Synthesis, anticoagulant and PIVKA-II induced by new 4-hydroxycoumarin derivatives

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 10, 2010, Pages 3371-3378

  Abdelhafez, Omaima M ^a   Amin, Kamelia M ^b   Batran, Rasha Z ^a   Maher, Timothy J ^c   Nada, Somaia A ^a   Sethumadhavan, Shalini ^c  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c BOSTON UNIVERSITY   (United States)

Author keywords

4 Hydroxycoumarin; Anticoagulant; PIVKA II; Pyrazoles; Pyridines; Pyrimidines

Indexed keywords

1,2 DIHYDRO 6 (4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 2 OXO 4 (PYRIDINE 3 YL)PYRIDIN 3 CARBONITRILE; 1,2 DIHYDRO 6 (4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 4 (3,4,5 TRIMETHOXYPHENYL) 2 OXOPYRIDIN 3 CARBONITRILE; 2 AMINO 4 (FURAN 2 YL) 6 (4 HYDROXY 2 OXO 2H CHROMEN 3 YL)PYRIDIN 3 CARBONITRILE; 2 AMINO 6 (4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 4 (3,4,5 TRIMETHOXYPHENYL)PYRIDINE 3 CARBONITRILE; 3 [1 ACETYL 4,5 DIHYDRO 5 (PYRIDIN 3 YL) 1H PYRAZOL 3 YL] 4 HYDROXY 2H CHROMEN 2 ONE; 3 [1,2,5,6 TETRAHYDRO 6 (3,4,5 TRIMETHOXYPHENYL) 2 THIOXOPYRIMIDIN 4 YL] 4 HYDROXY 2H CHROMEN 2 ONE; 3 [1,2,5,6 TETRAHYDRO 6 (PYRIDIN 3 YL) 2 THIOXOPYRIMIDIN 4 YL] 4 HYDROXY 2H CHROMEN 2 ONE; 3 [4,5 DIHYDRO 1 PHENYL 5 (PYRIDIN 3 YL) 1H PYRAZOL 3 YL] 4 HYDROXY 2H CHROMEN 2 ONE; 3 [4,5 DIHYDRO 5 (3,4,5 TRIMETHOXYPHENYL) 1 PHENYL 1H PYRAZOL 3 YL] 4 HYDROXY 2H CHROMEN 2 ONE; 3 [4,5 DIHYDRO 5 (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 3 YL] 4 HYDROXY 2H CHROMEN 2 ONE; 3 [4,5 DIHYDRO 5 (4 METHOXYPHENYL) 1H PYRAZOL 3 YL] 4 HYDROXY 2H CHROMEN 2 ONE; 3 [4,5 DIHYDRO 5 (PYRIDINE 3 YL) 1H PYRAZOL 3 YL] 4 HYDROXY 2H CHROMEN 2 ONE; 4 HYDROXYCOUMARIN DERIVATIVE; 4,5 DIHYDRO 3 (4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 5 (3,4,5 TRIMETHOXYPHENYL) N PHENYLPYRAZOL 1 CARBOTHIOAMIDE; 4,5 DIHYDRO 3 (4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 5 (4 METHOXYPHENYL) N PHENYLPYRAZOL 1 CARBOTHIOAMIDE; 4,5 DIHYDRO 3 (4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 5 (4 METHOXYPHENYL)PYRAZOL 1 CARBOTHIOAMIDE; 4,5 DIHYDRO 3 (4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 5 (PYRIDIN 3 YL)PYRAZOL 1 CARBOTHIOAMIDE; 4,5 DIHYDRO 3 (4 HYDROXY 2 OXO 2H CHROMEN 3 YL) N PHENYL 5 (PYRIDIN 3 YL)PYRAZOL 1 CARBOTHIOAMIDE; ANTICOAGULANT AGENT; DECARBOXYPROTHROMBIN; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; WARFARIN;

ANIMAL EXPERIMENT; ANTICOAGULATION; ARTICLE; BLOOD CLOTTING TIME; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROTHROMBIN TIME;

4-HYDROXYCOUMARINS; ADMINISTRATION, ORAL; ANTICOAGULANTS; BIOLOGICAL MARKERS; COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; LETHAL DOSE 50; MOLECULAR STRUCTURE; PLATELET AGGREGATION INHIBITORS; PROTEIN PRECURSORS; PROTHROMBIN; STRUCTURE-ACTIVITY RELATIONSHIP; WARFARIN;

EID: 77953323133     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.009     Document Type: Article

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