Vitamin E exhibits bone anabolic actions in normal male rats

Journal of Bone and Mineral Metabolism

Volumn 28, Issue 2, 2010, Pages 149-156

  Shuid, Ahmad Nazrun ^a   Mehat, Zulfadli ^a   Mohamed, Norazlina ^a   Muhammad, Norliza ^a   Soelaiman, Ima Nirwana ^a  

^a DEPARTMENT OF PHARMACOLOGY   (Malaysia)

Author keywords

Bone anabolic agent; Bone biomechanical test; Bone histomorphometry; Tocotrienol; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; GAMMA TOCOTRIENOL; NICOTINE; ANABOLIC AGENT; BONE DENSITY CONSERVATION AGENT; CHROMAN DERIVATIVE; DRUG DERIVATIVE; PLASTOCHROMANOL 8;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE STRENGTH; BONE STRUCTURE; CONTROLLED STUDY; MALE; MORPHOMETRICS; NONHUMAN; OSSIFICATION; OSTEOPOROSIS; PRIORITY JOURNAL; RAT; STRESS STRAIN RELATIONSHIP; TRABECULAR BONE; TREATMENT DURATION; TREATMENT OUTCOME; VISCOELASTICITY; VITAMIN SUPPLEMENTATION; ANIMAL; BONE; BONE DENSITY; CHEMISTRY; COMPARATIVE STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; FEMUR; HISTOLOGY; MECHANICAL STRESS; ORGAN SIZE; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ALPHA-TOCOPHEROL; ANABOLIC AGENTS; ANIMALS; BIOMECHANICS; BONE AND BONES; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; CHROMANS; DIETARY SUPPLEMENTS; FEMUR; MALE; ORGAN SIZE; OSTEOPOROSIS; RATS; RATS, SPRAGUE-DAWLEY; STRESS, MECHANICAL; VITAMIN E;

EID: 77952478816     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00774-009-0122-2     Document Type: Article

References (51)

1. Canalis E, Giustina A, Bilezikian JP (2007) Mechanisms of anabolic therapies for osteoporosis. N Engl J Med 357:905-916
2. Buehler J, Chappuis P, Saffar JL, Foos E, Vignery A (2001) Strontium ranelate inhibits bone resorption whilst maintaining bone formation in alveolar bone in monkeys. Bone 29:176-179
3. Delannoy P, Bazot D, Marie PJ (2002) Long-term treatment with strontium ranelate increases vertebral bone mass without deleterious effect in mice. Metabolism 51:906-911
4. Ammann P, Shen V, Robin B, Mauras Y, Bonjour JP, Rizzoli R (2004) Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats. J Bone Miner Res 19:2012-2020
5. Riggs BL, Parfitt AM (2005) Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling. J Bone Miner Res 20:177-184
6. Hermizi H, Faizah O, Ima-Nirwana S, Ahmad Nazrun S, Norazlina M (2009) Beneficial effects of tocotrienol and tocopherol on bone histomorphometric parameters in Sprague - Dawley male rats after nicotine cessation. Calcif Tissue Int 84:65-74
7. Azzi A, Strocker A (2000) Vitamin E: non-antioxidant roles. Prog Lipid Res 39:231-255
8. Qureshi AA, Sami SA, Salser WA, Khan FA (2002) Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans. Atherosclerosis 161:199-207
9. Mahadevappa VG, Sicilia F, Holub BJ (1991) Effect of tocotrienol derivatives on collagen and ADP-induced human platelet aggregation. In: Proceedings 1989 international palm oil conference on nutrition and health aspects of palm oil (PORIM), Kuala Lumpur, Malaysia, pp 36-38
10. Ngah WZ, Jarien Z, San MM, Marzuki A, Top GM, Shamaan NA, Kadir KA (1991) Effect of tocotrienols on hepatocarcinogenesis induced by 2-acetylaminofluorene in rats. Am J Clin Nutr 53:1076-1081
11. Nesaretnam K, Stephen R, Dils R, Darbre P (1998) Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status. Lipids 33:461-469
12. Melhus H, Michalsson K, Holmberg L, Wolk A, Ljunghall S (1999) Smoking, antioxidant vitamins, and the risk of hip fracture. J Bone Miner Res 14:129-135 (Pubitemid 29021613)
13. Xu H, Watkins BA, Seifert MF (1995) Vitamin E stimulates trabecular bone formation and alters epiphyseal cartilage morphometry. Calcif Tissue Int 57:293-300
14. Ima-Nirwana S, Kiftiah A, Sariza T, Gapor MT, Khalid BAK (1999) Palm vitamin E improves bone metabolism and survival rate in thyrotoxic rats. Gen Pharmacol 32:621-626 (Pubitemid 29219467)
15. Ima-Nirwana S, Norazlina M, Khalid BAK (2000) Palm vitamin E prevents osteoporosis in orchidectomized growing male rats. Nat Prod Sci 694:155-160
16. Norazlina M, Ima-Nirwana S, Gapor MT, Khalid BAK (2000) Palm vitamin E is comparable to alpha-tocopherol in maintaining bone mineral density in ovariectomised female rats. Exp Clin Endocrinol Diabetes 108:305-310
17. Ima-Nirwana S, Fakhrurazi H (2002) Palm vitamin E protects bone against dexamethasone-induced osteoporosis in male rats. Med J Malaysia 57:136-144
18. Ahmad NS, Khalid BAK, Luke DA, Ima-Nirwana S (2005) Tocotrienol offers better protection than tocopherol from free radical-induced damage of rat bone. Clin Exp Pharmacol Physiol 32:761-770
19. Czerny B, Pawlik A, Juzyszyn Z, Myśliwiec Z (2004) The effect of tamoxifen and fluoride on bone mineral density, biomechanical properties and blood lipids in ovariectomized rats. Basic Clin Pharmacol Toxicol 92:162-165
20. Turner CH, Hinckley WR, Wilson ME, Zhang W, Dunipace AJ (2001) Combined effects of diets with reduced calcium and phosphate and increased fluoride intake on vertebral bone strength and histology in rats. Calcif Tissue Int 69:51-57
21. Bohatyrewicz A (1999) Effects of fluoride on mechanical properties of femoral bone in growing rats. Fluoride 32:47-54
22. Chacha D, Turner CH, Dunipace AJ, Grynpas MD (1999) The effect of fluoride treatment on bone mineral in rabbits. Calcif Tissue Int 64:345-351
23. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR (1987) Bone histomorphometry: standardization of nomenclature, symbols and units. Report of the ASMBR Histomorphometry Nomenclature Committee. J Bone Miner Res 2:595-610
24. Difford J (1974) A simplified method for the preparation of methyl methacrylate embedding medium. Med Lab Technol 31:79-81
25. Von Kossa J (1974) Nachweis von Kalk. Beitrage zur pathologischen Anatomie und zur allgemeinen. Pathologie 29:163
26. Baldock PA, Morris HA, Need AG, Moore RJ, Durbridge TC (1998) Variation in the short-term changes in bone cell activity in three regions of the distal femur immediately following ovariectomy. J Bone Miner Res 13:1451-1457
27. Haffa A, Krueger D, Bruner J, Engelke J, Gundberg C, Akhter M, Binkley N (2000) Diet- or warfarin-induced vitamin K insufficiency elevates circulating undercarboxylated osteocalcin without altering skeletal status in growing female rats. J Bone Miner Res 15:872-878
28. Fort FL (1991) Drug safety evaluation. In: Swarbrick J, Boylan JC (eds) Encyclopedia of pharmaceutical technology, vol 4. Marcel Dekker, New York, pp 416-421
29. Rico H, Revilla M, Villa LF, Alvarez de Buergo M, Ruiz-Contreras D (1994) Determinants of total and regional bone mineral content and density in postpubertal normal women. Metabolism 43:263-266
30. Rico H, Amo C, Revilla M, Arribas I, González-Riola J et al (1994) Etidronate versus clodronate in the prevention of post-ovariectomy bone loss. An experimental study in rats. Clin Exp Rheumatol 12:301-304
31. Umegaki K, Itoh T, Ichikawa T (1994) Effect of vitamin E on chromosomal damage in bone marrow cells of mice having received low dose of X-ray irradiation. Int J Vitam Nutr Res 64:249-252
32. Meydani SN, Meydani M, Rall LC, Morrow F, Blumberg JB (1994) Assessment of the safety of high-dose, short-term supplementation with vitamin E in healthy older adults. Am J Clin Nutr 60:704-709
33. Nakamura H, Furukawa F, Nishikawa A, Miyauchi M, Son H-Y, Imazawa T, Hirose M (2001) Oral toxicity of a tocotrienol preparation in rats. Food Chem Toxicol 39:799-805
34. Oo SL, Chang P, Chan KE (1992) Toxicological and pharmacological studies on palm vitee. Nutr Res 2:217-222
35. Vignery A, Baron R (1980) Dynamic histomorphometry of alveolar bone remodeling in the adult rat. Anat Rec 196:191-200
36. Barengolts EL, Curry DJ, Bapna MS, Kukreja SC (1993) Effects of two non-endurance exercise protocols on established bone loss in ovariectomized adult rats. Calcif Tissue Int 52:239-243
37. Currey JD (1988) The effect of porosity and ash content on the Young's modulus of elasticity of compact bone. J Biomech 21:131-139
38. Schaffler MB, Burr DB (1988) Stiffness of compact bone: effects of porosity and density. J Biomech 21:13-16
39. Arjmandi BH, Juma S, Beharka A, Bapna S, Akhter M, Meydani SN (2002) Vitamin E improves bone quality in the aged but not in young adult male mice. J Nutr Biochem 13:543-549
40. Turan B, Balcik C, Akkas N (1997) Effect of dietary selenium and vitamin E on the biomechanical properties of rabbit bones. Clin Rheumatol 16:441-449 (Pubitemid 27425420)
41. Erikson EH (1950) Childhood and society. Norton, New York
42. Wang L, Banu J, McMahan CA, Kalu DN (2001) Male rodent model of age-related bone loss in men. Bone 29:141-148
43. Sandra M, Norazlina M, Nazrun AS, Ima Nirwana S (2008) Palm tocotrienol exerted better antioxidant activities in bone than alpha-tocopherol. Basic Clin Pharmacol Toxicol 103:55-60
44. Ebina Y, Okada S, Hamazaki S, Toda Y, Midorikawa O (1991) Impairment of bone formation with aluminium and ferric nitrilotriacetate complexes. Calcif Tissue Int 48:28-36
45. Abhaya A, Khatri K, Pradhan S, Prakash R (2003) Effect of alpha tocopherol on the growth plate of albino rats. J Anat Soc India 52:58-63
46. Meydani SN, Barklund MP, Liu S, Meydani M, Miller RA, Cannon JG, Morrow FD, Rocklin R, Blumberg JB (1990) Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am J Clin Nutr 52:557-563
47. Khanduja KL, Avti PK, Kumar S, Pathania V, Pathak CM (2005) Inhibitory effect of vitamin E on proinflammatory cytokines-and endotoxin-induced nitric oxide release in alveolar macrophages. Life Sci 76:2669-2680
48. Pathania V, Syal N, Pathak CM, Khanduja KL (1999) Vitamin E suppresses the induction of reactive oxygen species release by lipopolysaccharide, interleukin-1β and tumor necrosis factor-α in rat alveolar macrophages. J Nutr Sci Vitaminol 45:675-686
49. Devaraj S, Jialal I (2005) α-Tocopherol decreases tumor necrosis factor-α mRNA and protein from activated human monocytes by inhibition of 5-lipoxygenase. Free Radic Biol Med 38:1212-1220
50. Kamat JP, Devasagayam TPA (1995) Tocotrienols from palm oil as a potent inhibitor of lipid peroxidation and protein oxidation in rat brain mitochondria. Neurosci Lett 195:179-182
51. Serbinova E, Kagan V, Han D, Packer L (1991) Free radical recycling and intramembrane mobility in the antioxidant properties of tocopherol and tocotrienol. Free Radic Biol Med 10:263-275