Urea/oxalamide tethered β-lactam-7-chloroquinoline conjugates: Synthesis and in vitro antimalarial evaluation

European Journal of Medicinal Chemistry

Volumn 71, Issue , 2014, Pages 128-134

  Singh, Pardeep ^a   Raj, Raghu ^a   Singh, Parvesh ^b   Gut, Jiri ^c   Rosenthal, Philip J ^c   Kumar, Vipan ^a  

^a GURU NANAK DEV UNIVERSITY   (India)

^b DURBAN UNIVERSITY OF TECHNOLOGY   (South Africa)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antimalarial evaluation; beta; Lactam 7 chloroquinoline conjugates; Structure activity relationship; Urea oxalamide linker

Indexed keywords

(1 CYCLOHEXYL 2 OXO 4 STYRYL AZETIDIN 3 YL) CARBAMIC ACID ETHYL ESTER; (2 OXO 4 STYRYL 1 P TOLYL AZETIDIN 3 YL) CARBAMIC ACID ETHYL ESTER; 1 [2 (7 CHLORO QUINOLIN 4 YLAMINO) ETHYL] 3 (1 CYCLOHEXYL 2 OXO 4 STYRYL AZETIDIN 3 YL) UREA; 1 [2 (7 CHLORO QUINOLIN 4 YLAMINO) ETHYL] 3 (2 OXO 4 STYRYL 1 P TOLYL AZETIDIN 3 YL) UREA; 1 [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] 3 (1 CYCLOHEXYL 2 OXO 4 STYRYL AZETIDIN 3 YL) UREA; 1 [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] 3 (2 OXO 4 STYRYL 1 P TOLYL AZETIDIN 3 YL) UREA; 1 [4 (7 CHLORO QUINOLIN 4 YLAMINO) BUTYL] 3 (1 CYCLOHEXYL 2 OXO 4 STYRYL AZETIDIN 3 YL) UREA; 1 [4 (7 CHLORO QUINOLIN 4 YLAMINO) BUTYL] 3 (2 OXO 4 STYRYL 1 P TOLYL AZETIDIN 3 YL) UREA; 1 [6 ( 7 CHLORO QUINOLIN 4 YLAMINO) HEXYL] 3 (2 OXO 4 STYRYL 1 P TOLYL AZETIDIN 3 YL) UREA; 1 [6 (7 CHLORO QUINOLIN 4 YLAMINO) HEXYL] 3 (1 CYCLOHEXYL 2 OXO 4 STYRYL AZETIDIN 3 YL) UREA; ARTEMISININ; BLEOMYCIN; CHLOROQUINE; DEETHYLAMODIAQUINE; DOXORUBICIN; N (1 CYCLOHEXYL 2 OXO 4 STYRYL AZETIDIN 3 YL) OXALAMIC ACID ETHYL ESTER; N (2 OXO 4 STYRYL 1 P TOLYL AZETIDIN 3 YL) OXALAMIC ACID ETHYL ESTER; N [1 (4 CHLORO PHENYL) 2 OXO 4 STYRYL AZETIDIN 3 YL] N' [4 (7 CHLORO QUINOLIN 4 YLAMINO) BUTYL] OXALAMIDE; N [1 (4 CHLORO PHENYL) 2 OXO 4 STYRYL AZETIDIN 3 YL] OXALAMIC ACID ETHYL ESTER; N [2 (7 CHLORO QUINOLIN 4 YLAMINO) ETHYL] N' (1 CYCLOHEXYL 2 OXO 4 STYRYL AZETIDIN 3 YL OXALAMIDE; N [2 (7 CHLORO QUINOLIN 4 YLAMINO) ETHYL] N' (2 OXO 4 STYRYL 1 P TOLYL AZETIDIN 3 YL) OXALAMIDE; N [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] N' (1 CYCLOHEXYL 2 OXO 4-STYRY AZETIDIN 3 OXALIMIDE; N [4 (7 CHLORO QUINOLIN 4 YLAMINO) BUTYL] N' (1 CYCLOHEXYL 2 OXO 4 STYRYL AZETIIDN 3 OXALAMIDE; N [6 (7 CHLORO QUINOLIN 4 YLAMINO) HEXYL] N' (1 CYCLOHEXYL 2 OXO 4 STYRYL AZETIDIN 3 OXALAMIDE; N[1 (4 CHLORO PHENYL) 2 OXO 4 STYRYL AZETIDIN 3 YL] N' [6 (7 CHLORO QUINOLIN 4 YLAMINO) HEXYL] OXALAMIDE; N[3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] N' (2 OXO 4 STYRYL 1 P TOLYL AZETIDIN 3 YL) OXALAMIDE; QUININE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE; (2 OXO 4) STYRYL 1 4 TOLYL AZETIDIN 3 YL) CARBAMIC ACID ETHYL ESTER; 1 [2 (7 CHLORO QUINOLIN 4 YLAMINO) ETHYL] 3 (2 OXO 4 STYRYL 1 4 AZETIDIN 3 YL) UREA; 1 [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] 3 (2 OXO 4 STYRYL 1 4 AZETIDIN 3 YL) UREA; 1 [4 (7 CHLORO QUINOLIN 4 YLAMINO) BUTYL] 3 (2 OXO 4 STYRYL 1 4 AZETIDIN 3 YL) UREA; 1 [6 (7 CHLORO QUINOLIN 4 YLAMINO) HEXYL] 3 (2 OXO 4 STYRYL 1 4 AZETIDIN 3 YL) UREA; ANTIMALARIAL AGENT; BETA LACTAM 7 CHLOROQUINOLINE DERIVATIVE; N (2 OXO 4 STYRYL 1 4 TOLYL AZETIDIN 3 YL) OXALAMIC ACID ETHYL ESTER; N [1 (4 CHLORO PHENYL) 2 OXO 4 STYRYL AZETIDIN 3 YL] N' [6 (7 CHLORO QUINOLIN 4 YLAMINO) HEXYL] OXALAMIDE; N [2 (7 CHLORO QUINOLIN 4 YLAMINO) ETHYL] N' (1 CYCLOHEXYL 2 OXO 4 STYRYL AZETIDIN 3 YL) OXALAMIDE; N [2 (7 CHLORO QUINOLIN 4 YLAMINO) ETHYL] N' (2 OXO 4 STYRYL 1 4 TOLYL AZETIDIN 3 YL) OXALAMIDE; N [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] N' (1 CYCLOHEXYL 2 OXO 4 STYRYL AZETIDIN 3 YL) OXALAMIDE; N [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] N' (2 OXO 4 STYRYL 1 4 TOLYL AZETIDIN 3 YL) OXALAMIDE; N [4 (7 CHLORO QUINOLIN 4 YLAMINO) BUTYL] N' (1 CYCLOHEXYL 2 OXO 4 STYRYL AZETIDIN 3 YL) OXALAMIDE; N [6 (7 CHLORO QUINOLIN 4 YLAMINO) HEXYL] N' (1 CYCLOHEXYL 2 OXO 4 STYRYL AZETIDIN 3 YL) OXALAMIDE; OXALAMIDE; UREA;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MELTING POINT; PLASMODIUM FALCIPARUM; PROTON NUCLEAR MAGNETIC RESONANCE; THIN LAYER CHROMATOGRAPHY; ANTIMALARIAL DRUG RESISTANCE; CYTOTOXICITY; FEMALE; HELA CELL LINE; HYDROGEN BOND; IC50; NONHUMAN;

ANTIMALARIAL EVALUATION; STRUCTURE-ACTIVITY RELATIONSHIP; UREA/OXALAMIDE LINKER; Β-LACTAM-7-CHLOROQUINOLINE CONJUGATES;

ANTIMALARIALS; BETA-LACTAMS; CHLOROQUINE; HUMANS; MALARIA, FALCIPARUM; OXAMIC ACID; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 84888154310     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.079     Document Type: Article

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