메뉴 건너뛰기




Volumn 162, Issue 1, 2009, Pages 31-38

Selective sigma receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons

Author keywords

excitotoxicity; motoneuron; neurite elongation; neuroprotection; organotypic culture; spinal cord injury

Indexed keywords

1 PHENYLCYCLOHEXANECARBOXYLIC ACID 2 MORPHOLINOETHYL ESTER; CHELERYTHRINE; GLUTAMIC ACID; OPIATE AGONIST; OPIATE ANTAGONIST; PROTEIN KINASE C; SIGMA OPIATE RECEPTOR;

EID: 67349112448     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2009.03.067     Document Type: Article
Times cited : (53)

References (49)
  • 2
    • 0034034280 scopus 로고    scopus 로고
    • Immunocytochemical localization of the sigma (1) receptor in the adult rat central nervous system
    • Alonso G., Phan V., Guillemain I., Saunier M., Legrand A., Anoal M., and Maurice T. Immunocytochemical localization of the sigma (1) receptor in the adult rat central nervous system. Neuroscience 97 (2000) 155-170
    • (2000) Neuroscience , vol.97 , pp. 155-170
    • Alonso, G.1    Phan, V.2    Guillemain, I.3    Saunier, M.4    Legrand, A.5    Anoal, M.6    Maurice, T.7
  • 3
    • 0037171847 scopus 로고    scopus 로고
    • The sigma receptor as a ligand-regulated auxiliary potassium channel subunit
    • Aydar E., Palmer C.P., Klyachko V.A., and Jackson M.B. The sigma receptor as a ligand-regulated auxiliary potassium channel subunit. Neuron 34 (2002) 399-410
    • (2002) Neuron , vol.34 , pp. 399-410
    • Aydar, E.1    Palmer, C.P.2    Klyachko, V.A.3    Jackson, M.B.4
  • 4
    • 19444365374 scopus 로고    scopus 로고
    • Motoneuron loss associated with chronic locomotion impairments after spinal cord contusion in the rat
    • Collazos-Castro J.E., Soto V.M., Gutierrez-Davila M., and Nieto-Sampedro M. Motoneuron loss associated with chronic locomotion impairments after spinal cord contusion in the rat. J Neurotrauma 22 (2005) 544-558
    • (2005) J Neurotrauma , vol.22 , pp. 544-558
    • Collazos-Castro, J.E.1    Soto, V.M.2    Gutierrez-Davila, M.3    Nieto-Sampedro, M.4
  • 5
    • 33644835931 scopus 로고    scopus 로고
    • Conventional protein kinase C isoforms mediate neuroprotection induced by phorbol ester and estrogen
    • Cordey M., and Pike C.J. Conventional protein kinase C isoforms mediate neuroprotection induced by phorbol ester and estrogen. J Neurochem 96 (2006) 204-217
    • (2006) J Neurochem , vol.96 , pp. 204-217
    • Cordey, M.1    Pike, C.J.2
  • 6
    • 0028967328 scopus 로고
    • Sigma receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal cultures
    • DeCoster M.A., Klette K.L., Knight E.S., and Tortella F.C. Sigma receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal cultures. Brain Res 671 (1995) 45-53
    • (1995) Brain Res , vol.671 , pp. 45-53
    • DeCoster, M.A.1    Klette, K.L.2    Knight, E.S.3    Tortella, F.C.4
  • 7
    • 33744929368 scopus 로고    scopus 로고
    • Optimizing neurotrophic factor combinations for neurite outgrowth
    • Deister C., and Schmidt C.E. Optimizing neurotrophic factor combinations for neurite outgrowth. J Neural Eng 3 (2006) 172-179
    • (2006) J Neural Eng , vol.3 , pp. 172-179
    • Deister, C.1    Schmidt, C.E.2
  • 8
    • 0027478471 scopus 로고
    • Inhibitors of protein kinase C prevent the toxicity of glutamate in primary neuronal cultures
    • Felipo V., Minana M.D., and Grisolia S. Inhibitors of protein kinase C prevent the toxicity of glutamate in primary neuronal cultures. Brain Res 609 (1993) 192-196
    • (1993) Brain Res , vol.609 , pp. 192-196
    • Felipo, V.1    Minana, M.D.2    Grisolia, S.3
  • 9
    • 33747784580 scopus 로고    scopus 로고
    • Differential motor and electrophysiological outcome in rats with mid-thoracic or high lumbar incomplete spinal cord injuries
    • Garcia-Alias G., Valero-Cabre A., Lopez-Vales R., Fores J., Verdu E., and Navarro X. Differential motor and electrophysiological outcome in rats with mid-thoracic or high lumbar incomplete spinal cord injuries. Brain Res 1108 (2006) 195-204
    • (2006) Brain Res , vol.1108 , pp. 195-204
    • Garcia-Alias, G.1    Valero-Cabre, A.2    Lopez-Vales, R.3    Fores, J.4    Verdu, E.5    Navarro, X.6
  • 10
    • 0025376090 scopus 로고
    • A stable double-stranded DNA-ethidium homodimer complex: application to picogram fluorescence detection of DNA in agarose gels
    • Glazer A.N., Peck K., and Mathies R.A. A stable double-stranded DNA-ethidium homodimer complex: application to picogram fluorescence detection of DNA in agarose gels. Proc Natl Acad Sci U S A 87 (1990) 3851-3855
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 3851-3855
    • Glazer, A.N.1    Peck, K.2    Mathies, R.A.3
  • 11
    • 0037302002 scopus 로고    scopus 로고
    • Potent sigma 1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine provides ischemic neuroprotection without altering dopamine accumulation in vivo in rats
    • table of contents
    • Goyagi T., Bhardwaj A., Koehler R.C., Traystman R.J., Hurn P.D., and Kirsch J.R. Potent sigma 1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine provides ischemic neuroprotection without altering dopamine accumulation in vivo in rats. Anesth Analg 96 (2003) 532-538 table of contents
    • (2003) Anesth Analg , vol.96 , pp. 532-538
    • Goyagi, T.1    Bhardwaj, A.2    Koehler, R.C.3    Traystman, R.J.4    Hurn, P.D.5    Kirsch, J.R.6
  • 12
    • 0034930737 scopus 로고    scopus 로고
    • Neuroprotective effect of sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production
    • Goyagi T., Goto S., Bhardwaj A., Dawson V.L., Hurn P.D., and Kirsch J.R. Neuroprotective effect of sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production. Stroke 32 (2001) 1613-1620
    • (2001) Stroke , vol.32 , pp. 1613-1620
    • Goyagi, T.1    Goto, S.2    Bhardwaj, A.3    Dawson, V.L.4    Hurn, P.D.5    Kirsch, J.R.6
  • 13
    • 47249145512 scopus 로고    scopus 로고
    • Analysis of FK506-mediated protection in an organotypic model of spinal cord damage: Heat shock protein 70 levels are modulated in microglial cells
    • Guzman-Lenis M.S., Vallejo C., Navarro X., and Casas C. Analysis of FK506-mediated protection in an organotypic model of spinal cord damage: Heat shock protein 70 levels are modulated in microglial cells. Neuroscience 155 (2008) 104-113
    • (2008) Neuroscience , vol.155 , pp. 104-113
    • Guzman-Lenis, M.S.1    Vallejo, C.2    Navarro, X.3    Casas, C.4
  • 14
    • 1942472491 scopus 로고    scopus 로고
    • Neuroprotective effects of resveratrol against beta-amyloid-induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C
    • Han Y.S., Zheng W.H., Bastianetto S., Chabot J.G., and Quirion R. Neuroprotective effects of resveratrol against beta-amyloid-induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C. Br J Pharmacol 141 (2004) 997-1005
    • (2004) Br J Pharmacol , vol.141 , pp. 997-1005
    • Han, Y.S.1    Zheng, W.H.2    Bastianetto, S.3    Chabot, J.G.4    Quirion, R.5
  • 15
  • 17
    • 0034085467 scopus 로고    scopus 로고
    • Ca(2+) signaling via sigma(1)-receptors: novel regulatory mechanism affecting intracellular Ca(2+) concentration
    • Hayashi T., Maurice T., and Su T.P. Ca(2+) signaling via sigma(1)-receptors: novel regulatory mechanism affecting intracellular Ca(2+) concentration. J Pharmacol Exp Ther 293 (2000) 788-798
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 788-798
    • Hayashi, T.1    Maurice, T.2    Su, T.P.3
  • 18
    • 35549006797 scopus 로고    scopus 로고
    • Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival
    • Hayashi T., and Su T.P. Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival. Cell 131 (2007) 596-610
    • (2007) Cell , vol.131 , pp. 596-610
    • Hayashi, T.1    Su, T.P.2
  • 19
    • 0035895206 scopus 로고    scopus 로고
    • Regulating ankyrin dynamics: roles of sigma-1 receptors
    • Hayashi T., and Su T.P. Regulating ankyrin dynamics: roles of sigma-1 receptors. Proc Natl Acad Sci U S A 98 (2001) 491-496
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 491-496
    • Hayashi, T.1    Su, T.P.2
  • 20
    • 4744358688 scopus 로고    scopus 로고
    • Modulation of bradykinin-induced calcium changes in SH-SY5Y cells by neurosteroids and sigma receptor ligands via a shared mechanism
    • Hong W., Nuwayhid S.J., and Werling L.L. Modulation of bradykinin-induced calcium changes in SH-SY5Y cells by neurosteroids and sigma receptor ligands via a shared mechanism. Synapse 54 (2004) 102-110
    • (2004) Synapse , vol.54 , pp. 102-110
    • Hong, W.1    Nuwayhid, S.J.2    Werling, L.L.3
  • 21
    • 20044393676 scopus 로고    scopus 로고
    • Activation of protein kinase C-delta attenuates kainate-induced cell death of cortical neurons
    • Jung Y.S., Lee B.K., Park H.S., Shim J.K., Kim S.U., Lee S.H., Baik E.J., and Moon C.H. Activation of protein kinase C-delta attenuates kainate-induced cell death of cortical neurons. Neuroreport 16 (2005) 741-744
    • (2005) Neuroreport , vol.16 , pp. 741-744
    • Jung, Y.S.1    Lee, B.K.2    Park, H.S.3    Shim, J.K.4    Kim, S.U.5    Lee, S.H.6    Baik, E.J.7    Moon, C.H.8
  • 22
    • 0030903679 scopus 로고    scopus 로고
    • Neuroprotective sigma ligands attenuate NMDA and trans-ACPD-induced calcium signaling in rat primary neurons
    • Klette K.L., Lin Y., Clapp L.E., DeCoster M.A., Moreton J.E., and Tortella F.C. Neuroprotective sigma ligands attenuate NMDA and trans-ACPD-induced calcium signaling in rat primary neurons. Brain Res 756 (1997) 231-240
    • (1997) Brain Res , vol.756 , pp. 231-240
    • Klette, K.L.1    Lin, Y.2    Clapp, L.E.3    DeCoster, M.A.4    Moreton, J.E.5    Tortella, F.C.6
  • 23
    • 17444409625 scopus 로고    scopus 로고
    • Angiopoietin-1 promotes neurite outgrowth from dorsal root ganglion cells positive for tie-2 receptor
    • Kosacka J., Figiel M., Engele J., Hilbig H., Majewski M., and Spanel-Borowski K. Angiopoietin-1 promotes neurite outgrowth from dorsal root ganglion cells positive for tie-2 receptor. Cell Tissue Res 320 (2005) 11-19
    • (2005) Cell Tissue Res , vol.320 , pp. 11-19
    • Kosacka, J.1    Figiel, M.2    Engele, J.3    Hilbig, H.4    Majewski, M.5    Spanel-Borowski, K.6
  • 24
    • 0027221998 scopus 로고
    • NMDA-dependent superoxide production and neurotoxicity
    • Lafon-Cazal M., Pietri S., Culcasi M., and Bockaert J. NMDA-dependent superoxide production and neurotoxicity. Nature 364 (1993) 535-537
    • (1993) Nature , vol.364 , pp. 535-537
    • Lafon-Cazal, M.1    Pietri, S.2    Culcasi, M.3    Bockaert, J.4
  • 25
    • 0028762647 scopus 로고
    • Excitatory amino acids as a final common pathway for neurologic disorders
    • Lipton S.A., and Rosenberg P.A. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 330 (1994) 613-622
    • (1994) N Engl J Med , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 26
    • 0025907224 scopus 로고
    • Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord
    • Liu D., Thangnipon W., and McAdoo D.J. Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord. Brain Res 547 (1991) 344-348
    • (1991) Brain Res , vol.547 , pp. 344-348
    • Liu, D.1    Thangnipon, W.2    McAdoo, D.J.3
  • 27
    • 0034662011 scopus 로고    scopus 로고
    • Advances in secondary spinal cord injury: role of apoptosis
    • Lu J., Ashwell K.W., and Waite P. Advances in secondary spinal cord injury: role of apoptosis. Spine 25 (2000) 1859-1866
    • (2000) Spine , vol.25 , pp. 1859-1866
    • Lu, J.1    Ashwell, K.W.2    Waite, P.3
  • 28
    • 0032848944 scopus 로고    scopus 로고
    • Changes in amino acid concentrations over time and space around an impact injury and their diffusion through the rat spinal cord
    • McAdoo D.J., Xu G.Y., Robak G., and Hughes M.G. Changes in amino acid concentrations over time and space around an impact injury and their diffusion through the rat spinal cord. Exp Neurol 159 (1999) 538-544
    • (1999) Exp Neurol , vol.159 , pp. 538-544
    • McAdoo, D.J.1    Xu, G.Y.2    Robak, G.3    Hughes, M.G.4
  • 29
    • 0025714123 scopus 로고
    • Haloperidol-sensitive (+) [3H]SKF-10,047 binding sites (sigma sites) exhibit a unique distribution in rat brain subcellular fractions
    • McCann D.J., and Su T.P. Haloperidol-sensitive (+) [3H]SKF-10,047 binding sites (sigma sites) exhibit a unique distribution in rat brain subcellular fractions. Eur J Pharmacol 188 (1990) 211-218
    • (1990) Eur J Pharmacol , vol.188 , pp. 211-218
    • McCann, D.J.1    Su, T.P.2
  • 30
    • 29244470806 scopus 로고    scopus 로고
    • 2+: clinical and therapeutic relevance
    • 2+: clinical and therapeutic relevance. Biol Cell 97 (2005) 873-883
    • (2005) Biol Cell , vol.97 , pp. 873-883
    • Monnet, F.P.1
  • 31
    • 0142148147 scopus 로고    scopus 로고
    • Protein kinase C-dependent potentiation of intracellular calcium influx by sigma1 receptor agonists in rat hippocampal neurons
    • Monnet F.P., Morin-Surun M.P., Leger J., and Combettes L. Protein kinase C-dependent potentiation of intracellular calcium influx by sigma1 receptor agonists in rat hippocampal neurons. J Pharmacol Exp Ther 307 (2003) 705-712
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 705-712
    • Monnet, F.P.1    Morin-Surun, M.P.2    Leger, J.3    Combettes, L.4
  • 32
    • 34249862830 scopus 로고    scopus 로고
    • Rescue of rat anterior horn neurons after spinal cord injury by retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor gene
    • Nakajima H., Uchida K., Kobayashi S., Inukai T., Horiuchi Y., Yayama T., Sato R., and Baba H. Rescue of rat anterior horn neurons after spinal cord injury by retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor gene. J Neurotrauma 24 (2007) 703-712
    • (2007) J Neurotrauma , vol.24 , pp. 703-712
    • Nakajima, H.1    Uchida, K.2    Kobayashi, S.3    Inukai, T.4    Horiuchi, Y.5    Yayama, T.6    Sato, R.7    Baba, H.8
  • 33
    • 49749117054 scopus 로고    scopus 로고
    • Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways
    • Nishimura T., Ishima T., Iyo M., and Hashimoto K. Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways. PLoS ONE 3 (2008) e2558
    • (2008) PLoS ONE , vol.3
    • Nishimura, T.1    Ishima, T.2    Iyo, M.3    Hashimoto, K.4
  • 34
    • 0037207458 scopus 로고    scopus 로고
    • 3H]dopamine release is dependent upon protein kinase C
    • 3H]dopamine release is dependent upon protein kinase C. J Pharmacol Exp Ther 304 (2003) 364-369
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 364-369
    • Nuwayhid, S.J.1    Werling, L.L.2
  • 35
    • 0027274623 scopus 로고
    • Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity
    • Rothstein J.D., Jin L., Dykes-Hoberg M., and Kuncl R.W. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc Natl Acad Sci U S A 90 (1993) 6591-6595
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 6591-6595
    • Rothstein, J.D.1    Jin, L.2    Dykes-Hoberg, M.3    Kuncl, R.W.4
  • 36
    • 0035893632 scopus 로고    scopus 로고
    • Epidemiology, demographics, and pathophysiology of acute spinal cord injury
    • Sekhon L.H., and Fehlings M.G. Epidemiology, demographics, and pathophysiology of acute spinal cord injury. Spine 26 (2001) S2-S12
    • (2001) Spine , vol.26
    • Sekhon, L.H.1    Fehlings, M.G.2
  • 37
    • 0032545727 scopus 로고    scopus 로고
    • Effect of SA4503, a novel sigma1 receptor agonist, against glutamate neurotoxicity in cultured rat retinal neurons
    • Senda T., Mita S., Kaneda K., Kikuchi M., and Akaike A. Effect of SA4503, a novel sigma1 receptor agonist, against glutamate neurotoxicity in cultured rat retinal neurons. Eur J Pharmacol 342 (1998) 105-111
    • (1998) Eur J Pharmacol , vol.342 , pp. 105-111
    • Senda, T.1    Mita, S.2    Kaneda, K.3    Kikuchi, M.4    Akaike, A.5
  • 38
    • 0141426716 scopus 로고    scopus 로고
    • Understanding the molecular mechanism of sigma-1 receptors: towards a hypothesis that sigma-1 receptors are intracellular amplifiers for signal transduction
    • Su T.P., and Hayashi T. Understanding the molecular mechanism of sigma-1 receptors: towards a hypothesis that sigma-1 receptors are intracellular amplifiers for signal transduction. Curr Med Chem 10 (2003) 2073-2080
    • (2003) Curr Med Chem , vol.10 , pp. 2073-2080
    • Su, T.P.1    Hayashi, T.2
  • 39
    • 0029145972 scopus 로고
    • PPBP [4-phenyl-1-(4-phenylbutyl) piperidine], a potent sigma-receptor ligand, decreases brain injury after transient focal ischemia in cats
    • Takahashi H., Kirsch J.R., Hashimoto K., London E.D., Koehler R.C., and Traystman R.J. PPBP [4-phenyl-1-(4-phenylbutyl) piperidine], a potent sigma-receptor ligand, decreases brain injury after transient focal ischemia in cats. Stroke 26 (1995) 1676-1682
    • (1995) Stroke , vol.26 , pp. 1676-1682
    • Takahashi, H.1    Kirsch, J.R.2    Hashimoto, K.3    London, E.D.4    Koehler, R.C.5    Traystman, R.J.6
  • 40
    • 0036894824 scopus 로고    scopus 로고
    • Nerve growth factor-induced neurite sprouting in PC12 cells involves sigma-1 receptors: implications for antidepressants
    • Takebayashi M., Hayashi T., and Su T.P. Nerve growth factor-induced neurite sprouting in PC12 cells involves sigma-1 receptors: implications for antidepressants. J Pharmacol Exp Ther 303 (2002) 1227-1237
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 1227-1237
    • Takebayashi, M.1    Hayashi, T.2    Su, T.P.3
  • 41
    • 47249147955 scopus 로고    scopus 로고
    • Sigma-1 receptors protect RGC-5 cells from apoptosis by regulating intracellular calcium, bax levels, and caspase-3 activation
    • Tchedre K.T., and Yorio T. Sigma-1 receptors protect RGC-5 cells from apoptosis by regulating intracellular calcium, bax levels, and caspase-3 activation. Invest Ophthalmol Vis Sci 49 (2008) 2577-2588
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 2577-2588
    • Tchedre, K.T.1    Yorio, T.2
  • 42
    • 0006495387 scopus 로고    scopus 로고
    • Basic fibroblast growth factor increases long-term survival of spinal motor neurons and improves respiratory function after experimental spinal cord injury
    • Teng Y.D., Mocchetti I., Taveira-DaSilva A.M., Gillis R.A., and Wrathall J.R. Basic fibroblast growth factor increases long-term survival of spinal motor neurons and improves respiratory function after experimental spinal cord injury. J Neurosci 19 (1999) 7037-7047
    • (1999) J Neurosci , vol.19 , pp. 7037-7047
    • Teng, Y.D.1    Mocchetti, I.2    Taveira-DaSilva, A.M.3    Gillis, R.A.4    Wrathall, J.R.5
  • 43
    • 44649161175 scopus 로고    scopus 로고
    • Protein kinase C-mediated protection of motoneurons from excitotoxicity
    • Tomimatsu N., and Arakawa Y. Protein kinase C-mediated protection of motoneurons from excitotoxicity. Neurosci Lett 439 (2008) 143-146
    • (2008) Neurosci Lett , vol.439 , pp. 143-146
    • Tomimatsu, N.1    Arakawa, Y.2
  • 44
    • 0031795392 scopus 로고    scopus 로고
    • Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: involvement of glutamate-induced nitric oxide in motor neuron toxicity and nonmotor neuron protection
    • Urushitani M., Shimohama S., Kihara T., Sawada H., Akaike A., Ibi M., Inoue R., Kitamura Y., Taniguchi T., and Kimura J. Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: involvement of glutamate-induced nitric oxide in motor neuron toxicity and nonmotor neuron protection. Ann Neurol 44 (1998) 796-807
    • (1998) Ann Neurol , vol.44 , pp. 796-807
    • Urushitani, M.1    Shimohama, S.2    Kihara, T.3    Sawada, H.4    Akaike, A.5    Ibi, M.6    Inoue, R.7    Kitamura, Y.8    Taniguchi, T.9    Kimura, J.10
  • 45
    • 0036151857 scopus 로고    scopus 로고
    • Neuroprotection and neurodegenerative disease
    • Vajda F.J. Neuroprotection and neurodegenerative disease. J Clin Neurosci 9 (2002) 4-8
    • (2002) J Clin Neurosci , vol.9 , pp. 4-8
    • Vajda, F.J.1
  • 46
    • 0034889654 scopus 로고    scopus 로고
    • Modulation of NMDA-mediated excitotoxicity by protein kinase C
    • Wagey R., Hu J., Pelech S.L., Raymond L.A., and Krieger C. Modulation of NMDA-mediated excitotoxicity by protein kinase C. J Neurochem 78 (2001) 715-726
    • (2001) J Neurochem , vol.78 , pp. 715-726
    • Wagey, R.1    Hu, J.2    Pelech, S.L.3    Raymond, L.A.4    Krieger, C.5
  • 47
    • 0033979856 scopus 로고    scopus 로고
    • Cyclic GMP/cyclic GMP-dependent protein kinase system prevents excitotoxicity in an immortalized oligodendroglial cell line
    • Yoshioka A., Yamaya Y., Saiki S., Kanemoto M., Hirose G., and Pleasure D. Cyclic GMP/cyclic GMP-dependent protein kinase system prevents excitotoxicity in an immortalized oligodendroglial cell line. J Neurochem 74 (2000) 633-640
    • (2000) J Neurochem , vol.74 , pp. 633-640
    • Yoshioka, A.1    Yamaya, Y.2    Saiki, S.3    Kanemoto, M.4    Hirose, G.5    Pleasure, D.6
  • 48
    • 0034737435 scopus 로고    scopus 로고
    • Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C
    • Yu R., Mandlekar S., Tan T.H., and Kong A.N. Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. J Biol Chem 275 (2000) 9612-9619
    • (2000) J Biol Chem , vol.275 , pp. 9612-9619
    • Yu, R.1    Mandlekar, S.2    Tan, T.H.3    Kong, A.N.4
  • 49
    • 0036172694 scopus 로고    scopus 로고
    • Suppressive effects of phosphodiesterase type IV inhibitors on rat cultured microglial cells: comparison with other types of cAMP-elevating agents
    • Zhang B., Yang L., Konishi Y., Maeda N., Sakanaka M., and Tanaka J. Suppressive effects of phosphodiesterase type IV inhibitors on rat cultured microglial cells: comparison with other types of cAMP-elevating agents. Neuropharmacology 42 (2002) 262-269
    • (2002) Neuropharmacology , vol.42 , pp. 262-269
    • Zhang, B.1    Yang, L.2    Konishi, Y.3    Maeda, N.4    Sakanaka, M.5    Tanaka, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.