A small molecule screen identifies selective inhibitors of urea transporter UT-A

Chemistry and Biology

Volumn 20, Issue 10, 2013, Pages 1235-1244

  Esteva Font, Cristina ^a   Phuan, Puay Wah ^a   Anderson, Marc O ^b   Verkman, A S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 QUINOLINOL DERIVATIVE; [1,3,5]TRIAZINE DERIVATIVE; AMINOTHIAZOLONE DERIVATIVE; AQUAPORIN 1; CARRIER PROTEIN; DIURETIC AGENT; PROTEIN INHIBITOR; TRIAZOLOTHIENOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UREA TRANSPORTER A; UREA TRANSPORTER A INHIBITOR; UREA TRANSPORTER A1; UREA TRANSPORTER B; UREA TRANSPORTER B INHIBITOR;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL SHRINKAGE; CELL SWELLING; CONTROLLED STUDY; DIURETIC ACTIVITY; DRUG BINDING SITE; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; FLUORESCENCE ANALYSIS; HIGH THROUGHPUT SCREENING; IC 50; ION TRANSPORT; KIDNEY TUBULE EPITHELIUM; MDCK CELL; MOLECULAR DOCKING; MOLECULAR LIBRARY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; TRANSPORT KINETICS; UREA TRANSPORT;

ANIMALS; BINDING SITES; DOGS; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; MADIN DARBY CANINE KIDNEY CELLS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR DOCKING SIMULATION; PROTEIN CONFORMATION; RATS; REPRODUCIBILITY OF RESULTS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84886795054     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2013.08.005     Document Type: Article

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