-
1
-
-
3142590602
-
In vitro anti-resorptive activity and prevention of ovariectomy-induced osteoporosis in female Sprague-Dawley rats by ormeloxifene, a selective estrogen receptor modulator
-
Arshad, M., Sengupta, S., Sharma, S., Ghosh, R., Sawlani, V., Singh, M. M. (2004) In vitro anti-resorptive activity and prevention of ovariectomy-induced osteoporosis in female Sprague-Dawley rats by ormeloxifene, a selective estrogen receptor modulator. J. Steroid Biochem. Mol. Biol. 91: 67-78
-
(2004)
J. Steroid Biochem. Mol. Biol.
, vol.91
, pp. 67-78
-
-
Arshad, M.1
Sengupta, S.2
Sharma, S.3
Ghosh, R.4
Sawlani, V.5
Singh, M.M.6
-
2
-
-
26144431877
-
Inhibition of osteoclast formation by statins
-
Baumann, A. P., Grasser, W., Petras, S., Harwood, H., Thompson, D. D., Paralkar, V. (2001) Inhibition of osteoclast formation by statins. J. Bone Miner. Res. 16: S507
-
(2001)
J. Bone Miner. Res.
, vol.16
-
-
Baumann, A.P.1
Grasser, W.2
Petras, S.3
Harwood, H.4
Thompson, D.D.5
Paralkar, V.6
-
3
-
-
0032977444
-
The diagnosis and treatment of osteoporosis: Future prospects
-
Baylink, D. J., Strong, D. D., Mohan, S. (1999) The diagnosis and treatment of osteoporosis: future prospects. Mol. Med. 5: 133-140
-
(1999)
Mol. Med.
, vol.5
, pp. 133-140
-
-
Baylink, D.J.1
Strong, D.D.2
Mohan, S.3
-
4
-
-
0032996153
-
Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates; biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs
-
Benford, H. L., Frith, J. C., Auriola, S., Monkkonen, J., Rogers, M. J. (1999) Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates; biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs. Mol. Pharmacol. 56: 131-140
-
(1999)
Mol. Pharmacol.
, vol.56
, pp. 131-140
-
-
Benford, H.L.1
Frith, J.C.2
Auriola, S.3
Monkkonen, J.4
Rogers, M.J.5
-
5
-
-
0023860382
-
Quantitative analysis of the pyridinium crosslinks of collagen in urine using ion-paired reverse-phase high performance liquid chromatography
-
Black, D., Duncan, A., Robins, S. P. (1988) Quantitative analysis of the pyridinium crosslinks of collagen in urine using ion-paired reverse-phase high performance liquid chromatography. Anal. Biochem. 169: 197-203
-
(1988)
Anal. Biochem.
, vol.169
, pp. 197-203
-
-
Black, D.1
Duncan, A.2
Robins, S.P.3
-
6
-
-
0032805692
-
New insights into the pharmacodynamic and pharmacokinetic properties of statins
-
Corsino, A., Bellosta, S., Baetta, R., Fumagalli, R., Paoletti, R., Bernini, F. (1999) New insights into the pharmacodynamic and pharmacokinetic properties of statins. Pharmacol. Ther. 84: 413-428
-
(1999)
Pharmacol. Ther.
, vol.84
, pp. 413-428
-
-
Corsino, A.1
Bellosta, S.2
Baetta, R.3
Fumagalli, R.4
Paoletti, R.5
Bernini, F.6
-
7
-
-
0002130364
-
Statin increases cortical bone in young male rats by single, local administration but fails to restore bone in ovariectomized (OVX) rats by daily systemic administration
-
Crawford, D. T., Qi, H., Chidsey-Frink, K. L., Simmons, H. A., Thomson, D. D., Ke, H. Z. (2001) Statin increases cortical bone in young male rats by single, local administration but fails to restore bone in ovariectomized (OVX) rats by daily systemic administration. J. Bone Miner. Res. 16: S295
-
(2001)
J. Bone Miner. Res.
, vol.16
-
-
Crawford, D.T.1
Qi, H.2
Chidsey-Frink, K.L.3
Simmons, H.A.4
Thomson, D.D.5
Ke, H.Z.6
-
8
-
-
0029095910
-
Temporal changes in cancellous bone structure of rats immediately after ovariectomy
-
Dempster, D. W., Birchman, R., Xu, R., Lindsay, R., Shen, V. (1995) Temporal changes in cancellous bone structure of rats immediately after ovariectomy. Bone 16: 157-161
-
(1995)
Bone
, vol.16
, pp. 157-161
-
-
Dempster, D.W.1
Birchman, R.2
Xu, R.3
Lindsay, R.4
Shen, V.5
-
9
-
-
0035146537
-
Structure-activity relationship for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates
-
Dunford, J. E., Thompson, K., Coxon, F. P., Luckman, S. P., Hahn, F. M., Poulter, C. D., Ebetino, F. H., Rojers, M. J. (2001) Structure-activity relationship for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J. Pharmacol. Exp. Ther. 296: 235-242
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.296
, pp. 235-242
-
-
Dunford, J.E.1
Thompson, K.2
Coxon, F.P.3
Luckman, S.P.4
Hahn, F.M.5
Poulter, C.D.6
Ebetino, F.H.7
Rojers, M.J.8
-
10
-
-
13044283050
-
Alendronate mechanism of action: Geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption and kinase activation in vitro
-
Fisher, J. E., Rojers, M. J., Halasy, J. M., Luckman, S. P., Hughes, D. E., Masarachia, P. J., Wesolowski, G., Russell, R. G., Rodan, G. A., Reszka, A. A. (1999) Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption and kinase activation in vitro. Proc. Natl Acad. Sci. USA 96: 133-138
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 133-138
-
-
Fisher, J.E.1
Rojers, M.J.2
Halasy, J.M.3
Luckman, S.P.4
Hughes, D.E.5
Masarachia, P.J.6
Wesolowski, G.7
Russell, R.G.8
Rodan, G.A.9
Reszka, A.A.10
-
11
-
-
0024508358
-
Tissue selectivity of the cholesterol-lowering agents lovastatin, simvastatin and pravastatin in rats in vivo
-
Germershausen, J. I., Vincent, M. H., Bostedor, R. G., Bailey, P. J., Karkas, J. D., Alberts, A. W. (1989) Tissue selectivity of the cholesterol-lowering agents lovastatin, simvastatin and pravastatin in rats in vivo. Biochem. Biophys. Res. Commun. 158: 667-675
-
(1989)
Biochem. Biophys. Res. Commun.
, vol.158
, pp. 667-675
-
-
Germershausen, J.I.1
Vincent, M.H.2
Bostedor, R.G.3
Bailey, P.J.4
Karkas, J.D.5
Alberts, A.W.6
-
12
-
-
0001433806
-
Dermal application of lovastatin to rats causes greater increases in bone formation and plasma concentrations than when administered by oral gavage
-
Gutierrez, G., Garrett, J. R., Rossini, G., Castano, M., Chapa, G., Escobedo, J., Esparza, A., Horn, D., Qiao, M., Taylor, S., Lalka, D., Mundy, G. R. (2000) Dermal application of lovastatin to rats causes greater increases in bone formation and plasma concentrations than when administered by oral gavage. J. Bone Miner Res. 15: S427
-
(2000)
J. Bone Miner Res.
, vol.15
-
-
Gutierrez, G.1
Garrett, J.R.2
Rossini, G.3
Castano, M.4
Chapa, G.5
Escobedo, J.6
Esparza, A.7
Horn, D.8
Qiao, M.9
Taylor, S.10
Lalka, D.11
Mundy, G.R.12
-
13
-
-
0001433806
-
Dermal application of lovastatin for 5 days stimulates bone formation in ovariectomized rats by 160%
-
Gutierrez, G., Garrett, J. R., Rossini, G., Escobedo, A., Horn, D., Qiao, M., Esparza, J., Lalka, D., Mundy, G. R. (2001) Dermal application of lovastatin for 5 days stimulates bone formation in ovariectomized rats by 160%. J. Bone Miner. Res. 16: S222
-
(2001)
J. Bone Miner. Res.
, vol.16
-
-
Gutierrez, G.1
Garrett, J.R.2
Rossini, G.3
Escobedo, A.4
Horn, D.5
Qiao, M.6
Esparza, J.7
Lalka, D.8
Mundy, G.R.9
-
14
-
-
29944441329
-
Statins and osteoporosis: New role for old drugs
-
Jadhav, S. B., Jain, G. K. (2006) Statins and osteoporosis: new role for old drugs. J. Pharm. Pharmacol. 58: 3-18
-
(2006)
J. Pharm. Pharmacol.
, vol.58
, pp. 3-18
-
-
Jadhav, S.B.1
Jain, G.K.2
-
15
-
-
0019345680
-
3-Hydroxy-3-methylglutaryl-CoA reductase from rat liver
-
Kleinsek, D. A., Duggan, R. E., Baker, T. A., Porter, J. W. (1981) 3-Hydroxy-3-methylglutaryl-CoA reductase from rat liver. Methods Enzymol. 71: 462-479
-
(1981)
Methods Enzymol.
, vol.71
, pp. 462-479
-
-
Kleinsek, D.A.1
Duggan, R.E.2
Baker, T.A.3
Porter, J.W.4
-
16
-
-
0033596281
-
Effect of statins on risk of coronary disease: A meta-analysis of randomized controlled trials
-
LaRosa, J. C., He, J., Vupputuri, S. (1999) Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials. JAMA 282: 2340-2346
-
(1999)
JAMA
, vol.282
, pp. 2340-2346
-
-
Larosa, J.C.1
He, J.2
Vupputuri, S.3
-
17
-
-
0031741901
-
Grapefruit juice-simvastatin interaction: Effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors
-
Lilja, J. J., Kivisto, K. T., Neuvonen, P. J. (1998) Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors. Clin. Pharmacol. Ther. 64: 477-483
-
(1998)
Clin. Pharmacol. Ther.
, vol.64
, pp. 477-483
-
-
Lilja, J.J.1
Kivisto, K.T.2
Neuvonen, P.J.3
-
18
-
-
0037464444
-
Determination of simvastatin-derived HMG-CoA reductase inhibitors in biomatrices using an automated enzyme inhibition assay with radioactive detection
-
Liu, L., Zhang, R., Zhao, J. J., Rogers, J. D., Hsieh, J. Y. K., Fang, W., Matuszewski, B. K., Dobrinska, M. R. (2003) Determination of simvastatin-derived HMG-CoA reductase inhibitors in biomatrices using an automated enzyme inhibition assay with radioactive detection. J. Pharm. Biomed. Anal. 32: 107-123
-
(2003)
J. Pharm. Biomed. Anal.
, vol.32
, pp. 107-123
-
-
Liu, L.1
Zhang, R.2
Zhao, J.J.3
Rogers, J.D.4
Hsieh, J.Y.K.5
Fang, W.6
Matuszewski, B.K.7
Dobrinska, M.R.8
-
19
-
-
0031977199
-
Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras
-
Luckman, S. P., Hughes, D. E., Coxon, F. P., Graham, R., Russell, G., Rogers, M. J. (1998) Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J. Bone Miner. Res. 13: 581-589
-
(1998)
J. Bone Miner. Res.
, vol.13
, pp. 581-589
-
-
Luckman, S.P.1
Hughes, D.E.2
Coxon, F.P.3
Graham, R.4
Russell, G.5
Rogers, M.J.6
-
20
-
-
0034805319
-
Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells
-
Maeda, T., Matsunuma, A., Kawane, T., Horiuchi, N. (2001) Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells. Biochem. Biophys. Res. Commun. 280: 874-877
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.280
, pp. 874-877
-
-
Maeda, T.1
Matsunuma, A.2
Kawane, T.3
Horiuchi, N.4
-
21
-
-
0035724388
-
Effect of statins on bone mineral density and bone histomorphometry in rodents Arterioscler
-
Maritz, F. J., Conradie, M. M., Hulley, P. A., Gopal, R., Hough, S. (2001) Effect of statins on bone mineral density and bone histomorphometry in rodents Arterioscler. Thromb. Vasc. Biol. 21: 1636-1641
-
(2001)
Thromb. Vasc. Biol.
, vol.21
, pp. 1636-1641
-
-
Maritz, F.J.1
Conradie, M.M.2
Hulley, P.A.3
Gopal, R.4
Hough, S.5
-
22
-
-
0034725352
-
HMG-CoA reductase inhibitors and the risk of fractures
-
Meier, C. R., Schlienger, R. G., Kraenzlin, M. E., Schlegel, B., Jick, H. (2000) HMG-CoA reductase inhibitors and the risk of fractures. JAMA 283: 3205-3210
-
(2000)
JAMA
, vol.283
, pp. 3205-3210
-
-
Meier, C.R.1
Schlienger, R.G.2
Kraenzlin, M.E.3
Schlegel, B.4
Jick, H.5
-
23
-
-
0035673870
-
Anabolic agents for treating postmenopausal osteoporosis
-
Meunier, P. J. (2001) Anabolic agents for treating postmenopausal osteoporosis. Joint Bone Spine 68: 576-581
-
(2001)
Joint Bone Spine
, vol.68
, pp. 576-581
-
-
Meunier, P.J.1
-
24
-
-
0035212177
-
Statins and their potential for osteoporosis
-
Mundy, G. R. (2001) Statins and their potential for osteoporosis. Bone 29: 495-497
-
(2001)
Bone
, vol.29
, pp. 495-497
-
-
Mundy, G.R.1
-
25
-
-
0033521078
-
Stimulation of bone formation in vitro and in rodents by statins
-
Mundy, G., Garrett, R., Harris, S., Chan, J., Chen, D., Rossini, G., Boyce, B., Zhao, M., Gutierrez, G. (1999) Stimulation of bone formation in vitro and in rodents by statins. Science 286: 1946-1949
-
(1999)
Science
, vol.286
, pp. 1946-1949
-
-
Mundy, G.1
Garrett, R.2
Harris, S.3
Chan, J.4
Chen, D.5
Rossini, G.6
Boyce, B.7
Zhao, M.8
Gutierrez, G.9
-
26
-
-
1642341604
-
Simvastatin treatment partially prevents ovariectomy-induced bone loss while increasing cortical bone formation
-
Oxlund, H., Andreassen, T. T. (2004) Simvastatin treatment partially prevents ovariectomy-induced bone loss while increasing cortical bone formation. Bone 34: 609-618
-
(2004)
Bone
, vol.34
, pp. 609-618
-
-
Oxlund, H.1
Andreassen, T.T.2
-
27
-
-
0035211808
-
Statin given per orally to adult rats increases cancellous bone mass and compressive strength
-
Oxlund, H., Dalstra, M., Andreassen, T. T. (2001) Statin given per orally to adult rats increases cancellous bone mass and compressive strength. Calcif. Tissue Int. 69: 299-304
-
(2001)
Calcif. Tissue Int.
, vol.69
, pp. 299-304
-
-
Oxlund, H.1
Dalstra, M.2
Andreassen, T.T.3
-
28
-
-
12244292690
-
Preclinical pharmacokinetics of statins
-
Reinoso, R. F., SanchezNavarro, A., Garcia, M. J., Prous, J. R. (2002) Preclinical pharmacokinetics of statins. Methods Find. Clin. Pharmacol. 24: 593-613
-
(2002)
Methods Find. Clin. Pharmacol.
, vol.24
, pp. 593-613
-
-
Reinoso, R.F.1
Sancheznavarro, A.2
Garcia, M.J.3
Prous, J.R.4
-
29
-
-
3042590478
-
Hip fracture risk in statin users - A population-based Danish case-control study
-
Rejnmark, L., Olsen, M. L., Johnsen, P., Vestergaard, P., Sorensen, H. T., Mosekilde, L. (2004) Hip fracture risk in statin users-a population-based Danish case-control study. Osteoporos. Int. 15: 452-458
-
(2004)
Osteoporos. Int.
, vol.15
, pp. 452-458
-
-
Rejnmark, L.1
Olsen, M.L.2
Johnsen, P.3
Vestergaard, P.4
Sorensen, H.T.5
Mosekilde, L.6
-
30
-
-
0035047954
-
Clinical review 123: Hot topic anabolic therapy for osteoporosis
-
Rosen, C. J., Bilezikian, J. P. (2001) Clinical review 123: hot topic anabolic therapy for osteoporosis. J. Clin. Endocrinol. Metab. 86: 957-964
-
(2001)
J. Clin. Endocrinol. Metab.
, vol.86
, pp. 957-964
-
-
Rosen, C.J.1
Bilezikian, J.P.2
-
31
-
-
18144367680
-
Attainment of peak bone mass and bone turnover rate in relation to estrous cycle, pregnancy and lactation in colony-bred Sprague-Dawley rats: Suitability for studies on pathophysiology of bone and therapeutic measures for its management
-
Sengupta, S., Arshad, M., Sharma, S., Dubey, M., Singh, M. M. (2005) Attainment of peak bone mass and bone turnover rate in relation to estrous cycle, pregnancy and lactation in colony-bred Sprague-Dawley rats: suitability for studies on pathophysiology of bone and therapeutic measures for its management. J. Steroid Biochem. Mol. Biol. 94: 421-429
-
(2005)
J. Steroid Biochem. Mol. Biol.
, vol.94
, pp. 421-429
-
-
Sengupta, S.1
Arshad, M.2
Sharma, S.3
Dubey, M.4
Singh, M.M.5
-
32
-
-
0037214223
-
The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity
-
Staal, A., Frith, J. C., French, M. H., Swartz, J., Gungor, T., Harrity, T. W., Tamasi, J., Rogers, M. J., Feyen, J. H. (2003) The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity. J. Bone Miner Res. 18: 88-96
-
(2003)
J. Bone Miner Res.
, vol.18
, pp. 88-96
-
-
Staal, A.1
Frith, J.C.2
French, M.H.3
Swartz, J.4
Gungor, T.5
Harrity, T.W.6
Tamasi, J.7
Rogers, M.J.8
Feyen, J.H.9
-
33
-
-
0034685669
-
Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells
-
Sugiyama, M., Kodama, T., Konishi, K., Abe, K., Asami, S., Oikawa, S. (2000) Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. Biochem. Biophys. Res. Commun. 271: 688-692
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.271
, pp. 688-692
-
-
Sugiyama, M.1
Kodama, T.2
Konishi, K.3
Abe, K.4
Asami, S.5
Oikawa, S.6
-
34
-
-
0345161422
-
The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen containing bisphosphonates
-
van Beek, E., Lowik, C., van der Pluijm, G., Papapoulos, S. (1999) The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: a clue to the mechanism of action of nitrogen containing bisphosphonates. J. Bone Miner. Res. 14: 722-729
-
(1999)
J. Bone Miner. Res.
, vol.14
, pp. 722-729
-
-
Van Beek, E.1
Lowik, C.2
Van Der Pluijm, G.3
Papapoulos, S.4
-
35
-
-
0035843639
-
Use of statins and risk of fractures
-
van Staa, T. P., Wegman, S., de Vries, F., Leufkens, B., Cooper, C. (2001) Use of statins and risk of fractures. JAMA 285: 1850-1855
-
(2001)
JAMA
, vol.285
, pp. 1850-1855
-
-
Van Staa, T.P.1
Wegman, S.2
De Vries, F.3
Leufkens, B.4
Cooper, C.5
-
36
-
-
0038826568
-
Does simvastatin stimulate bone formation in vivo?
-
von Stechow, D., Fish, S., Yahalom, D., Bab, I., Chorev, M., Muller, R., Alexander, J. M. (2003) Does simvastatin stimulate bone formation in vivo? BMC Musculoskelet. Disord. 4: 8
-
(2003)
BMC Musculoskelet. Disord.
, vol.4
, pp. 8
-
-
Von Stechow, D.1
Fish, S.2
Yahalom, D.3
Bab, I.4
Chorev, M.5
Muller, R.6
Alexander, J.M.7
-
37
-
-
0034725357
-
HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients
-
Wang, P. S., Solomon, D. H., Mogun, H., Avorn, J. (2000) HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients. JAMA 283: 3211-3216
-
(2000)
JAMA
, vol.283
, pp. 3211-3216
-
-
Wang, P.S.1
Solomon, D.H.2
Mogun, H.3
Avorn, J.4
|