Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4, 3-d]pyrimidin-5-ones

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 1, 2006, Pages 121-130

  Bruno, Olga ^a   Brullo, Chiara ^a   Schenone, Silvia ^a   Bondavalli, Francesco ^a   Ranise, Angelo ^a   Tognolini, Massimiliano ^b   Impicciatore, Mariannina ^b   Ballabeni, Vigilio ^b   Barocelli, Elisabetta ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

4 Amino cycloamino 2 amino cycloamino methanesulfonyl methylthio methoxy benzopyrano 4,3 d pyrimidin 5 ones; 4 Amino cycloamino 2 methanesulfonyl methylthio benzopyrano 4,3 d pyrimidines; Antiplatelet activity; Antithrombotic activity

Indexed keywords

(2 METHANESULFONYL 5H [1]BENZOPYRANO[4,3 D]PYRIMIDINO) 4 MORPHOLINE; (2 METHANESULFONYL 5H [1]BENZOPYRANO[4,3 D]PYRIMIDINO) 4 PIPERIDINE; (2 METHANESULFONYL 5H [1]BENZOPYRANO[4,3 D]PYRIMIDINO) 4 PYRROLIDINE; (2 METHYLTHIO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDINO) 4 MORPHOLINE; (2 METHYLTHIO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDINO) 4 PIPERIDINE; (2 METHYLTHIO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDINO) 4 PYRROLIDINE; 2 METHANESULFONYL 4 MORPHOLINO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDIN 5 ONE; 2 METHANESULFONYL 4 PIPERIDINO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDIN 5 ONE; 2 METHANESULFONYL 4 PYRROLIDINO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDIN 5 ONE; 2 METHOXY 4 AMINO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDIN 5 ONE; 2 METHOXY 5H [1]BENZOPYRANO[4,3 D]PYRIMIDIN 5 ONE; 2 METHYLTHIO 4 AMINO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDIN 5 ONE; 2 METHYLTHIO 4 MORPHOLINO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDIN 5 ONE; 2 METHYLTHIO 4 PIPERIDINO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDIN 5 ONE; 2 METHYLTHIO 4 PYRROLIDINO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDIN 5 ONE; 2 METHYLTHIO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDIN 5 ONE; 2 MORPHOLINO 4 AMINO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDIN 5 ONE; 2 MORPHOLINO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDIN 5 ONE; 2 PYRROLIDINO 4 AMINO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDIN 5 ONE; 2 PYRROLIDINO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDIN 5 ONE; 2,4 DIAMINO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDIN 5 ONE; 4 AMINO 5H [1]BENZOPYRANO[4,3 D]PYRIMIDIN 5 ONE; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; BENZOPYRAN DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; WARFARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; BLEEDING; CONTROLLED STUDY; DRUG SYNTHESIS; HEMOSTASIS; MALE; MOUSE; NONHUMAN; RABBIT; RAT;

ANIMALS; ANTITHROMBINS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MOLECULAR STRUCTURE; PLATELET AGGREGATION INHIBITORS; PYRIMIDINES; RABBITS; RATS; SPECTROPHOTOMETRY, INFRARED;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 27744553753     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.07.066     Document Type: Article

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