Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 19, 2002, Pages 12351-12356

  Ulloa, Luis ^a   Ochani, Mahendar ^a   Yang, Huan ^a   Tanovic, Mahira ^a   Halperin, Daniel ^a   Yang, Runkuan ^b   Czura, Christopher J ^a   Fink, Mitchell P ^b   Tracey, Kevin J ^a  

^a North Shore LIJ Research Institute ^*  (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Lipopolysaccharide; NF B; Tumor necrosis factor

Indexed keywords

CYTOKINE; HIGH MOBILITY GROUP PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE; PYRUVIC ACID DERIVATIVE; PYRUVIC ACID ETHYL ESTER; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CYTOKINE RELEASE; ENDOTOXEMIA; ENZYME INHIBITION; HEMORRHAGIC SHOCK; INFLAMMATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ANIMALS; CELL LINE; ENDOTOXEMIA; ENZYME ACTIVATION; HMGB1 PROTEIN; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRUVATES; RNA, MESSENGER; SEPSIS; SIGNAL TRANSDUCTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0037125985     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.192222999     Document Type: Article

References (27)

1. Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J. & Pinsky, M. R. (2001) Crit. Care Med. 29, 1303-1310.
2. Marshall, J. C. (2001) Crit. Care Med. 29, S99-S106.
3. Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., III, Zentella, A., Albert, J. D., et al. (1986) Science 234, 470-474.
4. Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L., et al. (1999) Science 285, 248-251.
5. Abraham, E., Anzueto, A., Gutierrez, G., Tessler, S., San Pedro, G., Wunderink, R., Dal Nogare, A., Nasraway, S., Berman, S., Cooney, R., et al. (1998) Lancet 28, 929-933.
6. Fisher, C. J., Jr., Dhainaut, J. F., Opal, S. M., Pribble, J. P., Balk, R. A., Slotman, G. J., Iberti, T. J., Rackow, E. C., Shapiro, M. J., Greenman, R. L., et al. (1994) J. Am. Med. Assoc. 271, 1836-1843.
7. Abraham, E., Arcaroli, J., Carmody, A., Wang, H. & Tracey, K. J. (2000) J. Immunol. 165, 2950-2954.
8. Andersson, U., Wang, H., Palmblad, K., Aveberger, A. C., Bloom, O., Erlandsson-Harris, H., Janson, A., Kokkola, R., Zhang, M., Yang, H., et al. (2000) J. Exp. Med. 192, 565-570.
9. Wang, H., Vishnubhakat, J. M., Bloom, O., Zhang, M., Ombrellino, M., Sama, A. & Tracey, K. J. (1999) Surgery (St. Louis) 126, 389-392.
10. Fink, M. P. (2002) Curr. Opin. Clin. Nutr. Metab. Care 5, 167-174.
11. Sims, C. A., Wattanasirichaigoon, S., Menconi, M. J., Ajami, A. M. & Fink, M. P. (2001) Crit. Care Med. 29, 1513-1518.
12. Tawadrous, Z., Delude, R. L. & Fink, M. P. (2002) Shock 17, 473-477.
13. Yang, R., Gallo, D. J., Baust, J. J., Uchiyama, T., Watkins. S. K., Delude, R. L. & Fink, M. P. (2002) Am. J. Physiol. 283, G212-G221.
14. Wichmann, M. W., Haisken, J. M., Ayala, A. & Chaudry, I. H. (1996) J. Surg. Res. 65, 109-114.
15. Hesse, D. G., Tracey, K. J., Fong, Y., Manogue, K. R., Palladino, M. A., Jr., Cerami, A., Shires, G. T. & Lowry, S. F. (1988) Surg. Gynecol. Obstet. 166, 147-153.
16. Lee, J. C., Laydon, J. T., McDonnell, P. C, Gallagher, T. F., Kumar, S., Green, D., McNuity, D., Blumenthal, M. J., Heys, J. R., Landvatter, S. W., et al. (1994) Nature (London) 372, 739-746.
17. Derijard, B., Raingeaud, J., Barrett, T., Wu, I. H., Han, J., Ulevitch, R. J. & Davis, R. J. (1995) Science 267, 682-685.
18. Zhang, C., Baumgartner, R. A., Yamada, K. & Beaven, M. A. (1997) J. Biol. Chem. 272, 13397-13402.
19. Dong, Z., Qi, X. & Fidler, I. J. (1993) J. Exp. Med. 177, 1071-1077.
20. Hambleton, J., McMahon, M. & DeFranco, A. L. (1995) J. Exp. Med. 182, 147-154.
21. Cohen, P. S., Nakshatri, H., Dennis, J., Caragine, T., Bianchi, M., Cerami, A. & Tracey, K. J. (1996) Proc. Natl. Acad. Sci. USA 93, 3967-3971.
22. Ishikawa, Y., Mukaida, N., Kuno, K., Rice, N., Okamoto, S. & Matsushima, K. (1995) J. Biol. Chem. 270, 4158-4164.
23. Vincenti, M. P., Burrell, T. A. & Taffet, S. M. (1992) J. Cell. Physiol. 150, 204-213.
24. Brown, M. C., Tomaras, G. D., Vincenti, M. P. & Taffet, S. M. (1997) J. Interferon Cytokine Res. 17, 295-306.
25. Narravula, S. & Colgan, S. P. (2001) J. Immunol. 166, 7543-7548.
26. Czura, C. J., Wang, H. & Tracey, K. J. (2001) J. Endotoxin Res. 7, 315-321.
27. Wang, H., Yang, H., Czura, C. J., Sama, A. E. & Tracey, K. J. (2001) Am. J. Respir. Crit. Care Med. 164, 1768-1773.