Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts

European Journal of Medicinal Chemistry

Volumn 44, Issue 7, 2009, Pages 3020-3026

  Melagraki, Georgia ^a   Afantitis, Antreas ^a   Igglessi Markopoulou, Olga ^a   Detsi, Anastasia ^a   Koufaki, Maria ^b   Kontogiorgis, Christos ^c   Hadjipavlou Litina, Dimitra J ^c  

^a NATIONAL TECHNICAL UNIVERSITY OF ATHENS   (Greece)

^b INSTITUTE OF BIOLOGY   (Greece)

^c ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Anti inflammatory; Antioxidant; Coumarins; Lipoic acid

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; LIPOXYGENASE; N(2 AMINOETHYL) 4 HYDROXY 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N(2 AMINOETHYL) 4 HYDROXY 6 METHYL 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N(2 AMINOPHENYL) 4 HYDROXY 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N(2 AMINOPHENYL) 4 HYDROXY 6 METHYL 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N(6 AMINOHEXYL) 4 HYDROXY 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N(8 AMINOOCTYL) 4 HYDROXY 6 METHYL 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N(8 OCTYLAMINO) 4 HYDROXY 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N[2 [4 (1,2 DITHIOLAN 3 YL)BUTANAMIDO]ETHYL] 4 HYDROXY 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N[2 [4 (1,2 DITHIOLAN 3 YL)BUTANAMIDO]ETHYL] 4 HYDROXY 6 METHYL 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N[6 [5 (1,2 DITHIOLAN 3 YL)PENTANAMIDO]HEXYL] 4 HYDROXY 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N[8 [5 (1,2 DITHIOLAN 3 YL)PENTANAMIDO]OCTYL] 4 HYDROXY 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N[8 [5 (1,2 DITHIOLAN 3 YL)PENTANAMIDO]OCTYL] 4 HYDROXY 6 METHYL 2 OXO 2H CHROMENE 3 CARBOXAMIDE; THIOCTIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; EDEMA; ENZYME INHIBITION; FEMALE; MOUSE; NONHUMAN; PAW EDEMA; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; COUMARINS; EDEMA; FEMALE; LIPOXYGENASE; LIPOXYGENASE INHIBITORS; MALE; RATS; SOYBEANS; THIOCTIC ACID;

EID: 67349140661     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.12.027     Document Type: Article

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