Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells

Journal of Lipid Research

Volumn 53, Issue 6, 2012, Pages 1134-1143

  Ullio, Chiara ^a   Casas, Josefina ^b   Brunk, Ulf T ^c   Sala, Giuseppina ^d   Fabriàs, Gemma ^b   Ghidoni, Riccardo ^d   Bonelli, Gabriella ^a   Baccino, Francesco M ^a   Autelli, Riccardo ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

^c LINKÖPING UNIVERSITY   (Sweden)

^d SAN PAOLO HOSPITAL   (Italy)

Author keywords

Ceramide; Hepatocellular carcinoma; Lysosomes; Sphingolipids; Tumor necrosis factor

Indexed keywords

ACID CERAMIDASE; CATHEPSIN; CERAMIDE; CYCLOHEXIMIDE; SMALL INTERFERING RNA; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE; TUMOR NECROSIS FACTOR ALPHA;

ACIDITY; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOPLASM; HEPATOMA CELL; LYSOSOME; LYSOSOME MEMBRANE; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; RAT; RNA INTERFERENCE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL DEATH; CELL LINE, TUMOR; CERAMIDASES; CERAMIDES; CYCLOHEXIMIDE; GENE SILENCING; INTRACELLULAR MEMBRANES; LYSOSOMES; PERMEABILITY; RATS; RECEPTORS, TUMOR NECROSIS FACTOR; RNA, SMALL INTERFERING; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84861436735     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M022384     Document Type: Article

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