Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 23, 2010, Pages 8243-8256

  Guantai, Eric M ^a   Ncokazi, Kanyile ^a   Egan, Timothy J ^a   Gut, Jiri ^b   Rosenthal, Philip J ^b   Smith, Peter J ^a   Chibale, Kelly ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aminoquinolines; Chalcones; Dienones; Hybrid compounds; Malaria; Nucleosides; Plasmodium falciparum; Triazole

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (3 METHOXY 4 PROP 2 YNYLOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1 (2,4 DIFLUOROPHENYL) 5 (3 METHOXY 4 PROP 2 YNYLOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1 (2,4 DIMETHOXYPHENYL) 5 (3 METHOXY 4 PROP 2 YNYLOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1 (3 METHOXY 4 PROP 2 YNYLOXYPHENYL) 5 (2,3,4 TRIMETHOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1 (4 FLUOROPHENYL) 5 (3 METHOXY 4 PROP 2 YNYLOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1 (4 METHOXYPHENYL) 5 (3 METHOXY 4 PROP 2 YNYLOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1 [4 [4 [4 [3 (2,4 DICHLOROPHENYL)ACRYLOYL] 2 METHOXYPHENOXYMETHYL][1,2,3]TRIAZOL 1 YL] 5 HYDROXYMETHYLTETRAHYDROFURAN 2 YL] 5 METHYL 1H PYRIMIDINE 2,4 DIONE; 1 [4 [4 [4 [3 (2,4 DIMETHOXYPHENYL) 3 OXO PROPENYL] 2 METHOXYPHENOXYMETHYL] [1,2,3]TRIAZOL 1 YL] 5 HYDROXYMETHYLTETRAHYDROFURAN 2 YL] 5 METHYL 1H PYRIMIDINE 2,4 DIONE; 1 [4 [4 [4 [3 (2,4 DIMETHOXYPHENYL)ACRYLOYL] 2 METHOXYPHENOXYMETHYL][1,2,3]TRIAZOL 1 YL] 5 HYDROXYMETHYLTETRAHYDROFURAN 2 YL] 5 METHYL 1H PYRIMIDINE 2,4 DIONE; 1 [4 [4 [4 [5 (2,4 DIMETHOXYPHENYL) 3 OXOPENTA 1,4 DIENYL] 2 METHOXYPHENOXYMETHYL][1,2,3] TRIAZOL 1 YL] 5 HYDROXYMETHYLTETRAHYDROFURAN 2 YL] 5 METHYL 1H PYRIMIDINE 2,4 DIONE; 1 [5 HYDROXYMETHYL 4 [4 [2 METHOXY 4 [3 (2,3,4 TRIMETHOXYPHENYL)ACRYLOYL]PHENOXYMETHYL][1,2,3]TRIAZOL 1 YL]TETRAHYDROFURAN 2 YL] 5 METHYL 1H PYRIMIDINE 2,4 DIONE; 1 [5 HYDROXYMETHYL 4 [4 [2 METHOXY 4 [3 (4 METHOXYPHENYL) 3 OXOPROPENYL]PHENOXYMETHYL][1,2,3]TRIAZOL 1 YL]TETRAHYDROFURAN 2 YL] 5 METHYL 1H PYRIMIDINE 2,4 DIONE; 1 [5 HYDROXYMETHYL 4 [4 [2 METHOXY 4 [3 OXO 5 (2,3,4 TRIMETHOXYPHENYL)PENTA 1,4 DIENYL]PHENOXYMETHYL][1,2,3] TRIAZOL 1 YL]TETRAHYDROFURAN 2 YL] 5 METHYL 1H PYRIMIDINE 2,4 DIONE; 1 [5 HYDROXYMETHYL 4 [4 [2 METHOXY 4 [3-OXO-3-(2,3,4 TRIMETHOXYPHENYL)PROPENYL]PHENOXYMETHYL] [1,2,3]TRIAZOL 1 YL]TETRAHYDROFURAN 2 YL] 5 METHYL 1H PYRIMIDINE 2,4 DIONE; 3 [4 [1 (7 CHLOROQUINOLIN 4 YL) 1H [1,2,3]TRIAZOL 4 YLMETHOXY] 3 METHOXYPHENYL] 1 (2,3,4 TRIMETHOXYPHENYL)PROPENONE; 3 [4 [1 (7 CHLOROQUINOLIN 4 YL) 1H [1,2,3]TRIAZOL 4 YLMETHOXY] 3 METHOXYPHENYL] 1 (4 METHOXYPHENYL)PROPENONE; 3 [4 [1(7 CHLOROQUINOLIN 4 YL) 1H [1,2,3]TRIAZOL 4 YLMETHOXY] 3 METHOXYPHENYL] 1 (2,4 DIMETHOXYPHENYL)PROPENONE; 3 METHOXY 4 PROP 2 YNYLOXYBENZALDEHYDE; 4 (3 METHOXY 4 PROP 2 YNYLOXYPHENYL)BUT 3 EN 2 ONE; 4 AZIDO 7 CHLOROQUINOLINE; 7 CHLOROQUINOLINE; ALKYNE DERIVATIVE; AMINOQUINOLINE DERIVATIVE; AZIDE; CHALCONE DERIVATIVE; CHLOROQUINE; DIENONE HYBRID COMPOUND; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZIDOVUDINE;

ANTIMALARIAL ACTIVITY; ARTICLE; CATALYSIS; CYCLOADDITION; DNA TEMPLATE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HYBRIDIZATION; IC 50; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ALKYNES; AMINOQUINOLINES; ANIMALS; ANTIMALARIALS; AZIDES; CATALYSIS; CHALCONE; CHALCONES; COPPER; DRUG DESIGN; HEMIN; NUCLEOSIDES; PLASMODIUM FALCIPARUM; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

PLASMODIUM FALCIPARUM;

EID: 78249268250     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.10.009     Document Type: Article

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