Bone remodeling

Annals of the New York Academy of Sciences

Volumn 1092, Issue , 2006, Pages 385-396

  Hadjidakis, Dimitrios J ^a,b   Androulakis, Ioannis I ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

Author keywords

Bone remodeling; Cytokines; Osteoblast; Osteoclast

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CALCITRIOL; CALCIUM; CYTOKINE; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PARATHYROID HORMONE; SEX HORMONE; SOMATOMEDIN; THYROID HORMONE; TRANSFORMING GROWTH FACTOR BETA;

BONE CELL; BONE DEVELOPMENT; BONE MATRIX; BONE MINERALIZATION; BONE REMODELING; BONE STRENGTH; BONE STRUCTURE; BONE TISSUE; CELL FUNCTION; CONFERENCE PAPER; CORTICAL BONE; HUMAN; MONONUCLEAR CELL; ORTHOPEDIC SURGERY; OSTEOBLAST; OSTEOCLAST; OSTEOCYTE; OSTEOLYSIS; PROTEIN SYNTHESIS; TRABECULAR BONE; BONE; FEMALE; PATHOPHYSIOLOGY; PHYSIOLOGY; POSTMENOPAUSE OSTEOPOROSIS; REVIEW;

BONE AND BONES; BONE REMODELING; FEMALE; HUMANS; OSTEOBLASTS; OSTEOCLASTS; OSTEOCYTES; OSTEOPOROSIS, POSTMENOPAUSAL;

EID: 34247209572     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1365.035     Document Type: Conference Paper

References (67)

1. WELLIK, D.M. & M.R. CAPECCHI. 2003. Hox10 and Hox11 genes are required to lobally pattern the mammalian skeleton. Science 301: 363-367.
2. ADLER, C.P. 2000. Bones and bone tissue; normal anatomy and histology. In Bone Diseases. 1-30. Springer-Verlag. New York.
3. DUCY, P., C. DESBOIS, B. BOYCE, et al. 1996. Increased bone formation in osteocalcin-deficient mice. Nature 382: 448-452.
4. LUO, G., P. DUCY, M.D. MCKEE, et al. 1997. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386: 78-81.
5. XU, T., P. BIANCO, L.W. FISHER, et al. 1998. Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice. Nat. Genet. 20: 78-82.
6. ELMARDI, A.S., M.V. KATCHBURIAN & E. KATCHBURIAN. 1990. Electron microscopy of developing calvaria reveals images that suggest that osteoclasts engulf and destroy osteocytes during bone resorption. Calcif. Tissue Int. 46: 239-245.
7. LANYON, L.E. 1993. Osteocytes, strain detection, bone modeling and remodelling. Calcif. Tissue Int. 53(Suppl 1): S102-S106.
8. BIANCO, P., M. RIMINUCCI, S. GRONTHOS, et al. 2001. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 19: 180-192.
9. DUCY, P., R. ZHANG, V. GEOFFROY, et al. 1997. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89: 747-754.
10. CANALIS, E., J. PASH, B. GABBITAS, et al. 1993. Growth factors regulate the synthesis of insulin-like growth factor-I in bone cell cultures. Endocrinology 133: 33-38.
11. RYDZIEL, S., S. SHAIKH & E. CANALIS. 1994. Platelet-derived growth factor-AA and -BB (PDGF-AA and -BB) enhance the synthesis of PDGF-AA in bone cell cultures. Endocrinology 134: 2541-2546.
12. GLOBUS, R.K., J. PLOUET & D. GOSPODAROWICZ. 1989. Cultured bovine bone cells synthesize basic fibroblast growth factor and store it in their extracellular matrix. Endocrinology 124: 1539-1547.
13. CANALIS, E., J. PASH & S. VARGHESE. 1993. Skeletal growth factors. Crit. Rev. Eukaryot. Gene Expr. 3: 155-166.
14. CHEN, D., M. ZHAO & G.R. MUNDY. 2004. Bone morphogenetic proteins. Growth Factors 22: 233-241.
15. RIZZOLI, R., J. POSER & U. BURGI. 1986. Nuclear thyroid hormone receptors in cultured bone cells. Metabolism 35: 71-74.
16. BARNARD, R., K.W. NG, T.J. MARTIN, et al. 1991. Growth hormone (GH) receptors in clonal osteoblast-like cells mediate a mitogenic response to GH. Endocrinology 128: 1459-1464.
17. LEVY, J.R., E. MURRAY, S. MANOLAGAS, et al. 1986. Demonstration of insulin receptors and modulation of alkaline phosphatase activity by insulin in rat osteoblastic cells. Endocrinology 119: 1786-1792.
18. WEI, L.L., M.W. LEACH, R.S. MINER, et al. 1993. Evidence for progesterone receptors in human osteoblast-like cells. Biochem. Biophys. Res. Commun. 195: 525-532.
19. CLEMENT-LACROIX, P., C. ORMANDY, L. LEPESCHEUX, et al. 1999. Osteoblasts are a newtarget for prolactin: analysis of bone formation in prolactin receptor knockout mice. Endocrinology 140: 96-105.
20. ERIKSEN, E.F., D.S. COLVARD, N.J. BERG, et al. 1988. Evidence of estrogen receptors in normal human osteoblast-like cells. Science 241: 84-86.
21. COLVARD, D.S., E.F. ERIKSEN, P.E. KEETING, et al. 1989. Identification of androgen receptors in normal human osteoblast-like cells. Proc. Natl. Acad. Sci. USA 86: 854-857.
22. DARWISH, H.M. & H.F. DELUCA. 1996. Recent advances in the molecular biology of vitamin D action. Prog. Nucleic Acid Res. Mol. Biol. 53: 321-344.
23. KINDMARK, A., H. TORMA, A. JOHANSSON, et al. 1993. Reverse transcription-polymerase chain reaction assay demonstrates that the 9-cis retinoic acid receptor alpha is expressed in human osteoblasts. Biochem. Biophys. Res. Commun. 192: 1367-1372.
24. TEITELBAUM, S.L. 2000. Bone resorption by osteoclasts. Science 289: 1504-1508.
25. VAANANEN, H.K., H. ZHAO, M. MULARI, et al. 2000. The cell biology of osteoclast function. J. Cell Sci. 113(Pt 3): 377-381.
26. DAVIES, J., J. WARWICK, N. TOTTY, et al. 1989. The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. J. Cell Biol. 109: 1817-1826.
27. REINHOLT, F.P., K. HULTENBY, A. OLDBERG, et al. 1990. Osteopontin - a possible anchor of osteoclasts to bone. Proc. Natl. Acad. Sci. USA 87: 4473-4475.
28. SORIANO, P., C. MONTGOMERY, R. GESKE, et al. 1991. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64: 693-702.
29. WARSHAWSKY, H., D. GOLTZMAN, M.F. ROULEAU, et al. 1980. Direct in vivo demonstration by radioautography of specific binding sites for calcitonin in skeletal and renal tissues of the rat. J. Cell Biol. 85: 682-694.
30. MIZUNO, Y., T. HOSOI, S. INOUE, et al. 1994. Immunocytochemical identification of androgen receptor in mouse osteoclast-like multinucleated cells. Calcif. Tissue Int. 54: 325-326.
31. ABU, E.O., S. BORD, A. HORNER, et al. 1997. The expression of thyroid hormone receptors in human bone. Bone 21: 137-142.
32. THOMAS, D.M., N. UDAGAWA, D.K. HARDS, et al. 1998. Insulin receptor expression in primary and cultured osteoclast-like cells. Bone 23: 181-186.
33. TETI, A., R. RIZZOLI & Z.A. ZAMBONIN. 1991. Parathyroid hormone binding to cultured avian osteoclasts. Biochem. Biophys. Res. Commun. 174: 1217-1222.
34. HOU, P., T. SATO, W. HOFSTETTER, et al. 1997. Identification and characterization of the insulin-like growth factor I receptor in mature rabbit osteoclasts. J. Bone Miner. Res. 12: 534-540.
35. XU, L.X., T. KUKITA, Y. NAKANO, et al. 1996. Osteoclasts in normal and adjuvant arthritis bone tissues express the mRNA for both type I and II interleukin-1 receptors. Lab. Invest. 75: 677-687.
36. HOFSTETTER, W., A. WETTERWALD, M.C. CECCHINI, et al. 1992. Detection of transcripts for the receptor for macrophage colony-stimulating factor, c-fms, in murine osteoclasts. Proc. Natl. Acad. Sci. USA 89: 9637-9641.
37. ZHANG, Z., J. CHEN & D. JIN. 1998. Platelet-derived growth factor (PDGF)-BB stimulates osteoclastic bone resorption directly: the role of receptor beta. Biochem. Biophys. Res. Commun. 251: 190-194.
38. FROST, H.M. 1990. Skeletal structural adaptations to mechanical usage (SATMU): 2. Redefining Wolff's law: the remodeling problem. Anat. Rec. 226: 414-422.
39. PETRTYL, M., J. HERT & P. FIALA. 1996. Spatial organization of the haversian bone in man. J. Biomech. 29: 161-169.
40. PARFITT, A.M. 1994. Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. J. Cell Biochem. 55: 273-286.
41. FROST, H.M. 1996. Dynamics of bone remodeling. In Bone Biodynamics. H.M. Frost, Ed.: 315-333. Littel Brown. Boston, MA.
42. SUDA, T., N. TAKAHASHI, N. UDAGAWA, et al. 1999. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr. Rev. 20: 345-357.
43. HSU, H., D.L. LACEY, C.R. DUNSTAN, et al. 1999. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc. Natl. Acad. Sci. USA 96: 3540-3545.
44. HOFBAUER, L.C. & M. SCHOPPET. 2004. Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases. JAMA 292: 490-495.
45. SIMONET, W.S., D.L. LACEY, C.R. DUNSTAN, et al. 1997. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89: 309-319.
46. KIM, C.H., E. TAKAI, H. ZHOU, et al. 2003. Trabecular bone response to mechanical and parathyroid hormone stimulation: the role of mechanical microenvironment. J. Bone Miner. Res. 18: 2116-2125.
47. CHAPUY, M.C., M.E. ARLOT, F. DUBOEUF, et al. 1992. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N. Engl. J. Med. 327: 1637-1642.
48. WANG, J., J. ZHOU, C.M. CHENG, et al. 2004. Evidence supporting dual, IGF-I-independent and IGF-I-dependent, roles for GH in promoting longitudinal bone growth. J. Endocrinol. 180: 247-255.
49. WEINSTEIN, R.S., R.L. JILKA, A.M. PARFITT, et al. 1998. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J. Clin. Invest. 102: 274-282.
50. BRITTO, J.M., A.J. FENTON, W.R. HOLLOWAY, et al. 1994. Osteoblasts mediate thyroid hormone stimulation of osteoclastic bone resorption. Endocrinology 134: 169-176.
51. SRIVASTAVA, S., G. TORALDO, M.N. WEITZMANN, et al. 2001. Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kappa B ligand (RANKL)-induced JNK activation. J. Biol. Chem. 276: 8836-8840.
52. KAMEDA, T., H. MANO, T. YUASA, et al. 1997. Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts. J. Exp. Med. 186: 489-495.
53. MANOLAGAS, S.C. 2000. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr. Rev. 21: 115-137.
54. SATO, T., H. KAWANO, S. KATO, et al. 2002. Study of androgen action in bone by analysis of androgen-receptor deficient mice. J. Bone Miner. Metab. 20: 326-330.
55. UDAGAWA, N., N. TAKAHASHI, T. AKATSU, et al. 1990. Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc. Natl. Acad. Sci. USA 87: 7260-7264.
56. HOFBAUER, L.C., S. KHOSLA, C.R. DUNSTAN, et al. 2000. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J. Bone Miner. Res. 15: 2-12.
57. HOFBAUER, L.C., D.L. LACEY, C.R. DUNSTAN, et al. 1999. Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells. Bone 25: 255-259.
58. THIRUNAVUKKARASU, K., R.R. MILES, D.L. HALLADAY, et al. 2001. Stimulation of osteoprotegerin (OPG) gene expression by transforming growth factor-beta (TGF-beta). Mapping of the OPG promoter region that mediates TGF-beta effects. J. Biol. Chem. 276: 36241-36250.
59. MA, Y.L., R.L. CAIN, D.L. HALLADAY, et al. 2001. Catabolic effects of continuous human PTH (1-38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation. Endocrinology 142: 4047-4054.
60. KITAZAWA, R., S. KITAZAWA & S. MAEDA. 1999. Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene. Biochim. Biophys. Acta 1445: 134-141.
61. HOFBAUER, L.C., F. GORI, B.L. RIGGS, et al. 1999. Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis. Endocrinology 140: 4382-4389.
62. SAIKA, M., D. INOUE, S. KIDO, et al. 2001. 17beta-estradiol stimulates expression of osteoprotegerin by a mouse stromal cell line, ST-2, via estrogen receptor-alpha. Endocrinology 142: 2205-2212.
63. YANO, K., N. NAKAGAWA, H. YASUDA, et al. 2001. Synovial cells from a patient with rheumatoid arthritis produce osteoclastogenesis inhibitor factor/osteoprotegerin: reciprocal regulation of the production by inflammatory cytokines and basic fibroblast growth factor. J. Bone Miner. Metab. 6: 365-372.
64. LIU, X.H., A. KIRSCHENBAUM, S. YAO, et al. 2005. Cross-talk between the interleukin-6 and prostaglandin E(2) signaling systems results in enhancement of osteoclastogenesis through effects on the osteoprotegerin/receptor activator of nuclear factor-{kappa}B (RANK) ligand/RANK system. Endocrinology 146: 1991-1998.
65. MOONGA, B.S., O.A. ADEBANJO, H.J. WANG, et al. 2002. Differential effects of interleukin-6 receptor activation on intracellular signaling and bone resorption by isolated rat osteoclasts. J. Endocrinol. 173: 395-405.
66. SIMS, N.A., B.J. JENKINS, J.M. QUINN, et al. 2004. Gp130 regulates bone turnover and bone size by distinct downstream signaling pathways. J. Clin. Invest. 113: 379-389.
67. MIAO, D., B. HE, Y. JIANG, et al. 2005. Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34. J. Clin. Invest. 115: 2402-2411.