G1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: Phenotypes reversed by a tumorigenic mutation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 4, 1999, Pages 1427-1432

  Dai, Jia Le ^a   Bansal, Ravi K ^a   Kern, Scott E ^a,b  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA binding protein; Nuclear translocation; Pancreatic cancer; Signaling pathway; Type transforming growth factor

Indexed keywords

4 HYDROXYTAMOXIFEN; ARGININE; DNA; ESTROGEN RECEPTOR; PROTEIN; THREONINE; TRANSFORMING GROWTH FACTOR; DNA BINDING PROTEIN; HYBRID PROTEIN; SMAD4 PROTEIN; SMAD4 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN;

APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DNA SEQUENCE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MUTATION; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; AMINO ACID SUBSTITUTION; BIOSYNTHESIS; BREAST TUMOR; CELL CULTURE; CELL CYCLE; CELL DIVISION; CELL NUCLEUS; CELL TRANSFORMATION; FEMALE; GENETIC TRANSFECTION; GENETICS; KINETICS; NICK END LABELING; PHYSIOLOGY; REPORTER GENE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

MURINAE;

AMINO ACID SUBSTITUTION; APOPTOSIS; ARGININE; BREAST NEOPLASMS; CELL CYCLE; CELL DIVISION; CELL NUCLEUS; CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; FEMALE; G1 PHASE; GENES, REPORTER; GENES, TUMOR SUPPRESSOR; HUMANS; IN SITU NICK-END LABELING; KINETICS; MUTAGENESIS, SITE-DIRECTED; PHENOTYPE; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; THREONINE; TRANS-ACTIVATORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033573825     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.4.1427     Document Type: Article

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