메뉴 건너뛰기




Volumn 19, Issue 1, 2013, Pages 357-366

Emerging role of high-mobility group box 1 (HMGB1) in liver diseases

Author keywords

[No Author keywords available]

Indexed keywords

4 CHLORO N (3 QUINUCLIDINYL)BENZAMIDE; ACETYLCYSTEINE; ADVANCED GLYCATION END PRODUCT RECEPTOR; ALPHA SMOOTH MUSCLE ACTIN; ASCORBIC ACID 2 [3,4 DIHYDRO 2,5,7,8 TETRAMETHYL 2 (4,8,12 TRIMETHYLTRIDECYL) 2H 1 BENZOPYRAN 6 YL HYDROGEN PHOSPHATE] POTASSIUM; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CD11B ANTIGEN; CD14 ANTIGEN; CD24 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CISPLATIN; HIGH MOBILITY GROUP B1 PROTEIN; HISTONE DEACETYLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; MATRIX METALLOPROTEINASE; MELATONIN; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; NEUTRALIZING ANTIBODY; PARACETAMOL; SMALL INTERFERING RNA; SYNDECAN 1; T CELL IMMUNOGLOBULIN MUCIN 3; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 84888325591     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2013.00099     Document Type: Review
Times cited : (92)

References (121)
  • 1
    • 0015857760 scopus 로고
    • A new group of chromatin-associated proteins with a high content of acidic and basic amino acids
    • Goodwin GH, Sanders C, Johns EW. (1973) A new group of chromatin-associated proteins with a high content of acidic and basic amino acids. Eur. J. Biochem. 38:14-9.
    • (1973) Eur. J. Biochem , vol.38 , pp. 14-19
    • Goodwin, G.H.1    Sanders, C.2    Johns, E.W.3
  • 2
    • 0033052037 scopus 로고    scopus 로고
    • The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice
    • Calogero S, et al. (1999) The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice. Nat. Genet. 22:276-80.
    • (1999) Nat. Genet , vol.22 , pp. 276-280
    • Calogero, S.1
  • 3
    • 79953066407 scopus 로고    scopus 로고
    • HMGB1 is a therapeutic target for sterile inflammation and infection
    • Andersson U, Tracey KJ. (2011) HMGB1 is a therapeutic target for sterile inflammation and infection. Annu. Rev. Immunol. 29:139-62.
    • (2011) Annu. Rev. Immunol , vol.29 , pp. 139-162
    • Andersson, U.1    Tracey, K.J.2
  • 4
    • 84859440796 scopus 로고    scopus 로고
    • HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease
    • Harris HE, Andersson U, Pisetsky DS. (2012) HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease. Nat. Rev. Rheumatol. 8:195-202.
    • (2012) Nat. Rev. Rheumatol , vol.8 , pp. 195-202
    • Harris, H.E.1    Andersson, U.2    Pisetsky, D.S.3
  • 6
    • 0027414641 scopus 로고
    • Structure of the HMG box motif in the B-domain of HMG1
    • Weir HM, et al. (1993) Structure of the HMG box motif in the B-domain of HMG1. EMBO J. 12:1311-9.
    • (1993) EMBO J , vol.12 , pp. 1311-1319
    • Weir, H.M.1
  • 7
    • 0029563931 scopus 로고
    • Structure of the A-domain of HMG1 and its interaction with DNA as studied by heteronuclear three-and four-dimensional NMR spectroscopy
    • Hardman CH, et al. (1995) Structure of the A-domain of HMG1 and its interaction with DNA as studied by heteronuclear three-and four-dimensional NMR spectroscopy. Biochemistry. 34:16596-607.
    • (1995) Biochemistry , vol.34 , pp. 16596-16607
    • Hardman, C.H.1
  • 9
    • 0038276946 scopus 로고    scopus 로고
    • Structural basis for the proinflammatory cytokine activity of high mobility group box 1
    • Li J, et al. (2003) Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol. Med. 9:37-45.
    • (2003) Mol. Med , vol.9 , pp. 37-45
    • Li, J.1
  • 10
    • 9144241208 scopus 로고    scopus 로고
    • Reversing established sepsis with antagonists of endogenous high-mobility group box 1
    • Yang H, et al. (2004) Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc. Natl. Acad. Sci. U. S. A. 101:296-301.
    • (2004) Proc. Natl. Acad. Sci. U.S. A , vol.101 , pp. 296-301
    • Yang, H.1
  • 11
    • 0037102393 scopus 로고    scopus 로고
    • Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis
    • Huttunen HJ, Fages C, Kuja-Panula J, Ridley AJ, Rauvala H. (2002) Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis. Cancer Res. 62:4805-11.
    • (2002) Cancer Res , vol.62 , pp. 4805-4811
    • Huttunen, H.J.1    Fages, C.2    Kuja-Panula, J.3    Ridley, A.J.4    Rauvala, H.5
  • 12
    • 77955403878 scopus 로고    scopus 로고
    • A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
    • Yang HA, et al. (2010) A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release. Proc. Natl. Acad. Sci. U. S. A. 107:11942-7.
    • (2010) Proc. Natl. Acad. Sci. U.S. A , vol.107 , pp. 11942-11947
    • Yang, H.A.1
  • 13
    • 84866378556 scopus 로고    scopus 로고
    • Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release
    • Venereau E, et al. (2012) Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release. J. Exp. Med. 209:1519-28.
    • (2012) J. Exp. Med , vol.209 , pp. 1519-1528
    • Venereau, E.1
  • 14
    • 0017903484 scopus 로고
    • Nonhistone proteins HMG1 and HMG2 change the DNA helical structure
    • Javaherian K, Liu JF, Wang JC. (1978) Nonhistone proteins HMG1 and HMG2 change the DNA helical structure. Science. 199:1345-6.
    • (1978) Science , vol.199 , pp. 1345-1346
    • Javaherian, K.1    Liu, J.F.2    Wang, J.C.3
  • 15
    • 0033538467 scopus 로고    scopus 로고
    • HMG-1 as a late mediator of endotoxin lethality in mice
    • Wang H, et al. (1999) HMG-1 as a late mediator of endotoxin lethality in mice. Science. 285:248-51.
    • (1999) Science , vol.285 , pp. 248-251
    • Wang, H.1
  • 16
    • 77957106729 scopus 로고    scopus 로고
    • HMGB1 release and redox regulates autophagy and apoptosis in cancer cells
    • Tang D, et al. (2010) HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene. 29:5299-310.
    • (2010) Oncogene , vol.29 , pp. 5299-5310
    • Tang, D.1
  • 17
    • 84860862890 scopus 로고    scopus 로고
    • Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1)
    • Yang H, et al. (2012) Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1). Mol. Med. 18:250-9.
    • (2012) Mol. Med , vol.18 , pp. 250-259
    • Yang, H.1
  • 18
    • 70149098507 scopus 로고    scopus 로고
    • The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation
    • Hreggvidsdottir HS, et al. (2009) The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation. J. Leukoc. Biol. 86:655-62.
    • (2009) J. Leukoc. Biol , vol.86 , pp. 655-662
    • Hreggvidsdottir, H.S.1
  • 19
    • 80053261217 scopus 로고    scopus 로고
    • High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts
    • Wahamaa H, et al. (2011) High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts. Arthritis Res. Ther. 13:R136.
    • (2011) Arthritis Res. Ther , vol.13
    • Wahamaa, H.1
  • 20
    • 77956386515 scopus 로고    scopus 로고
    • Endogenous HMGB1 regulates autophagy
    • Tang D, et al. (2010) Endogenous HMGB1 regulates autophagy. J. Cell Biol. 190:881-92.
    • (2010) J. Cell Biol , vol.190 , pp. 881-892
    • Tang, D.1
  • 21
    • 79958050965 scopus 로고    scopus 로고
    • High-mobility group box 1 is essential for mitochondrial quality control
    • Tang D, et al. (2011) High-mobility group box 1 is essential for mitochondrial quality control. Cell Metab. 13:701-11.
    • (2011) Cell Metab , vol.13 , pp. 701-711
    • Tang, D.1
  • 22
    • 0142137129 scopus 로고    scopus 로고
    • Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
    • Bonaldi T, et al. (2003) Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J. 22:5551-60.
    • (2003) EMBO J , vol.22 , pp. 5551-5560
    • Bonaldi, T.1
  • 23
    • 33751584837 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion
    • Youn JH, Shin JS. (2006) Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion. J. Immunol. 177:7889-97.
    • (2006) J. Immunol , vol.177 , pp. 7889-7897
    • Youn, J.H.1    Shin, J.S.2
  • 24
    • 0036775236 scopus 로고    scopus 로고
    • The nuclear protein HMGB1 is secreted by monocytes via a nonclassical, vesicle-mediated secretory pathway
    • Gardella S, et al. (2002) The nuclear protein HMGB1 is secreted by monocytes via a nonclassical, vesicle-mediated secretory pathway. EMBO Rep. 3:995-1001.
    • (2002) EMBO Rep , vol.3 , pp. 995-1001
    • Gardella, S.1
  • 26
    • 84865511926 scopus 로고    scopus 로고
    • Novel role of PKR in inflammasome activation and HMGB1 release
    • Lu B, et al. (2012) Novel role of PKR in inflammasome activation and HMGB1 release. Nature. 488:670-4.
    • (2012) Nature , vol.488 , pp. 670-674
    • Lu, B.1
  • 27
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    • Scaffidi P, Misteli T, Bianchi ME. (2002) Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature. 418:191-5.
    • (2002) Nature , vol.418 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 28
    • 46749136790 scopus 로고    scopus 로고
    • Induction of immunological tolerance by apoptotic cells requires caspasedependent oxidation of high-mobility group box-1 protein
    • Kazama H, et al. (2008) Induction of immunological tolerance by apoptotic cells requires caspasedependent oxidation of high-mobility group box-1 protein. Immunity. 29:21-32.
    • (2008) Immunity , vol.29 , pp. 21-32
    • Kazama, H.1
  • 29
    • 82455210868 scopus 로고    scopus 로고
    • Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1beta
    • Dupont N, et al. (2011) Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1beta. EMBO J. 30:4701-11.
    • (2011) EMBO J , vol.30 , pp. 4701-4711
    • Dupont, N.1
  • 30
    • 0034682315 scopus 로고    scopus 로고
    • Blockade of RAGEamphoterin signalling suppresses tumour growth and metastases
    • Taguchi A, et al. (2000) Blockade of RAGEamphoterin signalling suppresses tumour growth and metastases. Nature. 405:354-60.
    • (2000) Nature , vol.405 , pp. 354-360
    • Taguchi, A.1
  • 31
    • 0842266582 scopus 로고    scopus 로고
    • Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation
    • Palumbo R, et al. (2004) Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation. J. Cell Biol. 164:441-9.
    • (2004) J. Cell Biol , vol.164 , pp. 441-449
    • Palumbo, R.1
  • 32
    • 33645461206 scopus 로고    scopus 로고
    • High mobility group box 1 protein interacts with multiple Toll-like receptors
    • Park JS, et al. (2006) High mobility group box 1 protein interacts with multiple Toll-like receptors. Am. J. Physiol. Cell Physiol. 290:C917-24.
    • (2006) Am. J. Physiol. Cell Physiol , vol.290
    • Park, J.S.1
  • 33
    • 34247236200 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
    • Tian J, et al. (2007) Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat. Immunol. 8:487-96.
    • (2007) Nat. Immunol , vol.8 , pp. 487-496
    • Tian, J.1
  • 34
    • 63149171602 scopus 로고    scopus 로고
    • CD24 and Siglec-10 selectively repress tissue damageinduced immune responses
    • Chen GY, Tang J, Zheng P, Liu Y. (2009) CD24 and Siglec-10 selectively repress tissue damageinduced immune responses. Science. 323:1722-5.
    • (2009) Science , vol.323 , pp. 1722-1725
    • Chen, G.Y.1    Tang, J.2    Zheng, P.3    Liu, Y.4
  • 35
    • 84865422909 scopus 로고    scopus 로고
    • Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1
    • Chiba S, et al. (2012) Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nat. Immunol. 13:832-42.
    • (2012) Nat. Immunol , vol.13 , pp. 832-842
    • Chiba, S.1
  • 36
    • 84860361435 scopus 로고    scopus 로고
    • HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4
    • Schiraldi M, et al. (2012) HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4. J. Exp. Med. 209:551-63.
    • (2012) J. Exp. Med , vol.209 , pp. 551-563
    • Schiraldi, M.1
  • 37
    • 84874357948 scopus 로고    scopus 로고
    • Sterile inflammation in hepatic ischemia/reperfusion injury: Present concepts and potential therapeutics
    • van Golen RF, Reiniers MJ, Olthof PB, van Gulik TM, Heger M. (2013) Sterile inflammation in hepatic ischemia/reperfusion injury: present concepts and potential therapeutics. J. Gastroenterol. Hepatol. 28:394-400.
    • (2013) J. Gastroenterol. Hepatol , vol.28 , pp. 394-400
    • van Golen, R.F.1    Reiniers, M.J.2    Olthof, P.B.3    van Gulik, T.M.4    Heger, M.5
  • 38
    • 20244373939 scopus 로고    scopus 로고
    • The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
    • Tsung A, et al. (2005) The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J. Exp. Med. 201:1135-43.
    • (2005) J. Exp. Med , vol.201 , pp. 1135-1143
    • Tsung, A.1
  • 39
    • 13944268827 scopus 로고    scopus 로고
    • The role of HMGB-1 on the development of necrosis during hepatic ischemia and hepatic ischemia/reperfusion injury in mice
    • Watanabe T, et al. (2005) The role of HMGB-1 on the development of necrosis during hepatic ischemia and hepatic ischemia/reperfusion injury in mice. J. Surg. Res. 124:59-66.
    • (2005) J. Surg. Res , vol.124 , pp. 59-66
    • Watanabe, T.1
  • 40
    • 84879605175 scopus 로고    scopus 로고
    • Cellular-specific role of tolllike receptor 4 in hepatic ischemia-reperfusion injury in mice
    • Nace GW, et al. (2013) Cellular-specific role of tolllike receptor 4 in hepatic ischemia-reperfusion injury in mice. Hepatology. 58:374-87.
    • (2013) Hepatology , vol.58 , pp. 374-387
    • Nace, G.W.1
  • 41
    • 84880821600 scopus 로고    scopus 로고
    • CD14 contributes to warm hepatic ischemia-reperfusion injury in mice
    • Cai C, et al. (2013) CD14 contributes to warm hepatic ischemia-reperfusion injury in mice. Shock. 40:115-21.
    • (2013) Shock , vol.40 , pp. 115-121
    • Cai, C.1
  • 42
    • 75449096565 scopus 로고    scopus 로고
    • Toll-like receptor 9 inhibition confers protection from liver ischemiareperfusion injury
    • Bamboat ZM, et al. (2010) Toll-like receptor 9 inhibition confers protection from liver ischemiareperfusion injury. Hepatology. 51:621-32.
    • (2010) Hepatology , vol.51 , pp. 621-632
    • Bamboat, Z.M.1
  • 43
    • 64549119691 scopus 로고    scopus 로고
    • Receptor for advanced glycation end product (RAGE)-dependent modulation of early growth response-1 in hepatic ischemia/reperfusion injury
    • Zeng S, et al. (2009) Receptor for advanced glycation end product (RAGE)-dependent modulation of early growth response-1 in hepatic ischemia/reperfusion injury. J. Hepatol. 50:929-36.
    • (2009) J. Hepatol , vol.50 , pp. 929-936
    • Zeng, S.1
  • 44
    • 79960371987 scopus 로고    scopus 로고
    • Gene silencing of NALP3 protects against liver ischemia-reperfusion injury in mice
    • Zhu P, et al. (2011) Gene silencing of NALP3 protects against liver ischemia-reperfusion injury in mice. Hum. Gene Ther. 22:853-64.
    • (2011) Hum. Gene Ther , vol.22 , pp. 853-864
    • Zhu, P.1
  • 45
    • 78650067155 scopus 로고    scopus 로고
    • High mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activity
    • Evankovich J, et al. (2010) High mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activity. J. Biol. Chem. 285:39888-97.
    • (2010) J. Biol. Chem , vol.285 , pp. 39888-39897
    • Evankovich, J.1
  • 46
    • 79952175742 scopus 로고    scopus 로고
    • Interferon regulatory factor 1 mediates acetylation and release of high mobility group box 1 from hepatocytes during murine liver ischemia-reperfusion injury
    • Dhupar R, et al. (2011) Interferon regulatory factor 1 mediates acetylation and release of high mobility group box 1 from hepatocytes during murine liver ischemia-reperfusion injury. Shock. 35:293-301.
    • (2011) Shock , vol.35 , pp. 293-301
    • Dhupar, R.1
  • 47
    • 68949194361 scopus 로고    scopus 로고
    • Cisplatin prevents high mobility group box 1 release and is protective in a murine model of hepatic ischemia/reperfusion injury
    • Cardinal J, et al. (2009) Cisplatin prevents high mobility group box 1 release and is protective in a murine model of hepatic ischemia/reperfusion injury. Hepatology. 50:565-74.
    • (2009) Hepatology , vol.50 , pp. 565-574
    • Cardinal, J.1
  • 48
    • 80053151867 scopus 로고    scopus 로고
    • Glycyrrhizin prevents liver injury by inhibition of high-mobility group box 1 production by Kupffer cells after ischemia-reperfusion in rats
    • Ogiku M, Kono H, Hara M, Tsuchiya M, Fujii H. (2011) Glycyrrhizin prevents liver injury by inhibition of high-mobility group box 1 production by Kupffer cells after ischemia-reperfusion in rats. J. Pharmacol. Exp. Ther. 339:93-8.
    • (2011) J. Pharmacol. Exp. Ther , vol.339 , pp. 93-98
    • Ogiku, M.1    Kono, H.2    Hara, M.3    Tsuchiya, M.4    Fujii, H.5
  • 49
    • 84872931968 scopus 로고    scopus 로고
    • The protective effect of PNU-282987, a selective alpha7 nicotinic acetylcholine receptor agonist, on the hepatic ischemiareperfusion injury is associated with the inhibition of high-mobility group box 1 protein expression and nuclear factor kappaB activation in mice
    • Li F, et al. (2013) The protective effect of PNU-282987, a selective alpha7 nicotinic acetylcholine receptor agonist, on the hepatic ischemiareperfusion injury is associated with the inhibition of high-mobility group box 1 protein expression and nuclear factor kappaB activation in mice. Shock. 39:197-203.
    • (2013) Shock , vol.39 , pp. 197-203
    • Li, F.1
  • 50
    • 84875366869 scopus 로고    scopus 로고
    • The fibrin-derived peptide Bss15-42 attenuates the liver damage in a rat model of liver ischemia reperfusion injury
    • 2013, Feb 20 [Epub ahead of print]
    • Liu A, et al. (2013) The fibrin-derived peptide Bss15-42 attenuates the liver damage in a rat model of liver ischemia reperfusion injury. Shock. 2013, Feb 20 [Epub ahead of print].
    • (2013) Shock
    • Liu, A.1
  • 51
    • 84862000682 scopus 로고    scopus 로고
    • The vitamin E derivative, EPC-K1, suppresses inflammation during hepatic ischemia-reperfusion injury and exerts hepatoprotective effects in rats
    • Oishi K, et al. (2012) The vitamin E derivative, EPC-K1, suppresses inflammation during hepatic ischemia-reperfusion injury and exerts hepatoprotective effects in rats. J. Surg. Res. 176:164-70.
    • (2012) J. Surg. Res , vol.176 , pp. 164-170
    • Oishi, K.1
  • 52
    • 79954419206 scopus 로고    scopus 로고
    • Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway
    • Kang JW, Koh EJ, Lee SM. (2011) Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway. J. Pineal Res. 50:403-11.
    • (2011) J. Pineal Res , vol.50 , pp. 403-411
    • Kang, J.W.1    Koh, E.J.2    Lee, S.M.3
  • 53
    • 33744932946 scopus 로고    scopus 로고
    • Cutting edge: High-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury
    • Izuishi K, et al. (2006) Cutting edge: high-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury. J. Immunol. 176:7154-8.
    • (2006) J. Immunol , vol.176 , pp. 7154-7158
    • Izuishi, K.1
  • 54
  • 55
    • 77956897433 scopus 로고    scopus 로고
    • Liver ischemia/reperfusion injury: Processes in inflammatory networks: A review
    • Abu-Amara M, et al. (2010) Liver ischemia/reperfusion injury: processes in inflammatory networks: a review. Liver Transpl. 16:1016-32.
    • (2010) Liver Transpl , vol.16 , pp. 1016-1032
    • Abu-Amara, M.1
  • 57
    • 57849094037 scopus 로고    scopus 로고
    • High mobility group box 1 protein as a marker of hepatocellular injury in human liver transplantation
    • Ilmakunnas M, et al. (2008) High mobility group box 1 protein as a marker of hepatocellular injury in human liver transplantation. Liver Transpl. 14:1517-25.
    • (2008) Liver Transpl , vol.14 , pp. 1517-1525
    • Ilmakunnas, M.1
  • 58
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL. (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 132:2557-76.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 59
    • 84873020277 scopus 로고    scopus 로고
    • Pathogenic mechanisms in HBV-and HCV-associated hepatocellular carcinoma
    • Arzumanyan A, Reis HM, Feitelson MA. (2013) Pathogenic mechanisms in HBV-and HCV-associated hepatocellular carcinoma. Nat. Rev. Cancer. 13:123-35.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 123-135
    • Arzumanyan, A.1    Reis, H.M.2    Feitelson, M.A.3
  • 60
    • 78650081462 scopus 로고    scopus 로고
    • Is HMGB1 a new indirect marker for revealing fibrosis in chronic hepatitis and a new therapeutic target in treatment?
    • Albayrak A, et al. (2010) Is HMGB1 a new indirect marker for revealing fibrosis in chronic hepatitis and a new therapeutic target in treatment? Viral Immunol. 23:633-8.
    • (2010) Viral Immunol , vol.23 , pp. 633-638
    • Albayrak, A.1
  • 61
    • 80052489035 scopus 로고    scopus 로고
    • Hepatitis C virus infection is blocked by HMGB1 released from virus-infected cells
    • Jung JH, et al. (2011) Hepatitis C virus infection is blocked by HMGB1 released from virus-infected cells. J. Virol. 85:9359-368.
    • (2011) J. Virol , vol.85 , pp. 9359-9368
    • Jung, J.H.1
  • 62
    • 77953745755 scopus 로고    scopus 로고
    • Serum level of HMGB1 in patients with hepatitis B and its clinical significance
    • Liu HB, et al. (2007) [Serum level of HMGB1 in patients with hepatitis B and its clinical significance.]. Zhonghua Gan Zang Bing Za Zhi 15:812-5.
    • (2007) Zhonghua Gan Zang Bing Za Zhi , vol.15 , pp. 812-815
    • Liu, H.B.1
  • 63
    • 79952553248 scopus 로고    scopus 로고
    • HMGB1 cytoplasmic translocation in patients with acute liver failure
    • Zhou RR, et al. (2011) HMGB1 cytoplasmic translocation in patients with acute liver failure. BMC Gastroenterol. 11:21.
    • (2011) BMC Gastroenterol , vol.11 , pp. 21
    • Zhou, R.R.1
  • 64
    • 42649090426 scopus 로고    scopus 로고
    • Serum high mobility group box chromosomal protein 1 is associated with clinicopathologic features in patients with hepatocellular carcinoma
    • Cheng BQ, et al. (2008) Serum high mobility group box chromosomal protein 1 is associated with clinicopathologic features in patients with hepatocellular carcinoma. Dig. Liver Dis. 40:446-52.
    • (2008) Dig. Liver Dis , vol.40 , pp. 446-452
    • Cheng, B.Q.1
  • 65
    • 78249287837 scopus 로고    scopus 로고
    • High mobility group box-1 protein inhibits regulatory T cell immune activity in liver failure in patients with chronic hepatitis B
    • Wang LW, Chen H, Gong ZJ. (2010) High mobility group box-1 protein inhibits regulatory T cell immune activity in liver failure in patients with chronic hepatitis B. Hepatobiliary Pancreat. Dis. Int. 9:499-507.
    • (2010) Hepatobiliary Pancreat. Dis. Int , vol.9 , pp. 499-507
    • Wang, L.W.1    Chen, H.2    Gong, Z.J.3
  • 66
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"?
    • Day CP, James OF. (1998) Steatohepatitis: a tale of two "hits"? Gastroenterology. 114:842-5.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 67
    • 84874473589 scopus 로고    scopus 로고
    • Allostery in the hsp70 chaperone proteins
    • Zuiderweg ER, et al. (2013) Allostery in the hsp70 chaperone proteins. Top. Curr. Chem. 328:99-153.
    • (2013) Top. Curr. Chem , vol.328 , pp. 99-153
    • Zuiderweg, E.R.1
  • 68
    • 80055043169 scopus 로고    scopus 로고
    • Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice
    • Li L, et al. (2011) Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. Hepatology. 54:1620-30.
    • (2011) Hepatology , vol.54 , pp. 1620-1630
    • Li, L.1
  • 70
    • 53149138198 scopus 로고    scopus 로고
    • High-mobility group box 1 protein activates hepatic stellate cells in vitro
    • Kao YH, et al. (2008) High-mobility group box 1 protein activates hepatic stellate cells in vitro. Transplant. Proc. 40:2704-5.
    • (2008) Transplant. Proc , vol.40 , pp. 2704-2705
    • Kao, Y.H.1
  • 71
    • 80155191192 scopus 로고    scopus 로고
    • Inhibition of high-mobility group box 1 expression by siRNA in rat hepatic stellate cells
    • Ge WS, Wu JX, Fan JG, Wang YJ, Chen YW. (2011) Inhibition of high-mobility group box 1 expression by siRNA in rat hepatic stellate cells. World J. Gastroenterol. 17:4090-8.
    • (2011) World J. Gastroenterol , vol.17 , pp. 4090-4098
    • Ge, W.S.1    Wu, J.X.2    Fan, J.G.3    Wang, Y.J.4    Chen, Y.W.5
  • 72
    • 84865236513 scopus 로고    scopus 로고
    • High mobility group box 1 activates toll like receptor 4 signaling in hepatic stellate cells
    • Zhang Z, et al. (2012) High mobility group box 1 activates toll like receptor 4 signaling in hepatic stellate cells. Life Sci. 91:207-12.
    • (2012) Life Sci , vol.91 , pp. 207-212
    • Zhang, Z.1
  • 73
    • 84877806447 scopus 로고    scopus 로고
    • High mobility group box-1 promotes the proliferation and migration of hepatic stellate cells via TLR4-dependent signal pathways of PI3K/Akt and JNK
    • Wang FP, et al. (2013) High mobility group box-1 promotes the proliferation and migration of hepatic stellate cells via TLR4-dependent signal pathways of PI3K/Akt and JNK. PLoS One. 8:e64373.
    • (2013) PLoS One , vol.8
    • Wang, F.P.1
  • 74
    • 77949656459 scopus 로고    scopus 로고
    • The expression of HMGB1 protein and its receptor RAGE in human malignant tumors
    • Kostova N, Zlateva S, Ugrinova I, Pasheva E. (2010) The expression of HMGB1 protein and its receptor RAGE in human malignant tumors. Mol. Cell Biochem. 337:251-8.
    • (2010) Mol. Cell Biochem , vol.337 , pp. 251-258
    • Kostova, N.1    Zlateva, S.2    Ugrinova, I.3    Pasheva, E.4
  • 75
    • 84863104777 scopus 로고    scopus 로고
    • High expression of high mobility group box 1 (hmgb1) predicts poor prognosis for hepatocellular carcinoma after curative hepatectomy
    • Liu F, et al. (2012) High expression of high mobility group box 1 (hmgb1) predicts poor prognosis for hepatocellular carcinoma after curative hepatectomy. J. Transl. Med. 10:135.
    • (2012) J. Transl. Med , vol.10 , pp. 135
    • Liu, F.1
  • 76
    • 84872863271 scopus 로고    scopus 로고
    • Expression and clinical significance of HMGB1 in human liver cancer: Knockdown inhibits tumor growth and metastasis in vitro and in vivo
    • Dong YD, et al. (2013) Expression and clinical significance of HMGB1 in human liver cancer: knockdown inhibits tumor growth and metastasis in vitro and in vivo. Oncol. Rep. 29:87-94.
    • (2013) Oncol. Rep , vol.29 , pp. 87-94
    • Dong, Y.D.1
  • 77
    • 84863447733 scopus 로고    scopus 로고
    • High-mobility group box 1 is associated with clinicopathologic features in patients with hepatocellular carcinoma
    • Jiang W, Wang Z, Li X, Fan X, Duan Y. (2012) High-mobility group box 1 is associated with clinicopathologic features in patients with hepatocellular carcinoma. Pathol. Oncol. Res. 18:293-8.
    • (2012) Pathol. Oncol. Res , vol.18 , pp. 293-298
    • Jiang, W.1    Wang, Z.2    Li, X.3    Fan, X.4    Duan, Y.5
  • 78
    • 70149087964 scopus 로고    scopus 로고
    • Ethyl pyruvate administration inhibits hepatic tumor growth
    • Liang X, et al. (2009) Ethyl pyruvate administration inhibits hepatic tumor growth. J. Leukoc. Biol. 86:599-607.
    • (2009) J. Leukoc. Biol , vol.86 , pp. 599-607
    • Liang, X.1
  • 79
    • 84861540170 scopus 로고    scopus 로고
    • The role of receptor for advanced glycation end products (RAGE) in the proliferation of hepatocellular carcinoma
    • Yaser AM, et al. (2012) The role of receptor for advanced glycation end products (RAGE) in the proliferation of hepatocellular carcinoma. Int. J. Mol. Sci. 13:5982-97.
    • (2012) Int. J. Mol. Sci , vol.13 , pp. 5982-5997
    • Yaser, A.M.1
  • 80
    • 84861536618 scopus 로고    scopus 로고
    • High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases
    • Yan W, et al. (2012) High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases. Hepatology. 55:1863-75.
    • (2012) Hepatology , vol.55 , pp. 1863-1875
    • Yan, W.1
  • 81
    • 84859812538 scopus 로고    scopus 로고
    • Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4
    • Dapito DH, et al. (2012) Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell. 21:504-16.
    • (2012) Cancer Cell , vol.21 , pp. 504-516
    • Dapito, D.H.1
  • 82
    • 3042738919 scopus 로고    scopus 로고
    • Acetaminophen and the U.S. Acute Liver Failure Study Group: Lowering the risks of hepatic failure
    • Lee WM. (2004) Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure. Hepatology. 40:6-9.
    • (2004) Hepatology , vol.40 , pp. 6-9
    • Lee, W.M.1
  • 83
    • 84862776783 scopus 로고    scopus 로고
    • Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity
    • Antoine DJ, et al. (2012) Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. J. Hepatol. 56:1070-9.
    • (2012) J. Hepatol , vol.56 , pp. 1070-1079
    • Antoine, D.J.1
  • 84
    • 84881027019 scopus 로고    scopus 로고
    • Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital
    • Antoine DJ, et al. (2013) Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology. 58:777-87.
    • (2013) Hepatology , vol.58 , pp. 777-787
    • Antoine, D.J.1
  • 85
    • 78149252824 scopus 로고    scopus 로고
    • Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity
    • Antoine DJ, Williams DP, Kipar A, Laverty H, Park BK. (2010) Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity. Mol. Med. 16:479-90.
    • (2010) Mol. Med , vol.16 , pp. 479-490
    • Antoine, D.J.1    Williams, D.P.2    Kipar, A.3    Laverty, H.4    Park, B.K.5
  • 87
    • 84872162386 scopus 로고    scopus 로고
    • Highmobility group box 1 (HMGB1)-toll-like receptor (TLR)4-interleukin (IL)-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: Interaction of gamma delta T cells with macrophages
    • Wang XF, Sun R, Wei HM, Tian ZG. (2013) Highmobility group box 1 (HMGB1)-toll-like receptor (TLR)4-interleukin (IL)-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: interaction of gamma delta T cells with macrophages. Hepatology. 57:373-84.
    • (2013) Hepatology , vol.57 , pp. 373-384
    • Wang, X.F.1    Sun, R.2    Wei, H.M.3    Tian, Z.G.4
  • 88
    • 84870781509 scopus 로고    scopus 로고
    • A Janus tale of two active high mobility group box 1 (HMGB1) redox states
    • Tang D, Billiar TR, Lotze MT. (2012) A Janus tale of two active high mobility group box 1 (HMGB1) redox states. Mol. Med. 18:1360-2.
    • (2012) Mol. Med , vol.18 , pp. 1360-1362
    • Tang, D.1    Billiar, T.R.2    Lotze, M.T.3
  • 89
    • 84862776783 scopus 로고    scopus 로고
    • Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity
    • Antoine DJ, et al. (2012) Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. J. Hepatol. 56:1070-9.
    • (2012) J. Hepatol , vol.56 , pp. 1070-1079
    • Antoine, D.J.1
  • 90
    • 74949101589 scopus 로고    scopus 로고
    • High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo
    • Antoine DJ, et al. (2009) High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo. Toxicol. Sci. 112:521-31.
    • (2009) Toxicol. Sci , vol.112 , pp. 521-531
    • Antoine, D.J.1
  • 91
    • 79956326320 scopus 로고    scopus 로고
    • Macrophage activation by factors released from acetaminophen-injured hepatocytes: Potential role of HMGB1
    • Dragomir AC, Laskin JD, Laskin DL. (2011) Macrophage activation by factors released from acetaminophen-injured hepatocytes: potential role of HMGB1. Toxicol. Appl. Pharmacol. 253:170-77.
    • (2011) Toxicol. Appl. Pharmacol , vol.253 , pp. 170-177
    • Dragomir, A.C.1    Laskin, J.D.2    Laskin, D.L.3
  • 92
    • 84860632523 scopus 로고    scopus 로고
    • High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity
    • Yang R, et al. (2012) High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity. BMC Gastroenterol. 12:45.
    • (2012) BMC Gastroenterol , vol.12 , pp. 45
    • Yang, R.1
  • 93
    • 78651328039 scopus 로고    scopus 로고
    • High-mobility group box 1 exacerbates concanavalin A-induced hepatic injury in mice
    • 1289-1288
    • Gong QA, et al. (2010) High-mobility group box 1 exacerbates concanavalin A-induced hepatic injury in mice. J. Mol. Med. 88:1289-8.
    • (2010) J. Mol. Med , vol.88
    • Gong, Q.A.1
  • 94
    • 79952553248 scopus 로고    scopus 로고
    • HMGB1 cytoplasmic translocation in patients with acute liver failure
    • Zhou RR, et al. (2011) HMGB1 cytoplasmic translocation in patients with acute liver failure. BMC Gastroenterol. 11:21-31.
    • (2011) BMC Gastroenterol , vol.11 , pp. 21-31
    • Zhou, R.R.1
  • 95
    • 5044232017 scopus 로고    scopus 로고
    • Liver regeneration: From myth to mechanism
    • Taub R. (2004) Liver regeneration: from myth to mechanism. Nat. Rev. Mol. Cell. Biol. 5:836-47.
    • (2004) Nat. Rev. Mol. Cell. Biol , vol.5 , pp. 836-847
    • Taub, R.1
  • 97
    • 35948985622 scopus 로고    scopus 로고
    • Innate immune response and hepatic inflammation
    • Szabo G, Mandrekar P, Dolganiuc A. (2007) Innate immune response and hepatic inflammation. Semin. Liver Dis. 27:339-50.
    • (2007) Semin. Liver Dis , vol.27 , pp. 339-350
    • Szabo, G.1    Mandrekar, P.2    Dolganiuc, A.3
  • 98
    • 61649106928 scopus 로고    scopus 로고
    • Inflammation and liver cancer: New molecular links
    • Berasain C, et al. (2009) Inflammation and liver cancer: new molecular links. Ann. N. Y. Acad. Sci. 1155:206-21.
    • (2009) Ann. N.Y. Acad. Sci , vol.1155 , pp. 206-221
    • Berasain, C.1
  • 99
    • 84866378556 scopus 로고    scopus 로고
    • Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release
    • Venereau E, et al. (2012) Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release. J. Exp. Med. 209:1519-28.
    • (2012) J. Exp. Med , vol.209 , pp. 1519-1528
    • Venereau, E.1
  • 100
    • 77955403878 scopus 로고    scopus 로고
    • A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
    • Yang H, et al. (2010) A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release. Proc. Natl. Acad. Sci. U. S. A. 107:11942-7.
    • (2010) Proc. Natl. Acad. Sci. U.S. A , vol.107 , pp. 11942-11947
    • Yang, H.1
  • 101
    • 20944436774 scopus 로고    scopus 로고
    • The N-terminal domain of thrombomodulin sequesters highmobility group-B1 protein, a novel antiinflammatory mechanism
    • Abeyama K, et al. (2005) The N-terminal domain of thrombomodulin sequesters highmobility group-B1 protein, a novel antiinflammatory mechanism. J. Clin. Invest. 115:1267-74.
    • (2005) J. Clin. Invest , vol.115 , pp. 1267-1274
    • Abeyama, K.1
  • 102
    • 84862819673 scopus 로고    scopus 로고
    • Intranasal delivery of HMGB1 siRNA confers target gene knockdown and robust neuroprotection in the postischemic brain
    • Kim ID, et al. (2012) Intranasal delivery of HMGB1 siRNA confers target gene knockdown and robust neuroprotection in the postischemic brain. Mol. Ther. 20:829-39.
    • (2012) Mol. Ther , vol.20 , pp. 829-839
    • Kim, I.D.1
  • 103
    • 84860163119 scopus 로고    scopus 로고
    • p53/HMGB1 complexes regulate autophagy and apoptosis
    • Livesey K, et al. (2012) p53/HMGB1 complexes regulate autophagy and apoptosis. Cancer Res. 72:1996-2005.
    • (2012) Cancer Res , vol.72 , pp. 1996-2005
    • Livesey, K.1
  • 104
    • 77249115188 scopus 로고    scopus 로고
    • Hemoperfusion with a high-mobility group box 1 adsorption column can prevent the occurrence of hepatic ischemia-reperfusion injury in rats
    • Yamamoto T, et al. (2010) Hemoperfusion with a high-mobility group box 1 adsorption column can prevent the occurrence of hepatic ischemia-reperfusion injury in rats. Crit. Care Med. 38:879-85.
    • (2010) Crit. Care Med , vol.38 , pp. 879-885
    • Yamamoto, T.1
  • 105
    • 77953903866 scopus 로고    scopus 로고
    • Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release
    • Xie K, et al. (2010) Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. Shock. 34:90-7.
    • (2010) Shock , vol.34 , pp. 90-97
    • Xie, K.1
  • 106
    • 71049128963 scopus 로고    scopus 로고
    • Quercetin prevents LPSinduced high-mobility group box 1 release and proinflammatory function
    • Tang D, et al. (2009) Quercetin prevents LPSinduced high-mobility group box 1 release and proinflammatory function. Am. J. Respir. Cell Mol. Biol. 41:651-60.
    • (2009) Am. J. Respir. Cell Mol. Biol , vol.41 , pp. 651-660
    • Tang, D.1
  • 107
    • 76749167941 scopus 로고    scopus 로고
    • Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1, HMGB1 receptors (RAGE and TLR4), NF-kappaB expression
    • Wang L, et al. (2010) Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1, HMGB1 receptors (RAGE and TLR4), NF-kappaB expression. Neurosci. Lett. 471:152-6.
    • (2010) Neurosci. Lett , vol.471 , pp. 152-156
    • Wang, L.1
  • 108
    • 77449130589 scopus 로고    scopus 로고
    • Tanshinone II A downregulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia
    • Wang L, et al. (2010) Tanshinone II A downregulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia. Brain Res. 1321:143-51.
    • (2010) Brain Res , vol.1321 , pp. 143-151
    • Wang, L.1
  • 109
    • 77956624951 scopus 로고    scopus 로고
    • Immunomodulatory drugs regulate HMGB1 release from activated human monocytes
    • Schierbeck H, Wahamaa H, Andersson U, Harris HE. (2010) Immunomodulatory drugs regulate HMGB1 release from activated human monocytes. Mol. Med. 16:343-51.
    • (2010) Mol. Med , vol.16 , pp. 343-351
    • Schierbeck, H.1    Wahamaa, H.2    Andersson, U.3    Harris, H.E.4
  • 110
    • 84884540574 scopus 로고    scopus 로고
    • Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis
    • Yang M, et al. (2013) Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis. Biochem. Pharmacol. 86:410-8.
    • (2013) Biochem. Pharmacol , vol.86 , pp. 410-418
    • Yang, M.1
  • 111
    • 0037125985 scopus 로고    scopus 로고
    • Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation
    • Ulloa L, et al. (2002) Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc. Natl. Acad. Sci. U. S. A. 99:12351-6.
    • (2002) Proc. Natl. Acad. Sci. U.S. A , vol.99 , pp. 12351-12356
    • Ulloa, L.1
  • 112
    • 34247181253 scopus 로고    scopus 로고
    • Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities
    • Mollica L, et al. (2007) Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities. Chem. Biol. 14:431-41.
    • (2007) Chem. Biol , vol.14 , pp. 431-441
    • Mollica, L.1
  • 113
    • 21744439466 scopus 로고    scopus 로고
    • Suppression of HMGB1 release by stearoyl lysophosphatidylcholine: An additional mechanism for its therapeutic effects in experimental sepsis
    • Chen G, et al. (2005) Suppression of HMGB1 release by stearoyl lysophosphatidylcholine: an additional mechanism for its therapeutic effects in experimental sepsis. J. Lipid Res. 46:623-7.
    • (2005) J. Lipid Res , vol.46 , pp. 623-627
    • Chen, G.1
  • 114
    • 32544438027 scopus 로고    scopus 로고
    • The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis
    • Wang H, et al. (2006) The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis. J. Nutr. 136:360-5.
    • (2006) J. Nutr , vol.136 , pp. 360-365
    • Wang, H.1
  • 115
    • 33947194239 scopus 로고    scopus 로고
    • A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1
    • Li W, et al. (2007) A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1. J. Immunol. 178:3856-64.
    • (2007) J. Immunol , vol.178 , pp. 3856-3864
    • Li, W.1
  • 116
    • 42649094198 scopus 로고    scopus 로고
    • A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1
    • Li W, et al. (2007) A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1. PLoS One. 2:e1153.
    • (2007) PLoS One , vol.2
    • Li, W.1
  • 117
    • 79953685881 scopus 로고    scopus 로고
    • EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages
    • Li W, et al. (2011) EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages. Biochem. Pharmacol. 81:1152-63.
    • (2011) Biochem. Pharmacol , vol.81 , pp. 1152-1163
    • Li, W.1
  • 118
    • 84870207332 scopus 로고    scopus 로고
    • It is not just folklore: The aqueous extract of mung bean coat is protective against sepsis
    • Zhu S, et al. (2012) It is not just folklore: the aqueous extract of mung bean coat is protective against sepsis. Evid. Based Complement Alternat. Med. 2012:498467.
    • (2012) Evid. Based Complement Alternat. Med , vol.2012 , pp. 498467
    • Zhu, S.1
  • 119
    • 2942756123 scopus 로고    scopus 로고
    • Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response
    • Liliensiek B, et al. (2004) Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response. J. Clin. Invest. 113:1641-50.
    • (2004) J. Clin. Invest , vol.113 , pp. 1641-1650
    • Liliensiek, B.1
  • 120
    • 49949089651 scopus 로고    scopus 로고
    • Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model
    • Hagiwara S, Iwasaka H, Hasegawa A, Koga H, Noguchi T. (2008) Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model. Crit. Care Med. 36:2407-13.
    • (2008) Crit. Care Med , vol.36 , pp. 2407-2413
    • Hagiwara, S.1    Iwasaka, H.2    Hasegawa, A.3    Koga, H.4    Noguchi, T.5
  • 121
    • 9144263639 scopus 로고    scopus 로고
    • Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
    • Wang H, et al. (2004) Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat. Med. 10:1216-21.
    • (2004) Nat. Med , vol.10 , pp. 1216-1221
    • Wang, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.