4-Alkylidene-azetidin-2-ones: Novel inhibitors of leukocyte elastase and gelatinase

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 24, 2003, Pages 5391-5399

  Cainelli, Gianfranco ^a   Galletti, Paola ^a   Garbisa, Spiridione ^b   Giacomini, Daria ^a   Sartor, Luigi ^b   Quintavalla, Arianna ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 (1 HYDROXYETHYL) 4 (ETHOXYCARBONYL)ETHYLIDENE AZETIDINONE; ALCOHOL DERIVATIVE; BENZYL 3 [1 (TERT BUTYLDIMETHYLSILANYLOXY)ETHYL] 2 ETHOXYCARBONYLMETHYLEN 4 OXOAZETIDINE 1 CARBOXYLATE; BETA LACTAM DERIVATIVE; CHROMOGENIC SUBSTRATE; ELASTASE; ETHYL[1 ACETYL 3 [1 (TERT BUTYLDIMETHYLSILANYLOXY)ETHYL] 4 OXOAZETIDIN 2 YLIDENE]ACETATE; ETHYL[1 BENZYL 3 [1 (TERT BUTYLDIMETHYLSILANYLOXY)ETHYL] 4 OXOAZETIDIN 2 YLIDENE]ACETATE; ETHYL[1 BENZYL 3 [1 (TERT BUTYLDIMETHYLSILANYLOXYL)ETHYL] 4 OXOAZETIDIN 2 YLIDENE]ACETATE; ETHYL[1 BENZYLCARBAMOYL 3 [1 (TERT BUTYLDIMETHYLSILANYLOXY)ETHYL] 4 OXOAZETIDIN 2 YLIDENE]ACETATE; ETHYL[3 [1 (TERT BUTYLDIMETHYLSILANYLOXY)ETHYL] 2 ETHOXYCARBONYLMETHYL 4 OXOAZETIDIN 1 YL] 3 OXOPROPIONATE; ETHYL[3 [1 (TERT BUTYLDIMETHYLSILANYLOXY)ETHYL] 2 ETHOXYCARBONYLMETHYLEN 4 OXOAZETIDIN 1 YL] 3 OXOPROPIONATE; ETHYL[3 [1 (TERT BUTYLDIMETHYLSILANYLOXY)ETHYL] 4 OXOAZETIDIN 2 YL]ACETATE; GELATIN; GELATINASE; GELATINASE INHIBITOR; LEUKOCYTE ELASTASE INHIBITOR; METALLOPROTEINASE; PHENYL[3 [1 (TERT BUTYLDIMETHYLSILANYLOXY)ETHYL] 4 OXOAZETIDIN 2 YLIDENE]THIOACETATE; PROTEIN MMP 2; PROTEIN MMP 9; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; ASSAY; CANCER INVASION; CELL STRAIN 3T3; CYTOTOXICITY; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; FIBROBLAST; FIBROSARCOMA; HUMAN; HUMAN CELL; IC 50; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; SUBSTITUTION REACTION; ZYMOGRAPHY;

MURINAE;

EID: 0344420063     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.09.035     Document Type: Article

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