Discovery of sulfonylalkylamides: A new class of orally active factor Xa inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 5, 2008, Pages 2243-2260

  Imaeda, Yasuhiro ^a   Miyawaki, Toshio ^a   Sakamoto, Hiroki ^a   Itoh, Fumio ^a   Konishi, Noriko ^a   Hiroe, Katsuhiko ^a   Kawamura, Masaki ^a   Tanaka, Toshimasa ^a   Kubo, Keiji ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Anticoagulant; CYP3A4; Factor Xa inhibitor; Sulfonylalkylamide

Indexed keywords

1 (PYRIDIN 4 YL)PIPERIDIN; 2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID; 3 [6 CHLORONAPHTHALEN 2 YL)SULFONYL] N METHYL N [1 (2 METHYLPYRIDIN 4 YL)PIPERIDIN 4 YL]PROPANAMIDE; 3 [6 CHLORONAPHTHALEN 2 YL)SULFONYL] N METHYL N [1 (PYRIDIN 4 YL)PIPERIDIN 4 YL]PROPANAMIDE; 6 CHLORONAPHTHALENE; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; CYTOCHROME P450 3A4; NAPHTHALENE DERIVATIVE; PICOLINE; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE; SULFANILAMIDE; UNCLASSIFIED DRUG;

ANTICOAGULATION; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MONKEY; NONHUMAN;

ADMINISTRATION, ORAL; ALKYLATION; AMIDES; ANIMALS; ANTITHROMBIN III; CROSS-LINKING REAGENTS; CYTOCHROME P-450 ENZYME SYSTEM; FACTOR XA; HAPLORHINI; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; SULFUR COMPOUNDS;

MACACA FASCICULARIS;

EID: 40749146731     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.073     Document Type: Article

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