Synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase A inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 23, 2012, Pages 10424-10436

  Abdelhafez, Omaima M ^a   Amin, Kamelia M ^b   Ali, Hamed I ^c   Abdalla, Mohamed M ^d   Batran, Rasha Z ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c Ein Helwan   (Egypt)

^d Mapco Pharmaceutical Industries Balteim   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (3,4 DIMETHYL 2 OXO 2H CHROMEN 7 YLOXY)ACETYL] 4 (4 CHLOROPHENYL)THIOSEMICARBAZIDE; 1,3,4 OXADIAZOLE DERIVATIVE; 1,3,4 THIADIAZOLE DERIVATIVE; 3,4 DIMETHYL 7 OXYCOUMARIN DERIVATIVE; 4 METHYL 7 OXYCOUMARIN DERIVATIVE; 7 [(5 MERCAPTO 1,3,4 OXADIAZOL 2 YL)METHOXY] 3,4 DIMETHYL 2H CHROMEN 2 ONE; 7 [(5 MERCAPTO 1,3,4 THIADIAZOL 2 YL)METHOXY] 3,4 DIMETHYL 2H CHROMEN 2 ONE; 7 [[4 (4 CHLOROPHENYL) 5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL]METHOXY] 3,4 DIMETHYL 2H CHROMEN 2 ONE; 7 [[5 (2 MORPHOLINOETHYLTHIO) 1,3,4 THIADIAZOL 2 YL]METHOXY] 3,4 DIMETHYL 2H CHROMEN 2 ONE; 7 [[5 (2 MORPHOLINOETHYLTHIO) 1,3,4 THIADIAZOL 2 YL]METHOXY] 4 METHYL 2H CHROMEN 2 ONE; 7 [[5 (2 MORPHOLINOETHYLTHIO) 4 (4 CHLOROPHENYL) 4H 1,2,4 TRIAZOL 3 YL]METHOXY] 3,4 DIMETHYL 2H CHROMEN 2 ONE; 7 [[5 (4 CHLOROPHENYLAMINO) 1,3,4 THIADIAZOL 2 YL]METHOXY] 3,4 DIMETHYL 2H CHROMEN 2 ONE; 7 [[5 [2 (DIETHYLAMINO)ETHYLTHIO] 1,3,4 OXADIAZOL 2 YL]METHOXY] 3,4 DIMETHYL 2H CHROMEN 2 ONE; 7 [[5 [2 (DIETHYLAMINO)ETHYLTHIO] 1,3,4 OXADIAZOL 2 YL]METHOXY] 4 METHYL 2H CHROMEN 2 ONE; 7 [[5 [2 (DIETHYLAMINO)ETHYLTHIO] 1,3,4 THIADIAZOL 2 YL]METHOXY] 3,4 DIMETHYL 2H CHROMEN 2 ONE; 7 [[5 [2 (DIETHYLAMINO)ETHYLTHIO] 1,3,4 THIADIAZOL 2 YL]METHOXY] 4 METHYL 2H CHROMEN 2 ONE; 7 [[5 [2 (DIETHYLAMINO)ETHYLTHIO] 4 (4 CHLOROPHENYL) 4H 1,2,4 TRIAZOL 3 YL]METHOXY] 3,4 DIMETHYL 2H CHROMEN 2 ONE; 7 [[5 [2 (DIETHYLAMINO)ETHYLTHIO] 4 (4 CHLOROPHENYL) 4H 1,2,4 TRIAZOL 3 YL]METHOXY] 4 METHYL 2H CHROMEN 2 ONE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CLORGYLINE; COUMARIN DERIVATIVE; IPRONIAZID; MOCLOBEMIDE; MONOAMINE OXIDASE A INHIBITOR; N [2 (4 CHLOROPHENYLIMINO) 4 OXOTHIAZOLIDIN 3 YL] 2 (3,4 DIMETHYL 2 OXO 2H CHROMEN 7 YLOXY)ACETAMIDE; N [2 (4 CHLOROPHENYLIMINO) 4 OXOTHIAZOLIDIN 3 YL] 2 (4 METHYL 2 OXO 2H CHROMEN 7 YLOXY)ACETAMIDE; SELEGILINE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IN VIVO STUDY; MALE; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; RAT; SEIZURE; STRUCTURE ACTIVITY RELATION;

COUMARINS; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; SPECTROPHOTOMETRY, INFRARED;

EID: 84871027554     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301014y     Document Type: Article

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