Lysosomal Membrane Permeabilization as a Key Player in Brain Ischemic Cell Death: A "Lysosomocentric" Hypothesis for Ischemic Brain Damage

Translational Stroke Research

Volumn 4, Issue 6, 2013, Pages 672-684

  Lipton, Peter ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Arachidonic acid; Brain; Cathepsins; Ischemia; Lysosome

Indexed keywords

AMINOPROPANOL; ARACHIDONIC ACID; CALPAIN; CALPASTATIN; CASPASE 3; CATHEPSIN B; CYCLOOXYGENASE 2; CYTOCHROME C; CYTOSOLIC PHOSPHOLIPASE A2; FREE RADICAL; HEAT SHOCK PROTEIN; LYSOSOME ENZYME; N (3 PROPYLCARBAMOYLOXIRANE 2 CARBONYL)ISOLEUCYLPROLINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PD 150606; PHOSPHOLIPASE A2; PROPRANOLOL DERIVATIVE; PROTEIN BAX; PROTEIN KINASE C DELTA; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SPHINGOSINE; UNCLASSIFIED DRUG;

APOPTOSIS; AUTOPHAGY; BRAIN CELL; BRAIN DAMAGE; BRAIN ISCHEMIA; BRAIN TISSUE; CELL DEATH; CELL PERMEABILIZATION; CYTOSOL; ENZYME ACTIVATION; HUMAN; LYSOSOME MEMBRANE; MITOCHONDRION; PRIORITY JOURNAL; REPERFUSION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN INJURIES; BRAIN ISCHEMIA; CALPAIN; CATHEPSINS; CELL DEATH; CEREBRUM; FREE RADICALS; HUMANS; INTRACELLULAR MEMBRANES; LYSOSOMES; PERMEABILITY; PHOSPHOLIPASES A2; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84888289357     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-013-0301-2     Document Type: Review

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