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Volumn 2, Issue 5, 2010, Pages 257-269

The role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) in modern rheumatology

Author keywords

connective tissue diseases; pleiotropic effect; rheumatology; statins

Indexed keywords


EID: 84993740371     PISSN: 1759720X     EISSN: None     Source Type: Journal    
DOI: 10.1177/1759720X10384307     Document Type: Review
Times cited : (26)

References (103)
  • 2
    • 0037451121 scopus 로고    scopus 로고
    • Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th 1 cells through atorvastatin
    • Aktas, O., Waiczies, S., Smorodchenko, A., Dorr, J., Seeger, B., Prozorovski, T. et al. (2003) Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th 1 cells through atorvastatin. J Exp Med 197: 725-733.
    • (2003) J Exp Med , vol.197 , pp. 725-733
    • Aktas, O.1    Waiczies, S.2    Smorodchenko, A.3    Dorr, J.4    Seeger, B.5    Prozorovski, T.6
  • 3
    • 0030837459 scopus 로고    scopus 로고
    • Platelet-dependent thrombin generation in patients with hyperlipidemia
    • Aoki, I., Aoki, N., Kawano, K., Shimoyama, K., Maki, A., Homori, M. et al. (1997) Platelet-dependent thrombin generation in patients with hyperlipidemia. J Am Coll Cardiol 30: 91-96.
    • (1997) J Am Coll Cardiol , vol.30 , pp. 91-96
    • Aoki, I.1    Aoki, N.2    Kawano, K.3    Shimoyama, K.4    Maki, A.5    Homori, M.6
  • 4
    • 0035413350 scopus 로고    scopus 로고
    • CD4+CD25 high regulatory cells in human peripheral blood
    • Baecher-Allan, C., Brown, J.A., Freeman, G.J. and Hafler, D.A. ( 2001) CD4+CD25 high regulatory cells in human peripheral blood. J Immunol 167: 1245-1253.
    • (2001) J Immunol , vol.167 , pp. 1245-1253
    • Baecher-Allan, C.1    Brown, J.A.2    Freeman, G.J.3    Hafler, D.A.4
  • 5
    • 0037292463 scopus 로고    scopus 로고
    • Small G proteins as novel therapeutic targets in cardiovascular medicine
    • Barandier, C., Ming, X.F. and Yang, Z. ( 2003) Small G proteins as novel therapeutic targets in cardiovascular medicine. News Physiol Sci 18: 18-22.
    • (2003) News Physiol Sci , vol.18 , pp. 18-22
    • Barandier, C.1    Ming, X.F.2    Yang, Z.3
  • 6
    • 0021034058 scopus 로고
    • Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity
    • Botazzo, G.F., Pujol-Borrel, R., Hanafusa, T. and Feldmann, M. ( 1983) Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet 2: 1115-1119.
    • (1983) Lancet , vol.2 , pp. 1115-1119
    • Botazzo, G.F.1    Pujol-Borrel, R.2    Hanafusa, T.3    Feldmann, M.4
  • 7
    • 0036774217 scopus 로고    scopus 로고
    • Cell-cell adhesion and signaling
    • Braga, V.M.M. ( 2002) Cell-cell adhesion and signaling. Curr Opin Cell Biol 14: 546-556.
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 546-556
    • Braga, V.M.M.1
  • 8
    • 0016428340 scopus 로고
    • The heart in systemic lupus erythematosus and the changes induced in it by the corticosteroid therapy. A study of 36 necropsy patients
    • Bulkley, B.H. and Roberts, W.C. ( 1975) The heart in systemic lupus erythematosus and the changes induced in it by the corticosteroid therapy. A study of 36 necropsy patients. Am J Med 58: 243-264.
    • (1975) Am J Med , vol.58 , pp. 243-264
    • Bulkley, B.H.1    Roberts, W.C.2
  • 9
    • 0036218237 scopus 로고    scopus 로고
    • Cholesterol-induced thrombogenicity of the vessel wall: Inhibitory effect of fluvastatin
    • Camera, M., Toschi, V., Comparato, C., Baetta, R., Rossi, F., Fuortes, M. et al. (2002) Cholesterol-induced thrombogenicity of the vessel wall: Inhibitory effect of fluvastatin. Thromb Haemost 87: 748-755.
    • (2002) Thromb Haemost , vol.87 , pp. 748-755
    • Camera, M.1    Toschi, V.2    Comparato, C.3    Baetta, R.4    Rossi, F.5    Fuortes, M.6
  • 10
    • 0037465733 scopus 로고    scopus 로고
    • Suppression of the functionally coupled cyclooxygenase-2/prostaglandin E synthase as a basis of simvastatin dependent plaque stabilization in humans
    • Cipollone, F., Fazia, M., Iezzi, A., Zucchelli, M., Pini, B., de Cesare, D. et al. (2003) Suppression of the functionally coupled cyclooxygenase-2/prostaglandin E synthase as a basis of simvastatin dependent plaque stabilization in humans. Circulation 107: 1479-1485.
    • (2003) Circulation , vol.107 , pp. 1479-1485
    • Cipollone, F.1    Fazia, M.2    Iezzi, A.3    Zucchelli, M.4    Pini, B.5    de Cesare, D.6
  • 11
    • 0031803208 scopus 로고    scopus 로고
    • Transforming growth facto-beta (TGF-β)
    • Clark, D.A. and Coker, R. ( 1998) Transforming growth facto-beta (TGF-β). Int J Biochem Cell Biol 30: 293-298.
    • (1998) Int J Biochem Cell Biol , vol.30 , pp. 293-298
    • Clark, D.A.1    Coker, R.2
  • 13
    • 16644370412 scopus 로고    scopus 로고
    • Human RAS superfamily proteins and related GTPases
    • Colicelli, J. ( 2004) Human RAS superfamily proteins and related GTPases. Sci STKE 250: RE13.
    • (2004) Sci STKE , vol.250 , pp. RE13
    • Colicelli, J.1
  • 14
    • 0031025656 scopus 로고    scopus 로고
    • Vastatins inhibit tissue factor in cultured human macrophages: A novel mechanism of protection against atherothrombosis
    • Colli, S., Eligini, S., Lalli, M., Camera, M., Paoletti, R. and Tremoli, E. ( 1997) Vastatins inhibit tissue factor in cultured human macrophages: A novel mechanism of protection against atherothrombosis. Arterioscler Thromb Vasc Biol 17: 265-272.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 265-272
    • Colli, S.1    Eligini, S.2    Lalli, M.3    Camera, M.4    Paoletti, R.5    Tremoli, E.6
  • 15
    • 0035495491 scopus 로고    scopus 로고
    • Clinically relevant pleiotropic effects of statins: Drug properties or effects of profound cholesterol reduction
    • Comparato, C., Altana, C., Bellosta, S., Baetta, R., Paoletti, R. and Corsini, A. ( 2001) Clinically relevant pleiotropic effects of statins: Drug properties or effects of profound cholesterol reduction? Nutr Metab Cardiovasc Dis 11: 328-343.
    • (2001) Nutr Metab Cardiovasc Dis , vol.11 , pp. 328-343
    • Comparato, C.1    Altana, C.2    Bellosta, S.3    Baetta, R.4    Paoletti, R.5    Corsini, A.6
  • 16
    • 0027185879 scopus 로고
    • Relationship between mevalonate pathway and arterial myocyte proliferation
    • In vitro studies with inhibitors of HMGCoA reductase
    • Corsini, A., Mazzotti, M., Raiteri, M., Soma, M.R., Gabbiani, G., Fumagalli, R. et al. (1993) Relationship between mevalonate pathway and arterial myocyte proliferation: In vitro studies with inhibitors of HMGCoA reductase. Atherosclerosis 1001: 117-125.
    • (1993) Atherosclerosis , vol.1001 , pp. 117-125
    • Corsini, A.1    Mazzotti, M.2    Raiteri, M.3    Soma, M.R.4    Gabbiani, G.5    Fumagalli, R.6
  • 19
    • 0022454580 scopus 로고
    • Characterization of circulating immune complexes in heart disease
    • Cristea, A., Rus, H., Niculescu, F., Bedeleanu, D. and Vlaicu, R. ( 1986) Characterization of circulating immune complexes in heart disease. Immunol Lett 13: 45-49.
    • (1986) Immunol Lett , vol.13 , pp. 45-49
    • Cristea, A.1    Rus, H.2    Niculescu, F.3    Bedeleanu, D.4    Vlaicu, R.5
  • 20
    • 0242585716 scopus 로고    scopus 로고
    • Blood coagulation
    • Dahlback, B. ( 2000) Blood coagulation. Lancet 355: 1627-1632.
    • (2000) Lancet , vol.355 , pp. 1627-1632
    • Dahlback, B.1
  • 21
    • 0344200064 scopus 로고    scopus 로고
    • Role of intracellular signaling events in ADP-induced platelet aggregation
    • Daniel, J.L., Dangelmaier, C., Jin, J., Kim, Y.B. and Kunapuli, S.P. ( 1999) Role of intracellular signaling events in ADP-induced platelet aggregation. Thromb Haemost 82: 1322-1326.
    • (1999) Thromb Haemost , vol.82 , pp. 1322-1326
    • Daniel, J.L.1    Dangelmaier, C.2    Jin, J.3    Kim, Y.B.4    Kunapuli, S.P.5
  • 22
  • 23
    • 0034761724 scopus 로고    scopus 로고
    • Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus
    • Esdaile, J.M., Abrahamowicz, M., Grodzicky, T., Li, Y., Panaritis, C., du Berger, R. et al. (2001) Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus. Arthritis Rheum 44: 2331-2337.
    • (2001) Arthritis Rheum , vol.44 , pp. 2331-2337
    • Esdaile, J.M.1    Abrahamowicz, M.2    Grodzicky, T.3    Li, Y.4    Panaritis, C.5    du Berger, R.6
  • 24
    • 34147092226 scopus 로고    scopus 로고
    • Serum interleukin-6 correlates with endothelial dysfunction in healthy men independently of insulin sensitivity
    • Esteve, E., Castro, A., Lopez-Bermejo, A., Endrell, J., Ricart, W. and Fernandez-Real, J.M. ( 2007) Serum interleukin-6 correlates with endothelial dysfunction in healthy men independently of insulin sensitivity. Diabetes Care 30: 939-945.
    • (2007) Diabetes Care , vol.30 , pp. 939-945
    • Esteve, E.1    Castro, A.2    Lopez-Bermejo, A.3    Endrell, J.4    Ricart, W.5    Fernandez-Real, J.M.6
  • 25
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville, S. and Hall, A. ( 2002) Rho GTPases in cell biology. Nature 420: 629-635.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 26
    • 0035964808 scopus 로고    scopus 로고
    • Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin converting enzyme-1 expression by distinct pathways: Role of Rho/ROCK and mitogen-activated protein kinase
    • Eto, M., Barandiér, C., Rathgeb, L., Kozai, T., Joch, H., Yang, Z. et al. (2001) Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin converting enzyme-1 expression by distinct pathways: Role of Rho/ROCK and mitogen-activated protein kinase. Circ Res 89: 583-590.
    • (2001) Circ Res , vol.89 , pp. 583-590
    • Eto, M.1    Barandiér, C.2    Rathgeb, L.3    Kozai, T.4    Joch, H.5    Yang, Z.6
  • 27
    • 84993758679 scopus 로고    scopus 로고
    • Statins prevent tissue factor expression in human endothelial cells: Role of Rho/Rho-kinase and Akt pathways
    • Eto, M., Kozai, T., Cosentino, F., Joch, H. and Lüscher, T.F. ( 2002) Statins prevent tissue factor expression in human endothelial cells: Role of Rho/Rho-kinase and Akt pathways. Circulation 87: 748-755.
    • (2002) Circulation , vol.87 , pp. 748-755
    • Eto, M.1    Kozai, T.2    Cosentino, F.3    Joch, H.4    Lüscher, T.F.5
  • 28
    • 34848831197 scopus 로고    scopus 로고
    • Atorvastatin therapy improves endothelial-dependent vasodilation in patients with systemic lupus erythematosus: An 8 week controlled trial
    • Oxford
    • Ferreira, G.A., Navarro, T.P., Telles, R.W., Andrade, L.E. and Sato, E.I. ( 2007) Atorvastatin therapy improves endothelial-dependent vasodilation in patients with systemic lupus erythematosus: An 8 week controlled trial. Rheumatology (Oxford) 46: 1560-1565.
    • (2007) Rheumatology , vol.46 , pp. 1560-1565
    • Ferreira, G.A.1    Navarro, T.P.2    Telles, R.W.3    Andrade, L.E.4    Sato, E.I.5
  • 29
    • 0033995229 scopus 로고    scopus 로고
    • Inhibition of tissue-factor-mediated thrombin generation by simvastatin
    • Ferro, D., Basili, S., Alessandri, C., Cara, D. and Violi, F. ( 2000) Inhibition of tissue-factor-mediated thrombin generation by simvastatin. Atherosclerosis 149: 111-116.
    • (2000) Atherosclerosis , vol.149 , pp. 111-116
    • Ferro, D.1    Basili, S.2    Alessandri, C.3    Cara, D.4    Violi, F.5
  • 30
    • 0029816069 scopus 로고    scopus 로고
    • Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor
    • Frazie, K., Williams, S., Kothapalli, D., Klapser, H. and Grotendorst, G.R. ( 1996) Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J Invest Dermatol 107: 404-411.
    • (1996) J Invest Dermatol , vol.107 , pp. 404-411
    • Frazie, K.1    Williams, S.2    Kothapalli, D.3    Klapser, H.4    Grotendorst, G.R.5
  • 31
    • 0026541706 scopus 로고
    • The pathogenesis of coronary artery disease and acute coronary syndromes 2
    • Fuster, V., Badimon, L., Badimon, J.J. and Chesebro, J.H. ( 1992) The pathogenesis of coronary artery disease and acute coronary syndromes 2. N Engl J Med 326: 310-318.
    • (1992) N Engl J Med , vol.326 , pp. 310-318
    • Fuster, V.1    Badimon, L.2    Badimon, J.J.3    Chesebro, J.H.4
  • 32
    • 0037150157 scopus 로고    scopus 로고
    • Functional inhibition of Ras by s-trans, trans-farnesyl thiosalicylic acid attenuates atherosclerosis in apolipoprotein E knockout mice
    • George, J., Afek, A., Keren, P., Herz, I., Goldberg, I., Haklai, R. et al. (2002) Functional inhibition of Ras by s-trans, trans-farnesyl thiosalicylic acid attenuates atherosclerosis in apolipoprotein E knockout mice. Circulation 105: 2416-2422.
    • (2002) Circulation , vol.105 , pp. 2416-2422
    • George, J.1    Afek, A.2    Keren, P.3    Herz, I.4    Goldberg, I.5    Haklai, R.6
  • 33
    • 0028170814 scopus 로고
    • Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes
    • Glomset, J.A. and Farnsworth, C.C. ( 1994) Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes. Annu Rev Cell Biol 10: 181-205.
    • (1994) Annu Rev Cell Biol , vol.10 , pp. 181-205
    • Glomset, J.A.1    Farnsworth, C.C.2
  • 34
    • 0344013648 scopus 로고    scopus 로고
    • Inhibition of hydroxymethylglutaryl coenzyme A reductase reduces Th 1 development and promotes Th 2 development
    • Hakamada-Taguchi, R., Uehara, Y., Kuribayashi, K., Numabe, A., Saito, K., Negoro, H. et al. (2003) Inhibition of hydroxymethylglutaryl coenzyme A reductase reduces Th 1 development and promotes Th 2 development. Circ Res 93: 948-956.
    • (2003) Circ Res , vol.93 , pp. 948-956
    • Hakamada-Taguchi, R.1    Uehara, Y.2    Kuribayashi, K.3    Numabe, A.4    Saito, K.5    Negoro, H.6
  • 35
    • 15444368304 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1 mediated monocyte recruitment in vivo
    • Han, K.H., Ryu, J., Hong, K.H., Ko, J., Pak, Y.K., Kim, J.B. et al. (2005) HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1 mediated monocyte recruitment in vivo. Circulation 111: 1439-1447.
    • (2005) Circulation , vol.111 , pp. 1439-1447
    • Han, K.H.1    Ryu, J.2    Hong, K.H.3    Ko, J.4    Pak, Y.K.5    Kim, J.B.6
  • 36
    • 0032569489 scopus 로고    scopus 로고
    • Lupus-like syndrome associated with simvastatin
    • Hanson, J. and Bossingham, D. ( 1998) Lupus-like syndrome associated with simvastatin. Lancet 352: 1070.
    • (1998) Lancet , vol.352 , pp. 1070
    • Hanson, J.1    Bossingham, D.2
  • 37
    • 0029089789 scopus 로고
    • Fibrinogen and cardiovascular risk
    • Heinrich, J. and Assmann, G. ( 1995) Fibrinogen and cardiovascular risk. J Cardiovasc Risk 2: 197-205.
    • (1995) J Cardiovasc Risk , vol.2 , pp. 197-205
    • Heinrich, J.1    Assmann, G.2
  • 38
    • 0025896236 scopus 로고
    • Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization
    • Henney, A.M., Wakeley, P.R., Davies, M.J., Foster, K., Hembry, R., Murphy, G. et al. (1991) Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization. Proc Natl Acad Sci U S A 88: 8154-8158.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 8154-8158
    • Henney, A.M.1    Wakeley, P.R.2    Davies, M.J.3    Foster, K.4    Hembry, R.5    Murphy, G.6
  • 39
    • 0024510595 scopus 로고
    • Outcome in systemic lupus erythematosus: A prospective study of patients from a defined population
    • Baltimore
    • Johnsson, H., Nived, O. and Sturfelt, G. ( 1989) Outcome in systemic lupus erythematosus: A prospective study of patients from a defined population. Medicine ( Baltimore) 68: 141-150.
    • (1989) Medicine , vol.68 , pp. 141-150
    • Johnsson, H.1    Nived, O.2    Sturfelt, G.3
  • 41
    • 84993807850 scopus 로고    scopus 로고
    • patients with rheumatoid arthritis
    • patients with rheumatoid arthritis. J Rheumatol 29: 2024-2026.
    • J Rheumatol , vol.29 , pp. 2024-2026
  • 42
    • 0036078415 scopus 로고    scopus 로고
    • Rho-GTPase-dependent platelet-neutrophil interaction affected by HMG-CoA reductase inhibition with altered adenosine nucleotide release and function
    • Kaneider, N.C., Egger, P., Dunzendorfer, S. and Wiedermann, C.J. ( 2002) Rho-GTPase-dependent platelet-neutrophil interaction affected by HMG-CoA reductase inhibition with altered adenosine nucleotide release and function. Arterioscler Thromb Vasc Biol 22: 1029-1035.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 1029-1035
    • Kaneider, N.C.1    Egger, P.2    Dunzendorfer, S.3    Wiedermann, C.J.4
  • 43
    • 77954497611 scopus 로고    scopus 로고
    • Simvastatin induces Foxp 3 T regulatory cells by modulation of transforming growth factor-beta signal transduction
    • Kim, Y.C., Kim, K.K. and Shevach, E.M. (2010) Simvastatin induces Foxp 3 T regulatory cells by modulation of transforming growth factor-beta signal transduction. Immunology 130: 484-493.
    • (2010) Immunology , vol.130 , pp. 484-493
    • Kim, Y.C.1    Kim, K.K.2    Shevach, E.M.3
  • 44
    • 57649166568 scopus 로고    scopus 로고
    • Pravastatin, a 3-hydroxy-3-methylglutharyl coenzyme A inhibitor does not show pleiotropic effects in patients with systemic lupus erythematosus
    • Kotyla, P.J. (2009) Pravastatin, a 3-hydroxy-3-methylglutharyl coenzyme A inhibitor does not show pleiotropic effects in patients with systemic lupus erythematosus. Rheumatol Int 29: 353-354.
    • (2009) Rheumatol Int , vol.29 , pp. 353-354
    • Kotyla, P.J.1
  • 45
    • 33751019456 scopus 로고    scopus 로고
    • TNF alpha as a potential target in the treatment of SLE: A Role for the HMG-CoA reductase inhibitor simvastatin
    • Kotyla, P.J., Sliwinska-Kotyla, B. and Kucharz, E.J. ( 2006) TNF alpha as a potential target in the treatment of SLE: A Role for the HMG-CoA reductase inhibitor simvastatin. J Rheumatol 33: 2361.
    • (2006) J Rheumatol , vol.33 , pp. 2361
    • Kotyla, P.J.1    Sliwinska-Kotyla, B.2    Kucharz, E.J.3
  • 46
    • 0042833280 scopus 로고    scopus 로고
    • Effects of HMG-CoA reductase inhibitors on coagulation and fibrinolysis processes
    • Krysiak, R., Okopień, B. and Herman, Z.S. ( 2003) Effects of HMG-CoA reductase inhibitors on coagulation and fibrinolysis processes. Drugs 63: 1821-1854.
    • (2003) Drugs , vol.63 , pp. 1821-1854
    • Krysiak, R.1    Okopień, B.2    Herman, Z.S.3
  • 47
    • 0034533147 scopus 로고    scopus 로고
    • Statins as newly recognized type of immunomodulator
    • Kwak, B., Mulhaupt, F., Myit, S. and Mach, F. ( 2000) Statins as newly recognized type of immunomodulator. Nat Med 6: 1399-1402.
    • (2000) Nat Med , vol.6 , pp. 1399-1402
    • Kwak, B.1    Mulhaupt, F.2    Myit, S.3    Mach, F.4
  • 48
    • 0035102526 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin inhibits IFN-gamma induced MHC class II expression in human vascular endothelial cells
    • Kwak, B., Mulhaupt, F., Veillard, N., Pelli, G. and Mach, F. ( 2001) The HMG-CoA reductase inhibitor simvastatin inhibits IFN-gamma induced MHC class II expression in human vascular endothelial cells. Swiss Med Wkly 131: 41-46.
    • (2001) Swiss Med Wkly , vol.131 , pp. 41-46
    • Kwak, B.1    Mulhaupt, F.2    Veillard, N.3    Pelli, G.4    Mach, F.5
  • 49
    • 10344253817 scopus 로고    scopus 로고
    • Atorvastatin inhibits auto-reactive B cell activation and delays lupus development in New Zeland Black/White F 1 mice
    • Lawman, S., Mauri, C., Jury, E.C., Cook, H.T. and Ehrenstein, M.R. ( 2004) Atorvastatin inhibits auto-reactive B cell activation and delays lupus development in New Zeland Black/White F 1 mice. J Immunol 173: 7641-7646.
    • (2004) J Immunol , vol.173 , pp. 7641-7646
    • Lawman, S.1    Mauri, C.2    Jury, E.C.3    Cook, H.T.4    Ehrenstein, M.R.5
  • 50
    • 0037309378 scopus 로고    scopus 로고
    • A novel antiinflammatory role for simvastatin in inflammatory arthritis
    • Leung, B.P., Sattar, N., Crilly, A., Prach, M., McCarey, D.W., Payne, H. et al. (2003) A novel antiinflammatory role for simvastatin in inflammatory arthritis. J Immunol 170: 1524-1530.
    • (2003) J Immunol , vol.170 , pp. 1524-1530
    • Leung, B.P.1    Sattar, N.2    Crilly, A.3    Prach, M.4    McCarey, D.W.5    Payne, H.6
  • 51
    • 29144455051 scopus 로고    scopus 로고
    • Inhibitory effect of pravastatin on transforming growth factor β1-inducible gene h 3 expression in a rat model of chronic cyclosporine nephropathy
    • Li, C., Lim, S.W., Choi, B.S., Lee, S.H., Cha, J.H., Kim, I.S. et al. (2005) Inhibitory effect of pravastatin on transforming growth factor β1-inducible gene h 3 expression in a rat model of chronic cyclosporine nephropathy. Am J Nephrol 25: 611-620.
    • (2005) Am J Nephrol , vol.25 , pp. 611-620
    • Li, C.1    Lim, S.W.2    Choi, B.S.3    Lee, S.H.4    Cha, J.H.5    Kim, I.S.6
  • 52
    • 0036322869 scopus 로고    scopus 로고
    • Isoprenoids as mediators of the biological effect of statins
    • Liao, J.K. ( 2002) Isoprenoids as mediators of the biological effect of statins. J Clin Invest 110: 285-288.
    • (2002) J Clin Invest , vol.110 , pp. 285-288
    • Liao, J.K.1
  • 53
    • 0037022910 scopus 로고    scopus 로고
    • Inflammation and atherosclerosis
    • Libby, P., Ridker, P.M. and Maseri, A. ( 2002) Inflammation and atherosclerosis. Circulation 105: 1135-1143.
    • (2002) Circulation , vol.105 , pp. 1135-1143
    • Libby, P.1    Ridker, P.M.2    Maseri, A.3
  • 55
    • 1342267617 scopus 로고    scopus 로고
    • Decreased CD4+CD25+ T cells in peripheral blood of patients with systemic lupus erythematosus
    • Liu, M.F., Wang, C.R., Fung, L.L. and Wu, C.R. ( 2004) Decreased CD4+CD25+ T cells in peripheral blood of patients with systemic lupus erythematosus. Scand J Immunol 59: 198-202.
    • (2004) Scand J Immunol , vol.59 , pp. 198-202
    • Liu, M.F.1    Wang, C.R.2    Fung, L.L.3    Wu, C.R.4
  • 57
    • 33646355930 scopus 로고    scopus 로고
    • Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin
    • Louneva, N., Huaman, G., Fertala, J. and Jimenez, S.A. ( 2006) Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin. Arthritis Rheum 54: 1298-1308.
    • (2006) Arthritis Rheum , vol.54 , pp. 1298-1308
    • Louneva, N.1    Huaman, G.2    Fertala, J.3    Jimenez, S.A.4
  • 58
    • 0032516846 scopus 로고    scopus 로고
    • Rho GTPases
    • Mackay, D.J. and Hall, A. ( 1998) Rho GTPases. J Biol Chem 273: 20685-20688.
    • (1998) J Biol Chem , vol.273 , pp. 20685-20688
    • Mackay, D.J.1    Hall, A.2
  • 59
    • 27444441660 scopus 로고    scopus 로고
    • Arterial stiffness is related to systemic inflammation in essential hypertension
    • Mahmud, A. and Feely, J. ( 2005) Arterial stiffness is related to systemic inflammation in essential hypertension. Hypertension 46: 1118-1122.
    • (2005) Hypertension , vol.46 , pp. 1118-1122
    • Mahmud, A.1    Feely, J.2
  • 60
    • 0031052874 scopus 로고    scopus 로고
    • Age specific incidence rates of myocardial infarction and angina in women with systemic lupus erythematosus: Comparison with the Framingham Study
    • Manzi, S., Meilahn, E.N., Rairie, J.E., Conte, C.G., Medsger Jr, T.A., Jansen-McWilliams, L. et al. (1997) Age specific incidence rates of myocardial infarction and angina in women with systemic lupus erythematosus: Comparison with the Framingham Study. Am J Epidemiol 145: 408-415.
    • (1997) Am J Epidemiol , vol.145 , pp. 408-415
    • Manzi, S.1    Meilahn, E.N.2    Rairie, J.E.3    Conte, C.G.4    Medsger Jr, T.A.5    Jansen-McWilliams, L.6
  • 61
    • 13444266513 scopus 로고    scopus 로고
    • Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: A population-based cohort study
    • Maradit-Kremers, H., Crownson, C.S., Nicola, P.J., Ballman, K.V., Roger, V.L., Jacobsen, S.J. et al. (2005) Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: A population-based cohort study. Arthritis Rheum 52: 402-411.
    • (2005) Arthritis Rheum , vol.52 , pp. 402-411
    • Maradit-Kremers, H.1    Crownson, C.S.2    Nicola, P.J.3    Ballman, K.V.4    Roger, V.L.5    Jacobsen, S.J.6
  • 62
    • 2942670131 scopus 로고    scopus 로고
    • Trial of atorvastatin in rheumatoid arthritis (TARA): Double blind, randomized placebo controlled trial
    • McCarey, D.W., McInnes, I.B., Madhok, R., Hampson, R., Scherbakov, O., Ford, I. et al. (2004) Trial of atorvastatin in rheumatoid arthritis (TARA): Double blind, randomized placebo controlled trial. Lancet 363: 2015-2021.
    • (2004) Lancet , vol.363 , pp. 2015-2021
    • McCarey, D.W.1    McInnes, I.B.2    Madhok, R.3    Hampson, R.4    Scherbakov, O.5    Ford, I.6
  • 63
    • 3042648466 scopus 로고    scopus 로고
    • Modulation of adhesion molecule expression on endothelial cells: To be or not to be
    • Meroni, P.L. and Tremoli, E. ( 2003) Modulation of adhesion molecule expression on endothelial cells: To be or not to be? J Thromb Haemost 1: 2280-2282.
    • (2003) J Thromb Haemost , vol.1 , pp. 2280-2282
    • Meroni, P.L.1    Tremoli, E.2
  • 64
    • 26244444313 scopus 로고    scopus 로고
    • Pharmacological modulation of plaque instability
    • Mezzetti, A. ( 2005) Pharmacological modulation of plaque instability. Lupus 14: 769-772.
    • (2005) Lupus , vol.14 , pp. 769-772
    • Mezzetti, A.1
  • 65
    • 0035126056 scopus 로고    scopus 로고
    • Treatment with simvastatin and low-dose aspirin depresses thrombin generation in patients with coronary heart disease and borderline-high cholesterol levels
    • Musiał, J., Undas, A., Undas, R., Brozek, J. and Szczeklik, A. ( 2001) Treatment with simvastatin and low-dose aspirin depresses thrombin generation in patients with coronary heart disease and borderline-high cholesterol levels. Thromb Haemost 85: 221-225.
    • (2001) Thromb Haemost , vol.85 , pp. 221-225
    • Musiał, J.1    Undas, A.2    Undas, R.3    Brozek, J.4    Szczeklik, A.5
  • 66
    • 0034700233 scopus 로고    scopus 로고
    • Circulating immune complexes in 50-year-old men as a strong and independent risk factor for myocardial infarction
    • Mustafa, A., Nityanand, S., Berglund, L., Lithell, H. and Lefvert, A.K. ( 2000) Circulating immune complexes in 50-year-old men as a strong and independent risk factor for myocardial infarction. Circulation 102: 2576-2581.
    • (2000) Circulation , vol.102 , pp. 2576-2581
    • Mustafa, A.1    Nityanand, S.2    Berglund, L.3    Lithell, H.4    Lefvert, A.K.5
  • 67
    • 8944258922 scopus 로고    scopus 로고
    • The yin and yang of oxidation in the development of fatty streak: A review based on 1994 George Lymann Duff Memorial Lecture
    • Navab, M., Berliner, J.A., Watson, A.D., Hama, S.Y., Territo, M.C., Lusis, A.J. et al. (1996) The yin and yang of oxidation in the development of fatty streak: A review based on 1994 George Lymann Duff Memorial Lecture. Arterioscler Thromb Vasc Biol 16: 831-842.
    • (1996) Arterioscler Thromb Vasc Biol , vol.16 , pp. 831-842
    • Navab, M.1    Berliner, J.A.2    Watson, A.D.3    Hama, S.Y.4    Territo, M.C.5    Lusis, A.J.6
  • 68
    • 0034109090 scopus 로고    scopus 로고
    • Detection of coronary artery disease and the role of traditional risk factors in the Hopkins lupus cohort
    • Petri, M. ( 2000) Detection of coronary artery disease and the role of traditional risk factors in the Hopkins lupus cohort. Lupus 9: 170-175.
    • (2000) Lupus , vol.9 , pp. 170-175
    • Petri, M.1
  • 69
    • 0141857806 scopus 로고    scopus 로고
    • Noncholesterollowering effects of statins
    • Pierre-Paul, D. and Gahtan, V. ( 2003) Noncholesterollowering effects of statins. Vasc Endovascular Surg 37: 301-313.
    • (2003) Vasc Endovascular Surg , vol.37 , pp. 301-313
    • Pierre-Paul, D.1    Gahtan, V.2
  • 70
    • 0037024272 scopus 로고    scopus 로고
    • Increased transforming growth factor-beta (1) circulating levels and production in human monocytes after 3-hydroxy-3-methyl-glutarylcoenzyme a reductase inhibition with pravastatin
    • Porreca, E., Di, F.C., Baccante, G., Di, N.M. and Cuccurullo, F. ( 2002) Increased transforming growth factor-beta (1) circulating levels and production in human monocytes after 3-hydroxy-3-methyl-glutarylcoenzyme a reductase inhibition with pravastatin. J Am Coll Cardiol 39: 1752-1757.
    • (2002) J Am Coll Cardiol , vol.39 , pp. 1752-1757
    • Porreca, E.1    Di, F.C.2    Baccante, G.3    Di, N.M.4    Cuccurullo, F.5
  • 71
    • 0029197845 scopus 로고
    • Role of T cells and cytokines in effecting fibrosis
    • Postlethwaite, A.E. ( 1995) Role of T cells and cytokines in effecting fibrosis. Int Rev Immunol 12: 247-258.
    • (1995) Int Rev Immunol , vol.12 , pp. 247-258
    • Postlethwaite, A.E.1
  • 72
    • 0032880948 scopus 로고    scopus 로고
    • Effect of HMG-CoA reductase inhibitors on extracellular matrix expression in human vascular smooth cells
    • Riessen, R., Axel, D.I., Fenchel, M., Herzog, U.U., Rossmann, H. and Karsch, K.R. ( 1999) Effect of HMG-CoA reductase inhibitors on extracellular matrix expression in human vascular smooth cells. Basic Res Cardiol 94: 322-332.
    • (1999) Basic Res Cardiol , vol.94 , pp. 322-332
    • Riessen, R.1    Axel, D.I.2    Fenchel, M.3    Herzog, U.U.4    Rossmann, H.5    Karsch, K.R.6
  • 73
    • 0035282653 scopus 로고    scopus 로고
    • Prevalance and relation to risk factors of carotid atherosclerosis and left ventricular hypertrophy in systemic lupus erythematosus and antiphospholipid antibody syndrome
    • Roman, M.J., Salmon, J.E., Sobel, R., Lockshin, M.D., Sammaritano, L., Schwartz, J.E. et al. (2001) Prevalance and relation to risk factors of carotid atherosclerosis and left ventricular hypertrophy in systemic lupus erythematosus and antiphospholipid antibody syndrome. Am J Cardiol 87: 663-666.
    • (2001) Am J Cardiol , vol.87 , pp. 663-666
    • Roman, M.J.1    Salmon, J.E.2    Sobel, R.3    Lockshin, M.D.4    Sammaritano, L.5    Schwartz, J.E.6
  • 75
    • 0033782877 scopus 로고    scopus 로고
    • Fluvastatin reduces soluble P-selectin and ICAM-1 levels in hypercholesterolemic patients: Role of nitric oxide
    • Romano, M., Mezzetti, A., Marulli, C., Ciabattoni, G., Febo, F., Di Ienno, S. et al. (2000 b) Fluvastatin reduces soluble P-selectin and ICAM-1 levels in hypercholesterolemic patients: Role of nitric oxide. J Investig Med 48: 183-189.
    • (2000) J Investig Med , vol.48 , pp. 183-189
    • Romano, M.1    Mezzetti, A.2    Marulli, C.3    Ciabattoni, G.4    Febo, F.5    Di Ienno, S.6
  • 76
    • 0033919245 scopus 로고    scopus 로고
    • Inhibition of type I gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase
    • Rosenbloom, J., Saitta, B., Gaidarova, S., Sandorfi, N., Rosenbloom, J.C., Abrams, W.R. et al. (2000) Inhibition of type I gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I. Arthritis Rheum 43: 1624-1632.
    • (2000) I. Arthritis Rheum , vol.43 , pp. 1624-1632
    • Rosenbloom, J.1    Saitta, B.2    Gaidarova, S.3    Sandorfi, N.4    Rosenbloom, J.C.5    Abrams, W.R.6
  • 77
    • 0032572043 scopus 로고    scopus 로고
    • Antiatherothrombotic properties of statins: Implications for cardiovascular event reduction
    • Rosenson, R.S. and Tangney, C.C. ( 1998) Antiatherothrombotic properties of statins: Implications for cardiovascular event reduction. JAMA 279: 1643-1650.
    • (1998) JAMA , vol.279 , pp. 1643-1650
    • Rosenson, R.S.1    Tangney, C.C.2
  • 78
    • 0035089758 scopus 로고    scopus 로고
    • Comparative study of HMG-CoA reductse inhibitors on fibrinogen
    • Rosenson, R.S., Tangney, C.C. and Schaefer, E.J. ( 2001) Comparative study of HMG-CoA reductse inhibitors on fibrinogen. Atherosclerosis 155: 463-466.
    • (2001) Atherosclerosis , vol.155 , pp. 463-466
    • Rosenson, R.S.1    Tangney, C.C.2    Schaefer, E.J.3
  • 79
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis an inflammatory disease
    • Ross, R. ( 1999) Atherosclerosis an inflammatory disease. N Eng J Med 340: 115-126.
    • (1999) N Eng J Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 80
    • 0037227418 scopus 로고    scopus 로고
    • Transforming growth factor-beta-dependent events in vascular remodeling following arterial injury
    • Ryan, S.T., Koteliansky, V.E., Gotwals, P.J. and Lindner, V. ( 2003) Transforming growth factor-beta-dependent events in vascular remodeling following arterial injury. J Vasc Res 40: 37-46.
    • (2003) J Vasc Res , vol.40 , pp. 37-46
    • Ryan, S.T.1    Koteliansky, V.E.2    Gotwals, P.J.3    Lindner, V.4
  • 81
    • 0035872757 scopus 로고    scopus 로고
    • Inhibition of interferon-gamma-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors
    • Sadeghi, M.M., Tiglio, A., Sadigh, K., O'Donnell, L., Collinge, M., Pardi, R. et al. (2001) Inhibition of interferon-gamma-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors. Transplantation 71: 1262-1268.
    • (2001) Transplantation , vol.71 , pp. 1262-1268
    • Sadeghi, M.M.1    Tiglio, A.2    Sadigh, K.3    O'Donnell, L.4    Collinge, M.5    Pardi, R.6
  • 82
    • 0029009904 scopus 로고
    • Antiplatelet drugs. A comparative review
    • Schror, K. ( 1995) Antiplatelet drugs. A comparative review. Drugs 50: 7-28.
    • (1995) Drugs , vol.50 , pp. 7-28
    • Schror, K.1
  • 83
    • 0034650714 scopus 로고    scopus 로고
    • Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
    • Somlyo, A.P. and Somlyo, A.V. ( 2000) Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 522: 177-185.
    • (2000) J Physiol , vol.522 , pp. 177-185
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 84
    • 0035140151 scopus 로고    scopus 로고
    • Do HMG-CoA reductase inhibitors affect fibrinogen
    • Song, J.C. and White, C.M. ( 2001) Do HMG-CoA reductase inhibitors affect fibrinogen. Ann Pharmacother 35: 236-241.
    • (2001) Ann Pharmacother , vol.35 , pp. 236-241
    • Song, J.C.1    White, C.M.2
  • 85
    • 0033117206 scopus 로고    scopus 로고
    • Inhibition of thrombin generation by simvastatin and lack of additive effects of aspirin in patients with marked hypercholesterolemia
    • Szczeklik, A., Musiał, J., Undas, A., Gajewski, P., Gόra, P. and Swadźba, J. ( 1999) Inhibition of thrombin generation by simvastatin and lack of additive effects of aspirin in patients with marked hypercholesterolemia. J Am Coll Cardiol 33: 1286-1293.
    • (1999) J Am Coll Cardiol , vol.33 , pp. 1286-1293
    • Szczeklik, A.1    Musiał, J.2    Undas, A.3    Gajewski, P.4    Gόra, P.5    Swadźba, J.6
  • 87
    • 0035572718 scopus 로고    scopus 로고
    • Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
    • Takemoto, M. and Liao, J.K. ( 2001) Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Arterioscler Thromb Vasc Biol 11: 328-343.
    • (2001) Arterioscler Thromb Vasc Biol , vol.11 , pp. 328-343
    • Takemoto, M.1    Liao, J.K.2
  • 88
    • 0013640830 scopus 로고    scopus 로고
    • Lovastatin induces fibroblast apoptosis in vitro and in vivo: A possible therapy for fibroproliferative disorders
    • Tan, A., Levrey, H., Dahm, C., Polunovsky, V.A., Rubins, J., Bitterman, P.B. et al. (1999) Lovastatin induces fibroblast apoptosis in vitro and in vivo: A possible therapy for fibroproliferative disorders. Am J Respir Crit Care Med 159: 220-227.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 220-227
    • Tan, A.1    Levrey, H.2    Dahm, C.3    Polunovsky, V.A.4    Rubins, J.5    Bitterman, P.B.6
  • 90
    • 33846900430 scopus 로고    scopus 로고
    • Deficient CD4+CD25 high T regulatory cell function in patients with active systemic lupus erythematosus
    • Valencia, X., Yarboro, C., Illei, G. and Lipsky, P.E. ( 2007) Deficient CD4+CD25 high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol 178: 2579-2588.
    • (2007) J Immunol , vol.178 , pp. 2579-2588
    • Valencia, X.1    Yarboro, C.2    Illei, G.3    Lipsky, P.E.4
  • 91
    • 0035186608 scopus 로고    scopus 로고
    • Secondary prevention with fluvastatin decreases levels of adhesion molecules, neopterin and C reactive protein
    • van Haelst, P.L., van Doormaal, J.J., May, J.F., Gans, R.O., Crijns, H.J. and Cohen-Tervaert, J.W. ( 2001) Secondary prevention with fluvastatin decreases levels of adhesion molecules, neopterin and C reactive protein. Eur J Intern Med 12: 503-509.
    • (2001) Eur J Intern Med , vol.12 , pp. 503-509
    • van Haelst, P.L.1    van Doormaal, J.J.2    May, J.F.3    Gans, R.O.4    Crijns, H.J.5    Cohen-Tervaert, J.W.6
  • 92
    • 0023631004 scopus 로고
    • Transforming growth factor beta (TGF-beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts
    • Varga, J., Rosenbloom, J. and Jimenez, S.A. ( 1987) Transforming growth factor beta (TGF-beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts. Biochem J 247: 597-604.
    • (1987) Biochem J , vol.247 , pp. 597-604
    • Varga, J.1    Rosenbloom, J.2    Jimenez, S.A.3
  • 93
    • 4143055661 scopus 로고    scopus 로고
    • Update on statins: 2003
    • Vaughan, C.J. and Gotto, A.M. ( 2004) Update on statins: 2003. Circulation 110: 886-892.
    • (2004) Circulation , vol.110 , pp. 886-892
    • Vaughan, C.J.1    Gotto, A.M.2
  • 94
    • 0033984125 scopus 로고    scopus 로고
    • The evolving role of statins in the management of atherosclerosis
    • Vaughan, C.J., Gotto, A.M. and Basson, C.T. ( 2000) The evolving role of statins in the management of atherosclerosis. J Am Coll Cardiol 35: 1-10.
    • (2000) J Am Coll Cardiol , vol.35 , pp. 1-10
    • Vaughan, C.J.1    Gotto, A.M.2    Basson, C.T.3
  • 95
    • 0028789033 scopus 로고
    • Hemostasis and atherosclerosis
    • (Suppl
    • Warkentin, T.E. ( 1995) Hemostasis and atherosclerosis. Can J Cardiol 11(Suppl C): 29-34.
    • (1995) Can J Cardiol , vol.11 , Issue.C , pp. 29-34
    • Warkentin, T.E.1
  • 97
    • 34247550969 scopus 로고    scopus 로고
    • RhoA signaling modulates cyclin D 1 expression in human lung fibroblasts: Implication for idiopathic pulmonary fibrosis
    • Watts, K.L., Cottrell, E., Hoban, P.R. and Spiteri, M.A. ( 2006) RhoA signaling modulates cyclin D 1 expression in human lung fibroblasts: Implication for idiopathic pulmonary fibrosis. Respir Res 7: 88-102.
    • (2006) Respir Res , vol.7 , pp. 88-102
    • Watts, K.L.1    Cottrell, E.2    Hoban, P.R.3    Spiteri, M.A.4
  • 98
    • 8644245963 scopus 로고    scopus 로고
    • Connective tissue growth factor expression and induction by transforming growth factor is abrogated by simvastatin via Rho signaling mechanism
    • Watts, K.L. and Spiteri, M. ( 2004) Connective tissue growth factor expression and induction by transforming growth factor is abrogated by simvastatin via Rho signaling mechanism. Am J Physiol Lung Cell Mol Physiol 287: L1323-L1332.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287 , pp. L1323-L1332
    • Watts, K.L.1    Spiteri, M.2
  • 99
    • 0034948339 scopus 로고    scopus 로고
    • Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site
    • Weitz-Schmidt, G., Welzenbach, K., Brinkmann, V., Kamata, T., Kallen, J., Bruns, C. et al. (2001) Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med 7: 687-692.
    • (2001) Nat Med , vol.7 , pp. 687-692
    • Weitz-Schmidt, G.1    Welzenbach, K.2    Brinkmann, V.3    Kamata, T.4    Kallen, J.5    Bruns, C.6
  • 100
    • 33644696725 scopus 로고    scopus 로고
    • Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosing factor-α in fibroblast-like synoviocytes from patients with rheumatoid arthritis
    • Yokota, K., Miyazaki, T., Hirano, M., Akiyama, Y. and Mimura, T. ( 2006) Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosing factor-α in fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Rheumatol 33: 463-471.
    • (2006) J Rheumatol , vol.33 , pp. 463-471
    • Yokota, K.1    Miyazaki, T.2    Hirano, M.3    Akiyama, Y.4    Mimura, T.5
  • 101
    • 39549106513 scopus 로고    scopus 로고
    • High concentration simvastatin induces apoptosis in fibroblast-like synoviocytes from patients with rheumatoid arthritis
    • Yokota, K., Miyoshi, F., Miyazaki, T., Sato, K., Yoshida, Y. and Asanuma, Y. ( 2008) High concentration simvastatin induces apoptosis in fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Rheumatol 35: 193-200.
    • (2008) J Rheumatol , vol.35 , pp. 193-200
    • Yokota, K.1    Miyoshi, F.2    Miyazaki, T.3    Sato, K.4    Yoshida, Y.5    Asanuma, Y.6
  • 102
    • 0037038402 scopus 로고    scopus 로고
    • The HMGCoA reductase inhibitor, atorvastatin, promotes a Th 2 bias and reverses paralysis in central nervous system autoimmune disease
    • Youssef, S., Stüve, O., Patarroyo, J.C., Ruiz, P.J., Radosevich, J.L., Hur, E.M. et al. (2002) The HMGCoA reductase inhibitor, atorvastatin, promotes a Th 2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 420: 78-84.
    • (2002) Nature , vol.420 , pp. 78-84
    • Youssef, S.1    Stüve, O.2    Patarroyo, J.C.3    Ruiz, P.J.4    Radosevich, J.L.5    Hur, E.M.6
  • 103
    • 0029898894 scopus 로고    scopus 로고
    • Protein prenylation: Molecular mechanism and functional consequences
    • Zhang, F.L. and Casey, P.J. ( 1996) Protein prenylation: Molecular mechanism and functional consequences. Annu Rev Biochem 65: 241-269.
    • (1996) Annu Rev Biochem , vol.65 , pp. 241-269
    • Zhang, F.L.1    Casey, P.J.2


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