-
1
-
-
34247269026
-
Genetic determinants of cancer metastasis
-
Nguyen DX, Massague J. Genetic determinants of cancer metastasis. Nat Rev Genet 2007; 8: 341-352.
-
(2007)
Nat Rev Genet
, vol.8
, pp. 341-352
-
-
Nguyen, D.X.1
Massague, J.2
-
2
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
-
(2011)
Cell
, Issue.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
3
-
-
63049090100
-
Metastasis: From dissemination to organ-specific colonization
-
Nguyen DX, Bos PD, Massague J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 2009; 9: 274-284.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 274-284
-
-
Nguyen, D.X.1
Bos, P.D.2
Massague, J.3
-
4
-
-
79952073341
-
The biology of cancer metastasis
-
Fidler IJ. The biology of cancer metastasis. Semin Cancer Biol 2011; 21: 71.
-
(2011)
Semin Cancer Biol
, Issue.21
, pp. 71
-
-
Fidler, I.J.1
-
5
-
-
79953300698
-
The seed and soil hypothesis revisited-The role of tumorstroma interactions in metastasis to different organs
-
Langley RR, Fidler IJ. The seed and soil hypothesis revisited-the role of tumorstroma interactions in metastasis to different organs. Int J Cancer 2011; 128: 2527-2535.
-
(2011)
Int J Cancer
, vol.128
, pp. 2527-2535
-
-
Langley, R.R.1
Fidler, I.J.2
-
9
-
-
84862907854
-
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
-
Wu J, Jiao Y, Dal Molin M, Maitra A, de Wilde RF, Wood LD et al. Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci USA 2011; 108: 21188-21193.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 21188-21193
-
-
Wu, J.1
Jiao, Y.2
Dal Molin, M.3
Maitra, A.4
De Wilde, R.F.5
Wood, L.D.6
-
12
-
-
62249108705
-
The pathology and genetics of metastatic pancreatic cancer
-
Yachida S, Iacobuzio-Donahue CA. The pathology and genetics of metastatic pancreatic cancer. Arch Pathol Lab Med 2009; 133: 413-422.
-
(2009)
Arch Pathol Lab Med
, vol.133
, pp. 413-422
-
-
Yachida, S.1
Iacobuzio-Donahue, C.A.2
-
13
-
-
0034329115
-
Resected adenocarcinoma of the pancreas-616 patients: Results, outcomes, and prognostic indicators
-
Sohn TA, Yeo CJ, Cameron JL, Koniaris L, Kaushal S, Abrams RA et al. Resected adenocarcinoma of the pancreas-616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg 2000; 4: 567-579.
-
(2000)
J Gastrointest Surg
, vol.4
, pp. 567-579
-
-
Sohn, T.A.1
Yeo, C.J.2
Cameron, J.L.3
Koniaris, L.4
Kaushal, S.5
Abrams, R.A.6
-
14
-
-
77949264996
-
Advanced pancreatic carcinoma: Current treatment and future challenges
-
Stathis A, Moore MJ. Advanced pancreatic carcinoma: current treatment and future challenges. Nat Rev Clin Oncol 2010; 7: 163-172.
-
(2010)
Nat Rev Clin Oncol
, Issue.7
, pp. 163-172
-
-
Stathis, A.1
Moore, M.J.2
-
15
-
-
80051580618
-
Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
-
Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011; 61: 212-236.
-
(2011)
CA Cancer J Clin
, vol.61
, pp. 212-236
-
-
Siegel, R.1
Ward, E.2
Brawley, O.3
Jemal, A.4
-
16
-
-
77951755278
-
Pancreatic cancer
-
Hidalgo M. Pancreatic cancer. N Engl J Med 2010; 362: 1605-1617.
-
(2010)
N Engl J Med
, Issue.362
, pp. 1605-1617
-
-
Hidalgo, M.1
-
17
-
-
0035020633
-
Pancreatic intraepithelial neoplasia: A new nomenclature and classification system for pancreatic duct lesions
-
Hruban RH, Adsay NV, Albores-Saavedra J, Compton C, Garrett ES, Goodman SN et al. Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol 2001; 25: 579-586.
-
(2001)
Am J Surg Pathol
, vol.25
, pp. 579-586
-
-
Hruban, R.H.1
Adsay, N.V.2
Albores-Saavedra, J.3
Compton, C.4
Garrett, E.S.5
Goodman, S.N.6
-
18
-
-
84862777152
-
Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia 2012
-
Kanda M, Matthaei H, Wu J, Hong S-M, Yu J, Borges M et al. Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia 2012Gastroenterology 142: 730-733.e9.
-
Gastroenterology
, vol.142
-
-
Kanda, M.1
Matthaei, H.2
Wu, J.3
Hong, S.-M.4
Yu, J.5
Borges, M.6
-
19
-
-
0032532379
-
Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: Loss of intranuclear expression
-
Wilentz RE, Geradts J, Maynard R, Offerhaus GJ, Kang M, Goggins M et al. Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression. Cancer Res 1998; 58: 4740-4744.
-
(1998)
Cancer Res
, vol.58
, pp. 4740-4744
-
-
Wilentz, R.E.1
Geradts, J.2
Maynard, R.3
Offerhaus, G.J.4
Kang, M.5
Goggins, M.6
-
20
-
-
0033891752
-
Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas: A new marker of DPC4 inactivation
-
Wilentz RE, Su GH, Dai JL, Sparks AB, Argani P, Sohn TA et al. Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas: a new marker of DPC4 inactivation. Am J Pathol 2000; 156: 37-43.
-
(2000)
Am J Pathol
, vol.156
, pp. 37-43
-
-
Wilentz, R.E.1
Su, G.H.2
Dai, J.L.3
Sparks, A.B.4
Argani, P.5
Sohn, T.A.6
-
21
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones S, Zhang X, Parsons DW, Lin JC-H, Leary RJ, Angenendt P et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008; 321: 1801-1806.
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
Jc-H, L.4
Leary, R.J.5
Angenendt, P.6
-
22
-
-
34248547564
-
Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma
-
Balakrishnan A, Bleeker FE, Lamba S, Rodolfo M, Daniotti M, Scarpa A et al. Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma. Cancer Res 2007; 67: 3545-3550.
-
(2007)
Cancer Res
, vol.67
, pp. 3545-3550
-
-
Balakrishnan, A.1
Bleeker, F.E.2
Lamba, S.3
Rodolfo, M.4
Daniotti, M.5
Scarpa, A.6
-
23
-
-
84857129204
-
Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/ SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer
-
Shain AH, Giacomini CP, Matsukuma K, Karikari CA, Bashyam MD, Hidalgo M et al. Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/ SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer. Proc Natl Acad Sci USA 2012; 109: E252-E259.
-
(2012)
Proc Natl Acad Sci USA
, Issue.109
-
-
Shain, A.H.1
Giacomini, C.P.2
Matsukuma, K.3
Karikari, C.A.4
Bashyam, M.D.5
Hidalgo, M.6
-
24
-
-
84869091997
-
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
-
Biankin AV, Waddell N, Kassahn KS, Gingras M-C, Muthuswamy LB, Johns AL et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 2012; 491: 399-405.
-
(2012)
Nature
, Issue.491
, pp. 399-405
-
-
Biankin, A.V.1
Waddell, N.2
Kassahn, K.S.3
Gingras, M.-C.4
Muthuswamy, L.B.5
Johns, A.L.6
-
25
-
-
19944431321
-
A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner
-
Attwooll C, Oddi S, Cartwright P, Prosperini E, Agger K, Steensgaard P et al. A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner. J Biol Chem 2005; 280: 1199-1208.
-
(2005)
J Biol Chem
, vol.280
, pp. 1199-1208
-
-
Attwooll, C.1
Oddi, S.2
Cartwright, P.3
Prosperini, E.4
Agger, K.5
Steensgaard, P.6
-
26
-
-
77958191599
-
ATM activation by oxidative stress
-
Guo Z, Kozlov S, Lavin MF, Person MD, Paull TT. ATM activation by oxidative stress. Science 2010; 330: 517-521.
-
(2010)
Science
, Issue.330
, pp. 517-521
-
-
Guo, Z.1
Kozlov, S.2
Lavin, M.F.3
Person, M.D.4
Paull, T.T.5
-
27
-
-
84860826598
-
A roundabout way to cancer
-
Ballard MS, Hinck L. A roundabout way to cancer. Adv Cancer Res 2012; 114: 187-235.
-
(2012)
Adv Cancer Res
, vol.114
, pp. 187-235
-
-
Ballard, M.S.1
Hinck, L.2
-
28
-
-
62249176551
-
DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
-
Iacobuzio-Donahue CA, Fu B, Yachida S, Luo M, Abe H, Henderson CM et al. DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol 2009; 27: 1806-1813.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1806-1813
-
-
Iacobuzio-Donahue, C.A.1
Fu, B.2
Yachida, S.3
Luo, M.4
Abe, H.5
Henderson, C.M.6
-
30
-
-
68049115773
-
SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer
-
Blackford A, Serrano OK, Wolfgang CL, Parmigiani G, Jones S, Zhang X et al. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res 2009; 15: 4674-4679.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4674-4679
-
-
Blackford, A.1
Serrano, O.K.2
Wolfgang, C.L.3
Parmigiani, G.4
Jones, S.5
Zhang, X.6
-
31
-
-
0035671396
-
The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma
-
Tascilar M, Skinner HG, Rosty C, Sohn T, Wilentz RE, Offerhaus GJ et al. The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma. Clin Cancer Res 2001; 7: 4115-4121.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 4115-4121
-
-
Tascilar, M.1
Skinner, H.G.2
Rosty, C.3
Sohn, T.4
Wilentz, R.E.5
Offerhaus, G.J.6
-
32
-
-
47549090432
-
TGFbeta in cancer
-
Massague J. TGFbeta in cancer. Cell 2008; 134: 215-230.
-
(2008)
Cell
, vol.134
, pp. 215-230
-
-
Massague, J.1
-
33
-
-
0032478143
-
Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells
-
Zhou S, Buckhaults P, Zawel L, Bunz F, Riggins G, Dai JL et al. Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells. Proc Natl Acad Sci USA 1998; 95: 2412-2416.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 2412-2416
-
-
Zhou, S.1
Buckhaults, P.2
Zawel, L.3
Bunz, F.4
Riggins, G.5
Dai, J.L.6
-
34
-
-
0032014216
-
Human Smad3 and Smad4 are sequence-specific transcription activators
-
Zawel L, Dai JL, Buckhaults P, Zhou S, Kinzler KW, Vogelstein B et al. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell 1998; 1: 611-617.
-
(1998)
Mol Cell
, vol.1
, pp. 611-617
-
-
Zawel, L.1
Dai, J.L.2
Buckhaults, P.3
Zhou, S.4
Kinzler, K.W.5
Vogelstein, B.6
-
35
-
-
0030612484
-
Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells
-
Grau AM, Zhang L, Wang W, Ruan S, Evans DB, Abbruzzese JL et al. Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells. Cancer Res 1997; 57: 3929-3934.
-
(1997)
Cancer Res
, vol.57
, pp. 3929-3934
-
-
Grau, A.M.1
Zhang, L.2
Wang, W.3
Ruan, S.4
Evans, D.B.5
Abbruzzese, J.L.6
-
36
-
-
0033573825
-
G1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: Phenotypes reversed by a tumorigenic mutation
-
Dai JL, Bansal RK, Kern SE. G1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: phenotypes reversed by a tumorigenic mutation. Proc Natl Acad Sci USA 1999; 96: 1427-1432.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 1427-1432
-
-
Dai, J.L.1
Bansal, R.K.2
Kern, S.E.3
-
37
-
-
0000128027
-
Dpc4 transcriptional activation and dysfunction in cancer cells
-
Dai JL, Turnacioglu KK, Schutte M, Sugar AY, Kern SE. Dpc4 transcriptional activation and dysfunction in cancer cells. Cancer Res 1998; 58: 4592-4597.
-
(1998)
Cancer Res
, vol.58
, pp. 4592-4597
-
-
Dai, J.L.1
Turnacioglu, K.K.2
Schutte, M.3
Sugar, A.Y.4
Kern, S.E.5
-
38
-
-
0036848885
-
Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells
-
Peng B, Fleming JB, Breslin T, Grau AM, Fojioka S, Abbruzzese JL et al. Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells. Clin Cancer Res 2002; 8: 3628-3638.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3628-3638
-
-
Peng, B.1
Fleming, J.B.2
Breslin, T.3
Grau, A.M.4
Fojioka, S.5
Abbruzzese, J.L.6
-
39
-
-
77951906896
-
Regulatory expression of genes related to metastasis by TGF-beta and activin A in B16 murine melanoma cells
-
Murakami M, Suzuki M, Nishino Y, Funaba M. Regulatory expression of genes related to metastasis by TGF-beta and activin A in B16 murine melanoma cells. Mol Biol Rep 2010; 37: 1279-1286.
-
(2010)
Mol Biol Rep
, vol.37
, pp. 1279-1286
-
-
Murakami, M.1
Suzuki, M.2
Nishino, Y.3
Funaba, M.4
-
40
-
-
84862012341
-
Prostate cancer cells and bone stromal cells mutually interact with each other through bone morphogenetic protein-mediated signals
-
Nishimori H, Ehata S, Suzuki HI, Katsuno Y, Miyazono K. Prostate cancer cells and bone stromal cells mutually interact with each other through bone morphogenetic protein-mediated signals. J Biol Chem 2012; 287: 20037-20046.
-
(2012)
J Biol Chem
, vol.287
, pp. 20037-20046
-
-
Nishimori, H.1
Ehata, S.2
Suzuki, H.I.3
Katsuno, Y.4
Miyazono, K.5
-
41
-
-
84863011208
-
EW-7203, a novel small molecule inhibitor of transforming growth factor-b (TGF-b) type i receptor/activin receptor-like kinase- 5, blocks TGF-b1-mediated epithelial-to-mesenchymal transition in mammary epithelial cells
-
Park C-Y, Kim D-K, Sheen YY. EW-7203, a novel small molecule inhibitor of transforming growth factor-b (TGF-b) type I receptor/activin receptor-like kinase- 5, blocks TGF-b1-mediated epithelial-to-mesenchymal transition in mammary epithelial cells. Cancer Sci 2011; 102: 1889-1896.
-
(2011)
Cancer Sci
, vol.102
, pp. 1889-1896
-
-
Park, C.-Y.1
Kim, D.-K.2
Sheen, Y.Y.3
-
42
-
-
84869236330
-
Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long term survivors
-
Yachida S, White C, Naito Y, Zhong Y, Brosnan JA, Macgregor-Das AM et al. Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long term survivors. Clin Cancer Res 2012; 18: 6339-6347.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 6339-6347
-
-
Yachida, S.1
White, C.2
Naito, Y.3
Zhong, Y.4
Brosnan, J.A.5
Macgregor-Das, A.M.6
-
43
-
-
76249108357
-
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
-
Morton JP, Timpson P, Karim SA, Ridgway RA, Athineos D, Doyle B et al. Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci USA 2010; 107: 246-251.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 246-251
-
-
Morton, J.P.1
Timpson, P.2
Karim, S.A.3
Ridgway, R.A.4
Athineos, D.5
Doyle, B.6
-
44
-
-
84880571709
-
Immunohistochemically detected expression of three major genes (CDKN2A/p16, TP53 and SMAD4/DPC4) strongly predicts survival in patients with resectable pancreatic cancer
-
in press
-
Oshima M, Keiichi O, Shinobu M, Reiji H, Takashi M, Yasuyuki S et al. Immunohistochemically detected expression of three major genes (CDKN2A/p16, TP53 and SMAD4/DPC4) strongly predicts survival in patients with resectable pancreatic cancer. Ann Surg 2013 (in press).
-
(2013)
Ann Surg
-
-
Oshima, M.1
Keiichi, O.2
Shinobu, M.3
Reiji, H.4
Takashi, M.5
Yasuyuki, S.6
-
45
-
-
84869456305
-
Keys to personalized care in pancreatic oncology
-
Crane CH, Iacobuzio-Donahue CA. Keys to personalized care in pancreatic oncology. J Clin Oncol 2012; 30: 4049-4050.
-
(2012)
J Clin Oncol
, vol.30
, pp. 4049-4050
-
-
Crane, C.H.1
Iacobuzio-Donahue, C.A.2
-
46
-
-
80051613675
-
Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: Correlation of Smad4(Dpc4) immunostaining with pattern of disease progression
-
Crane CH, Varadhachary GR, Yordy JS, Staerkel GA, Javle MM, Safran H et al. Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: correlation of Smad4(Dpc4) immunostaining with pattern of disease progression. J Clin Oncol 2011; 29: 3037-3043.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3037-3043
-
-
Crane, C.H.1
Varadhachary, G.R.2
Yordy, J.S.3
Staerkel, G.A.4
Javle, M.M.5
Safran, H.6
-
47
-
-
77955015464
-
AACR centennial series: The biology of cancer metastasis: Historical perspective
-
Talmadge JE, Fidler IJ. AACR centennial series: the biology of cancer metastasis: historical perspective. Cancer Res 2010; 70: 5649-5669.
-
(2010)
Cancer Res
, vol.70
, pp. 5649-5669
-
-
Talmadge, J.E.1
Fidler, I.J.2
-
48
-
-
43049165453
-
The epithelialmesenchymal transition generates cells with properties of stem cells
-
Mani SA, Guo W, Liao M-J, Eaton EN, Ayyanan A, Zhou AY et al. The epithelialmesenchymal transition generates cells with properties of stem cells. Cell 2008; 133: 704-715.
-
(2008)
Cell
, vol.133
, pp. 704-715
-
-
Mani, S.A.1
Guo, W.2
Liao, M.-J.3
Eaton, E.N.4
Ayyanan, A.5
Zhou, A.Y.6
-
49
-
-
77649275464
-
MiR-9, a MYC/MYCNactivated microRNA, regulates E-cadherin and cancer metastasis
-
Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D et al. miR-9, a MYC/MYCNactivated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 2010; 12: 247-256.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 247-256
-
-
Ma, L.1
Young, J.2
Prabhala, H.3
Pan, E.4
Mestdagh, P.5
Muth, D.6
-
50
-
-
79960117895
-
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs
-
Oskarsson T, Acharyya S, XH-F Zhang, Vanharanta S, Tavazoie SF, Morris PG et al. Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nat Med 2011; 17: 867-874.
-
(2011)
Nat Med
, vol.17
, pp. 867-874
-
-
Oskarsson, T.1
Acharyya, S.2
Zhang, X.3
Vanharanta, S.4
Tavazoie, S.F.5
Morris, P.G.6
-
51
-
-
84869021181
-
Dependency of colorectal cancer on a TGF-b-driven program in stromal cells for metastasis initiation
-
Calon A, Espinet E, Palomo-Ponce S, Tauriello DVF, Iglesias M, Cespedes MV et al. Dependency of colorectal cancer on a TGF-b-driven program in stromal cells for metastasis initiation. Cancer Cell 2012; 22: 571-584.
-
(2012)
Cancer Cell
, vol.22
, pp. 571-584
-
-
Calon, A.1
Espinet, E.2
Palomo-Ponce, S.3
Dvf, T.4
Iglesias, M.5
Cespedes, M.V.6
-
52
-
-
84883490063
-
Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis
-
Semenza GL. Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis. Oncogene 2013; 32: 4057-4063.
-
(2013)
Oncogene
, vol.32
, pp. 4057-4063
-
-
Semenza, G.L.1
-
54
-
-
78049398107
-
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
-
Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 2010; 467: 1114-1117.
-
(2010)
Nature
, vol.467
, pp. 1114-1117
-
-
Yachida, S.1
Jones, S.2
Bozic, I.3
Antal, T.4
Leary, R.5
Fu, B.6
-
55
-
-
41949139438
-
Comparative lesion sequencing provides insights into tumor evolution
-
Jones S, Chen W-D, Parmigiani G, Diehl F, Beerenwinkel N, Antal T et al. Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci USA 2008; 105: 4283-4288.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 4283-4288
-
-
Jones, S.1
Chen, W.-D.2
Parmigiani, G.3
Diehl, F.4
Beerenwinkel, N.5
Antal, T.6
-
56
-
-
84861574101
-
Genetic evolution of pancreatic cancer: Lessons learnt from the pancreatic cancer genome sequencing project
-
Iacobuzio-Donahue CA. Genetic evolution of pancreatic cancer: lessons learnt from the pancreatic cancer genome sequencing project. Gut 2012; 61: 1085-1094.
-
(2012)
Gut
, vol.61
, pp. 1085-1094
-
-
Iacobuzio-Donahue, C.A.1
-
57
-
-
78049380554
-
The patterns and dynamics of genomic instability in metastatic pancreatic cancer
-
Campbell PJ, Yachida S, Mudie LJ, Stephens PJ, Pleasance ED, Stebbings LA et al. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature 2010; 467: 1109-1113.
-
(2010)
Nature
, vol.467
, pp. 1109-1113
-
-
Campbell, P.J.1
Yachida, S.2
Mudie, L.J.3
Stephens, P.J.4
Pleasance, E.D.5
Stebbings, L.A.6
-
58
-
-
82755186408
-
Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence
-
Larsson L-G. Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence. Semin Cancer Biol 2011; 21: 367-376.
-
(2011)
Semin Cancer Biol
, Issue.21
, pp. 367-376
-
-
Larsson, L.-G.1
-
59
-
-
67349257845
-
Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer
-
Liu W, Laitinen S, Khan S, Vihinen M, Kowalski J, Yu G et al. Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer. Nat Med 2009; 15: 559-565.
-
(2009)
Nat Med
, vol.15
, pp. 559-565
-
-
Liu, W.1
Laitinen, S.2
Khan, S.3
Vihinen, M.4
Kowalski, J.5
Yu, G.6
-
60
-
-
79953766940
-
Tumour evolution inferred by single-cell sequencing
-
Navin N, Kendall J, Troge J, Andrews P, Rodgers L, McIndoo J et al. Tumour evolution inferred by single-cell sequencing. Nature 2011; 472: 90-94.
-
(2011)
Nature
, vol.472
, pp. 90-94
-
-
Navin, N.1
Kendall, J.2
Troge, J.3
Andrews, P.4
Rodgers, L.5
McIndoo, J.6
-
61
-
-
74949101897
-
Inferring tumor progression from genomic heterogeneity
-
Navin N, Krasnitz A, Rodgers L, Cook K, Meth J, Kendall J et al. Inferring tumor progression from genomic heterogeneity. Genome Res 2010; 20: 68-80.
-
(2010)
Genome Res
, vol.20
, pp. 68-80
-
-
Navin, N.1
Krasnitz, A.2
Rodgers, L.3
Cook, K.4
Meth, J.5
Kendall, J.6
-
62
-
-
60849118132
-
Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA)
-
Grubor V, Krasnitz A, Troge JE, Meth JL, Lakshmi B, Kendall JT et al. Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA). Blood 2009; 113: 1294-1303.
-
(2009)
Blood
, vol.113
, pp. 1294-1303
-
-
Grubor, V.1
Krasnitz, A.2
Troge, J.E.3
Meth, J.L.4
Lakshmi, B.5
Kendall, J.T.6
-
63
-
-
84864561961
-
Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides
-
Egan JB, Shi C-X, Tembe W, Christoforides A, Kurdoglu A, Sinari S et al. Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides. Blood 2012; 120: 1060-1066.
-
(2012)
Blood
, Issue.120
, pp. 1060-1066
-
-
Egan, J.B.1
Shi, C.-X.2
Tembe, W.3
Christoforides, A.4
Kurdoglu, A.5
Sinari, S.6
-
64
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012; 366: 883-892.
-
(2012)
N Engl J Med
, Issue.366
, pp. 883-892
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
Larkin, J.4
Endesfelder, D.5
Gronroos, E.6
-
65
-
-
84861550476
-
The life history of 21 breast cancers
-
Nik-Zainal S, Van Loo P, Wedge DC, Alexandrov LB, Greenman CD, Lau KW et al. The life history of 21 breast cancers. Cell 2012; 149: 994-1007.
-
(2012)
Cell
, Issue.149
, pp. 994-1007
-
-
Nik-Zainal, S.1
Van Loo, P.2
Wedge, D.C.3
Alexandrov, L.B.4
Greenman, C.D.5
Lau, K.W.6
-
66
-
-
84863393606
-
Whole genome sequencing of matched primary and metastatic acral melanomas
-
Turajlic S, Furney SJ, Lambros MB, Mitsopoulos C, Kozarewa I, Geyer FC et al. Whole genome sequencing of matched primary and metastatic acral melanomas. Genome Res 2012; 22: 196-207.
-
(2012)
Genome Res
, vol.22
, pp. 196-207
-
-
Turajlic, S.1
Furney, S.J.2
Lambros, M.B.3
Mitsopoulos, C.4
Kozarewa, I.5
Geyer, F.C.6
-
67
-
-
84858608410
-
Cancer stem cells: Impact, heterogeneity, and uncertainty
-
Magee JA, Piskounova E, Morrison SJ. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell 2012; 21: 283-296.
-
(2012)
Cancer Cell
, vol.21
, pp. 283-296
-
-
Magee, J.A.1
Piskounova, E.2
Morrison, S.J.3
-
68
-
-
33847052127
-
Identification of pancreatic cancer stem cells
-
Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V et al. Identification of pancreatic cancer stem cells. Cancer Res 2007; 67: 1030-1037.
-
(2007)
Cancer Res
, vol.67
, pp. 1030-1037
-
-
Li, C.1
Heidt, D.G.2
Dalerba, P.3
Burant, C.F.4
Zhang, L.5
Adsay, V.6
-
69
-
-
84866875005
-
Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential
-
Salnikov AV, Liu L, Platen M, Gladkich J, Salnikova O, Ryschich E et al. Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential. PLoS ONE 2012; 7: e46391.
-
(2012)
PLoS ONE
, Issue.7
-
-
Salnikov, A.V.1
Liu, L.2
Platen, M.3
Gladkich, J.4
Salnikova, O.5
Ryschich, E.6
-
70
-
-
80052993287
-
Intratumor diversity and clonal evolution in cancer-A skeptical standpoint
-
Gisselsson D. Intratumor diversity and clonal evolution in cancer-a skeptical standpoint. Adv Cancer Res 2011; 112: 1-9.
-
(2011)
Adv Cancer Res
, Issue.112
, pp. 1-9
-
-
Gisselsson, D.1
-
71
-
-
78249261016
-
Accumulation of driver and passenger mutations during tumor progression
-
Bozic I, Antal T, Ohtsuki H, Carter H, Kim D, Chen S et al. Accumulation of driver and passenger mutations during tumor progression. Proc Natl Acad Sci USA 2010; 107: 18545-18550.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 18545-18550
-
-
Bozic, I.1
Antal, T.2
Ohtsuki, H.3
Carter, H.4
Kim, D.5
Chen, S.6
-
73
-
-
84859393143
-
Frequent detection of pancreatic lesions in asymptomatic high-risk individuals
-
Canto MI, Hruban RH, Fishman EK, Kamel IR, Schulick R, Zhang Z et al. Frequent detection of pancreatic lesions in asymptomatic high-risk individuals. Gastroenterology 2012; 142: 796-804.
-
(2012)
Gastroenterology
, Issue.142
, pp. 796-804
-
-
Canto, M.I.1
Hruban, R.H.2
Fishman, E.K.3
Kamel, I.R.4
Schulick, R.5
Zhang, Z.6
-
74
-
-
84856082746
-
Computational modeling of pancreatic cancer reveals kinetics of metastasis suggesting optimum treatment strategies
-
Haeno H, Gonen M, Davis MB, Herman JM, Iacobuzio-Donahue CA, Michor F. Computational modeling of pancreatic cancer reveals kinetics of metastasis suggesting optimum treatment strategies. Cell 2012; 148: 362-375.
-
(2012)
Cell
, vol.148
, pp. 362-375
-
-
Haeno, H.1
Gonen, M.2
Davis, M.B.3
Herman, J.M.4
Iacobuzio-Donahue, C.A.5
Michor, F.6
-
75
-
-
1842587668
-
Clinicopathological aspects of small pancreatic cancer
-
Egawa S, Takeda K, Fukuyama S, Motoi F, Sunamura M, Matsuno S. Clinicopathological aspects of small pancreatic cancer. Pancreas 2004; 28: 235-240.
-
(2004)
Pancreas
, vol.28
, pp. 235-240
-
-
Egawa, S.1
Takeda, K.2
Fukuyama, S.3
Motoi, F.4
Sunamura, M.5
Matsuno, S.6
-
77
-
-
79953158399
-
Exploring the genomes of cancer cells: Progress and promise
-
Stratton MR. Exploring the genomes of cancer cells: progress and promise. Science 2011; 331: 1553-1558.
-
(2011)
Science
, vol.331
, pp. 1553-1558
-
-
Stratton, M.R.1
-
78
-
-
84859187259
-
Systematic identification of genomic markers of drug sensitivity in cancer cells
-
Garnett MJ, Edelman EJ, Heidorn SJ, Greenman CD, Dastur A, Lau KW et al. Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature 2012; 483: 570-575.
-
(2012)
Nature
, vol.483
, pp. 570-575
-
-
Garnett, M.J.1
Edelman, E.J.2
Heidorn, S.J.3
Greenman, C.D.4
Dastur, A.5
Lau, K.W.6
-
79
-
-
84859169877
-
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
-
Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 2012; 483: 603-607.
-
(2012)
Nature
, vol.483
, pp. 603-607
-
-
Barretina, J.1
Caponigro, G.2
Stransky, N.3
Venkatesan, K.4
Margolin, A.A.5
Kim, S.6
-
80
-
-
84863000299
-
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
-
Diaz LA, Williams RT, Wu J, Kinde I, Hecht JR, Berlin J et al. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 2012; 486: 537-540.
-
(2012)
Nature
, Issue.486
, pp. 537-540
-
-
Diaz, L.A.1
Williams, R.T.2
Wu, J.3
Kinde, I.4
Hecht, J.R.5
Berlin, J.6
-
81
-
-
84862999938
-
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
-
Misale S, Yaeger R, Hobor S, Scala E, Janakiraman M, Liska D et al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature 2012; 486: 532-536.
-
(2012)
Nature
, Issue.486
, pp. 532-536
-
-
Misale, S.1
Yaeger, R.2
Hobor, S.3
Scala, E.4
Janakiraman, M.5
Liska, D.6
-
83
-
-
79959966013
-
Myeloid-derived suppressor cells: General characteristics and relevance to clinical management of pancreatic cancer
-
Goedegebuure P, Mitchem JB, Porembka MR, Tan MCB, Belt BA, Wang-Gillam A et al. Myeloid-derived suppressor cells: general characteristics and relevance to clinical management of pancreatic cancer. Curr Cancer Drug Targets 2011; 11: 734-751.
-
(2011)
Curr Cancer Drug Targets
, Issue.11
, pp. 734-751
-
-
Goedegebuure, P.1
Mitchem, J.B.2
Porembka, M.R.3
McB, T.4
Belt, B.A.5
Wang-Gillam, A.6
-
84
-
-
84866537713
-
Pancreatic adenocarcinoma induces bone marrow mobilization of myeloidderived suppressor cells which promote primary tumor growth
-
Porembka MR, Mitchem JB, Belt BA, Hsieh C-S, Lee H-M, Herndon J et al. Pancreatic adenocarcinoma induces bone marrow mobilization of myeloidderived suppressor cells which promote primary tumor growth. Cancer Immunol Immunother 2012; 61: 1373-1385.
-
(2012)
Cancer Immunol Immunother
, vol.61
, pp. 1373-1385
-
-
Porembka, M.R.1
Mitchem, J.B.2
Belt, B.A.3
Hsieh, C.-S.4
Lee, H.-M.5
Herndon, J.6
-
85
-
-
33749317518
-
Prevalence of FOXP3 regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions
-
Hiraoka N, Onozato K, Kosuge T, Hirohashi S. Prevalence of FOXP3 regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions. Clin Cancer Res 2006; 12: 5423-5434.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5423-5434
-
-
Hiraoka, N.1
Onozato, K.2
Kosuge, T.3
Hirohashi, S.4
-
86
-
-
37349100945
-
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1CD11b myeloid cells that promote metastasis
-
Yang L, Huang J, Ren X, Gorska AE, Chytil A, Aakre M et al. Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1CD11b myeloid cells that promote metastasis. Cancer Cell 2008; 13: 23-35.
-
(2008)
Cancer Cell
, vol.13
, pp. 23-35
-
-
Yang, L.1
Huang, J.2
Ren, X.3
Gorska, A.E.4
Chytil, A.5
Aakre, M.6
-
87
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009; 324: 1457-1461.
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
Gopinathan, A.4
McIntyre, D.5
Honess, D.6
-
88
-
-
84858602107
-
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
-
Provenzano PP, Cuevas C, Chang AE, Goel VK, Hoff Von DD, Hingorani SR. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 2012; 21: 418-429.
-
(2012)
Cancer Cell
, vol.21
, pp. 418-429
-
-
Provenzano, P.P.1
Cuevas, C.2
Chang, A.E.3
Goel, V.K.4
Von Dd, H.5
Hingorani, S.R.6
|