 309-14.
    • (2005) Indian J Pharmacol , vol.37 , pp. 309-314
    • Norazlina, M.1    Ng, F.W.2    Ima-Nirwana, S.3
  • 131
    • 1842476274 scopus 로고    scopus 로고
    • Effects of tocopherols and tocotrienolson body composition and bone calcium content in adrenalectomized rats replaced with dexamethasone
    • Ima-Nirwana S, Suhaniza S. Effects of tocopherols and tocotrienolson body composition and bone calcium content in adrenalectomized rats replaced with dexamethasone. J Med Food 2004; 7: 45-51.
    • (2004) J Med Food , vol.7 , pp. 45-51
    • Ima-Nirwana, S.1    Suhaniza, S.2
  • 132
    • 77956856747 scopus 로고    scopus 로고
    • Nicotine impairedbone histomorphometric parameters and bone remodeling biomarkers in Sprague-Dawley male rats
    • Hermizi H, Faizah O, Ima-Nirwana S, et al. Nicotine impairedbone histomorphometric parameters and bone remodeling biomarkers in Sprague-Dawley male rats. Annals of Microscopy 2007; 7: 10-24.
    • (2007) Annals of Microscopy , vol.7 , pp. 10-24
    • Hermizi, H.1    Faizah, O.2    Ima-Nirwana, S.3
  • 133
    • 33847282407 scopus 로고    scopus 로고
    • Negative effects ofnicotine on bone-resorbing cytokines and bone histomorphometric parameters in male rats
    • Hapidin H, Othman F, Soelaiman IN, et al. Negative effects ofnicotine on bone-resorbing cytokines and bone histomorphometric parameters in male rats. J Bone Miner Metab 2007; 25: 93-98.
    • (2007) J Bone Miner Metab , vol.25 , pp. 93-98
    • Hapidin, H.1    Othman, F.2    Soelaiman, I.N.3
  • 135
    • 77956846760 scopus 로고    scopus 로고
    • Vitamin Ereversed nicotine-induced toxic effects on bone biochemical markers in male rats
    • Norazlina M, Hermizi H, Faizah O, Ima-Nirwana S. Vitamin Ereversed nicotine-induced toxic effects on bone biochemical markers in male rats. Arch Med Sci 2010; 6: 505-12.
    • (2010) Arch Med Sci , vol.6 , pp. 505-512
    • Norazlina, M.1    Hermizi, H.2    Faizah, O.3    Ima-Nirwana, S.4
  • 136
    • 78951468929 scopus 로고    scopus 로고
    • Effects of nicotine administration and nicotine cessation on bone histomorphometry and bone biomarkers in Sprague-Dawley male rats
    • Hapidin H, Othman F, Soelaiman IN, Shuid AN, Mohamed N. Effects of nicotine administration and nicotine cessation on bone histomorphometry and bone biomarkers in Sprague-Dawley male rats. Calcif Tissue Int 2011; 88: 41-7.
    • (2011) Calcif Tissue Int , vol.88 , pp. 41-47
    • Hapidin, H.1    Othman, F.2    Soelaiman, I.N.3    Shuid, A.N.4    Mohamed, N.5
  • 137
    • 58149314166 scopus 로고    scopus 로고
    • Beneficial effects of tocotrienol and tocopherol on bone histomorphometric parameters in Sprague-Dawley male rats after nicotine cessation
    • Hermizi H, Faizah O, Ima-Nirwana S, Ahmad Nazrun S, Norazlina M. Beneficial effects of tocotrienol and tocopherol on bone histomorphometric parameters in Sprague-Dawley male rats after nicotine cessation. Calcif Tissue Int 2009; 84: 65-74.
    • (2009) Calcif Tissue Int , vol.84 , pp. 65-74
    • Hermizi, H.1    Faizah, O.2    Ima-Nirwana, S.3    Ahmad, N.S.4    Norazlina, M.5
  • 138
    • 84866170149 scopus 로고    scopus 로고
    • Effects ofpalm vitamin e on bone-formation-related gene expression in nicotine-treated rats
    • Abukhadir SS, Mohamed N, Makpol S, Muhammad N. Effects ofpalm vitamin e on bone-formation-related gene expression in nicotine-treated rats. Evid Based Complement Alternat Med 2012; 2012: 656025.
    • (2012) Evid Based Complement Alternat Med , vol.2012 , pp. 656025
    • Abukhadir, S.S.1    Mohamed, N.2    Makpol, S.3    Muhammad, N.4
  • 139
    • 80755171878 scopus 로고    scopus 로고
    • Vitamin Eprotects from free-radical damage on femur of rats treated with ferric nitrilotriacetate
    • Nazrun AS, Luke DA, Khalid BAK, Ima-Nirwana S. Vitamin Eprotects from free-radical damage on femur of rats treated with ferric nitrilotriacetate. Curr Top Pharmacol 2005; 9: 107-15.
    • (2005) Curr Top Pharmacol , vol.9 , pp. 107-115
    • Nazrun, A.S.1    Luke, D.A.2    Khalid, B.A.K.3    Ima-Nirwana, S.4
  • 140
    • 26944436739 scopus 로고    scopus 로고
    • Tocotrienoloffers better protection than tocopherol from free radical-induced damage of rat bone
    • Ahmad NS, Khalid BAK, Luke DA, Ima-Nirwana S. Tocotrienoloffers better protection than tocopherol from free radical-induced damage of rat bone. Clin Exp Pharmacol Physiol 2005; 32: 761-770.
    • (2005) Clin Exp Pharmacol Physiol , vol.32 , pp. 761-770
    • Ahmad, N.S.1    Khalid, B.A.K.2    Luke, D.A.3    Ima-Nirwana, S.4
  • 141
    • 45749091674 scopus 로고    scopus 로고
    • Palm to-cotrienol exerted better antioxidant activities in bone than alphatocopherol
    • Maniam S, Mohamed N, Shuid AN, Soelaiman IN. Palm to-cotrienol exerted better antioxidant activities in bone than alphatocopherol. Basic Clin Pharmacol Toxicol 2008; 103: 55-60.
    • (2008) Basic Clin Pharmacol Toxicol , vol.103 , pp. 55-60
    • Maniam, S.1    Mohamed, N.2    Shuid, A.N.3    Soelaiman, I.N.4
  • 144
    • 77956900893 scopus 로고    scopus 로고
    • Beneficial effects of vitamin E isomer supplementation on static and dynamic bone histomorphometry parameters in normal male rats
    • Mehat MZ, Shuid AN, Mohamed N, Muhammad N, Soelaiman IN. Beneficial effects of vitamin E isomer supplementation on static and dynamic bone histomorphometry parameters in normal male rats. J Bone Miner Metab 2010; 28: 503-9.
    • (2010) J Bone Miner Metab , vol.28 , pp. 503-509
    • Mehat, M.Z.1    Shuid, A.N.2    Mohamed, N.3    Muhammad, N.4    Soelaiman, I.N.5
  • 145
    • 84991208754 scopus 로고    scopus 로고
    • American Associa-tion of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis
    • Watts NB, Bilezikian JP, Camacho PM, et al. American Associa-tion of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis. Endocr Pract 2010; 3: 1-37.
    • (2010) Endocr Pract , vol.3 , pp. 1-37
    • Watts, N.B.1    Bilezikian, J.P.2    Camacho, P.M.3
  • 146
    • 84855959739 scopus 로고    scopus 로고
    • Comparison of theeffects of tocotrienol and estrogen on the bone markers and dynamic changes in postmenopausal osteoporosis rat model
    • Aktifanus AT, Shuid AN, Rashid NHA, et al. Comparison of theeffects of tocotrienol and estrogen on the bone markers and dynamic changes in postmenopausal osteoporosis rat model. Asian J Anim Vet Adv 2012; 7: 225-34.
    • (2012) Asian J Anim Vet Adv , vol.7 , pp. 225-234
    • Aktifanus, A.T.1    Shuid, A.N.2    Rashid, N.H.A.3
  • 147
    • 84869016849 scopus 로고    scopus 로고
    • Palm tocotrienol sup-plementation enhanced bone formation in oestrogen-deficient rats
    • Soelaiman IN, Ming W, Abu Bakar R, et al. Palm tocotrienol sup-plementation enhanced bone formation in oestrogen-deficient rats. Int J Endocrinol 2012; 2012: 532862.
    • Int J Endocrinol , vol.2012 , Issue.53 , pp. 2012
    • Soelaiman, I.N.1    Ming, W.2    Abu, B.R.3
  • 149
    • 84864933844 scopus 로고    scopus 로고
    • Tocotrienol supplementation improves late-phase fracture healing compared to alpha-tocopherol in a rat model of postmenopausal osteoporosis: A biomechanical evaluation
    • Mohamad S, Shuid AN, Mokhtar SA, Abdullah S, Soelaiman IN.Tocotrienol supplementation improves late-phase fracture healing compared to alpha-tocopherol in a rat model of postmenopausal osteoporosis: a biomechanical evaluation. Evid Based Complement Alternat Med 2012; 2012: 372-878.
    • Evid Based Complement Alternat Med , vol.2012 , pp. 372-878
    • Mohamad, S.1    Shuid, A.N.2    Mokhtar, S.A.3    Abdullah, S.4    Soelaiman, I.N.5
  • 150
    • 84869084681 scopus 로고    scopus 로고
    • Mevalonate-suppressive die-tary isoprenoids for bone health
    • Mo H, Yeganehjoo H, Shah A, et al. Mevalonate-suppressive die-tary isoprenoids for bone health. J Nutr Biochem 2012; 23: 1543-51.
    • (2012) J Nutr Biochem , vol.23 , pp. 1543-1551
    • Mo, H.1    Yeganehjoo, H.2    Shah, A.3
  • 151
    • 84866177921 scopus 로고    scopus 로고
    • Vitamin E as an Antiosteoporotic Agentvia Receptor Activator of Nuclear Factor Kappa-B Ligand Signaling Disruption: Current Evidence and Other Potential Research Areas
    • Chin KY, Ima-Nirwana S. Vitamin E as an Antiosteoporotic Agentvia Receptor Activator of Nuclear Factor Kappa-B Ligand Signaling Disruption: Current Evidence and Other Potential Research Areas. Evid Based Complement Alternat Med 2012; 2012: 747020.
    • (2012) Evid Based Complement Alternat Med , vol.2012 , pp. 747020
    • Chin, K.Y.1    Ima-Nirwana, S.2
  • 152
    • 33746941768 scopus 로고    scopus 로고
    • Dose-response impact ofvarious tocotrienols on serum lipid parameters in 5-week-old female chickens
    • Yu SG, Thomas AM, Gapor A, et al. Dose-response impact ofvarious tocotrienols on serum lipid parameters in 5-week-old female chickens. Lipids 2006; 41: 453-61.
    • (2006) Lipids , vol.41 , pp. 453-461
    • Yu, S.G.1    Thomas, A.M.2    Gapor, A.3
  • 155
    • 34047096023 scopus 로고    scopus 로고
    • Tocotrienolspotentiate lovastatin-mediated growth suppression in vitro and in vivo
    • McAnally JA, Gupta J, Sodhani S, Bravo L, Mo H. Tocotrienolspotentiate lovastatin-mediated growth suppression in vitro and in vivo. Exp Biol Med (Maywood) 2007; 232: 523-31.
    • (2007) Exp Biol Med (Maywood) , vol.232 , pp. 523-531
    • McAnally, J.A.1    Gupta, J.2    Sodhani, S.3    Bravo, L.4    Mo, H.5
  • 156
    • 37349000972 scopus 로고    scopus 로고
    • Synergistic antiproliferative effects of-tocotrienol and statin treatment on mammary tumor cells
    • Wali VB, Sylvester PW. Synergistic antiproliferative effects of-tocotrienol and statin treatment on mammary tumor cells. Lipids2007; 42: 1113-23.
    • (2007) Lipids , vol.42 , pp. 1113-1123
    • Wali, V.B.1    Sylvester, P.W.2
  • 157
    • 66149087341 scopus 로고    scopus 로고
    • D-Tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa2 and BxPC-3 pancreatic carcinoma cells
    • Hussein D, Mo H. D-Tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa2 and BxPC-3 pancreatic carcinoma cells. Pancreas 2009; 38: e124-36.
    • (2009) Pancreas , vol.38
    • Hussein, D.1    Mo, H.2
  • 158
    • 84860772715 scopus 로고    scopus 로고
    • Synergistic anticancer effects of combined-tocotrienol with statin or receptor tyrosine kinase inhibitor treatment
    • Sylvester PW. Synergistic anticancer effects of combined-tocotrienol with statin or receptor tyrosine kinase inhibitor treatment. Genes Nutr 2012; 7: 63-74.
    • (2012) Genes Nutr , vol.7 , pp. 63-74
    • Sylvester, P.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.