Statin given perorally to adult rats increases cancellous bone mass and compressive strength

Calcified Tissue International

Volumn 69, Issue 5, 2001, Pages 299-304

  Oxlund, H ^a   Dalstra, M ^a   Andreassen, T T ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Bone compressive strength; Bone formation; Cancellous bone; Micro CT scanning; Statin

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; SIMVASTATIN;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; BONE MASS; BONE STRENGTH; CANCELLOUS BONE; COMPRESSIVE STRENGTH; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG EFFECT; FEMALE; LUMBAR VERTEBRA; MORPHOMETRICS; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; RAT;

EID: 0035211808     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-001-2027-5     Document Type: Article

References (23)

1. Stimulation of bone formation in vitro and in rodents by statins
2. Dermal application of lovastatin to rats causes greater increases in bone formation and plasma concentrations than when administered by oral gavage
3. Cerivastatin increases cortical bone formation in OVX rats
4. Surface-specific bone remodeling in health and disease
5. The mechanical properties of cancellous bone in the proximal tibia of ovariectomized rats
6. Basic biomechanical measurements of bone: A tutorial
7. The influence of growth hormone on cancellous and cortical bone of the vertebral body in aged rats
8. Growth hormone stimulates bone formation and strength of cortical bone in aged rats
9. Growth hormone and mild exercise in combination markedly enhance cortical bone formation and strength in old rats
10. Parathyroid hormone (1-34) and (1-84) stimulate cortical bone formation both from periosteum and endosteum
11. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras
12. Alendronate mechanism of action: Geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption and kinase activation in vitro
13. Statin use, bone mass and fracture: An analysis of two prospective studies
14. Statin use and bone mineral density (BMD) in older women: The women's health initiative observational study (WHI-OS)
15. Effect of one year treatment with statins on bone mass and metabolism
16. Inhibitors of hydroxymethylglutaryl-coenzyme. A reductase and risk of fracture among older women
17. HMG-CoA reductase inhibitors and the risk of fractures
18. HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients
19. Does statin use reduce risk of fracture in postmenopausal women? Results from the women's health initiative observational study (WHI-OS)
20. Effect of pravastatin on fracture incidence in the lipid study: A randomized controlled trial
21. Use of statins and risk of fractures