3,6-Disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa

Journal of Medicinal Chemistry

Volumn 48, Issue 24, 2005, Pages 7592-7603

  Frédérick, Raphaël ^a   Robert, Séverine ^a   Charlier, Caroline ^b   De Ruyck, Jérôme ^b   Wouters, Johan ^b   Pirotte, Bernard ^a   Masereel, Bernard ^a   Pochet, Lionel ^a  

^a UNIVERSITY OF NAMUR   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2,5 DICHLOROPHENYL ESTER; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; CHYMOTRYPSIN A; COUMARIN DERIVATIVE; HYDRAZINE; METHYL GROUP; PHENYL GROUP; THROMBIN; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE PERMEABILITY; DRUG SELECTIVITY; ENZYMATIC ASSAY; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CACO-2 CELLS; CATTLE; CELL MEMBRANE PERMEABILITY; CHROMATOGRAPHY, LIQUID; COMPUTER SIMULATION; COUMARINS; ENZYME ACTIVATION; FACTOR XA; HUMANS; KINETICS; MASS SPECTROMETRY; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 28144446421     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050448g     Document Type: Article

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