Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa

Journal of Medicinal Chemistry

Volumn 42, Issue 18, 1999, Pages 3557-3571

  Ewing, William R ^a   Becker, Michael R ^a   Manetta, Vincent E ^a   Davis, Roderick S ^a   Pauls, Henry W ^a   Mason, Helen ^a,c   Choi Sledeski, Yong Mi ^a   Green, Daniel ^a,b   Cha, Don ^a   Spada, Alfred P ^a   Cheney, Daniel L ^a,c   Mason, Jonathan S ^a,c   Maignan, Sebastien ^a   Guilloteau, Jean Pierre ^a   Brown, Karen ^a   Colussi, Dennis ^a   Bentley, Ross ^a   Bostwick, Jeff ^a   Kasiewski, Charles J ^a   Morgan, Suzanne R ^a   Leadley, Robert J ^a   Dunwiddie, Christopher T ^a,d   Perrone, Mark H ^a   Chu, Valeria ^a   more..

^a Depts Cardiovasc Drug Discov/N   (United States)

^b WYETH AYERST RESEARCH   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A INHIBITOR; N [1 (2 AMINOIMINOMETHYL 4 THIENYLMETHYL) 2 OXO 3 PYRROLIDINYL] 7 METHOXY N METHYL 2 NAPHTHALENESULFONAMIDE; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; CRYSTAL STRUCTURE; DRUG EFFECT; DRUG POTENCY; FIBRINOLYSIS; JUGULAR VEIN; LIPOPHILICITY; PHOSPHOLIPID MEMBRANE; PROTEIN MODIFICATION; STRUCTURE ACTIVITY RELATION; THROMBOGENESIS;

ANIMALS; ANTICOAGULANTS; CRYSTALLOGRAPHY, X-RAY; FACTOR XA; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRROLIDINONES; RABBITS; RATS; SERINE PROTEINASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIOPHENES; THROMBOSIS;

EID: 0033539050     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990040h     Document Type: Article

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