Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis

Biochemical Pharmacology

Volumn 86, Issue 3, 2013, Pages 410-418

  Yang, Minghua ^a   Cao, Lizhi ^a   Xie, Min ^a   Yu, Yan ^a   Kang, Rui ^b   Yang, Liangchun ^a   Zhao, Mingyi ^a   Tang, Daolin ^a,b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Autophagy; Beclin 1; Chloroquine; HMGB1; NF kB; Sepsis

Indexed keywords

CHLOROQUINE; HIGH MOBILITY GROUP B1 PROTEIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ANTIMALARIAL AGENT; AUTACOID; BECLIN 1; HMGB1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOPHAGY; ENDOTHELIUM CELL; ENDOTOXEMIA; ENZYMATIC DEGRADATION; INFLAMMATION; LETHALITY; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; HMGB1; MALE; METABOLISM; MORTALITY; NF-ΚB; PATHOLOGY; PHYSIOLOGY; SECRETION (PROCESS); SIGNAL TRANSDUCTION; SURVIVAL RATE;

AUTOPHAGY; BECLIN 1; CHLOROQUINE; HMGB1; NF-ΚB; SEPSIS;

ANIMALS; ANTIMALARIALS; CELL LINE; CHLOROQUINE; HMGB1 PROTEIN; INFLAMMATION MEDIATORS; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; SEPSIS; SIGNAL TRANSDUCTION; SURVIVAL RATE;

EID: 84884540574     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.05.013     Document Type: Article

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