Recombinant human TNF-binding protein-1 (rhTBP-1) treatment delays both symptoms progression and motor neuron loss in the wobbler mouse

Neurobiology of Disease

Volumn 29, Issue 3, 2008, Pages 465-476

  Bigini, Paolo ^a   Repici, Mariaelena ^b   Cantarella, Giuseppina ^c   Fumagalli, Elena ^a   Barbera, Sara ^a   Cagnotto, Alfredo ^a   De Luigi, Ada ^a   Tonelli, Rossella ^a   Bernardini, Renato ^c   Borsello, Tiziana ^a,b   Mennini, Tiziana ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c UNIVERSITY OF CATANIA   (Italy)

Author keywords

Amyotrophic lateral sclerosis; Glial activation; JNK; Motor neuron degeneration; p38MAPK; rhTBP 1; TNF ; TNFR1; Wobbler

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38; ONERCEPT; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; TUMOR NECROSIS FACTOR BINDING PROTEIN; TUMOR NECROSIS FACTOR BINDING PROTEIN 1; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN NERVE CELL; CELL LOSS; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFECT; ENZYME ACTIVATION; ENZYME BLOOD LEVEL; GLIOSIS; MICROGLIA; MOTOR NEURON DISEASE; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SYMPTOM; THERAPY DELAY;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL COUNT; DISEASE PROGRESSION; FEMALE; HUMANS; MALE; MICE; MICE, NEUROLOGIC MUTANTS; MOTOR NEURONS; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECOMBINANT PROTEINS; TUMOR NECROSIS FACTOR DECOY RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 39249083637     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2007.11.005     Document Type: Article

References (46)

1. Barone F.C., Irving E.A., Ray A.M., Lee J.C., Kassis S., Kumar S., Badger A.M., White R.F., McVey M.J., Legos J.J., Erhardt J.A., Nelson A.H., Ohlstein E.H., Hunter A.J., Ward K., Smith B.R., Adams J.L., and Parsons A.A. SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia. J. Pharmacol. Exp. Ther. 296 (2001) 312-321
2. Beers D.R., Henkel J.S., Xiao Q., Zhao W., Wang J., Yen A.A., Siklos L., McKercher S.R., and Appel S.H. Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 16021-16026
3. Beghi E., and Mennini T. Basic and clinical research on amyotrophic lateral sclerosis and other motor neuron disorders in Italy: recent findings and achievements from a network of laboratories. Neurol. Sci. 25 Suppl 2 (2004) S41-S60
4. Benigni F., Faggioni R., Sironi M., Fantuzzi G., Vandenabeele P., Takahashi N., Sacco S., Fiers W., Buurman W.A., and Ghezzi P. TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF. J. Immunol. 157 (1996) 5563-5568
5. Bigini P., and Mennini T. Immunohistochemical localization of TNFalpha and its receptors in the rodent central nervous system. Methods Mol. Med. 98 (2004) 73-80
6. Bigini P., Bastone A., and Mennini T. Glutamate transporters in the spinal cord of the wobbler mouse. NeuroReport 12 (2001) 1815-1820
7. Bigini P., Gardoni F., Barbera S., Cagnotto A., Fumagalli E., Longhi A., Corsi M.M., Di Luca M., and Mennini T. Expression of AMPA and NMDA receptor subunits in the cervical spinal cord of wobbler mice. BMC Neurosci. 7 (2006) 71
8. Blondet B., Hantaz-Ambroise D., Ait-Ikhlef A., Cambier D., and Murawsky M. Astrocytosis in wobbler mouse spinal cord involves a population of astrocytes which is glutamine synthetase-negative. Neurosci. Lett. 183 (1995) 179-182
9. Boillee S., Viala L., Peschanski M., and Dreyfus P.A. Differential microglial response to progressive neurodegeneration in the murine mutant Wobbler. Glia 33 (2001) 277-287
10. Boillee S., Yamanaka K., Lobsiger C.S., Copeland N.G., Jenkins N.A., Kassiotis G., Kollias G., and Cleveland D.W. Onset and progression in inherited ALS determined by motor neurons and microglia. Science 312 (2006) 1389-1392
11. Bonny C., Oberson A., Negri S., Sauser C., and Schorderet C.F. Cell-permeablepeptide inhibitors of JNK: novel blockers of beta cell death. Diabetes 50 (2001) 77-82
12. Borsello T., Clarke P.G., Hirt L., Vercelli A., Repici M., Schorderet D.F., Bogousslavsky J., and Bonny C. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat. Med. 9 (2003) 1180-1186
13. Cahill M.A., Peter M.E., Kischkel F.C., Chinnaiyan A.M., Dixit V.M., Krammer P.H., and Nordheim A. CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases. Oncogene 13 (1996) 2087-2096
14. Ding M., Hart R.P., and Jonakait G.M. Tumor necrosis factor-alpha induces substance P in sympathetic ganglia through sequential induction of interleukin-1 and leukemia inhibitory factor. J. Neurobiol. 28 (1995) 445-454
15. Fontaine V., Mohand-Said S., Hanoteau N., Fuchs C., Pfizenmaier K., and Eisel U. Neurodegenerative and neuroprotective effects of tumor necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J. Neurosci. 22 (2002) RC216
16. Fumagalli E., Bigini P., Barbera S., De Paola M., and Mennini T. Riluzole, unlike the AMPA antagonist RPR119990, reduces motor impairment and partially prevents motor neuron death in the wobbler mouse, a model of neurodegenerative disease. Exp. Neurol. 198 (2006) 114-128
17. George A., Buehl A., and Sommer C. Tumor necrosis factor receptor 1 and 2 proteins are differentially regulated during Wallerian degeneration of mouse sciatic nerve. Exp. Neurol. 192 (2005) 163-166
18. Ghezzi P., and Mennini T. Tumor necrosis factor and motor neuronal degeneration: an open problem. Neuroimmunomodulation 9 (2001) 178-182
19. Gowing G., Dequen F., Soucy G., and Julien J.P. Absence of tumor necrosis factor-alpha does not affect motor neuron disease caused by superoxide dismutase 1 mutations. J. Neurosci. 26 (2006) 11397-11402
20. Harper S.J., and Wilkie N. MAPKs: new targets for neurodegeneration. Expert Opin. Ther. Targets 7 (2003) 187-200
21. He B.P., Wen W., and Strong M.J. Activated microglia (BV-2) facilitation of TNF-alpha-mediated motor neuron death in vitro. J. Neuroimmunol. 128 (2002) 31-38
22. Hentati A., Bejaoui K., Pericak-Vance M.A., Hentati F., Speer M.C., Hung W.Y., Figlewicz D.A., Haines J., Rimmler J., Ben Hamida C., et al. Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33-q35. Nat. Genet. 7 (1994) 425-428
23. Ikeda K., Iwasaki Y., Tagaya N., Shiojima T., and Kinoshita M. Neuroprotective effect of cholinergic differentiation factor/leukemia inhibitory factor on wobbler murine motor neuron disease. Muscle Nerve 18 (1995) 1344-1347
24. Jiang Y.M., Yamamoto M., Kobayashi Y., Yoshihara T., Liang Y., Terao S., Takeuchi H., Ishigaki S., Katsuno M., Adachi H., Niwa J., Tanaka F., Doyu M., Yoshida M., Hashizume Y., and Sobue G. Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis. Ann. Neurol. 57 (2005) 236-251
25. Kiaei M., Petri S., Kipiani K., Gardian G., Choi D.K., Chen J., Calingasan N.Y., Schafer P., Muller G.W., Stewart C., Hensley K., and Beal M.F. Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis. J. Neurosci. 26 (2006) 2467-2473
26. Kurek J.B., Radford A.J., Crump D.E., Bower J.J., Feeney S.J., Austin L., and Byrne E. LIF (AM424), a promising growth factor for the treatment of ALS. J. Neurol. Sci. 160 Suppl 1 (1998) S106-S113 (Review, 64 refs)
27. Liewen H., Meinhold-Heerlein I., Oliveira V., Schwarzenbacher R., Luo G., Wadle A., Jung M., Pfreundschuh M., and Stenner-Liewen F. Characterization of the human GARP (Golgi associated retrograde protein) complex. Exp. Cell Res. 306 (2005) 24-34
28. Malaspina A., Kaushik N., and de Belleroche J. Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays. J. Neurochem. 77 (2001) 132-145
29. Mennini T., Bigini P., Cagnotto A., Carvelli L., Di Nunno P., Fumagalli E., Tortarolo M., Buurman W.A., Ghezzi P., and Bendotti C. Glial activation and TNFR-I upregulation precedes motor dysfunction in the spinal cord of mnd mice. Cytokine 25 (2004) 127-135
30. Mennini T., De Paola M., Bigini P., Mastrotto C., Fumagalli E., Barbera S., Mengozzi M., Viviani B., Corsini E., Marinovich M., Torup L., Van Beek J., Leist M., Brines M., Cerami A., and Ghezzi P. Nonhematopoietic erythropoietin derivatives prevent motor neuron degeneration in vitro and in vivo. Mol. Med. 12 (2006) 153-160
31. Mitsumoto H., Ikeda K., Klinkosz B., Cedarbaum J.M., Wong V., and Lindsay R.M. Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF. Science 265 (1994) 1107-1110
32. Nawashiro H., Martin D., and Hallenbeck J.M. Inhibition of tumor necrosis factor and amelioration of brain infarction in mice. J. Cereb. Blood Flow Metab. 17 (1997) 229-232
33. Nawashiro H., Martin D., and Hallenbeck J.M. Neuroprotective effects of TNF binding protein in focal cerebral ischemia. Brain Res. 778 (1997) 265-271
34. Park E., Liu Y., and Fehlings M.G. Changes in glial cell white matter AMPA receptor expression after spinal cord injury and relationship to apoptotic cell death. Exp. Neurol. 182 (2003) 35-48
35. Poloni M., Facchetti D., Mai R., Micheli A., Agnoletti L., Francolini G., Mora G., Camana C., Mazzini L., and Bachetti T. Circulating levels of tumour necrosis factor-alpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis. Neurosci. Lett. 287 (2000) 211-214
36. Raoul C., Estevez A.G., Nishimune H., Cleveland D.W., deLapeyriere O., Henderson C.E., Haase G., and Pettmann B. Motor neuron death triggered by a specific pathway downstream of Fas. Potentiation by ALS-linked SOD1 mutations. Neuron 35 (2002) 1067-1083
37. Rathke-Hartlieb S., Schmidt V.C., Jockusch H., Schmitt-John T., and Bartsch J.W. Spatiotemporal progression of neurodegeneration and glia activation in the wobbler neuropathy of the mouse. NeuroReport 10 (1999) 3411-3416
38. Rosen D.R. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 364 (1993) 362
39. Schlomann U., Rathke-Hartlieb S., Yamamoto S., Jockusch H., and Bartsch J.W. Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): implications for neuron-glia interactions during neurodegeneration. J. Neurosci. 20 (2000) 7964-7971
40. Schmitt-John T., Drepper C., Mussmann A., Hahn P., Kuhlmann M., Thiel C., Hafner M., Lengeling A., Heimann P., Jones J.M., Meisler M.H., and Jockusch H. Mutation of Vps54 causes motor neuron disease and defective spermiogenesis in the wobbler mouse. Nat. Genet. 37 (2005) 1213-1215
41. Shohami E., Bass R., Wallach D., Yamin A., and Gallily R. Inhibition of tumor necrosis factor alpha (TNFalpha) activity in rat brain is associated with cerebroprotection after closed head injury. J. Cereb. Blood Flow Metab. 16 (1996) 378-384
42. Sluss H.K., Barrett T., Derijard B., and Davis R.J. Signal transduction by tumor necrosis factor mediated by JNK protein kinases. Mol. Cell. Biol. 14 (1994) 8376-8384
43. Terrado J., Monnier D., Perrelet D., Vesin D., Jemelin S., Buurman W.A., Mattenberger L., King B., Kato A.C., and Garcia I. Soluble TNF receptors partially protect injured motor neurons in the postnatal CNS. Eur. J. Neurosci. 12 (2000) 3443-3447
44. Veglianese P., Lo Coco D., Bao Cutrona M., Magnoni R., Pennacchini D., Pozzi B., Gowing G., Julien J.P., Tortarolo M., and Bendotti C. Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS. Mol. Cell. Neurosci. 31 (2006) 218-231
45. Wessig J., Brecht S., Claussen M., Roemer L., Goetz M., Bigini P., Schutze S., and Herdegen T. Tumor necrosis factor-alpha receptor 1 (p55) knockout only transiently decreases the activation of c-Jun and does not affect the survival of axotomized dopaminergic nigral neurons. Eur. J. Neurosci. 22 (2005) 267-272
46. Woo M.S., Jang P.G., Park J.S., Kim W.K., Joh T.H., and Kim H.S. Selective modulation of lipopolysaccharide-stimulated cytokine expression and mitogen-activated protein kinase pathways by dibutyryl-cAMP in BV2 microglial cells. Brain Res. Mol. Brain Res. 113 (2003) 86-96