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Volumn 78, Issue 6, 2011, Pages 393-403

Statin myopathy: A common dilemma not reflected in clinical trials

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

EID: 79958264458     PISSN: 08911150     EISSN: None     Source Type: Journal    
DOI: 10.3949/ccjm.78a.10073     Document Type: Review
Times cited : (194)

References (67)
  • 1
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    • Baigent C, Keech A, Kearney PM, et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 2005; 366:1267-1278.
    • (2005) Lancet , vol.366 , pp. 1267-1278
    • Baigent, C.1    Keech, A.2    Kearney, P.M.3
  • 2
    • 0037524291 scopus 로고    scopus 로고
    • Effectiveness of statin titration on low-density lipoprotein cholesterol goal attainment in patients at high risk of atherogenic events
    • Foley KA, Simpson RJ Jr, Crouse JR 3rd, et al. Effectiveness of statin titration on low-density lipoprotein cholesterol goal attainment in patients at high risk of atherogenic events. Am J Cardiol 2003; 92:79-81.
    • (2003) Am J Cardiol , vol.92 , pp. 79-81
    • Foley, K.A.1    Simpson Jr., R.J.2    Crouse J.R., III.3
  • 3
    • 3042551237 scopus 로고    scopus 로고
    • Ethnic and sex differences in the prevalence, treatment, and control of dyslipidemia among hypertensive adults in the GENOA study
    • O'Meara JG, Kardia SL, Armon JJ, et al. Ethnic and sex differences in the prevalence, treatment, and control of dyslipidemia among hypertensive adults in the GENOA study. Arch Intern Med 2004; 164:1313-1318.
    • (2004) Arch Intern Med , vol.164 , pp. 1313-1318
    • O'Meara, J.G.1    Kardia, S.L.2    Armon, J.J.3
  • 4
    • 0037167013 scopus 로고    scopus 로고
    • Adherence with statin therapy in elderly patients with and without acute coronary syndromes
    • Jackevicius CA, Mamdani M, Tu JV. Adherence with statin therapy in elderly patients with and without acute coronary syndromes. JAMA 2002; 288:462-467.
    • (2002) JAMA , vol.288 , pp. 462-467
    • Jackevicius, C.A.1    Mamdani, M.2    Tu, J.V.3
  • 5
    • 67249111853 scopus 로고    scopus 로고
    • Narrative review: statin-related myopathy
    • Joy TR, Hegele RA. Narrative review: statin-related myopathy. Ann Intern Med 2009; 150:858-868.
    • (2009) Ann Intern Med , vol.150 , pp. 858-868
    • Joy, T.R.1    Hegele, R.A.2
  • 7
    • 0023710476 scopus 로고
    • Factors predictive of acute renal failure in rhabdomyolysis
    • Ward MM. Factors predictive of acute renal failure in rhabdomyolysis. Arch Intern Med 1988; 148:1553-1557.
    • (1988) Arch Intern Med , vol.148 , pp. 1553-1557
    • Ward, M.M.1
  • 8
    • 33645889332 scopus 로고    scopus 로고
    • National Lipid Association Statin Safety Assessment Task Force. Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force
    • McKenney JM, Davidson MH, Jacobson TA, et al. National Lipid Association Statin Safety Assessment Task Force. Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force. Am J Cardiol 2006; 97:89C-84C.
    • (2006) Am J Cardiol , vol.97
    • McKenney, J.M.1    Davidson, M.H.2    Jacobson, T.A.3
  • 9
    • 0037036822 scopus 로고    scopus 로고
    • ACC/AHA/NHLBI clinical advisory on the use and safety of statins
    • Pasternak RC, Smith SC Jr, Bairey-Merz CN, et al. ACC/AHA/NHLBI clinical advisory on the use and safety of statins. J Am Coll Cardiol 2002; 40:567-572.
    • (2002) J Am Coll Cardiol , vol.40 , pp. 567-572
    • Pasternak, R.C.1    Smith Jr., S.C.2    Bairey-Merz, C.N.3
  • 11
    • 73349103163 scopus 로고    scopus 로고
    • The modern spectrum of rhabdomyolysis: drug toxicity revealed by creatine kinase screening
    • Linares LA, Golomb BA, Jaojoco JA, et al. The modern spectrum of rhabdomyolysis: drug toxicity revealed by creatine kinase screening. Curr Drug Saf 2009; 4:181-187.
    • (2009) Curr Drug Saf , vol.4 , pp. 181-187
    • Linares, L.A.1    Golomb, B.A.2    Jaojoco, J.A.3
  • 12
    • 35748962429 scopus 로고    scopus 로고
    • The safety of statins in clinical practice
    • Armitage J. The safety of statins in clinical practice. Lancet 2007; 370:1781-1790.
    • (2007) Lancet , vol.370 , pp. 1781-1790
    • Armitage, J.1
  • 13
    • 0037840242 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial
    • Collins R, Armitage J, Parish S, et al. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. Lancet 2003; 361:2005-2016.
    • (2003) Lancet , vol.361 , pp. 2005-2016
    • Collins, R.1    Armitage, J.2    Parish, S.3
  • 14
    • 15944410609 scopus 로고    scopus 로고
    • Intensive lipid lowering with atorvastatin in patients with stable coronary disease
    • LaRosa JC, Grundy SM, Waters DD, et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Med 2005; 352:1425-1435.
    • (2005) N Engl J Med , vol.352 , pp. 1425-1435
    • LaRosa, J.C.1    Grundy, S.M.2    Waters, D.D.3
  • 15
    • 49649091314 scopus 로고    scopus 로고
    • Prevalence of musculoskeletal pain and statin use
    • Buettner C, Davis RB, Leveille SG, et al. Prevalence of musculoskeletal pain and statin use. J Gen Intern Med 2008; 23:1182-1186.
    • (2008) J Gen Intern Med , vol.23 , pp. 1182-1186
    • Buettner, C.1    Davis, R.B.2    Leveille, S.G.3
  • 17
    • 0037099283 scopus 로고    scopus 로고
    • Two-year efficacy and safety of simvastatin 80 mg in familial hypercholesterolemia (the Examination of Probands and Relatives in Statin Studies With Familial Hypercholesterolemia [ExPRESS FH])
    • de Sauvage Nolting PR, Buirma RJ, et al. Two-year efficacy and safety of simvastatin 80 mg in familial hypercholesterolemia (the Examination of Probands and Relatives in Statin Studies With Familial Hypercholesterolemia [ExPRESS FH]). Am J Cardiol 2002; 90:181-184.
    • (2002) Am J Cardiol , vol.90 , pp. 181-184
    • de Sauvage Nolting, P.R.1    Buirma, R.J.2
  • 18
    • 1542405145 scopus 로고    scopus 로고
    • A comprehensive description of muscle symptoms associated with lipid-lowering drugs
    • Franc S, Dejager S, Bruckert E, et al. A comprehensive description of muscle symptoms associated with lipid-lowering drugs. Cardiovasc Drugs Ther 2003; 17:459-465.
    • (2003) Cardiovasc Drugs Ther , vol.17 , pp. 459-465
    • Franc, S.1    Dejager, S.2    Bruckert, E.3
  • 19
    • 33845876333 scopus 로고    scopus 로고
    • Risks associated with statin therapy: a systematic overview of randomized clinical trials
    • Kashani A, Phillips CO, Foody JM, et al. Risks associated with statin therapy: a systematic overview of randomized clinical trials. Circulation 2006; 114:2788-2797.
    • (2006) Circulation , vol.114 , pp. 2788-2797
    • Kashani, A.1    Phillips, C.O.2    Foody, J.M.3
  • 20
    • 32444444724 scopus 로고    scopus 로고
    • Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients-the PRIMO study
    • Bruckert E, Hayem G, Dejager S, et al. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients-the PRIMO study. Cardiovasc Drugs Ther 2005; 19:403-414.
    • (2005) Cardiovasc Drugs Ther , vol.19 , pp. 403-414
    • Bruckert, E.1    Hayem, G.2    Dejager, S.3
  • 21
    • 49649091314 scopus 로고    scopus 로고
    • Prevalence of musculoskeletal pain and statin use
    • Buettner C, Davis RB, Leveille SG, et al. Prevalence of musculoskeletal pain and statin use. J Gen Intern Med 2008; 23:1182-1186.
    • (2008) J Gen Intern Med , vol.23 , pp. 1182-1186
    • Buettner, C.1    Davis, R.B.2    Leveille, S.G.3
  • 22
    • 67049119523 scopus 로고    scopus 로고
    • From here to JUPITER: identifying new patients for statin therapy using data from the 1999-2004 National Health and Nutrition Examination Survey
    • Spatz ES, Canavan ME, Desai MM. From here to JUPITER: identifying new patients for statin therapy using data from the 1999-2004 National Health and Nutrition Examination Survey. Circ Cardiovasc Qual Outcomes 2009; 2:41-48.
    • (2009) Circ Cardiovasc Qual Outcomes , vol.2 , pp. 41-48
    • Spatz, E.S.1    Canavan, M.E.2    Desai, M.M.3
  • 23
    • 33746665298 scopus 로고    scopus 로고
    • Genetic risk factors associated with lipid-lowering drug-induced myopathies
    • Vladutiu GD, Simmons Z, Isackson PJ, et al. Genetic risk factors associated with lipid-lowering drug-induced myopathies. Muscle Nerve 2006; 34:153-162.
    • (2006) Muscle Nerve , vol.34 , pp. 153-162
    • Vladutiu, G.D.1    Simmons, Z.2    Isackson, P.J.3
  • 24
    • 56249093499 scopus 로고    scopus 로고
    • Genetic predisposition to statin myopathy
    • Vladutiu GD. Genetic predisposition to statin myopathy. Curr Opin Rheumatol 2008; 20:648-655.
    • (2008) Curr Opin Rheumatol , vol.20 , pp. 648-655
    • Vladutiu, G.D.1
  • 25
    • 5444271174 scopus 로고    scopus 로고
    • Statin myotoxicity is associ ated with changes in the cardiopulmonary function
    • Phillips PS, Phillips CT, Sullivan MJ, et al. Statin myotoxicity is associ ated with changes in the cardiopulmonary function. Atherosclerosis 2004; 177:183-188.
    • (2004) Atherosclerosis , vol.177 , pp. 183-188
    • Phillips, P.S.1    Phillips, C.T.2    Sullivan, M.J.3
  • 26
    • 63449088307 scopus 로고    scopus 로고
    • Myotoxic reactions to lipidlowering therapy are associated with altered oxidation of fatty acids
    • Phillips PS, Ciaraldi TP, Kim DL, et al. Myotoxic reactions to lipidlowering therapy are associated with altered oxidation of fatty acids. Endocrine 2009; 35:38-46.
    • (2009) Endocrine , vol.35 , pp. 38-46
    • Phillips, P.S.1    Ciaraldi, T.P.2    Kim, D.L.3
  • 27
  • 28
  • 29
    • 32844468448 scopus 로고    scopus 로고
    • Monotherapy with Ezetimibe Causing Myopathy
    • Havranek JM, Wolfsen A, Warnke GA, et al. Monotherapy with Ezetimibe Causing Myopathy. Am J Med 2006;119:285-286.
    • (2006) Am J Med , vol.119 , pp. 285-286
    • Havranek, J.M.1    Wolfsen, A.2    Warnke, G.A.3
  • 30
    • 6344290071 scopus 로고    scopus 로고
    • Ezetimibe and statin-associated myopathy
    • Phillips PS. Ezetimibe and statin-associated myopathy. Ann Intern Med 2004; 141:649.
    • (2004) Ann Intern Med , vol.141 , pp. 649
    • Phillips, P.S.1
  • 31
    • 0036727068 scopus 로고    scopus 로고
    • One year experience with a low density lipoprotein apheresis system
    • Durst R, Rund D, Schurr D, et al. One year experience with a low density lipoprotein apheresis system. Isr Med Assoc J 2002; 4:677-680.
    • (2002) Isr Med Assoc J , vol.4 , pp. 677-680
    • Durst, R.1    Rund, D.2    Schurr, D.3
  • 32
    • 0030972796 scopus 로고    scopus 로고
    • The rule of 5 and the rule of 7 in lipid-lowering by statin drugs
    • Roberts WC. The rule of 5 and the rule of 7 in lipid-lowering by statin drugs. Am J Cardiol 1997; 80:106-107.
    • (1997) Am J Cardiol , vol.80 , pp. 106-107
    • Roberts, W.C.1
  • 33
    • 0141612021 scopus 로고    scopus 로고
    • Benefit-risk assessment of rosuvastatin 10 to 40 milligrams
    • Brewer HB Jr. Benefit-risk assessment of rosuvastatin 10 to 40 milligrams. Am J Cardiol 2003; 92:23K-29K.
    • (2003) Am J Cardiol , vol.92
    • Brewer Jr., H.B.1
  • 35
    • 33745951478 scopus 로고    scopus 로고
    • Rosuvastatin 5 and 10 mg/d: a pilot study of the effects in hypercholesterolemic adults unable to tolerate other statins and reach LDL cholesterol goals with nonstatin lipid-lowering therapies
    • Glueck CJ, Aregawi D, Agloria M, et al. Rosuvastatin 5 and 10 mg/d: a pilot study of the effects in hypercholesterolemic adults unable to tolerate other statins and reach LDL cholesterol goals with nonstatin lipid-lowering therapies. Clin Ther 2006; 28:933-942.
    • (2006) Clin Ther , vol.28 , pp. 933-942
    • Glueck, C.J.1    Aregawi, D.2    Agloria, M.3
  • 36
    • 41149180129 scopus 로고    scopus 로고
    • Effectiveness and tolerability of every-other-day rosuvastatin dosing in patients with prior statin intolerance
    • Backes JM, Venero CV, Gibson CA, et al. Effectiveness and tolerability of every-other-day rosuvastatin dosing in patients with prior statin intolerance. Ann Pharmacother 2008; 42:341-346.
    • (2008) Ann Pharmacother , vol.42 , pp. 341-346
    • Backes, J.M.1    Venero, C.V.2    Gibson, C.A.3
  • 37
    • 34547109869 scopus 로고    scopus 로고
    • Effects of once weekly rosuvastatin among patients with a prior statin intolerance
    • Backes JM, Moriarty PM, Ruisinger JF, et al. Effects of once weekly rosuvastatin among patients with a prior statin intolerance. Am J Cardiol 2007; 100:554-555.
    • (2007) Am J Cardiol , vol.100 , pp. 554-555
    • Backes, J.M.1    Moriarty, P.M.2    Ruisinger, J.F.3
  • 38
    • 33646558252 scopus 로고    scopus 로고
    • Clinical perspectives of statininduced rhabdomyolysis
    • Antons KA, Williams CD, Baker SK, et al. Clinical perspectives of statininduced rhabdomyolysis. Am J Med 2006; 119:400-409.
    • (2006) Am J Med , vol.119 , pp. 400-409
    • Antons, K.A.1    Williams, C.D.2    Baker, S.K.3
  • 39
    • 44949247555 scopus 로고    scopus 로고
    • Toward "pain-free" statin prescribing: clinical algorithm for diagnosis and management of myalgia
    • Jacobson TA. Toward "pain-free" statin prescribing: clinical algorithm for diagnosis and management of myalgia. Mayo Clin Proc 2008; 83:687-700.
    • (2008) Mayo Clin Proc , vol.83 , pp. 687-700
    • Jacobson, T.A.1
  • 40
    • 0036787034 scopus 로고    scopus 로고
    • Statin-associated myopathy with normal creatine kinase levels
    • Phillips PS, Haas RH, Bannykh S, et al. Statin-associated myopathy with normal creatine kinase levels. Ann Intern Med 2002; 137:581-585.
    • (2002) Ann Intern Med , vol.137 , pp. 581-585
    • Phillips, P.S.1    Haas, R.H.2    Bannykh, S.3
  • 41
    • 1942519775 scopus 로고    scopus 로고
    • Professional athletes suffering from familial hypercholesterolaemia rarely tolerate statin treatment because of muscular problems
    • Sinzinger H, O'Grady J. Professional athletes suffering from familial hypercholesterolaemia rarely tolerate statin treatment because of muscular problems. Br J Clin Pharmacol 2004; 57:525-528.
    • (2004) Br J Clin Pharmacol , vol.57 , pp. 525-528
    • Sinzinger, H.1    O'Grady, J.2
  • 42
    • 13444260767 scopus 로고    scopus 로고
    • Alendronate and risedronate: reports of severe bone, joint, and muscle pain
    • Wysowski DK, Chang JT. Alendronate and risedronate: reports of severe bone, joint, and muscle pain. Arch Intern Med 2005; 165:346-347.
    • (2005) Arch Intern Med , vol.165 , pp. 346-347
    • Wysowski, D.K.1    Chang, J.T.2
  • 43
    • 25444486711 scopus 로고    scopus 로고
    • Safety assessment of raloxifene over eight years in a clinical trial setting
    • Martino S, Disch D, Dowsett SA, et al. Safety assessment of raloxifene over eight years in a clinical trial setting. Curr Med Res Opin 2005; 21:1441-1452.
    • (2005) Curr Med Res Opin , vol.21 , pp. 1441-1452
    • Martino, S.1    Disch, D.2    Dowsett, S.A.3
  • 44
    • 5444269581 scopus 로고    scopus 로고
    • Feasibility of using the internet to perform medical research: observations from a statin-myopathy public information web site
    • Phillips PS, Kimura BJ, Kelley R, et al. Feasibility of using the internet to perform medical research: observations from a statin-myopathy public information web site. Circulation 2003; 107:e7001-e7039.
    • (2003) Circulation , vol.107
    • Phillips, P.S.1    Kimura, B.J.2    Kelley, R.3
  • 45
    • 0034779017 scopus 로고    scopus 로고
    • Four cases of tendinopathy in patients on statin therapy
    • Chazerain P, Hayem G, Hamza S, et al. Four cases of tendinopathy in patients on statin therapy. Joint Bone Spine 2001; 68:430-433.
    • (2001) Joint Bone Spine , vol.68 , pp. 430-433
    • Chazerain, P.1    Hayem, G.2    Hamza, S.3
  • 46
    • 4544275379 scopus 로고    scopus 로고
    • Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
    • Grundy SM, Cleeman JI, Merz CN, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. J Am Coll Cardiol 2004; 44:720-732.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 720-732
    • Grundy, S.M.1    Cleeman, J.I.2    Merz, C.N.3
  • 47
    • 0032554686 scopus 로고    scopus 로고
    • Lipoprotein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian Simvastatin Survival Study (4S)
    • Pedersen TR, Olsson AG, Faergeman O, et al. Lipoprotein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian Simvastatin Survival Study (4S). Circulation 1998; 97:1453-1460.
    • (1998) Circulation , vol.97 , pp. 1453-1460
    • Pedersen, T.R.1    Olsson, A.G.2    Faergeman, O.3
  • 48
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002; 360:7-22.
    • (2002) Lancet , vol.360 , pp. 7-22
  • 49
    • 11144355354 scopus 로고    scopus 로고
    • Intensive versus moderate lipid lowering with statins after acute coronary syndromes
    • Cannon CP, Braunwald E, McCabe CH, et al. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med 2004; 350:1495-1504.
    • (2004) N Engl J Med , vol.350 , pp. 1495-1504
    • Cannon, C.P.1    Braunwald, E.2    McCabe, C.H.3
  • 50
    • 0032487931 scopus 로고    scopus 로고
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
    • The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
    • The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339:1349-1357.
    • (1998) N Engl J Med , vol.339 , pp. 1349-1357
  • 51
    • 0342981862 scopus 로고    scopus 로고
    • The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators
    • Sacks FM, Pfeffer MA, Moye LA, et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. N Engl J Med 1996; 335:1001-1009.
    • (1996) N Engl J Med , vol.335 , pp. 1001-1009
    • Sacks, F.M.1    Pfeffer, M.A.2    Moye, L.A.3
  • 52
    • 0037164314 scopus 로고    scopus 로고
    • Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial
    • Shepherd J, Blauw GJ, Murphy MB, et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet 2002; 360:1623-1630.
    • (2002) Lancet , vol.360 , pp. 1623-1630
    • Shepherd, J.1    Blauw, G.J.2    Murphy, M.B.3
  • 53
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
    • Shepherd J, Cobbe SM, Ford I, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med 1995; 333:1301-1307.
    • (1995) N Engl J Med , vol.333 , pp. 1301-1307
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3
  • 54
    • 0032572086 scopus 로고    scopus 로고
    • Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study
    • Downs JR, Clearfield M, Weis S, et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA 1998; 279:1615-1622.
    • (1998) JAMA , vol.279 , pp. 1615-1622
    • Downs, J.R.1    Clearfield, M.2    Weis, S.3
  • 55
    • 56749106312 scopus 로고    scopus 로고
    • Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    • Ridker PM, Danielson E, Fonseca FA, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008; 359:2195-2207.
    • (2008) N Engl J Med , vol.359 , pp. 2195-2207
    • Ridker, P.M.1    Danielson, E.2    Fonseca, F.A.3
  • 56
    • 0037420492 scopus 로고    scopus 로고
    • Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
    • Sever PS, Dahlof B, Poulter NR, et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet 2003; 361:1149-1158.
    • (2003) Lancet , vol.361 , pp. 1149-1158
    • Sever, P.S.1    Dahlof, B.2    Poulter, N.R.3
  • 57
    • 33748952489 scopus 로고    scopus 로고
    • Primary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): a prospective randomised controlled trial
    • Nakamura H, Arakawa K, Itakura H, et al. Primary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): a prospective randomised controlled trial. Lancet 2006; 368:1155-1163.
    • (2006) Lancet , vol.368 , pp. 1155-1163
    • Nakamura, H.1    Arakawa, K.2    Itakura, H.3
  • 58
    • 0037132607 scopus 로고    scopus 로고
    • Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHATLLT)
    • Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHATLLT). JAMA 2002; 288:2998-3007.
    • (2002) JAMA , vol.288 , pp. 2998-3007
  • 59
    • 38849083283 scopus 로고    scopus 로고
    • Efficacy and tolerability of fluvastatin XL 80 mg alone, ezetimibe alone, and the combination of fluvastatin XL 80 mg with ezetimibe in patients with a history of muscle-related side effects with other statins
    • Stein EA, Ballantyne CM, Windler E, et al. Efficacy and tolerability of fluvastatin XL 80 mg alone, ezetimibe alone, and the combination of fluvastatin XL 80 mg with ezetimibe in patients with a history of muscle-related side effects with other statins. Am J Cardiol 2008; 101:490-496.
    • (2008) Am J Cardiol , vol.101 , pp. 490-496
    • Stein, E.A.1    Ballantyne, C.M.2    Windler, E.3
  • 60
    • 33745951478 scopus 로고    scopus 로고
    • Rosuvastatin 5 and 10 mg/d: a pilot study of the effects in hypercholesterolemic adults unable to tolerate other statins and reach LDL cholesterol goals with nonstatin lipid-lowering therapies
    • Glueck CJ, Aregawi D, Agloria M, et al. Rosuvastatin 5 and 10 mg/d: a pilot study of the effects in hypercholesterolemic adults unable to tolerate other statins and reach LDL cholesterol goals with nonstatin lipid-lowering therapies. Clin Ther 2006; 28:933-942.
    • (2006) Clin Ther , vol.28 , pp. 933-942
    • Glueck, C.J.1    Aregawi, D.2    Agloria, M.3
  • 62
    • 67249100852 scopus 로고    scopus 로고
    • Balancing randomized trials with anecdote
    • Phillips PS. Balancing randomized trials with anecdote. Ann Intern Med 2009; 150:885-886.
    • (2009) Ann Intern Med , vol.150 , pp. 885-886
    • Phillips, P.S.1
  • 63
    • 78049264831 scopus 로고    scopus 로고
    • Marked variability of monacolin levels in commercial red yeast rice products: buyer beware
    • Gordon RY, Cooperman T, Obermeyer W, et al. Marked variability of monacolin levels in commercial red yeast rice products: buyer beware! Arch Intern Med 2010; 170:1722-1727.
    • (2010) Arch Intern Med , vol.170 , pp. 1722-1727
    • Gordon, R.Y.1    Cooperman, T.2    Obermeyer, W.3
  • 64
    • 9644252909 scopus 로고    scopus 로고
    • Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs
    • Graham DJ, Staffa JA, Shatin D, et al. Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs. JAMA 2004; 292:2585-2590.
    • (2004) JAMA , vol.292 , pp. 2585-2590
    • Graham, D.J.1    Staffa, J.A.2    Shatin, D.3
  • 65
    • 0034887738 scopus 로고    scopus 로고
    • Lipid-lowering drugs and risk of myopathy: a population-based follow-up study
    • Gaist D, Rodríguez LA, Huerta C, et al. Lipid-lowering drugs and risk of myopathy: a population-based follow-up study. Epidemiology 2001; 12:565-569.
    • (2001) Epidemiology , vol.12 , pp. 565-569
    • Gaist, D.1    Rodríguez, L.A.2    Huerta, C.3
  • 66
    • 28044452217 scopus 로고    scopus 로고
    • Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial
    • Keech A, Simes RJ, Barter P, et al. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 2005; 366:1849-1861.
    • (2005) Lancet , vol.366 , pp. 1849-1861
    • Keech, A.1    Simes, R.J.2    Barter, P.3
  • 67
    • 77951704587 scopus 로고    scopus 로고
    • Effects of combination lipid therapy in type 2 diabetes mellitus
    • Accord Study Group
    • ACCORD Study Group, Ginsberg HN, Elam MB, Lovato LC, et al. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med 2010; 362:1563-1574.
    • (2010) N Engl J Med , vol.362 , pp. 1563-1574
    • Ginsberg, H.N.1    Elam, M.B.2    Lovato, L.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.