Azide-alkyne cycloaddition en route to 1H-1,2,3-triazole-tethered 7-chloroquinoline-isatin chimeras: Synthesis and antimalarial evaluation

European Journal of Medicinal Chemistry

Volumn 62, Issue , 2013, Pages 590-596

  Raj, Raghu ^a   Singh, Pardeep ^a   Singh, Parvesh ^b   Gut, Jiri ^c   Rosenthal, Philip J ^c   Kumar, Vipan ^a  

^a GURU NANAK DEV UNIVERSITY   (India)

^b DURBAN UNIVERSITY OF TECHNOLOGY   (South Africa)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

1H 1,2,3 triazole; 7 Chloroquinoline isatin conjugates; Antimalarial evaluation; Structure activity relationship

Indexed keywords

1 [1 (7 CHLORO QUINOLIN 4 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 1 [1 (7 CHLORO QUINOLIN 4 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 5 FLUORO 1H INDOLE 2,3 DIONE; 1 [1 (7 CHLORO QUINOLIN 4 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 5 METHYL 1H INDOLE 2,3 DIONE; 1 [1 [2 (7 CHLORO QUINOLIN 4 YLAMINO) ETHYL] 1H [1,2,3] TRIAZOL 4 YLMETHYL] 5 METHYL 1H INDOLE 2,3 DIONE; 1 [1 [2 (7 CHLORO QUINOLIN 4 YLAMINO) ETHYL] 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 1 [1 [2 (7 CHLORO QUINOLIN 4 YLAMINO) ETHYL] 1H [1,2,3]TRIAZOL 4 YLMETHYL} 5 FLUORO 1H INDOLE 2,3 DIONE; 1 [1 [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] 1H [1,2,3] TRIAZOL 4 YLMETHYL] 5 FLUORO 1H INDOLE 2,3 DIONE; 1 [1 [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 1 [1 [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] 1H [1,2,3]TRIAZOL 4 YLMETHYL] 5 METHYL 1H INDOLE 2,3 DIONE; 5 BROMO 1 [1 [2 (7 CHLORO QUINOLIN 4 YLAMINO) ETHYL] 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 5 BROMO 1 [1 [3 (7 CHLORO QUINOLIN 4 YLAMINO) PROPYL] 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 5 BROMO1 [1 (7 CHLORO QUINOLIN 4 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 5 CHLORO 1 [1 (7 CHLORO QUINOLIN 4 YL) 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 5 CHLORO 1 [1 [2 (7 CHLORO QUINOLIN 4 YLAMINO) ETHYL] 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; 5 CHLORO 1 [1 [3 (7 CHLORO QUINOLIN 4 YLAMINO)PROPYL] 1H [1,2,3]TRIAZOL 4 YLMETHYL] 1H INDOLE 2,3 DIONE; ALKYNE DERIVATIVE; ANTIMALARIAL AGENT; AZIDE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CHIMERA; CYCLOADDITION; IC 50; NONHUMAN; PLASMODIUM FALCIPARUM;

ALKYNES; AMINOQUINOLINES; ANTIMALARIALS; AZIDES; CYCLIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ISATIN; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84874159362     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.01.032     Document Type: Article

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