-
3
-
-
0021345926
-
N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen
-
Dahlin DC, Miwa GT, Lu AY, Nelson SD. N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Proc Natl Acad Sci U S A 1984; 81: 1327-1331.
-
(1984)
Proc Natl Acad Sci U S A
, vol.81
, pp. 1327-1331
-
-
Dahlin, D.C.1
Miwa, G.T.2
Lu, A.Y.3
Nelson, S.D.4
-
4
-
-
77949328370
-
Signal transduction pathways involved in drug-induced liver injury
-
Han D, Shinohara M, Ybanez MD, Saberi B, Kaplowitz N. Signal transduction pathways involved in drug-induced liver injury. Handb Exp Pharmacol 2010: 267-310.
-
(2010)
Handb Exp Pharmacol
, pp. 267-310
-
-
Han, D.1
Shinohara, M.2
Ybanez, M.D.3
Saberi, B.4
Kaplowitz, N.5
-
5
-
-
61749096745
-
DAMPs ramp up drug toxicity
-
Maher JJ. DAMPs ramp up drug toxicity. J Clin Invest 2009; 119: 246-249.
-
(2009)
J Clin Invest
, vol.119
, pp. 246-249
-
-
Maher, J.J.1
-
6
-
-
33747834655
-
Role of innate immunity in acetaminophen-induced hepatotoxicity
-
Liu ZX, Kaplowitz N. Role of innate immunity in acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol 2006; 2: 493-503.
-
(2006)
Expert Opin Drug Metab Toxicol
, vol.2
, pp. 493-503
-
-
Liu, Z.X.1
Kaplowitz, N.2
-
7
-
-
80052037842
-
Dendritic cell depletion exacerbates acetaminophen hepatotoxicity
-
Connolly MK, Ayo D, Malhotra A, Hackman M, Bedrosian AS, Ibrahim J, et al. Dendritic cell depletion exacerbates acetaminophen hepatotoxicity. HEPATOLOGY 2011; 54: 959-968.
-
(2011)
HEPATOLOGY
, vol.54
, pp. 959-968
-
-
Connolly, M.K.1
Ayo, D.2
Malhotra, A.3
Hackman, M.4
Bedrosian, A.S.5
Ibrahim, J.6
-
8
-
-
9644289366
-
Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity
-
Liu ZX, Govindarajan S, Kaplowitz N. Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology 2004; 127: 1760-1774.
-
(2004)
Gastroenterology
, vol.127
, pp. 1760-1774
-
-
Liu, Z.X.1
Govindarajan, S.2
Kaplowitz, N.3
-
9
-
-
51349122739
-
Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide
-
Masson MJ, Carpenter LD, Graf ML, Pohl LR. Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide. HEPATOLOGY 2008; 48: 889-897.
-
(2008)
HEPATOLOGY
, vol.48
, pp. 889-897
-
-
Masson, M.J.1
Carpenter, L.D.2
Graf, M.L.3
Pohl, L.R.4
-
10
-
-
61749099391
-
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome
-
Imaeda AB, Watanabe A, Sohail MA, Mahmood S, Mohamadnejad M, Sutterwala FS, et al. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest 2009; 119: 305-314.
-
(2009)
J Clin Invest
, vol.119
, pp. 305-314
-
-
Imaeda, A.B.1
Watanabe, A.2
Sohail, M.A.3
Mahmood, S.4
Mohamadnejad, M.5
Sutterwala, F.S.6
-
11
-
-
33745549377
-
Neutrophil depletion protects against murine acetaminophen hepatotoxicity
-
Liu ZX, Han D, Gunawan B, Kaplowitz N. Neutrophil depletion protects against murine acetaminophen hepatotoxicity. HEPATOLOGY 2006; 43: 1220-1230.
-
(2006)
HEPATOLOGY
, vol.43
, pp. 1220-1230
-
-
Liu, Z.X.1
Han, D.2
Gunawan, B.3
Kaplowitz, N.4
-
12
-
-
33745522546
-
Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity
-
Cover C, Liu J, Farhood A, Malle E, Waalkes MP, Bajt ML, et al. Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 2006; 216: 98-107.
-
(2006)
Toxicol Appl Pharmacol
, vol.216
, pp. 98-107
-
-
Cover, C.1
Liu, J.2
Farhood, A.3
Malle, E.4
Waalkes, M.P.5
Bajt, M.L.6
-
13
-
-
51349169595
-
Innate immunity and acetaminophen-induced liver injury: why so many controversies?
-
Jaeschke H. Innate immunity and acetaminophen-induced liver injury: why so many controversies? HEPATOLOGY 2008; 48: 699-701.
-
(2008)
HEPATOLOGY
, vol.48
, pp. 699-701
-
-
Jaeschke, H.1
-
14
-
-
77955922658
-
Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury
-
Williams CD, Farhood A, Jaeschke H. Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury. Toxicol Appl Pharmacol 2010; 247: 169-178.
-
(2010)
Toxicol Appl Pharmacol
, vol.247
, pp. 169-178
-
-
Williams, C.D.1
Farhood, A.2
Jaeschke, H.3
-
15
-
-
0347703417
-
[Protective effect of interleukin-1 beta on acetaminophen induced liver damage in mice.]
-
Sun H, Li JY, Yu JR. [Protective effect of interleukin-1 beta on acetaminophen induced liver damage in mice.] Sheng Li Xue Bao 1997; 49: 153-159.
-
(1997)
Sheng Li Xue Bao
, vol.49
, pp. 153-159
-
-
Sun, H.1
Li, J.Y.2
Yu, J.R.3
-
16
-
-
0027215897
-
CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene
-
Rouvier E, Luciani MF, Mattei MG, Denizot F, Golstein P. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J Immunol 1993; 150: 5445-5456.
-
(1993)
J Immunol
, vol.150
, pp. 5445-5456
-
-
Rouvier, E.1
Luciani, M.F.2
Mattei, M.G.3
Denizot, F.4
Golstein, P.5
-
17
-
-
27544490377
-
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
-
Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005; 6: 1123-1132.
-
(2005)
Nat Immunol
, vol.6
, pp. 1123-1132
-
-
Harrington, L.E.1
Hatton, R.D.2
Mangan, P.R.3
Turner, H.4
Murphy, T.L.5
Murphy, K.M.6
-
18
-
-
77954143695
-
Innate IL-17-producing cells: the sentinels of the immune system
-
Cua DJ, Tato CM. Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol 2010; 10: 479-489.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 479-489
-
-
Cua, D.J.1
Tato, C.M.2
-
19
-
-
5644277476
-
Interleukin-17 family members and inflammation
-
Kolls JK, Linden A. Interleukin-17 family members and inflammation. Immunity 2004; 21: 467-476.
-
(2004)
Immunity
, vol.21
, pp. 467-476
-
-
Kolls, J.K.1
Linden, A.2
-
20
-
-
77954143558
-
Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity
-
Bonneville M, O'Brien RL, Born WK. Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity. Nat Rev Immunol 2010; 10: 467-478.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 467-478
-
-
Bonneville, M.1
O'Brien, R.L.2
Born, W.K.3
-
21
-
-
46749113368
-
Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma
-
Jensen KD, Su X, Shin S, Li L, Youssef S, Yamasaki S, et al. Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity 2008; 29: 90-100.
-
(2008)
Immunity
, vol.29
, pp. 90-100
-
-
Jensen, K.D.1
Su, X.2
Shin, S.3
Li, L.4
Youssef, S.5
Yamasaki, S.6
-
22
-
-
51549115916
-
IL-17A produced by gammadelta T cells plays a critical role in innate immunity against Listeria monocytogenes infection in the liver
-
Hamada S, Umemura M, Shiono T, Tanaka K, Yahagi A, Begum MD, et al. IL-17A produced by gammadelta T cells plays a critical role in innate immunity against Listeria monocytogenes infection in the liver. J Immunol 2008; 181: 3456-3463.
-
(2008)
J Immunol
, vol.181
, pp. 3456-3463
-
-
Hamada, S.1
Umemura, M.2
Shiono, T.3
Tanaka, K.4
Yahagi, A.5
Begum, M.D.6
-
23
-
-
38449093216
-
Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells
-
Roark CL, French JD, Taylor MA, Bendele AM, Born WK, O'Brien RL. Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells. J Immunol 2007; 179: 5576-5583.
-
(2007)
J Immunol
, vol.179
, pp. 5576-5583
-
-
Roark, C.L.1
French, J.D.2
Taylor, M.A.3
Bendele, A.M.4
Born, W.K.5
O'Brien, R.L.6
-
24
-
-
75349095405
-
The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice
-
Martin-Murphy BV, Holt MP, Ju C. The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice. Toxicol Lett 2010; 192: 387-394.
-
(2010)
Toxicol Lett
, vol.192
, pp. 387-394
-
-
Martin-Murphy, B.V.1
Holt, M.P.2
Ju, C.3
-
25
-
-
80053075831
-
Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury
-
Dear JW, Simpson KJ, Nicolai MP, Catterson JH, Street J, Huizinga T, et al. Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury. J Immunol 2011; 187: 3347-3352.
-
(2011)
J Immunol
, vol.187
, pp. 3347-3352
-
-
Dear, J.W.1
Simpson, K.J.2
Nicolai, M.P.3
Catterson, J.H.4
Street, J.5
Huizinga, T.6
-
26
-
-
79953066407
-
HMGB1 is a therapeutic target for sterile inflammation and infection
-
Andersson U, Tracey KJ. HMGB1 is a therapeutic target for sterile inflammation and infection. Annu Rev Immunol 2011; 29: 139-162.
-
(2011)
Annu Rev Immunol
, vol.29
, pp. 139-162
-
-
Andersson, U.1
Tracey, K.J.2
-
27
-
-
17144376810
-
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
-
Lotze MT, Tracey KJ. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 2005; 5: 331-342.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 331-342
-
-
Lotze, M.T.1
Tracey, K.J.2
-
28
-
-
0037062934
-
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
-
Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002; 418: 191-195.
-
(2002)
Nature
, vol.418
, pp. 191-195
-
-
Scaffidi, P.1
Misteli, T.2
Bianchi, M.E.3
-
29
-
-
63149171602
-
CD24 and Siglec-10 selectively repress tissue damage-induced immune responses
-
Chen GY, Tang J, Zheng P, Liu Y. CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science 2009; 323: 1722-1725.
-
(2009)
Science
, vol.323
, pp. 1722-1725
-
-
Chen, G.Y.1
Tang, J.2
Zheng, P.3
Liu, Y.4
-
30
-
-
20244373939
-
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
-
Tsung A, Sahai R, Tanaka H, Nakao A, Fink MP, Lotze MT, et al. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 2005; 201: 1135-1143.
-
(2005)
J Exp Med
, vol.201
, pp. 1135-1143
-
-
Tsung, A.1
Sahai, R.2
Tanaka, H.3
Nakao, A.4
Fink, M.P.5
Lotze, M.T.6
-
31
-
-
79956326320
-
Macrophage activation by factors released from acetaminophen-injured hepatocytes: potential role of HMGB1
-
Dragomir AC, Laskin JD, Laskin DL. Macrophage activation by factors released from acetaminophen-injured hepatocytes: potential role of HMGB1. Toxicol Appl Pharmacol 2011; 253: 170-177.
-
(2011)
Toxicol Appl Pharmacol
, vol.253
, pp. 170-177
-
-
Dragomir, A.C.1
Laskin, J.D.2
Laskin, D.L.3
-
32
-
-
77954947251
-
Cytokine and autoantibody patterns in acute liver failure
-
Li J, Zhu X, Liu F, Cai P, Sanders C, Lee WM, et al. Cytokine and autoantibody patterns in acute liver failure. J Immunotoxicol 2010; 7: 157-164.
-
(2010)
J Immunotoxicol
, vol.7
, pp. 157-164
-
-
Li, J.1
Zhu, X.2
Liu, F.3
Cai, P.4
Sanders, C.5
Lee, W.M.6
-
33
-
-
79251575277
-
Role of IL-17 and Th17 cells in liver diseases
-
Hammerich L, Heymann F, Tacke F. Role of IL-17 and Th17 cells in liver diseases. Clin Dev Immunol 2011; 2011: 345803.
-
(2011)
Clin Dev Immunol
, vol.2011
, pp. 345803
-
-
Hammerich, L.1
Heymann, F.2
Tacke, F.3
-
34
-
-
33646874825
-
Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity
-
Yohe HC, O'Hara KA, Hunt JA, Kitzmiller TJ, Wood SG, Bement JL, et al. Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity. Am J Physiol Gastrointest Liver Physiol 2006; 290: G1269-G1279.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
-
-
Yohe, H.C.1
O'Hara, K.A.2
Hunt, J.A.3
Kitzmiller, T.J.4
Wood, S.G.5
Bement, J.L.6
-
35
-
-
56749174940
-
Exploring the full spectrum of macrophage activation
-
Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008; 8: 958-069.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 958-069
-
-
Mosser, D.M.1
Edwards, J.P.2
-
36
-
-
0033000310
-
Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species
-
Michael SL, Pumford NR, Mayeux PR, Niesman MR, Hinson JA. Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species. HEPATOLOGY 1999; 30: 186-195.
-
(1999)
HEPATOLOGY
, vol.30
, pp. 186-195
-
-
Michael, S.L.1
Pumford, N.R.2
Mayeux, P.R.3
Niesman, M.R.4
Hinson, J.A.5
-
37
-
-
0036913249
-
Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice
-
Ju C, Reilly TP, Bourdi M, Radonovich MF, Brady JN, George JW, et al. Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice. Chem Res Toxicol 2002; 15: 1504-1513.
-
(2002)
Chem Res Toxicol
, vol.15
, pp. 1504-1513
-
-
Ju, C.1
Reilly, T.P.2
Bourdi, M.3
Radonovich, M.F.4
Brady, J.N.5
George, J.W.6
-
38
-
-
57149108312
-
Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury
-
Holt MP, Cheng L, Ju C. Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury. J Leukoc Biol 2008; 84: 1410-1421.
-
(2008)
J Leukoc Biol
, vol.84
, pp. 1410-1421
-
-
Holt, M.P.1
Cheng, L.2
Ju, C.3
-
39
-
-
33749138039
-
IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection
-
Lockhart E, Green AM, Flynn JL. IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol 2006; 177: 4662-4669.
-
(2006)
J Immunol
, vol.177
, pp. 4662-4669
-
-
Lockhart, E.1
Green, A.M.2
Flynn, J.L.3
-
40
-
-
68649088121
-
Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity
-
Sutton CE, Lalor SJ, Sweeney CM, et al. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 2009; 31: 331-341.
-
(2009)
Immunity
, vol.31
, pp. 331-341
-
-
Sutton, C.E.1
Lalor, S.J.2
Sweeney, C.M.3
-
41
-
-
39549097751
-
Liver: An organ with predominant innate immunity
-
Gao B, Jeong WI, Tian Z. Liver: An organ with predominant innate immunity. HEPATOLOGY 2008; 47: 729-736.
-
(2008)
HEPATOLOGY
, vol.47
, pp. 729-736
-
-
Gao, B.1
Jeong, W.I.2
Tian, Z.3
-
42
-
-
0032055597
-
IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages
-
Jovanovic DV, Di Battista JA, Martel-Pelletier J, Jolicoeur FC, He Y, Zhang M, et al. IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages. J Immunol 1998; 160: 3513-3521.
-
(1998)
J Immunol
, vol.160
, pp. 3513-3521
-
-
Jovanovic, D.V.1
Di Battista, J.A.2
Martel-Pelletier, J.3
Jolicoeur, F.C.4
He, Y.5
Zhang, M.6
-
43
-
-
84859516946
-
Macrophages participate in IL-17-mediated inflammation
-
Barin JG, Baldeviano GC, Talor MV, Wu L, Ong S, Quader F, et al. Macrophages participate in IL-17-mediated inflammation. Eur J Immunol 2012; 42: 726-736.
-
(2012)
Eur J Immunol
, vol.42
, pp. 726-736
-
-
Barin, J.G.1
Baldeviano, G.C.2
Talor, M.V.3
Wu, L.4
Ong, S.5
Quader, F.6
|