Afobazole modulates microglial function via activation of both σ-1 and σ-2 receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 339, Issue 1, 2011, Pages 161-172

  Cuevas, Javier ^a   Rodriguez, Alex ^a   Behensky, Adam ^a   Katnik, Chris ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (3,4 DICHLOROPHENYL)ETHYL] 4 METHYLPIPERAZINE; 2 [4 METHOXY 3 (2 PHENYLETHOXY)PHENYL] N,N DIPROPYLETHYLAMINE; ADENOSINE TRIPHOSPHATE; AFOBAZOLE; BD 1063; CALCIUM ION; METAPHIT; N [2 (3,4 DICHLOROPHENYL)ETHYL] 2 DIMETHYLAMINO N METHYLETHYLAMINE; NEUROPROTECTIVE AGENT; PIPERAZINE DERIVATIVE; PURINERGIC P2X RECEPTOR; PURINERGIC P2Y RECEPTOR; RIMCAZOLE; SIGMA 1 OPIATE RECEPTOR; SIGMA 2 OPIATE RECEPTOR; SM 21; TROPANYL 2 (4 CHLOROPHENOXY)BUTANOATE MALEATE; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE;

ANIMAL CELL; ARTICLE; BRAIN ISCHEMIA; CALCIUM CELL LEVEL; CELL DEATH; CELL MIGRATION; CELL PROTECTION; CELL SURVIVAL; CHEMOTAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; IN VITRO STUDY; MEMBRANE CURRENT; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTI-ANXIETY AGENTS; BENZIMIDAZOLES; BRAIN ISCHEMIA; BUTYRATES; CALCIUM; CELL DEATH; CELL SURVIVAL; ETHYLENEDIAMINES; FEMALE; MEMBRANE POTENTIALS; MICROGLIA; MORPHOLINES; PATCH-CLAMP TECHNIQUES; PIPERAZINES; PREGNANCY; PURINERGIC P2X RECEPTOR ANTAGONISTS; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SIGMA; TROPANES; URIDINE TRIPHOSPHATE;

EID: 80053136199     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.182816     Document Type: Article

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