High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity

BMC Gastroenterology

Volumn 12, Issue , 2012, Pages

  Yang, Runkuan ^a,b   Zhang, Shutian ^c   Cotoia, Antonella ^b   Oksala, Niku ^d   Zhu, Shengtao ^c   Tenhunen, Jyrki ^a,e  

^a UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c Friendship Hospital   (China)

^d TAMPERE UNIVERSITY HOSPITAL   (Finland)

^e UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; DNA; HIGH MOBILITY GROUP B1 PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN ANTIBODY; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G; PARACETAMOL; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ACUTE LIVER FAILURE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL INFILTRATION; CELL REGENERATION; CONTROLLED STUDY; DRUG OVERDOSE; HISTOPATHOLOGY; INFLAMMATORY CELL; LIVER CELL; LIVER NECROSIS; MALE; MICROSCOPY; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PROTEIN BLOOD LEVEL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RANDOMIZATION; SINGLE DRUG DOSE;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ASPARTATE AMINOTRANSFERASES; CELL PROLIFERATION; CYCLIN D1; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; HEPATOCYTES; HMGB1 PROTEIN; IMMUNOGLOBULIN G; LIVER REGENERATION; MALE; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; NF-KAPPA B;

EID: 84860632523     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-12-45     Document Type: Article

References (30)

1. Lee WM. Acetaminophen and the U.S. Acute liver failure study group: lowering the risks of hepatic failure. Hepatology 2004, 40:6-9.
2. Nelson SD. Molecular mechanisms of the hepatotoxicity caused by acetaminophen. Semin Liver Dis 1990, 10:267-278.
3. Cohen SD, Khairallah EA. Selective protein arylation and acetaminophen-induced hepatotoxicity. Drug Metab Rev 1997, 29:59-77.
4. Cressman DE, Greenbaum LE, DeAngelis RA, et al. Liver failure and defective Hepatocyte regeneration in interleukin-6 deficient mice. Science 1996, 274:1379-1383.
5. Jaeschke H, Bajt ML. Intracellular signaling mechanisms of acetaminophen-induced liver cell death. Toxicol Sci 2006, 89:31-41.
6. Yamada Y, Kirillova I, Peschon JJ, Fausto N. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type 1 tumor necrosis factor receptor. Proc Natl Acad Sci 1997, 94:1441-1446.
7. Wang H, Li W, Goldstein R, Tracey KJ, Sama AE. HMGB1 as a potential therapeutic target. Novartis Found Symp 2007, 280:73-85.
8. Yang H, Wang H, Czura CJ, Tracey KJ. The cytokine activity of HMGB1. J Leukocyte Biology 2005, 78:1-8.
9. Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002, 418:191-195.
10. Ulloa L, Ochani M, Yang H, Tanovic M, Halperin D, Yang R, Czura CJ, Fink MP, Tracey KJ. Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci 2002, 99:12351-12356.
11. Sappington PL, Yang R, Yang H, Tracey KJ, Deluder RL, Fink MP. HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice. Gastroenterology 2002, 123:790-802.
12. Tsung A, Sahai R, Tanaka H, Nakao A, Fink MP, Lotze MT, Yang H, Li J, Tracey KJ, Geller DA, Billiar TR. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. JEM 2005, 201:1135-1143.
13. Yang R, Harada T, Mollen KP, Prince JM, Levy RM, Englert JA, Galloitsch-Peerta M, Yang L, Yang H, Tracey KJ, Harbrecht BG, Billiar TR, Fink MP. Anti- HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock. Mol Med 2006, 12:105-114.
14. Martinez-Mier G, Toledo-Pereyra LH, McDuffie E, Warner RL, Ward PA. L-selectin and chemokine response after liver ischemia and reperfusion. JSR 2000, 93:156-162.
15. Su GL, Gong KQ, Fan MH, Kelley WM, Hsieh J, Sun JM, Hemmila MR, Arbabi S, Remick DG, Wang SC. Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice. Hepatology 2005, 41:187-195.
16. Yang R, Gallo DJ, Baust JJ, Uchiyama T, Watkins SK, Delude RL, Fink MP. Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol 2002, 283:G212-G222.
17. Vaquero J, Belanger M, James L, et al. Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity. Gastroenterology 2007, 132:372-408.
18. Fausto N. Liver regeneration. J Hepatology 2000, 32:19-31.
19. Bianchi ME, Manfredi AA. High mobility group B1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol Rev 2007, 220:35-46.
20. Antoine DJ, Williams DP, Kipar A, Laverty H, Park BK. Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity. Mol Med 2010, 16:479-490.
21. Cataldegirmen G, Zeng S, Feirt N, Ippagunta N, Dun H, Qu W, Lu Y, Rong L, Hofmann MA MA, Kislinger T, Pachydaki SI, Jenkins DG, Weinberg A, Lefkowitch J, Rogiers X, Yan S, Schmidt AM, Emond JC. Rage limits regeneration after massive liver injury by coordinated suppression of TNF-α and NF-κB. JEM 2005, 201:473-484.
22. Yang R, Zhang S, Kajander H, Zhu S, Koskinen ML, Tenhunen J. Ringer's lactate improves liver recovery in a murine model of acetaminophen toxicity. BMC Gastroenterol 2011, 11:125.
23. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grishma JW, Brenner DA. NF kappa B prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest 1998, 101:802-811.
24. Kaplowitz N. Acetaminophen hepatotoxicity. What do we know, what don't we know, and what do we do next?. Hepatology 2004, 40:23-26.
25. Chanda S, Mehendale HM. Hepatic cell division and tissue repair: a key to survival after liver injury. Mol Med Today 1996, 2:82-89.
26. Akerman P, Coto P, Yang SQ, McClain C, Nelson S, Bagby GJ, Diehl AM. Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. Am J Physiol 1992, 263:G579-G585.
27. Mehendale HM. Tissue repair: an important determinant of final outcome of toxicant-induced injury. Toxicol Pathol 2005, 33:41-51.
28. Whyte IM, Francis B, Dawson AH. Safety and efficacy of intravenous N-acetylcystine for acetaminophen overdose: analysis of the Hunter Area Toxicity service (HATS) Database. Curr Med Res Opin 2007, 23:2359-2368.
29. Kerr F, Dawson A, Whyte IH, Buckley N, Murray L, Graudins A, Chan B, Trudinger B. The austrilian clinical toxicology investigators collaboration Randomized trial of different loading infusion rates of N-acetylcystine. Annals of Emergency Med 2005, 45:402-408.
30. Yang R, Miki K, He X, Killeen EM, Fink MP. Prolonged treatment with N-acetylcysteine delays liver recovery from acetaminophen hepatotoxicity. Crit Care 2009, 13:R55.