3,3′-Diindolylmethane induces a G1 arrest in human prostate cancer cells irrespective of androgen receptor and p53 status

Biochemical Pharmacology

Volumn 78, Issue 5, 2009, Pages 469-476

  Vivar, Omar I ^a   Lin, Chia Lei ^a   Firestone, Gary L ^b   Bjeldanes, Leonard F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California Berkeley   (United States)

Author keywords

3,3 Diindolylmethane; Cancer; Cell cycle arrest; p27Kip1; p38 MAPK; Prostate cancer

Indexed keywords

3,3' DIINDOLYLMETHANE; ANDROGEN; ANDROGEN RECEPTOR; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PROTEIN P27; PROTEIN P53; THYMIDINE; TRANSCRIPTION FACTOR SP1; 3,3'-DIINDOLYLMETHANE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; INDOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38; PRIMER DNA;

ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; FLUORESCENCE ACTIVATED CELL SORTING; GENE DELETION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; PROTEIN EXPRESSION; REPORTER GENE; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; FLOW CYTOMETRY; GENETICS; MALE; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; PROSTATE TUMOR; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; DNA PRIMERS; FLOW CYTOMETRY; G1 PHASE; HUMANS; INDOLES; MALE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 67649464189     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.05.008     Document Type: Article

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