메뉴 건너뛰기




Volumn 7, Issue 1, 2012, Pages 63-74

Synergistic anticancer effects of combined γ-tocotrienol with statin or receptor tyrosine kinase inhibitor treatment

Author keywords

Tocotrienol; Breast cancer; Erlotinib; Gefitinib; Statins; Vitamin E

Indexed keywords

ATORVASTATIN; CERIVASTATIN; COMPACTIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FLUINDOSTATIN; GAMMA TOCOTRIENOL; GEFITINIB; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVALONIC ACID; MEVINOLIN; PITAVASTATIN; PRAVASTATIN; PROTEIN TYROSINE KINASE INHIBITOR; ROSUVASTATIN; SIMVASTATIN;

EID: 84860772715     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-011-0225-y     Document Type: Conference Paper
Times cited : (20)

References (80)
  • 1
    • 67650385302 scopus 로고    scopus 로고
    • American Cancer Society, American Cancer Society Inc., Atlanta, GA
    • American Cancer Society (2009) Cancer facts and figures. American Cancer Society Inc., Atlanta, GA
    • (2009) Cancer Facts and Figures
  • 3
    • 23044508946 scopus 로고    scopus 로고
    • Cyclin D1 in breast cancer pathogenesis
    • DOI 10.1200/JCO.2005.05.064
    • Arnold A, Papanikolaou A (2005) Cyclin D1 in breast cancer pathogenesis. J Clin Oncol 23:4215-4224 (Pubitemid 46211327)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.18 , pp. 4215-4224
    • Arnold, A.1    Papanikolaou, A.2
  • 4
    • 77950545758 scopus 로고    scopus 로고
    • Combined gammatocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in murine mammary tumor cells
    • Bachawal SV, Wali VB, Sylvester PW (2010a) Combined gammatocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in murine mammary tumor cells. Anticancer Res 30:429-437
    • (2010) Anticancer Res , vol.30 , pp. 429-437
    • Bachawal, S.V.1    Wali, V.B.2    Sylvester, P.W.3
  • 5
    • 77950448927 scopus 로고    scopus 로고
    • Enhanced antiproliferative and apoptotic response to combined treatment of gammatocotrienol with erlotinib or gefitinib in mammary tumor cells
    • Bachawal SV, Wali VB, Sylvester PW (2010b) Enhanced antiproliferative and apoptotic response to combined treatment of gammatocotrienol with erlotinib or gefitinib in mammary tumor cells. BMC Cancer 10:84
    • (2010) BMC Cancer , vol.10 , pp. 84
    • Bachawal, S.V.1    Wali, V.B.2    Sylvester, P.W.3
  • 7
  • 8
  • 9
    • 7444239715 scopus 로고    scopus 로고
    • Targeting ErbB receptors signaling: A pan-ErbB approach to cancer
    • Britten CD (2004) Targeting ErbB receptor signaling: a pan-ErbB approach to cancer. Mol Cancer Ther 3:1335-1342 (Pubitemid 39440177)
    • (2004) Molecular Cancer Therapeutics , vol.3 , Issue.10 , pp. 1335-1342
    • Britten, C.D.1
  • 10
    • 0017894322 scopus 로고
    • Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase
    • Brown MS, Faust JR, Goldstein JL, Kaneko I, Endo A (1978) Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML- 236B), a competitive inhibitor of the reductase. J Biol Chem 253:1121-1128 (Pubitemid 8288831)
    • (1978) Journal of Biological Chemistry , vol.253 , Issue.4 , pp. 1121-1128
    • Brown, M.S.1    Faust, J.R.2    Goldstein, J.L.3
  • 13
    • 0028176477 scopus 로고
    • A neu acquaintance for erbB3 and erbB4: A role for receptor heterodimerization in growth signaling
    • Carraway KL 3rd, Cantley LC (1994) A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling. Cell 78:5-8
    • (1994) Cell , vol.78 , pp. 5-8
    • Carraway III, K.L.1    Cantley, L.C.2
  • 16
    • 0025731874 scopus 로고
    • Introduction: Nutritional aspects of palm oil
    • Cottrell RC (1991) Introduction: nutritional aspects of palm oil. Am J Clin Nutr 53:989S-1009S
    • (1991) Am J Clin Nutr , vol.53
    • Cottrell, R.C.1
  • 17
    • 0032053709 scopus 로고    scopus 로고
    • Mechanisms and consequences of activation of protein kinase B/Akt
    • DOI 10.1016/S0955-0674(98)80149-X
    • Downward J (1998) Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol 10:262-267 (Pubitemid 28174769)
    • (1998) Current Opinion in Cell Biology , vol.10 , Issue.2 , pp. 262-267
    • Downward, J.1
  • 20
    • 0028225147 scopus 로고
    • Inhibition of tumour promotion by various palm-oil tocotrienols
    • DOI 10.1002/ijc.2910570415
    • Goh SH, Hew NF, Norhanom AW, Yadav M (1994) Inhibition of tumour promotion by various palm-oil tocotrienols. Int J Cancer 57:529-531 (Pubitemid 24173098)
    • (1994) International Journal of Cancer , vol.57 , Issue.4 , pp. 529-531
    • Goh, S.H.1    Hew, N.F.2    Norhanom, A.W.3    Yadav, M.4
  • 21
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein JL, Brown MS (1990) Regulation of the mevalonate pathway. Nature 343:425-430
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 23
    • 7544219925 scopus 로고    scopus 로고
    • Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer
    • DOI 10.1016/j.ctrv.2004.06.010, PII S0305737204001240
    • Graaf MR, Richel DJ, van Noorden CJ, Guchelaar HJ (2004) Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer. Cancer Treat Rev 30:609-641 (Pubitemid 39451828)
    • (2004) Cancer Treatment Reviews , vol.30 , Issue.7 , pp. 609-641
    • Graaf, M.R.1    Richel, D.J.2    Van Noorden, C.J.F.3    Guchelaar, H.-J.4
  • 24
    • 33645278944 scopus 로고    scopus 로고
    • Validation of cyclin D1/CDK4 as an anticancer drug target in MCF-7 breast cancer cells: Effect of regulated overexpression of cyclin D1 and siRNA-mediated inhibition of endogenous cyclin D1 and CDK4 expression
    • Grillo M, Bott MJ, Khandke N, McGinnis JP, Miranda M, Meyyappan M, Rosfjord EC, Rabindran SK (2006) Validation of cyclin D1/CDK4 as an anticancer drug target in MCF-7 breast cancer cells: effect of regulated overexpression of cyclin D1 and siRNA-mediated inhibition of endogenous cyclin D1 and CDK4 expression. Breast Cancer Res Treat 95:185-194
    • (2006) Breast Cancer Res Treat , vol.95 , pp. 185-194
    • Grillo, M.1    Bott, M.J.2    Khandke, N.3    McGinnis, J.P.4    Miranda, M.5    Meyyappan, M.6    Rosfjord, E.C.7    Rabindran, S.K.8
  • 25
    • 0029921317 scopus 로고    scopus 로고
    • Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer
    • Hall M, Peters G (1996) Genetic alterations of cyclins, cyclindependent kinases, and Cdk inhibitors in human cancer. Adv Cancer Res 68:67-108 (Pubitemid 26099813)
    • (1996) Advances in Cancer Research , vol.68 , pp. 67-108
    • Hall, M.1    Peters, G.2
  • 30
    • 2342618936 scopus 로고    scopus 로고
    • Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression
    • Liang J, Slingerland JM (2003) Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2:339-345
    • (2003) Cell Cycle , vol.2 , pp. 339-345
    • Liang, J.1    Slingerland, J.M.2
  • 31
    • 50449087729 scopus 로고    scopus 로고
    • Erlotinib induces mitochondrial- mediated apoptosis in human H3255 non-small-cell lung cancer cells with epidermal growth factor receptorL858R mutation through mitochondrial oxidative phosphorylationdependent activation of BAX and BAK
    • Ling YH, Lin R, Perez-Soler R (2008) Erlotinib induces mitochondrial- mediated apoptosis in human H3255 non-small-cell lung cancer cells with epidermal growth factor receptorL858R mutation through mitochondrial oxidative phosphorylationdependent activation of BAX and BAK. Mol Pharmacol 74:793-806
    • (2008) Mol Pharmacol , vol.74 , pp. 793-806
    • Ling, Y.H.1    Lin, R.2    Perez-Soler, R.3
  • 32
    • 0022413876 scopus 로고
    • Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    • Maltese WA, Defendini R, Green RA, Sheridan KM, Donley DK (1985) Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl- coenzyme A reductase. J Clin Invest 76:1748-1754 (Pubitemid 16196041)
    • (1985) Journal of Clinical Investigation , vol.76 , Issue.5 , pp. 1748-1754
    • Maltese, W.A.1    Defendini, R.2    Green, R.A.3
  • 33
    • 16844384956 scopus 로고    scopus 로고
    • Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor
    • DOI 10.1158/1078-0432.CCR-04-1951
    • Mantha AJ, Hanson JE, Goss G, Lagarde AE, Lorimer IA, Dimitroulakos J (2005) Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor. Clin Cancer Res 11:2398-2407 (Pubitemid 40490201)
    • (2005) Clinical Cancer Research , vol.11 , Issue.6 , pp. 2398-2407
    • Mantha, A.J.1    Hanson, J.E.L.2    Goss, G.3    Lagarde, A.E.4    Lorimer, I.A.5    Dimitroulakos, J.6
  • 34
    • 0027925617 scopus 로고
    • Epidemiology. Search for a killer: Focus shifts from fat to hormones [news] [see comments]
    • Marshall E (1993) Epidemiology. Search for a killer: focus shifts from fat to hormones [news] [see comments]. Science 259:618-621
    • (1993) Science , vol.259 , pp. 618-621
    • Marshall, E.1
  • 35
    • 9244239811 scopus 로고    scopus 로고
    • G1 cell-cycle control and cancer
    • DOI 10.1038/nature03094
    • Massague J (2004) G1 cell-cycle control and cancer. Nature 432:298-306 (Pubitemid 39551657)
    • (2004) Nature , vol.432 , Issue.7015 , pp. 298-306
    • Massague, J.1
  • 39
    • 0034034058 scopus 로고    scopus 로고
    • Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary epithelial cells
    • McIntyre BS, Briski KP, Tirmenstein MA, Fariss MW, Gapor A, Sylvester PW (2000b) Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary epithelial cells. Lipids 35:171-180 (Pubitemid 30183648)
    • (2000) Lipids , vol.35 , Issue.2 , pp. 171-180
    • McIntyre, B.S.1    Briski, K.P.2    Tirmenstein, M.A.3    Fariss, M.W.4    Gapor, A.5    Sylvester, P.W.6
  • 40
    • 0016253027 scopus 로고
    • Mammary tumorigenesis in chemical carcinogentreated mice. II. Dependence on hormone stimulation for tumorigenesis
    • Medina D (1974) Mammary tumorigenesis in chemical carcinogentreated mice. II. Dependence on hormone stimulation for tumorigenesis. J Natl Cancer Inst 53:223-226
    • (1974) J Natl Cancer Inst , vol.53 , pp. 223-226
    • Medina, D.1
  • 41
    • 3042736080 scopus 로고    scopus 로고
    • Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention
    • Mo H, Elson CE (2004) Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention. Exp Biol Med (Maywood) 229:567-585 (Pubitemid 38878903)
    • (2004) Experimental Biology and Medicine , vol.229 , Issue.7 , pp. 567-585
    • Mo, H.1    Elson, C.E.2
  • 42
    • 0017117866 scopus 로고
    • Importance of mammary gland DNA synthesis on carcinogen-induced mammary tumorigenesis in rats
    • Nagasawa H, Yanai R, Taniguchi H (1976) Importance of mammary gland DNA synthesis on carcinogen-induced mammary tumorigenesis in rats. Cancer Res 36:2223-2226
    • (1976) Cancer Res , vol.36 , pp. 2223-2226
    • Nagasawa, H.1    Yanai, R.2    Taniguchi, H.3
  • 43
    • 0023902411 scopus 로고
    • Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonatederived product inhibits translation of mRNA and accelerates degradation of enzyme
    • Nakanishi M, Goldstein JL, Brown MS (1988) Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonatederived product inhibits translation of mRNA and accelerates degradation of enzyme. J Biol Chem 263:8929-8937
    • (1988) J Biol Chem , vol.263 , pp. 8929-8937
    • Nakanishi, M.1    Goldstein, J.L.2    Brown, M.S.3
  • 44
    • 0027184434 scopus 로고
    • Effect of dietary fat and cholesterol on dimethylbenz[a]-anthracene- induced mammary tumorigenesis in Sprague-Dawley rats
    • Nakayama M, Ju HR, Sugano M, Hirose N, Ueki T, Doi F, Eynard AR (1993) Effect of dietary fat and cholesterol on dimethylbenz[a]-anthracene-induced mammary tumorigenesis in Sprague- Dawley rats. Anticancer Res 13:691-698 (Pubitemid 23216968)
    • (1993) Anticancer Research , vol.13 , Issue.3 , pp. 691-698
    • Nakayama, M.1    Ju, H.R.2    Sugano, M.3    Hirose, N.4    Ueki, T.5    Doi, F.6    Eynard, A.R.7
  • 45
    • 0029036480 scopus 로고
    • Hormones and mammary carcinogenesis in mice, rats, and humans: A unifying hypothesis
    • Nandi S, Guzman RC, Yang J (1995) Hormones and mammary carcinogenesis in mice, rats, and humans: a unifying hypothesis. Proc Natl Acad Sci USA 92:3650-3657
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3650-3657
    • Nandi, S.1    Guzman, R.C.2    Yang, J.3
  • 46
    • 0026693966 scopus 로고
    • Animal cell cycles and their control
    • Norbury C, Nurse P (1992) Animal cell cycles and their control. Annu Rev Biochem 61:441-470
    • (1992) Annu Rev Biochem , vol.61 , pp. 441-470
    • Norbury, C.1    Nurse, P.2
  • 47
  • 48
    • 1642421130 scopus 로고    scopus 로고
    • Target-based agents against ErbB receptors and their ligands: A novel approach to cancer treatment
    • DOI 10.1677/erc.0.0100001
    • Normanno N, Bianco C, De Luca A, Maiello MR, Salomon DS (2003) Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment. Endocr Relat Cancer 10:1-21 (Pubitemid 36457237)
    • (2003) Endocrine-Related Cancer , vol.10 , Issue.1 , pp. 1-21
    • Normanno, N.1    Bianco, C.2    De Luca, A.3    Maiello, M.R.4    Salomon, D.S.5
  • 49
    • 0842286818 scopus 로고    scopus 로고
    • Additive antitumour effect of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (Iressa, ZD1839) and the antioestrogen fulvestrant (Faslodex, ICI 182,780) in breast cancer cells
    • DOI 10.1038/sj.bjc.6601504
    • Okubo S, Kurebayashi J, Otsuki T, Yamamoto Y, Tanaka K, Sonoo H (2004) Additive antitumour effect of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (Iressa, ZD1839) and the antioestrogen fulvestrant (Faslodex, ICI 182, 780) in breast cancer cells. Br J Cancer 90:236-244 (Pubitemid 38174967)
    • (2004) British Journal of Cancer , vol.90 , Issue.1 , pp. 236-244
    • Okubo, S.1    Kurebayashi, J.2    Otsuki, T.3    Yamamoto, Y.4    Tanaka, K.5    Sonoo, H.6
  • 50
    • 0033546315 scopus 로고    scopus 로고
    • ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases
    • Olayioye MA, Beuvink I, Horsch K, Daly JM, Hynes NE (1999) ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. J Biol Chem 274:17209-17218
    • (1999) J Biol Chem , vol.274 , pp. 17209-17218
    • Olayioye, M.A.1    Beuvink, I.2    Horsch, K.3    Daly, J.M.4    Hynes, N.E.5
  • 51
    • 0034600849 scopus 로고    scopus 로고
    • The ErbB signaling network: Receptor heterodimerization in development and cancer
    • Olayioye MA, Neve RM, Lane HA, Hynes NE (2000) The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J 19:3159-3167 (Pubitemid 30428195)
    • (2000) EMBO Journal , vol.19 , Issue.13 , pp. 3159-3167
    • Olayioye, M.A.1    Neve, R.M.2    Lane, H.A.3    Hynes, N.E.4
  • 52
    • 0027288196 scopus 로고
    • Tocotrienols regulate cholesterol production in mammalian cells by post- transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    • Parker RA, Pearce BC, Clark RW, Gordon DA, Wright JJ (1993) Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl- coenzyme A reductase. J Biol Chem 268:11230-11238 (Pubitemid 23162316)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.15 , pp. 11230-11238
    • Parker, R.A.1    Pearce, B.C.2    Clark, R.W.3    Gordon, D.A.4    Wright, J.J.K.5
  • 53
    • 0022962322 scopus 로고
    • Chemically-induced mammary gland tumors in rats: Modulation by dietary fat
    • Rogers AE, Lee SY (1986) Chemically-induced mammary gland tumors in rats: modulation by dietary fat. Prog Clin Biol Res 222:255-282
    • (1986) Prog Clin Biol Res , vol.222 , pp. 255-282
    • Rogers, A.E.1    Lee, S.Y.2
  • 54
    • 0018117242 scopus 로고
    • Developmental stage of the rat mammary gland as determinant of its susceptibility to 7,12-dimethylbenz[a]anthracene
    • Russo IH, Russo J (1978) Developmental stage of the rat mammary gland as determinant of its susceptibility to 7, 12-dimethylbenz[a]anthracene. J Natl Cancer Inst 61:1439-1449 (Pubitemid 9070679)
    • (1978) Journal of the National Cancer Institute , vol.61 , Issue.6 , pp. 1439-1449
    • Russo, I.H.1    Russo, J.2
  • 55
    • 33751061128 scopus 로고    scopus 로고
    • γ-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells
    • DOI 10.1111/j.1365-2184.2006.00412.x
    • Samant GV, Sylvester PW (2006) gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells. Cell Prolif 39:563-574 (Pubitemid 44760206)
    • (2006) Cell Proliferation , vol.39 , Issue.6 , pp. 563-574
    • Samant, G.V.1    Sylvester, P.W.2
  • 56
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J (2000) Cell signaling by receptor tyrosine kinases. Cell 103:211-225
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 57
    • 0037023755 scopus 로고    scopus 로고
    • Signaling networks that link cell proliferation and cell fate
    • DOI 10.1074/jbc.R100063200
    • Sears RC, Nevins JR (2002) Signaling networks that link cell proliferation and cell fate. J Biol Chem 277:11617-11620 (Pubitemid 34952710)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.14 , pp. 11617-11620
    • Sears, R.C.1    Nevins, J.R.2
  • 59
    • 16444387293 scopus 로고    scopus 로고
    • γ-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor κB activity
    • Shah SJ, Sylvester PW (2005) Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity. Exp Biol Med 230:235-241 (Pubitemid 40478247)
    • (2005) Experimental Biology and Medicine , vol.230 , Issue.4 , pp. 235-241
    • Shah, S.J.1    Sylvester, P.W.2
  • 60
    • 33645802169 scopus 로고    scopus 로고
    • Cyclin-dependent kinase pathways as targets for cancer treatment
    • DOI 10.1200/JCO.2005.03.7689
    • Shapiro GI (2006) Cyclin-dependent kinase pathways as targets for cancer treatment. J Clin Oncol 24:1770-1783 (Pubitemid 46628473)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.11 , pp. 1770-1783
    • Shapiro, G.I.1
  • 61
    • 0027336491 scopus 로고
    • Mammalian G1 cyclins
    • Sherr CJ (1993) Mammalian G1 cyclins. Cell 73:1059-1065
    • (1993) Cell , vol.73 , pp. 1059-1065
    • Sherr, C.J.1
  • 62
    • 0344406230 scopus 로고    scopus 로고
    • Comparative effects of lovastatin on mammary and prostate oncogenesis in transgenic mouse models
    • DOI 10.1093/carcin/24.3.453
    • Shibata MA, Kavanaugh C, Shibata E, Abe H, Nguyen P, Otsuki Y, Trepel JB, Green JE (2003) Comparative effects of lovastatin on mammary and prostate oncogenesis in transgenic mouse models. Carcinogenesis 24:453-459 (Pubitemid 36432640)
    • (2003) Carcinogenesis , vol.24 , Issue.3 , pp. 453-459
    • Shibata, M.-A.1    Kavanaugh, C.2    Shibata, E.3    Abe, H.4    Nguyen, P.M.5    Otsuki, Y.6    Trepel, J.B.7    Green, J.E.8
  • 63
    • 6444230927 scopus 로고    scopus 로고
    • Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: A p53-independent mitochondrial-mediated apoptotic mechanism
    • DOI 10.1093/carcin/bgh201
    • Shibata MA, Ito Y, Morimoto J, Otsuki Y (2004) Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism. Carcinogenesis 25:1887-1898 (Pubitemid 39405908)
    • (2004) Carcinogenesis , vol.25 , Issue.10 , pp. 1887-1898
    • Shibata, M.-A.1    Ito, Y.2    Morimoto, J.3    Otsuki, Y.4
  • 64
    • 77953285620 scopus 로고    scopus 로고
    • Synergistic anticancer effects of combined gamma-tocotrienol and celecoxib treatment are associated with suppression in Akt and NFkappaB signaling
    • Shirode AB, Sylvester PW (2010) Synergistic anticancer effects of combined gamma-tocotrienol and celecoxib treatment are associated with suppression in Akt and NFkappaB signaling. Biomed Pharmacother 64:327-332
    • (2010) Biomed Pharmacother , vol.64 , pp. 327-332
    • Shirode, A.B.1    Sylvester, P.W.2
  • 65
    • 0025212293 scopus 로고
    • Effect of dietary palm oil and its fractions on rat plasma and high density lipoprotein lipids
    • Sundram K, Khor HT, Ong AS (1990) Effect of dietary palm oil and its fractions on rat plasma and high density lipoprotein lipids. Lipids 25:187-193 (Pubitemid 20135049)
    • (1990) Lipids , vol.25 , Issue.4 , pp. 187-193
    • Sundram, K.1    Khor, H.T.2    Ong, A.S.H.3
  • 66
    • 20144385472 scopus 로고    scopus 로고
    • Mechanisms mediating the antiproliferative and apoptotic effects of vitamin E in mammary cancer cells
    • Sylvester PW, Shah SJ (2005) Mechanisms mediating the antiproliferative and apoptotic effects of vitamin E in mammary cancer cells. Front Biosci 10:699-709
    • (2005) Front Biosci , vol.10 , pp. 699-709
    • Sylvester, P.W.1    Shah, S.J.2
  • 67
    • 4444301697 scopus 로고    scopus 로고
    • Role of tocotrienols in the prevention of cardiovascular disease and breast cancer
    • Sylvester PW, Theriault A (2003) Role of tocotrienols in the prevention of cardiovascular disease and breast cancer. Curr Top Nutraceutical Res 1:121-136
    • (2003) Curr Top Nutraceutical Res , vol.1 , pp. 121-136
    • Sylvester, P.W.1    Theriault, A.2
  • 68
    • 0021079470 scopus 로고
    • Effects of alterations in early hormonal environment on development and hormone dependency of carcinogen-induced mammary tumors in rats
    • Sylvester PW, Aylsworth CF, Van Vugt DA, Meites J (1983) Effects of alterations in early hormonal environment on development and hormone dependency of carcinogen-induced mammary tumors in rats. Cancer Res 43:5342-5346 (Pubitemid 14230149)
    • (1983) Cancer Research , vol.43 , Issue.11 , pp. 5342-5346
    • Sylvester, P.W.1    Aylsworth, C.F.2    Van Vugt, D.A.3    Meites, J.4
  • 69
    • 0022622532 scopus 로고
    • Effects of high dietary fat on the growth and development of ovarian-independent carcinogen-induced mammary tumors in rats
    • Sylvester PW, Ip C, Ip MM (1986a) Effects of high dietary fat on the growth and development of ovarian-independent carcinogeninduced mammary tumors in rats. Cancer Res 46:763-769 (Pubitemid 16145435)
    • (1986) Cancer Research , vol.46 , Issue.2 , pp. 763-769
    • Sylvester, P.W.1    Ip, C.2    Ip, M.M.3
  • 70
    • 0022627388 scopus 로고
    • Comparative effects of different animal and vegetable fats fed before and during carcinogen administration on mammary tumorigenesis, sexual maturation, and endocrine function in rats
    • Sylvester PW, Russell M, Ip MM, Ip C (1986b) Comparative effects of different animal and vegetable fats fed before and during carcinogen administration on mammary tumorigenesis, sexual maturation, and endocrine function in rats. Cancer Res 46:757-762 (Pubitemid 16145434)
    • (1986) Cancer Research , vol.46 , Issue.2 , pp. 757-762
    • Sylvester, P.W.1    Russell, M.2    Ip, M.M.3    Ip, C.4
  • 72
    • 0034074486 scopus 로고    scopus 로고
    • Protein kinases as mediators of phosphoinositide 3-kinase signaling
    • Toker A (2000) Protein kinases as mediators of phosphoinositide 3-kinase signaling. Mol Pharmacol 57:652-658 (Pubitemid 30183703)
    • (2000) Molecular Pharmacology , vol.57 , Issue.4 , pp. 652-658
    • Toker, A.1
  • 73
    • 33745590413 scopus 로고    scopus 로고
    • 1 cell cycle progression and cancer
    • DOI 10.1111/j.1349-7006.2006.00244.x
    • Torii S, Yamamoto T, Tsuchiya Y, Nishida E (2006) ERK MAP kinase in G cell cycle progression and cancer. Cancer Sci 97:697-702 (Pubitemid 43983780)
    • (2006) Cancer Science , vol.97 , Issue.8 , pp. 697-702
    • Torii, S.1    Yamamoto, T.2    Tsuchiya, Y.3    Nishida, E.4
  • 76
    • 0027689310 scopus 로고
    • Introduction - Breast cancer risk: Weaving facts into fabric
    • Vogel VG (1993) Breast cancer risk: weaving facts into fabric. Breast Cancer Res Treat 28:91-96 (Pubitemid 24056080)
    • (1993) Breast Cancer Research and Treatment , vol.28 , Issue.2 , pp. 91-96
    • Vogel, V.G.1
  • 77
    • 37349000972 scopus 로고    scopus 로고
    • Synergistic antiproliferative effects of γ-tocotrienol and statin treatment on mammary tumor cells
    • DOI 10.1007/s11745-007-3102-0
    • Wali VB, Sylvester PW (2007) Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells. Lipids 42:1113-1123 (Pubitemid 350303593)
    • (2007) Lipids , vol.42 , Issue.12 , pp. 1113-1123
    • Wali, V.B.1    Sylvester, P.W.2
  • 78
    • 70350215619 scopus 로고    scopus 로고
    • Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment
    • Wali VB, Bachawal SV, Sylvester PW (2009a) Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. Lipids 44:925-934
    • (2009) Lipids , vol.44 , pp. 925-934
    • Wali, V.B.1    Bachawal, S.V.2    Sylvester, P.W.3
  • 79
    • 66449118770 scopus 로고    scopus 로고
    • Combined treatment of gamma-tocotrienol with statins induce mammary tumor cell cycle arrest in G1
    • Wali VB, Bachawal SV, Sylvester PW (2009b) Combined treatment of gamma-tocotrienol with statins induce mammary tumor cell cycle arrest in G1. Exp Biol Med (Maywood) 234:639-650
    • (2009) Exp Biol Med (Maywood) , vol.234 , pp. 639-650
    • Wali, V.B.1    Bachawal, S.V.2    Sylvester, P.W.3
  • 80
    • 0034766736 scopus 로고    scopus 로고
    • Biology of HER2 and its importance in breast cancer
    • Yarden Y (2001) Biology of HER2 and its importance in breast cancer. Oncology 61(Suppl 2):1-13 (Pubitemid 33033419)
    • (2001) Oncology , vol.61 , Issue.SUPPL. 2 , pp. 1-13
    • Yarden, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.