메뉴 건너뛰기




Volumn 15, Issue 4, 2013, Pages 951-961

Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention

Author keywords

epigenetic; I3C; prostate cancer; sulforaphane

Indexed keywords

3 INDOLEMETHANOL; GLUCOBRASSICIN; GLUCORAPHANIN; GLUCOSINOLATE; SULFORAPHANE; UNCLASSIFIED DRUG;

EID: 84887994742     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-013-9504-4     Document Type: Review
Times cited : (69)

References (100)
  • 1
    • 84860222189 scopus 로고    scopus 로고
    • Vegetable and fruit intake after diagnosis and risk of prostate cancer progression
    • 21823116 10.1002/ijc.26348
    • Richman EL, Carroll PR, Chan JM. Vegetable and fruit intake after diagnosis and risk of prostate cancer progression. Int J Cancer. 2011;131(1):201-10.
    • (2011) Int J Cancer , vol.131 , Issue.1 , pp. 201-210
    • Richman, E.L.1    Carroll, P.R.2    Chan, J.M.3
  • 2
    • 84856235306 scopus 로고    scopus 로고
    • Cruciferous vegetables intake and risk of prostate cancer: A meta-analysis
    • 22121852 10.1111/j.1442-2042.2011.02906.x
    • Liu B, Mao Q, Cao M, Xie L. Cruciferous vegetables intake and risk of prostate cancer: a meta-analysis. Int J Urol. 2012;19(2):134-41.
    • (2012) Int J Urol , vol.19 , Issue.2 , pp. 134-141
    • Liu, B.1    Mao, Q.2    Cao, M.3    Xie, L.4
  • 3
    • 70249140956 scopus 로고    scopus 로고
    • Dietary glucosinolate intake and risk of prostate cancer in the EPIC-Heidelberg cohort study
    • 19585501 10.1002/ijc.24555 1:CAS:528:DC%2BD1MXhtVOms73F
    • Steinbrecher A, Nimptsch K, Husing A, Rohrmann S, Linseisen J. Dietary glucosinolate intake and risk of prostate cancer in the EPIC-Heidelberg cohort study. Int J Cancer. 2009;125(9):2179-86.
    • (2009) Int J Cancer , vol.125 , Issue.9 , pp. 2179-2186
    • Steinbrecher, A.1    Nimptsch, K.2    Husing, A.3    Rohrmann, S.4    Linseisen, J.5
  • 6
    • 0025769201 scopus 로고
    • Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County
    • 2069852 10.1038/bjc.1991.210 1:STN:280:DyaK3M3pvFCqtw%3D%3D
    • Shimizu H, Ross RK, Bernstein L, Yatani R, Henderson BE, Mack TM. Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County. Br J Cancer. 1991;63(6):963-6.
    • (1991) Br J Cancer , vol.63 , Issue.6 , pp. 963-966
    • Shimizu, H.1    Ross, R.K.2    Bernstein, L.3    Yatani, R.4    Henderson, B.E.5    Mack, T.M.6
  • 7
    • 33846602824 scopus 로고    scopus 로고
    • Cancer incidence among Korean-American immigrants in the United States and native Koreans in South Korea
    • 17242674
    • Lee J, Demissie K, Lu SE, Rhoads GG. Cancer incidence among Korean-American immigrants in the United States and native Koreans in South Korea. Cancer Control. 2007;14(1):78-85.
    • (2007) Cancer Control , vol.14 , Issue.1 , pp. 78-85
    • Lee, J.1    Demissie, K.2    Lu, S.E.3    Rhoads, G.G.4
  • 9
    • 0141830017 scopus 로고    scopus 로고
    • Development of a food composition database for the estimation of dietary intakes of glucosinolates, the biologically active constituents of cruciferous vegetables
    • 13129476 10.1079/BJN2003917 1:CAS:528:DC%2BD3sXnsFygu7c%3D
    • McNaughton SA, Marks GC. Development of a food composition database for the estimation of dietary intakes of glucosinolates, the biologically active constituents of cruciferous vegetables. Br J Nutr. 2003;90(3):687-97.
    • (2003) Br J Nutr , vol.90 , Issue.3 , pp. 687-697
    • McNaughton, S.A.1    Marks, G.C.2
  • 10
    • 69049120201 scopus 로고    scopus 로고
    • Repeated intake of broccoli does not lead to higher plasma levels of sulforaphane in human volunteers
    • 19409695 10.1016/j.canlet.2009.04.004 1:CAS:528:DC%2BD1MXhtVKlsLjF
    • Hanlon N, Coldham N, Gielbert A, Sauer MJ, Ioannides C. Repeated intake of broccoli does not lead to higher plasma levels of sulforaphane in human volunteers. Cancer Lett. 2009;284(1):15-20.
    • (2009) Cancer Lett , vol.284 , Issue.1 , pp. 15-20
    • Hanlon, N.1    Coldham, N.2    Gielbert, A.3    Sauer, M.J.4    Ioannides, C.5
  • 11
    • 79961130966 scopus 로고    scopus 로고
    • LC-MS/MS quantification of sulforaphane and indole-3-carbinol metabolites in human plasma and urine after dietary intake of selenium-fortified broccoli
    • 21732669 10.1021/jf201501x 1:CAS:528:DC%2BC3MXosVCksrY%3D
    • Hauder J, Winkler S, Bub A, Rufer CE, Pignitter M, Somoza V. LC-MS/MS quantification of sulforaphane and indole-3-carbinol metabolites in human plasma and urine after dietary intake of selenium-fortified broccoli. J Agric Food Chem. 2011;59(15):8047-57.
    • (2011) J Agric Food Chem , vol.59 , Issue.15 , pp. 8047-8057
    • Hauder, J.1    Winkler, S.2    Bub, A.3    Rufer, C.E.4    Pignitter, M.5    Somoza, V.6
  • 12
    • 84887999151 scopus 로고    scopus 로고
    • Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: Implications for cancer prevention
    • Veeranki OL, Bhattacharya A, Marshall JR, Zhang Y. Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer prevention. Br J Nutr. 2012;2:1-8.
    • (2012) Br J Nutr , vol.2 , pp. 1-8
    • Veeranki, O.L.1    Bhattacharya, A.2    Marshall, J.R.3    Zhang, Y.4
  • 13
    • 83555173511 scopus 로고    scopus 로고
    • Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice
    • 21681606 10.1007/s11095-011-0500-z 1:CAS:528:DC%2BC3MXnsF2ltbg%3D
    • Clarke JD, Hsu A, Williams DE, Dashwood RH, Stevens JF, Yamamoto M, et al. Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. Pharm Res. 2011;28(12):3171-9.
    • (2011) Pharm Res , vol.28 , Issue.12 , pp. 3171-3179
    • Clarke, J.D.1    Hsu, A.2    Williams, D.E.3    Dashwood, R.H.4    Stevens, J.F.5    Yamamoto, M.6
  • 14
    • 69949157311 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: Implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway
    • 19669099 10.1007/s11095-009-9948-5 1:CAS:528:DC%2BD1MXpsF2itL4%3D
    • Keum YS, Khor TO, Lin W, Shen G, Kwon KH, Barve A, et al. Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway. Pharm Res. 2009;26(10):2324-31.
    • (2009) Pharm Res , vol.26 , Issue.10 , pp. 2324-2331
    • Keum, Y.S.1    Khor, T.O.2    Lin, W.3    Shen, G.4    Kwon, K.H.5    Barve, A.6
  • 15
    • 77954409309 scopus 로고    scopus 로고
    • The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer
    • 20626841 10.1186/1476-4598-9-189
    • Traka MH, Spinks CA, Doleman JF, Melchini A, Ball RY, Mills RD, et al. The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer. Mol Cancer. 2010;9:189.
    • (2010) Mol Cancer. , vol.9 , pp. 189
    • Traka, M.H.1    Spinks, C.A.2    Doleman, J.F.3    Melchini, A.4    Ball, R.Y.5    Mills, R.D.6
  • 16
    • 49849087443 scopus 로고    scopus 로고
    • Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate
    • 18596959 10.1371/journal.pone.0002568
    • Traka M, Gasper AV, Melchini A, Bacon JR, Needs PW, Frost V, et al. Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate. PLoS One. 2008;3(7):e2568.
    • (2008) PLoS One , vol.3 , Issue.7 , pp. 2568
    • Traka, M.1    Gasper, A.V.2    Melchini, A.3    Bacon, J.R.4    Needs, P.W.5    Frost, V.6
  • 17
    • 0026591316 scopus 로고
    • Oligomerization of indole-3-carbinol in aqueous acid
    • 1643248 10.1021/tx00026a007 1:CAS:528:DyaK38XhsVehsL0%3D
    • Grose KR, Bjeldanes LF. Oligomerization of indole-3-carbinol in aqueous acid. Chem Res Toxicol. 1992;5(2):188-93.
    • (1992) Chem Res Toxicol , vol.5 , Issue.2 , pp. 188-193
    • Grose, K.R.1    Bjeldanes, L.F.2
  • 18
    • 4143051307 scopus 로고    scopus 로고
    • Pharmacokinetics and tissue disposition of indole-3-carbinol and its acid condensation products after oral administration to mice
    • 15297427 10.1158/1078-0432.CCR-04-0163 1:CAS:528:DC%2BD2cXmtlSiu7w%3D
    • Anderton MJ, Manson MM, Verschoyle RD, Gescher A, Lamb JH, Farmer PB, et al. Pharmacokinetics and tissue disposition of indole-3-carbinol and its acid condensation products after oral administration to mice. Clin Cancer Res. 2004;10(15):5233-41.
    • (2004) Clin Cancer Res , vol.10 , Issue.15 , pp. 5233-5241
    • Anderton, M.J.1    Manson, M.M.2    Verschoyle, R.D.3    Gescher, A.4    Lamb, J.H.5    Farmer, P.B.6
  • 19
    • 33846024022 scopus 로고    scopus 로고
    • Single-dose and multiple-dose administration of indole-3-carbinol to women: Pharmacokinetics based on 3,3′-diindolylmethane
    • 17164373 10.1158/1055-9965.EPI-06-0396 1:CAS:528:DC%2BD28XhtlCrtrvL
    • Reed GA, Arneson DW, Putnam WC, Smith HJ, Gray JC, Sullivan DK, et al. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3′-diindolylmethane. Cancer Epidemiol Biomarkers Prev. 2006;15(12):2477-81.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , Issue.12 , pp. 2477-2481
    • Reed, G.A.1    Arneson, D.W.2    Putnam, W.C.3    Smith, H.J.4    Gray, J.C.5    Sullivan, D.K.6
  • 20
    • 38649100664 scopus 로고    scopus 로고
    • Indole-3-carbinol (I3C) exhibits inhibitory and preventive effects on prostate tumors in mice
    • 18063461 10.1016/j.fct.2007.10.026 1:CAS:528:DC%2BD1cXhsVCrt74%3D
    • Souli E, Machluf M, Morgenstern A, Sabo E, Yannai S. Indole-3-carbinol (I3C) exhibits inhibitory and preventive effects on prostate tumors in mice. Food Chem Toxicol. 2008;46(3):863-70.
    • (2008) Food Chem Toxicol , vol.46 , Issue.3 , pp. 863-870
    • Souli, E.1    Machluf, M.2    Morgenstern, A.3    Sabo, E.4    Yannai, S.5
  • 21
    • 77955893766 scopus 로고    scopus 로고
    • Diindolylmethane (DIM) spontaneously forms from indole-3-carbinol (I3C) during cell culture experiments
    • 1:CAS:528:DC%2BC3cXhtFCrtLzI
    • Bradlow HL, Zeligs MA. Diindolylmethane (DIM) spontaneously forms from indole-3-carbinol (I3C) during cell culture experiments. In Vivo (Athens, Greece). 2010;24(4):387-91.
    • (2010) Vivo (Athens, Greece) , vol.24 , Issue.4 , pp. 387-391
    • Bradlow, H.L.1    Zeligs, M.A.2
  • 22
    • 48349127559 scopus 로고    scopus 로고
    • Review. Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer
    • 1:CAS:528:DC%2BD1cXpvFGlsLs%3D
    • Bradlow HL. Review. Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer. In Vivo (Athens, Greece). 2008;22(4):441-5.
    • (2008) Vivo (Athens, Greece) , vol.22 , Issue.4 , pp. 441-445
    • Bradlow, H.L.1
  • 23
    • 78651430467 scopus 로고    scopus 로고
    • 3,3′-diindolylmethane inhibits prostate cancer development in the transgenic adenocarcinoma mouse prostate model
    • 21229607 10.1002/mc.20698 1:CAS:528:DC%2BC3MXksFKqtg%3D%3D
    • Cho HJ, Park SY, Kim EJ, Kim JK, Park JH. 3,3′-diindolylmethane inhibits prostate cancer development in the transgenic adenocarcinoma mouse prostate model. Mol Carcinog. 2011;50(2):100-12.
    • (2011) Mol Carcinog , vol.50 , Issue.2 , pp. 100-112
    • Cho, H.J.1    Park, S.Y.2    Kim, E.J.3    Kim, J.K.4    Park, J.H.5
  • 24
    • 33644688761 scopus 로고    scopus 로고
    • Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli
    • 16332662 1:CAS:528:DC%2BD2MXhtlehurfE
    • Gasper AV, Al-Janobi A, Smith JA, Bacon JR, Fortun P, Atherton C, et al. Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli. Am J Clin Nutr. 2005;82(6):1283-91.
    • (2005) Am J Clin Nutr , vol.82 , Issue.6 , pp. 1283-1291
    • Gasper, A.V.1    Al-Janobi, A.2    Smith, J.A.3    Bacon, J.R.4    Fortun, P.5    Atherton, C.6
  • 25
    • 77957372039 scopus 로고    scopus 로고
    • A phase i dose-escalation study of oral BR-DIM (BioResponse 3,3′-diindolylmethane) in castrate-resistant, non-metastatic prostate cancer
    • 1:CAS:528:DC%2BC3cXps1GmtLc%3D
    • Heath EI, Heilbrun LK, Li J, Vaishampayan U, Harper F, Pemberton P, et al. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3′-diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am J Trans Res. 2010;2(4):402-11.
    • (2010) Am J Trans Res , vol.2 , Issue.4 , pp. 402-411
    • Heath, E.I.1    Heilbrun, L.K.2    Li, J.3    Vaishampayan, U.4    Harper, F.5    Pemberton, P.6
  • 26
    • 0034854057 scopus 로고    scopus 로고
    • Potent induction of phase 2 enzymes in human prostate cells by sulforaphane
    • 11535546 1:CAS:528:DC%2BD3MXnt1Gis7s%3D
    • Brooks JD, Paton VG, Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Cancer Epidemiol Biomarkers Prev. 2001;10(9):949-54.
    • (2001) Cancer Epidemiol Biomarkers Prev , vol.10 , Issue.9 , pp. 949-954
    • Brooks, J.D.1    Paton, V.G.2    Vidanes, G.3
  • 27
    • 0032841203 scopus 로고    scopus 로고
    • Antioxidant functions of sulforaphane: A potent inducer of phase II detoxication enzymes
    • 10541453 10.1016/S0278-6915(99)00082-4 1:CAS:528:DyaK1MXnsFSrsr4%3D
    • Fahey JW, Talalay P. Antioxidant functions of sulforaphane: a potent inducer of phase II detoxication enzymes. Food Chem Toxicol. 1999;37(9-10):973-9.
    • (1999) Food Chem Toxicol , vol.37 , Issue.9-10 , pp. 973-979
    • Fahey, J.W.1    Talalay, P.2
  • 28
    • 84860447071 scopus 로고    scopus 로고
    • Protective effect of sulforaphane against oxidative stress: Recent advances
    • 21129940 10.1016/j.etp.2010.11.005 1:CAS:528:DC%2BC38XmsVGktL4%3D
    • Guerrero-Beltran CE, Calderon-Oliver M, Pedraza-Chaverri J, Chirino YI. Protective effect of sulforaphane against oxidative stress: recent advances. Exp Toxicol Pathol. 2012;64(5):503-8.
    • (2012) Exp Toxicol Pathol , vol.64 , Issue.5 , pp. 503-508
    • Guerrero-Beltran, C.E.1    Calderon-Oliver, M.2    Pedraza-Chaverri, J.3    Chirino, Y.I.4
  • 29
    • 84855850877 scopus 로고    scopus 로고
    • Broccoli-derived phytochemicals indole-3-carbinol and 3,3′-diindolylmethane exerts concentration-dependent pleiotropic effects on prostate cancer cells: Comparison with other cancer preventive phytochemicals
    • 21520295 10.1002/mc.20774
    • Wang TT, Schoene NW, Milner JA, Kim YS. Broccoli-derived phytochemicals indole-3-carbinol and 3,3′-diindolylmethane exerts concentration-dependent pleiotropic effects on prostate cancer cells: comparison with other cancer preventive phytochemicals. Mol Carcinog. 2012;51(3):244-56.
    • (2012) Mol Carcinog , vol.51 , Issue.3 , pp. 244-256
    • Wang, T.T.1    Schoene, N.W.2    Milner, J.A.3    Kim, Y.S.4
  • 30
    • 79960075372 scopus 로고    scopus 로고
    • 3,3′-diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts
    • 21615272 10.3109/10715762.2011.571683 1:CAS:528:DC%2BC3MXosFehsbk%3D
    • Ernst IM, Schuemann C, Wagner AE, Rimbach G. 3,3′-diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts. Free Radic Res. 2011;45(8):941-9.
    • (2011) Free Radic Res , vol.45 , Issue.8 , pp. 941-949
    • Ernst, I.M.1    Schuemann, C.2    Wagner, A.E.3    Rimbach, G.4
  • 31
    • 79959751713 scopus 로고    scopus 로고
    • Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates
    • 21656528 10.1002/bdd.759 1:CAS:528:DC%2BC3MXnvFamt74%3D
    • Saw CL, Cintron M, Wu TY, Guo Y, Huang Y, Jeong WS, et al. Pharmacodynamics of dietary phytochemical indoles I3C and DIM: induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates. Biopharm Drug Dispos. 2011;32(5):289-300.
    • (2011) Biopharm Drug Dispos , vol.32 , Issue.5 , pp. 289-300
    • Saw, C.L.1    Cintron, M.2    Wu, T.Y.3    Guo, Y.4    Huang, Y.5    Jeong, W.S.6
  • 33
    • 12744269542 scopus 로고    scopus 로고
    • Pilot study: Effect of 3,3′-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer
    • 15623462 10.1207/s15327914nc5002-5 1:CAS:528:DC%2BD2MXht1Kisrs%3D
    • Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF. Pilot study: effect of 3,3′-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Cancer. 2004;50(2):161-7.
    • (2004) Nutr Cancer , vol.50 , Issue.2 , pp. 161-167
    • Dalessandri, K.M.1    Firestone, G.L.2    Fitch, M.D.3    Bradlow, H.L.4    Bjeldanes, L.F.5
  • 34
    • 0030954304 scopus 로고    scopus 로고
    • Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans
    • 9168187 10.1093/jnci/89.10.718 1:CAS:528:DyaK2sXjvFaqsLc%3D
    • Michnovicz JJ, Adlercreutz H, Bradlow HL. Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans. J Natl Cancer Inst. 1997;89(10):718-23.
    • (1997) J Natl Cancer Inst , vol.89 , Issue.10 , pp. 718-723
    • Michnovicz, J.J.1    Adlercreutz, H.2    Bradlow, H.L.3
  • 35
    • 0025781767 scopus 로고
    • Altered estrogen metabolism and excretion in humans following consumption of indole-3-carbinol
    • 1656396 10.1080/01635589109514141 1:CAS:528:DyaK38Xht1Omtr4%3D
    • Michnovicz JJ, Bradlow HL. Altered estrogen metabolism and excretion in humans following consumption of indole-3-carbinol. Nutr Cancer. 1991;16(1):59-66.
    • (1991) Nutr Cancer , vol.16 , Issue.1 , pp. 59-66
    • Michnovicz, J.J.1    Bradlow, H.L.2
  • 36
    • 0033847346 scopus 로고    scopus 로고
    • Brassica vegetable consumption shifts estrogen metabolism in healthy postmenopausal women
    • 10952093 1:STN:280:DC%2BD3M%2FksVeisQ%3D%3D
    • Fowke JH, Longcope C, Hebert JR. Brassica vegetable consumption shifts estrogen metabolism in healthy postmenopausal women. Cancer Epidemiol Biomarkers Prev. 2000;9(8):773-9.
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , Issue.8 , pp. 773-779
    • Fowke, J.H.1    Longcope, C.2    Hebert, J.R.3
  • 37
    • 0028948092 scopus 로고
    • Growth of LNCaP human prostate cancer cells is stimulated by estradiol via its own receptor
    • 7536668 10.1210/en.136.5.2309 1:CAS:528:DyaK2MXltFKjurw%3D
    • Castagnetta LA, Miceli MD, Sorci CM, Pfeffer U, Farruggio R, Oliveri G, et al. Growth of LNCaP human prostate cancer cells is stimulated by estradiol via its own receptor. Endocrinology. 1995;136(5):2309-19.
    • (1995) Endocrinology , vol.136 , Issue.5 , pp. 2309-2319
    • Castagnetta, L.A.1    Miceli, M.D.2    Sorci, C.M.3    Pfeffer, U.4    Farruggio, R.5    Oliveri, G.6
  • 38
    • 58549108859 scopus 로고    scopus 로고
    • The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations
    • 19116269 10.1073/pnas.0810956106 1:CAS:528:DC%2BD1MXltF2rtw%3D%3D
    • Dubrovska A, Kim S, Salamone RJ, Walker JR, Maira SM, Garcia-Echeverria C, et al. The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations. Proc Natl Acad Sci U S A. 2009;106(1):268-73.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.1 , pp. 268-273
    • Dubrovska, A.1    Kim, S.2    Salamone, R.J.3    Walker, J.R.4    Maira, S.M.5    Garcia-Echeverria, C.6
  • 39
    • 27844506524 scopus 로고    scopus 로고
    • Akt-regulated pathways in prostate cancer
    • 16288293 10.1038/sj.onc.1209096 1:CAS:528:DC%2BD2MXht1Wis7vF
    • Majumder PK, Sellers WR. Akt-regulated pathways in prostate cancer. Oncogene. 2005;24(50):7465-74.
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7465-7474
    • Majumder, P.K.1    Sellers, W.R.2
  • 40
    • 68049137909 scopus 로고    scopus 로고
    • Targeting the PI3K/AKT pathway for the treatment of prostate cancer
    • 19638457 10.1158/1078-0432.CCR-08-0125 1:CAS:528:DC%2BD1MXptl2gsLo%3D
    • Sarker D, Reid AH, Yap TA, de Bono JS. Targeting the PI3K/AKT pathway for the treatment of prostate cancer. Clin Cancer Res. 2009;15(15):4799-805.
    • (2009) Clin Cancer Res , vol.15 , Issue.15 , pp. 4799-4805
    • Sarker, D.1    Reid, A.H.2    Yap, T.A.3    De Bono, J.S.4
  • 41
    • 51349111250 scopus 로고    scopus 로고
    • Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model
    • 18725989 1:CAS:528:DC%2BD1cXhtV2isb3N
    • Kinkade CW, Castillo-Martin M, Puzio-Kuter A, Yan J, Foster TH, Gao H, et al. Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model. J Clin Investig. 2008;118(9):3051-64.
    • (2008) J Clin Investig , vol.118 , Issue.9 , pp. 3051-3064
    • Kinkade, C.W.1    Castillo-Martin, M.2    Puzio-Kuter, A.3    Yan, J.4    Foster, T.H.5    Gao, H.6
  • 42
    • 62549100016 scopus 로고    scopus 로고
    • Targeted therapy for advanced prostate cancer: Inhibition of the PI3K/Akt/mTOR pathway
    • 19275762 10.2174/156800909787580999 1:CAS:528:DC%2BD1MXks1Wjs7s%3D
    • Morgan TM, Koreckij TD, Corey E. Targeted therapy for advanced prostate cancer: inhibition of the PI3K/Akt/mTOR pathway. Curr Cancer Drug Targets. 2009;9(2):237-49.
    • (2009) Curr Cancer Drug Targets , vol.9 , Issue.2 , pp. 237-249
    • Morgan, T.M.1    Koreckij, T.D.2    Corey, E.3
  • 43
    • 84862272583 scopus 로고    scopus 로고
    • Sulforaphane, a cruciferous vegetable-derived isothiocyanate, inhibits protein synthesis in human prostate cancer cells
    • 22640870 10.1016/j.bbamcr.2012.05.020 1:CAS:528:DC%2BC38XpsVOntrk%3D
    • Wiczk A, Hofman D, Konopa G, Herman-Antosiewicz A. Sulforaphane, a cruciferous vegetable-derived isothiocyanate, inhibits protein synthesis in human prostate cancer cells. Biochim Biophys Acta. 2012;1823(8):1295-305.
    • (2012) Biochim Biophys Acta , vol.1823 , Issue.8 , pp. 1295-1305
    • Wiczk, A.1    Hofman, D.2    Konopa, G.3    Herman-Antosiewicz, A.4
  • 45
    • 17144395975 scopus 로고    scopus 로고
    • The activation of Akt/PKB signaling pathway and cell survival
    • 15784165 10.1111/j.1582-4934.2005.tb00337.x 1:CAS:528: DC%2BD2MXlt1eqtLo%3D
    • Song G, Ouyang G, Bao S. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med. 2005;9(1):59-71.
    • (2005) J Cell Mol Med , vol.9 , Issue.1 , pp. 59-71
    • Song, G.1    Ouyang, G.2    Bao, S.3
  • 46
    • 22744440329 scopus 로고    scopus 로고
    • Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells
    • 15856023 10.1038/sj.onc.1208656 1:CAS:528:DC%2BD2MXls1Onu7w%3D
    • Xu C, Shen G, Chen C, Gelinas C, Kong AN. Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells. Oncogene. 2005;24(28):4486-95.
    • (2005) Oncogene , vol.24 , Issue.28 , pp. 4486-4495
    • Xu, C.1    Shen, G.2    Chen, C.3    Gelinas, C.4    Kong, A.N.5
  • 47
    • 0030904561 scopus 로고    scopus 로고
    • The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal
    • 9087425 10.1101/gad.11.6.701 1:CAS:528:DyaK2sXisVCrsrc%3D
    • Kennedy SG, Wagner AJ, Conzen SD, Jordan J, Bellacosa A, Tsichlis PN, et al. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 1997;11(6):701-13.
    • (1997) Genes Dev , vol.11 , Issue.6 , pp. 701-713
    • Kennedy, S.G.1    Wagner, A.J.2    Conzen, S.D.3    Jordan, J.4    Bellacosa, A.5    Tsichlis, P.N.6
  • 48
    • 33644865443 scopus 로고    scopus 로고
    • ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells
    • 16272172 10.1093/carcin/bgi251
    • Xu C, Shen G, Yuan X, Kim JH, Gopalkrishnan A, Keum YS, et al. ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells. Carcinogenesis. 2006;27(3):437-45.
    • (2006) Carcinogenesis , vol.27 , Issue.3 , pp. 437-445
    • Xu, C.1    Shen, G.2    Yuan, X.3    Kim, J.H.4    Gopalkrishnan, A.5    Keum, Y.S.6
  • 49
    • 33845623882 scopus 로고    scopus 로고
    • D,l-sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1
    • 16920735 10.1093/carcin/bgl144 1:CAS:528:DC%2BD28XhtlChtbjF
    • Choi S, Lew KL, Xiao H, Herman-Antosiewicz A, Xiao D, Brown CK, et al. d,l-sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1. Carcinogenesis. 2007;28(1):151-62.
    • (2007) Carcinogenesis , vol.28 , Issue.1 , pp. 151-162
    • Choi, S.1    Lew, K.L.2    Xiao, H.3    Herman-Antosiewicz, A.4    Xiao, D.5    Brown, C.K.6
  • 50
    • 44849117768 scopus 로고    scopus 로고
    • Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK
    • 18519641 10.1101/gad.1662308 1:CAS:528:DC%2BD1cXnsVOlu7o%3D
    • Dan HC, Cooper MJ, Cogswell PC, Duncan JA, Ting JP, Baldwin AS. Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev. 2008;22(11):1490-500.
    • (2008) Genes Dev , vol.22 , Issue.11 , pp. 1490-1500
    • Dan, H.C.1    Cooper, M.J.2    Cogswell, P.C.3    Duncan, J.A.4    Ting, J.P.5    Baldwin, A.S.6
  • 51
    • 16444382033 scopus 로고    scopus 로고
    • Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent
    • 15753404 10.1158/0008-5472.CAN-04-3616 1:CAS:528:DC%2BD2MXitVOjtL8%3D
    • Choi S, Singh SV. Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent. Cancer Res. 2005;65(5):2035-43.
    • (2005) Cancer Res , vol.65 , Issue.5 , pp. 2035-2043
    • Choi, S.1    Singh, S.V.2
  • 52
    • 0030885421 scopus 로고    scopus 로고
    • Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control
    • 9294162 10.1073/pnas.94.19.10057 1:CAS:528:DyaK2sXmt1Cquro%3D
    • Chu ZL, McKinsey TA, Liu L, Gentry JJ, Malim MH, Ballard DW. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control. Proc Natl Acad Sci U S A. 1997;94(19):10057-62.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.19 , pp. 10057-10062
    • Chu, Z.L.1    McKinsey, T.A.2    Liu, L.3    Gentry, J.J.4    Malim, M.H.5    Ballard, D.W.6
  • 53
    • 0032490670 scopus 로고    scopus 로고
    • Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis
    • 9653098 10.1084/jem.188.1.211 1:CAS:528:DyaK1cXksFyjsLw%3D
    • Stehlik C, de Martin R, Kumabashiri I, Schmid JA, Binder BR, Lipp J. Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis. J Exp Med. 1998;188(1):211-6.
    • (1998) J Exp Med , vol.188 , Issue.1 , pp. 211-216
    • Stehlik, C.1    De Martin, R.2    Kumabashiri, I.3    Schmid, J.A.4    Binder, B.R.5    Lipp, J.6
  • 54
    • 2442712632 scopus 로고    scopus 로고
    • An antisense oligonucleotide to cIAP-1 sensitizes prostate cancer cells to fas and TNFalpha mediated apoptosis
    • 15065090 10.1002/pros.10371 1:CAS:528:DC%2BD2cXltVamu78%3D
    • McEleny K, Coffey R, Morrissey C, Williamson K, Zangemeister-Wittke U, Fitzpatrick JM, et al. An antisense oligonucleotide to cIAP-1 sensitizes prostate cancer cells to fas and TNFalpha mediated apoptosis. Prostate. 2004;59(4):419-25.
    • (2004) Prostate , vol.59 , Issue.4 , pp. 419-425
    • McEleny, K.1    Coffey, R.2    Morrissey, C.3    Williamson, K.4    Zangemeister-Wittke, U.5    Fitzpatrick, J.M.6
  • 55
    • 67349224358 scopus 로고    scopus 로고
    • Cellular responses to cancer chemopreventive agent d,l-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species
    • 19384467 10.1007/s11095-009-9883-5 1:CAS:528:DC%2BD1MXkvValtb4%3D
    • Xiao D, Powolny AA, Antosiewicz J, Hahm ER, Bommareddy A, Zeng Y, et al. Cellular responses to cancer chemopreventive agent d,l-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species. Pharm Res. 2009;26(7):1729-38.
    • (2009) Pharm Res , vol.26 , Issue.7 , pp. 1729-1738
    • Xiao, D.1    Powolny, A.A.2    Antosiewicz, J.3    Hahm, E.R.4    Bommareddy, A.5    Zeng, Y.6
  • 56
    • 1642545614 scopus 로고    scopus 로고
    • Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo
    • 14514658 10.1093/carcin/bgg178 1:CAS:528:DC%2BD2cXnslSn
    • Singh AV, Xiao D, Lew KL, Dhir R, Singh SV. Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis. 2004;25(1):83-90.
    • (2004) Carcinogenesis , vol.25 , Issue.1 , pp. 83-90
    • Singh, A.V.1    Xiao, D.2    Lew, K.L.3    Dhir, R.4    Singh, S.V.5
  • 57
    • 62449233418 scopus 로고    scopus 로고
    • Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells
    • 19223537 10.1158/0008-5472.CAN-08-3502 1:CAS:528:DC%2BD1MXisFSru74%3D
    • Singh SV, Warin R, Xiao D, Powolny AA, Stan SD, Arlotti JA, et al. Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells. Cancer Res. 2009;69(5):2117-25.
    • (2009) Cancer Res , vol.69 , Issue.5 , pp. 2117-2125
    • Singh, S.V.1    Warin, R.2    Xiao, D.3    Powolny, A.A.4    Stan, S.D.5    Arlotti, J.A.6
  • 58
    • 51349088974 scopus 로고    scopus 로고
    • Multi-targeted prevention of cancer by sulforaphane
    • 18504070 10.1016/j.canlet.2008.04.018 1:CAS:528:DC%2BD1cXhtFWlsrjK
    • Clarke JD, Dashwood RH, Ho E. Multi-targeted prevention of cancer by sulforaphane. Cancer Lett. 2008;269(2):291-304.
    • (2008) Cancer Lett , vol.269 , Issue.2 , pp. 291-304
    • Clarke, J.D.1    Dashwood, R.H.2    Ho, E.3
  • 59
    • 34247606510 scopus 로고    scopus 로고
    • Molecular basis for chemoprevention by sulforaphane: A comprehensive review
    • 17396224 10.1007/s00018-007-6484-5 1:CAS:528:DC%2BD2sXlsVWltLk%3D
    • Juge N, Mithen RF, Traka M. Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cell Mol Life Sci. 2007;64(9):1105-27.
    • (2007) Cell Mol Life Sci , vol.64 , Issue.9 , pp. 1105-1127
    • Juge, N.1    Mithen, R.F.2    Traka, M.3
  • 60
    • 0035942499 scopus 로고    scopus 로고
    • Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells
    • 11420705 10.1038/sj.onc.1204365 1:CAS:528:DC%2BD3MXktlSjt7Y%3D
    • Chinni SR, Li Y, Upadhyay S, Koppolu PK, Sarkar FH. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells. Oncogene. 2001;20(23):2927-36.
    • (2001) Oncogene , vol.20 , Issue.23 , pp. 2927-2936
    • Chinni, S.R.1    Li, Y.2    Upadhyay, S.3    Koppolu, P.K.4    Sarkar, F.H.5
  • 61
    • 0038402729 scopus 로고    scopus 로고
    • Indole-3-carbinol and 3,3′-diindolylmethane induce apoptosis in human prostate cancer cells
    • 12738179 10.1016/S0278-6915(03)00004-8 1:CAS:528:DC%2BD3sXjsVGgtrc%3D
    • Nachshon-Kedmi M, Yannai S, Haj A, Fares FA. Indole-3-carbinol and 3,3′-diindolylmethane induce apoptosis in human prostate cancer cells. Food Chem Toxicol. 2003;41(6):745-52.
    • (2003) Food Chem Toxicol , vol.41 , Issue.6 , pp. 745-752
    • Nachshon-Kedmi, M.1    Yannai, S.2    Haj, A.3    Fares, F.A.4
  • 62
    • 67649464189 scopus 로고    scopus 로고
    • 3,3′-diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 status
    • 19433067 10.1016/j.bcp.2009.05.008 1:CAS:528:DC%2BD1MXotFOlt7k%3D
    • Vivar OI, Lin CL, Firestone GL, Bjeldanes LF. 3,3′-diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 status. Biochem Pharmacol. 2009;78(5):469-76.
    • (2009) Biochem Pharmacol , vol.78 , Issue.5 , pp. 469-476
    • Vivar, O.I.1    Lin, C.L.2    Firestone, G.L.3    Bjeldanes, L.F.4
  • 63
    • 6944231023 scopus 로고    scopus 로고
    • Induction of apoptosis in human prostate cancer cell line, PC3, by 3,3′-diindolylmethane through the mitochondrial pathway
    • 15328526 10.1038/sj.bjc.6602145 1:CAS:528:DC%2BD2cXnvFCgtbk%3D
    • Nachshon-Kedmi M, Yannai S, Fares FA. Induction of apoptosis in human prostate cancer cell line, PC3, by 3,3′-diindolylmethane through the mitochondrial pathway. Br J Cancer. 2004;91(7):1358-63.
    • (2004) Br J Cancer , vol.91 , Issue.7 , pp. 1358-1363
    • Nachshon-Kedmi, M.1    Yannai, S.2    Fares, F.A.3
  • 64
    • 29644444307 scopus 로고    scopus 로고
    • 3,3′-diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancer
    • 16380095 10.1016/j.bbrc.2005.12.059 1:CAS:528:DC%2BD28XhvFKksQ%3D%3D
    • Garikapaty VP, Ashok BT, Tadi K, Mittelman A, Tiwari RK. 3,3′-diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancer. Biochem Biophys Res Commun. 2006;340(2):718-25.
    • (2006) Biochem Biophys Res Commun , vol.340 , Issue.2 , pp. 718-725
    • Garikapaty, V.P.1    Ashok, B.T.2    Tadi, K.3    Mittelman, A.4    Tiwari, R.K.5
  • 65
    • 33750541268 scopus 로고    scopus 로고
    • Down-regulation of androgen receptor by 3,3′-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells
    • 17047070 10.1158/0008-5472.CAN-06-2011 1:CAS:528:DC%2BD28XhtVyiur7J
    • Bhuiyan MM, Li Y, Banerjee S, Ahmed F, Wang Z, Ali S, et al. Down-regulation of androgen receptor by 3,3′-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells. Cancer Res. 2006;66(20):10064-72.
    • (2006) Cancer Res , vol.66 , Issue.20 , pp. 10064-10072
    • Bhuiyan, M.M.1    Li, Y.2    Banerjee, S.3    Ahmed, F.4    Wang, Z.5    Ali, S.6
  • 66
    • 40949131914 scopus 로고    scopus 로고
    • Mammalian target of rapamycin repression by 3,3′-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-d-overexpressing PC3 cells
    • 18339874 10.1158/0008-5472.CAN-07-3241 1:CAS:528:DC%2BD1cXjtFOhtr8%3D
    • Kong D, Banerjee S, Huang W, Li Y, Wang Z, Kim HR, et al. Mammalian target of rapamycin repression by 3,3′-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-d-overexpressing PC3 cells. Cancer Res. 2008;68(6):1927-34.
    • (2008) Cancer Res , vol.68 , Issue.6 , pp. 1927-1934
    • Kong, D.1    Banerjee, S.2    Huang, W.3    Li, Y.4    Wang, Z.5    Kim, H.R.6
  • 67
    • 34248178375 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and invasion by 3,3′-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer
    • 17409440 10.1158/0008-5472.CAN-06-4277 1:CAS:528:DC%2BD2sXksVGks7Y%3D
    • Kong D, Li Y, Wang Z, Banerjee S, Sarkar FH. Inhibition of angiogenesis and invasion by 3,3′-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer. Cancer Res. 2007;67(7):3310-9.
    • (2007) Cancer Res , vol.67 , Issue.7 , pp. 3310-3319
    • Kong, D.1    Li, Y.2    Wang, Z.3    Banerjee, S.4    Sarkar, F.H.5
  • 68
    • 17444430817 scopus 로고    scopus 로고
    • Selective growth regulatory and pro-apoptotic effects of DIM is mediated by AKT and NF-kappaB pathways in prostate cancer cells
    • 15574364 10.2741/1523 1:CAS:528:DC%2BD2MXis1SnsLo%3D
    • Li Y, Chinni SR, Sarkar FH. Selective growth regulatory and pro-apoptotic effects of DIM is mediated by AKT and NF-kappaB pathways in prostate cancer cells. Front Biosci. 2005;10:236-43.
    • (2005) Front Biosci , vol.10 , pp. 236-243
    • Li, Y.1    Chinni, S.R.2    Sarkar, F.H.3
  • 69
    • 84867327385 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase by 3,3′-diindolylmethane (DIM) is associated with human prostate cancer cell death in vitro and in vivo
    • 23056607 10.1371/journal.pone.0047186 1:CAS:528:DC%2BC38XhsFCku7rK
    • Chen D, Banerjee S, Cui QC, Kong D, Sarkar FH, Dou QP. Activation of AMP-activated protein kinase by 3,3′-diindolylmethane (DIM) is associated with human prostate cancer cell death in vitro and in vivo. PLoS One. 2012;7(10):e47186.
    • (2012) PLoS One , vol.7 , Issue.10 , pp. 47186
    • Chen, D.1    Banerjee, S.2    Cui, Q.C.3    Kong, D.4    Sarkar, F.H.5    Dou, Q.P.6
  • 70
    • 0038418500 scopus 로고    scopus 로고
    • Plant-derived 3,3′-diindolylmethane is a strong androgen antagonist in human prostate cancer cells
    • 12665522 10.1074/jbc.M300588200 1:CAS:528:DC%2BD3sXkt1Wit7c%3D
    • Le HT, Schaldach CM, Firestone GL, Bjeldanes LF. Plant-derived 3,3′-diindolylmethane is a strong androgen antagonist in human prostate cancer cells. J Biol Chem. 2003;278(23):21136-45.
    • (2003) J Biol Chem , vol.278 , Issue.23 , pp. 21136-21145
    • Le, H.T.1    Schaldach, C.M.2    Firestone, G.L.3    Bjeldanes, L.F.4
  • 71
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome - Biological and translational implications
    • 10.1038/nrc3130 1:CAS:528:DC%2BC3MXht1ajur7K
    • Baylin SB, Jones PA. A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev. 2011;11(10):726-34.
    • (2011) Nat Rev , vol.11 , Issue.10 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 72
    • 74049141478 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • 19752007 10.1093/carcin/bgp220 1:CAS:528:DC%2BC3cXktlCntw%3D%3D
    • Sharma S, Kelly TK, Jones PA. Epigenetics in cancer. Carcinogenesis. 2010;31(1):27-36.
    • (2010) Carcinogenesis , vol.31 , Issue.1 , pp. 27-36
    • Sharma, S.1    Kelly, T.K.2    Jones, P.A.3
  • 73
    • 79952932076 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Molecular mechanisms of action and clinical trials as anti-cancer drugs
    • 21416059 1:CAS:528:DC%2BC3MXjtVSqur0%3D
    • Kim HJ, Bae SC. Histone deacetylase inhibitors: molecular mechanisms of action and clinical trials as anti-cancer drugs. Am J Transl Res. 2011;3(2):166-79.
    • (2011) Am J Transl Res , vol.3 , Issue.2 , pp. 166-179
    • Kim, H.J.1    Bae, S.C.2
  • 74
    • 31544436888 scopus 로고    scopus 로고
    • Dietary HDAC inhibitors: Time to rethink weak ligands in cancer chemoprevention?
    • 16267097 10.1093/carcin/bgi253 1:CAS:528:DC%2BD28XmslyrtQ%3D%3D
    • Dashwood RH, Myzak MC, Ho E. Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention? Carcinogenesis. 2006;27(2):344-9.
    • (2006) Carcinogenesis , vol.27 , Issue.2 , pp. 344-349
    • Dashwood, R.H.1    Myzak, M.C.2    Ho, E.3
  • 75
    • 38949086502 scopus 로고    scopus 로고
    • Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy
    • 18212746 10.1038/sj.bjc.6604199 1:CAS:528:DC%2BD1cXhs1Krsbo%3D
    • Weichert W, Roske A, Gekeler V, Beckers T, Stephan C, Jung K, et al. Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. Br J Cancer. 2008;98(3):604-10.
    • (2008) Br J Cancer , vol.98 , Issue.3 , pp. 604-610
    • Weichert, W.1    Roske, A.2    Gekeler, V.3    Beckers, T.4    Stephan, C.5    Jung, K.6
  • 76
    • 70349741087 scopus 로고    scopus 로고
    • Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6
    • 19805354 10.1073/pnas.0908908106 1:CAS:528:DC%2BD1MXht1Ogs7%2FL
    • Gibbs A, Schwartzman J, Deng V, Alumkal J. Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6. Proc Natl Acad Sci U S A. 2009;106(39):16663-8.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.39 , pp. 16663-16668
    • Gibbs, A.1    Schwartzman, J.2    Deng, V.3    Alumkal, J.4
  • 77
    • 64949190804 scopus 로고    scopus 로고
    • MiR-449a targets HDAC-1 and induces growth arrest in prostate cancer
    • 19252524 10.1038/onc.2009.19 1:CAS:528:DC%2BD1MXisVOrtrk%3D
    • Noonan EJ, Place RF, Pookot D, Basak S, Whitson JM, Hirata H, et al. miR-449a targets HDAC-1 and induces growth arrest in prostate cancer. Oncogene. 2009;28(14):1714-24.
    • (2009) Oncogene , vol.28 , Issue.14 , pp. 1714-1724
    • Noonan, E.J.1    Place, R.F.2    Pookot, D.3    Basak, S.4    Whitson, J.M.5    Hirata, H.6
  • 78
    • 33645324413 scopus 로고    scopus 로고
    • Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells
    • 16280330 10.1093/carcin/bgi265 1:CAS:528:DC%2BD28XivVOgu7o%3D
    • Myzak MC, Hardin K, Wang R, Dashwood RH, Ho E. Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis. 2006;27(4):811-9.
    • (2006) Carcinogenesis , vol.27 , Issue.4 , pp. 811-819
    • Myzak, M.C.1    Hardin, K.2    Wang, R.3    Dashwood, R.H.4    Ho, E.5
  • 79
    • 33846838750 scopus 로고    scopus 로고
    • Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects
    • 1:CAS:528:DC%2BD2sXhsVWjt7g%3D
    • Myzak MC, Tong P, Dashwood WM, Dashwood RH, Ho E. Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. Exp Biol Med (Maywood, NJ). 2007;232(2):227-34.
    • (2007) Exp Biol Med (Maywood, NJ) , vol.232 , Issue.2 , pp. 227-234
    • Myzak, M.C.1    Tong, P.2    Dashwood, W.M.3    Dashwood, R.H.4    Ho, E.5
  • 80
    • 79959742774 scopus 로고    scopus 로고
    • Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells
    • 21374800 10.1002/mnfr.201000547 1:CAS:528:DC%2BC3MXotlKhs78%3D
    • Clarke JD, Hsu A, Yu Z, Dashwood RH, Ho E. Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol Nutr Food Res. 2011;55(7):999-1009.
    • (2011) Mol Nutr Food Res , vol.55 , Issue.7 , pp. 999-1009
    • Clarke, J.D.1    Hsu, A.2    Yu, Z.3    Dashwood, R.H.4    Ho, E.5
  • 81
    • 84869082989 scopus 로고    scopus 로고
    • Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells
    • 22303414 10.1186/1868-7083-3-3 1:CAS:528:DC%2BC3MXhsFSrur%2FO
    • Hsu A, Wong CP, Yu Z, Williams DE, Dashwood RH, Ho E. Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells. Clin Epigenetics. 2011;3:3.
    • (2011) Clin Epigenetics , vol.3 , pp. 3
    • Hsu, A.1    Wong, C.P.2    Yu, Z.3    Williams, D.E.4    Dashwood, R.H.5    Ho, E.6
  • 82
    • 0142188174 scopus 로고    scopus 로고
    • Inactivation of cyclin D2 gene in prostate cancers by aberrant promoter methylation
    • 14581343 1:CAS:528:DC%2BD3sXosVGjs7c%3D
    • Padar A, Sathyanarayana UG, Suzuki M, Maruyama R, Hsieh JT, Frenkel EP, et al. Inactivation of cyclin D2 gene in prostate cancers by aberrant promoter methylation. Clin Cancer Res. 2003;9(13):4730-4.
    • (2003) Clin Cancer Res , vol.9 , Issue.13 , pp. 4730-4734
    • Padar, A.1    Sathyanarayana, U.G.2    Suzuki, M.3    Maruyama, R.4    Hsieh, J.T.5    Frenkel, E.P.6
  • 83
    • 77955352742 scopus 로고    scopus 로고
    • Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines
    • 20625516 10.1371/journal.pone.0011457
    • Meeran SM, Patel SN, Tollefsbol TO. Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. PLoS One. 2010;5(7):e11457.
    • (2010) PLoS One , vol.5 , Issue.7 , pp. 11457
    • Meeran, S.M.1    Patel, S.N.2    Tollefsbol, T.O.3
  • 84
    • 44649158252 scopus 로고    scopus 로고
    • HDAC6: A key regulator of cytoskeleton, cell migration and cell-cell interactions
    • 18472263 10.1016/j.tcb.2008.04.003 1:CAS:528:DC%2BD1cXmvVymu7g%3D
    • Valenzuela-Fernandez A, Cabrero JR, Serrador JM, Sanchez-Madrid F. HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions. Trends Cell Biol. 2008;18(6):291-7.
    • (2008) Trends Cell Biol , vol.18 , Issue.6 , pp. 291-297
    • Valenzuela-Fernandez, A.1    Cabrero, J.R.2    Serrador, J.M.3    Sanchez-Madrid, F.4
  • 85
    • 57349126748 scopus 로고    scopus 로고
    • Suppression of microtubule dynamic instability and turnover in MCF7 breast cancer cells by sulforaphane
    • 18952594 10.1093/carcin/bgn241 1:CAS:528:DC%2BD1cXhsVOgsLfI
    • Azarenko O, Okouneva T, Singletary KW, Jordan MA, Wilson L. Suppression of microtubule dynamic instability and turnover in MCF7 breast cancer cells by sulforaphane. Carcinogenesis. 2008;29(12):2360-8.
    • (2008) Carcinogenesis , vol.29 , Issue.12 , pp. 2360-2368
    • Azarenko, O.1    Okouneva, T.2    Singletary, K.W.3    Jordan, M.A.4    Wilson, L.5
  • 86
    • 52049113028 scopus 로고    scopus 로고
    • Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis
    • 18524779 10.1074/jbc.M802330200 1:CAS:528:DC%2BD1cXpt1artLc%3D
    • Mi L, Xiao Z, Hood BL, Dakshanamurthy S, Wang X, Govind S, et al. Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis. J Biol Chem. 2008;283(32):22136-46.
    • (2008) J Biol Chem , vol.283 , Issue.32 , pp. 22136-22146
    • Mi, L.1    Xiao, Z.2    Hood, B.L.3    Dakshanamurthy, S.4    Wang, X.5    Govind, S.6
  • 87
    • 84863551515 scopus 로고    scopus 로고
    • Proteomic analysis of covalent modifications of tubulins by isothiocyanates
    • 22649267 10.3945/jn.111.152041 1:CAS:528:DC%2BC38XpsV2jt7g%3D
    • Xiao Z, Mi L, Chung FL, Veenstra TD. Proteomic analysis of covalent modifications of tubulins by isothiocyanates. J Nutr. 2012;142(7):1377S-81S.
    • (2012) J Nutr , vol.142 , Issue.7
    • Xiao, Z.1    Mi, L.2    Chung, F.L.3    Veenstra, T.D.4
  • 88
    • 58149234401 scopus 로고    scopus 로고
    • Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis
    • 18980980 10.1158/1078-0432.CCR-08-0903 1:CAS:528:DC%2BD1cXhtlens7nN
    • Shankar S, Ganapathy S, Srivastava RK. Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis. Clin Cancer Res. 2008;14(21):6855-66.
    • (2008) Clin Cancer Res , vol.14 , Issue.21 , pp. 6855-6866
    • Shankar, S.1    Ganapathy, S.2    Srivastava, R.K.3
  • 89
    • 73249149751 scopus 로고    scopus 로고
    • HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer
    • 10.1210/me.2009-0188 1:CAS:528:DC%2BD1MXhsFKlurzK
    • Ai J, Wang Y, Dar JA, Liu J, Liu L, Nelson JB, et al. HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer. Mol Endocrinol (Baltimore, Md). 2009;23(12):1963-72.
    • (2009) Mol Endocrinol (Baltimore, Md.) , vol.23 , Issue.12 , pp. 1963-1972
    • Ai, J.1    Wang, Y.2    Dar, J.A.3    Liu, J.4    Liu, L.5    Nelson, J.B.6
  • 90
    • 84865429801 scopus 로고    scopus 로고
    • 3,3′-diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells
    • 22800507 10.1016/j.taap.2012.07.007 1:CAS:528:DC%2BC38XhtFahs7vN
    • Beaver LM, Yu TW, Sokolowski EI, Williams DE, Dashwood RH, Ho E. 3,3′-diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicol Appl Pharmacol. 2012;263(3):345-51.
    • (2012) Toxicol Appl Pharmacol , vol.263 , Issue.3 , pp. 345-351
    • Beaver, L.M.1    Yu, T.W.2    Sokolowski, E.I.3    Williams, D.E.4    Dashwood, R.H.5    Ho, E.6
  • 91
    • 76549093815 scopus 로고    scopus 로고
    • Chemopreventive agent 3,3′-diindolylmethane selectively induces proteasomal degradation of class i histone deacetylases
    • 20068155 10.1158/0008-5472.CAN-09-1924 1:CAS:528:DC%2BC3cXltlWqtg%3D%3D
    • Li Y, Li X, Guo B. Chemopreventive agent 3,3′-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases. Cancer Res. 2010;70(2):646-54.
    • (2010) Cancer Res , vol.70 , Issue.2 , pp. 646-654
    • Li, Y.1    Li, X.2    Guo, B.3
  • 92
    • 84863343713 scopus 로고    scopus 로고
    • Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM
    • 22442719 10.1371/journal.pone.0033729 1:CAS:528:DC%2BC38XkvVyitb8%3D
    • Kong D, Heath E, Chen W, Cher ML, Powell I, Heilbrun L, et al. Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM. PLoS One. 2012;7(3):e33729.
    • (2012) PLoS One , vol.7 , Issue.3 , pp. 33729
    • Kong, D.1    Heath, E.2    Chen, W.3    Cher, M.L.4    Powell, I.5    Heilbrun, L.6
  • 93
    • 33644822360 scopus 로고    scopus 로고
    • EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
    • 16330673 10.1200/JCO.2005.01.5180 1:CAS:528:DC%2BD28XhtVKqtrg%3D
    • Bachmann IM, Halvorsen OJ, Collett K, Stefansson IM, Straume O, Haukaas SA, et al. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J Clin Oncol. 2006;24(2):268-73.
    • (2006) J Clin Oncol , vol.24 , Issue.2 , pp. 268-273
    • Bachmann, I.M.1    Halvorsen, O.J.2    Collett, K.3    Stefansson, I.M.4    Straume, O.5    Haukaas, S.A.6
  • 94
    • 34250706864 scopus 로고    scopus 로고
    • Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features
    • 17134822 10.1016/j.eururo.2006.11.020
    • van Leenders GJ, Dukers D, Hessels D, van den Kieboom SW, Hulsbergen CA, Witjes JA, et al. Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features. Eur Urol. 2007;52(2):455-63.
    • (2007) Eur Urol , vol.52 , Issue.2 , pp. 455-463
    • Van Leenders, G.J.1    Dukers, D.2    Hessels, D.3    Van Den Kieboom, S.W.4    Hulsbergen, C.A.5    Witjes, J.A.6
  • 95
    • 84863050461 scopus 로고    scopus 로고
    • Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment
    • 22347519 1:CAS:528:DC%2BC38Xitl2isL8%3D
    • Kong D, Heath E, Chen W, Cher M, Powell I, Heilbrun L, et al. Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment. Am J Transl Res. 2012;4(1):14-23.
    • (2012) Am J Transl Res , vol.4 , Issue.1 , pp. 14-23
    • Kong, D.1    Heath, E.2    Chen, W.3    Cher, M.4    Powell, I.5    Heilbrun, L.6
  • 96
    • 34248547027 scopus 로고    scopus 로고
    • Sulforaphane as a promising molecule for fighting cancer
    • 17134937 10.1016/j.mrrev.2006.10.004 1:CAS:528:DC%2BD2sXls1Sjs7c%3D
    • Fimognari C, Hrelia P. Sulforaphane as a promising molecule for fighting cancer. Mutat Res. 2007;635(2-3):90-104.
    • (2007) Mutat Res , vol.635 , Issue.2-3 , pp. 90-104
    • Fimognari, C.1    Hrelia, P.2
  • 97
    • 40649107590 scopus 로고    scopus 로고
    • Indole-3-carbinol as a chemopreventive and anti-cancer agent
    • 18314259 10.1016/j.canlet.2008.01.033 1:CAS:528:DC%2BD1cXjtlWgs7g%3D
    • Weng JR, Tsai CH, Kulp SK, Chen CS. Indole-3-carbinol as a chemopreventive and anti-cancer agent. Cancer Lett. 2008;262(2):153-63.
    • (2008) Cancer Lett , vol.262 , Issue.2 , pp. 153-163
    • Weng, J.R.1    Tsai, C.H.2    Kulp, S.K.3    Chen, C.S.4
  • 98
    • 77649163840 scopus 로고    scopus 로고
    • Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice
    • 20062804 10.1371/journal.pone.0008579
    • Yu S, Khor TO, Cheung KL, Li W, Wu TY, Huang Y, et al. Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice. PLoS One. 2010;5(1):e8579.
    • (2010) PLoS One , vol.5 , Issue.1 , pp. 8579
    • Yu, S.1    Khor, T.O.2    Cheung, K.L.3    Li, W.4    Wu, T.Y.5    Huang, Y.6
  • 99
    • 68949212379 scopus 로고    scopus 로고
    • Lysine acetylation targets protein complexes and co-regulates major cellular functions
    • 10.1126/science.1175371 1:CAS:528:DC%2BD1MXps1Ogt70%3D
    • Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, et al. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science (New York, NY). 2009;325(5942):834-40.
    • (2009) Science (New York, NY) , vol.325 , Issue.5942 , pp. 834-840
    • Choudhary, C.1    Kumar, C.2    Gnad, F.3    Nielsen, M.L.4    Rehman, M.5    Walther, T.C.6
  • 100
    • 79952396960 scopus 로고    scopus 로고
    • Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
    • 21258344 10.1038/nbt.1759 1:CAS:528:DC%2BC3MXps1ahug%3D%3D
    • Bantscheff M, Hopf C, Savitski MM, Dittmann A, Grandi P, Michon AM, et al. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol. 2011;29(3):255-65.
    • (2011) Nat Biotechnol , vol.29 , Issue.3 , pp. 255-265
    • Bantscheff, M.1    Hopf, C.2    Savitski, M.M.3    Dittmann, A.4    Grandi, P.5    Michon, A.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.