An improved oxadiazole synthesis using peptide coupling reagents

Tetrahedron Letters

Volumn 37, Issue 37, 1996, Pages 6627-6630

  Liang, Gui Bai ^a   Feng, Danqing D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXADIAZOLE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; TECHNIQUE;

EID: 0030576920     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(96)01492-X     Document Type: Article

References (9)

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2. 2. Watjen, F.; Baker, R.; Engelstoff, M.; Herbert, R.; MacLeod, A.; Knight, A.; Merchant, K.; Moseley, J.; Saunders, J.; Swain, C. J.; Wong, E.; Springer, J. P. J. Med. Chem. 1989, 32, 2282-2291.
3. 3. Showell, G. A.; Gibbons, T. L.; Kneen, C. O.; MacLeod, A. M.; Merchant, K; Saunders, J.; Freedman, S. B.; Patel, S.; Baker, R. J. Med. Chem. 1991, 34, 1086-1094.
4. 4. Orlek, B. S.; Blaney, F. E.; Brown, F.; Clark, M. S. G.; Hadley, M. S.; Hatcher, J.; Riley, G. J.; Rosenberg, H. E.; Wadsworth, H. J.; Wyman, P. J. Med. Chem. 1991, 34, 2726-2735.
5. 5. Diana, G. D.; Volkots, D. L.; Hitz, T. J.; Bailey, T. R.; Long, M. A.; Vescio, N.; Aldous, S.; Pevear, D. C.; Dutko, F. J. J. Med. Chem. 1994, 37, 2421-2436.
6. 6. Lenaers, R.; Moussebois, C.; Eloy, F. Helv. Chim. Acta 1962, 45, 441-446.
7. 1H NMR and MS.
8. 3, ppm): 0.998 (t, J=7.4 Hz, 3H), 1.75 (sextet, J=7.4 Hz, 2H), 2.36 (s, 3H), 2.46 (t, J=7.4 Hz, 2H), 5.00 (broad s, 2H), 7.20 (m, 2H), 7.59 (m, 2H).
9. 9. Oussaid, B.; Moeini, L.; Martin, B,; Villemin, D.; Garrigues, B. Synth. Commun. 1995, 25, 1451-1459.