Discovery of novel benzo[ a ]phenoxazine SSJ-183 as a drug candidate for malaria

ACS Medicinal Chemistry Letters

Volumn 1, Issue 7, 2010, Pages 360-364

  Ge, Jian Feng ^a,b   Arai, Chika ^a   Yang, Mei ^a   Bakar Md , Abu ^a   Lu, Jun ^a   Ismail, Nasser S M ^a,c   Wittlin, Sergio ^d   Kaiser, Marcel ^d   Brun, Reto ^d   Charman, Susan A ^e   Nguyen, Tien ^e   Morizzi, Julia ^e   Itoh, Isamu ^f   Ihara, Masataka ^a  

^a HOSHI UNIVERSITY   (Japan)

^b SOOCHOW UNIVERSITY   (China)

^c African Union Organization St Abbassia   (Egypt)

^d UNIVERSITY OF BASEL   (Switzerland)

^e MONASH UNIVERSITY   (Australia)

^f Synstar Japan Co Ltd   (Japan)

Author keywords

Antimalarial activity; benzo a phenoxazine; oral administration; Plasmodium berghei; Plasmodium falciparum

Indexed keywords

4 AMINOPYRIDINE; ANTIMALARIAL AGENT; BENZO[A]PHENOXAZINE; SSJ 183; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CHROMOSOME ANALYSIS; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALARIA; MICRONUCLEUS TEST; MYOBLAST; NONHUMAN; PHOTOTOXICITY; PLASMA CONCENTRATION-TIME CURVE; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SINGLE DRUG DOSE;

MUS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 77958105230     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml100120a     Document Type: Article

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