Critical role of urea in the urine-concentrating mechanism

Journal of the American Society of Nephrology

Volumn 18, Issue 3, 2007, Pages 670-671

  Sands, Jeff M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; UNCLASSIFIED DRUG; UREA; UREA TRANSPORTER A1; UREA TRANSPORTER A2; UREA TRANSPORTER A3; UREA TRSNSPORTER B;

DIURESIS; EDITORIAL; FLUID INTAKE; HUMAN; KIDNEY FUNCTION; KIDNEY MEDULLA; KIDNEY TUBULE ABSORPTION; NONHUMAN; PLASMA OSMOLALITY; PRIORITY JOURNAL; SIMULATION;

EID: 33947228754     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2006121314     Document Type: Editorial

References (24)

1. Kokko JP, Rector FC: Countercurrent multiplication system without active transport in inner medulla. Kidney Int 2: 214-223, 1972
2. Stephenson JL: Concentration of urine in a central core model of the renal counterflow system. Kidney Int 2: 85-94, 1972
3. Pennell JP, Sanjana V, Frey NR, Jamison RL: The effect of urea infusion on the urinary concentrating mechanism in protein-depleted rats. J Clin Invest 55: 399-409, 1975
4. Gamble JL, McKhann CF, Butler AM, Tuthill E: An economy of water in renal function referable to urea. Am J Physiol 109: 139-154, 1934
5. Crawford JD, Doyle AP, Probst H: Service of urea in renal water conservation. Am J Physiol 196: 545-548, 1959
6. Levinsky NG, Berliner RW: The role of urea in the urine concentrating mechanism. J Clin Invest 38: 741-748, 1959
7. Peil AE, Stolte H, Schmidt-Nielsen B: Uncoupling of glomerular and tubular regulations of urea excretion in rat. Am J Physiol Renal Physiol 258: F1666-F1674, 1990
8. Epstein FH, Kleeman CR, Pursel S, Hendrikx A: The effect of feeding protein and urea on the renal concentrating process. J Clin Invest 36: 635-641, 1957
9. Klahr S, Alleyne GAO: Effects of chronic protein-calorie malnutrition on the kidney. Kidney Int 3: 129-141, 1973
10. Hendrikx A, Epstein FH: Effect of feeding protein and urea on renal concentrating ability in the rat. Am J Physiol 195: 539-542, 1958
11. Sands JM: Molecular approaches to urea transporters. J Am Soc Nephrol 13: 2795-2806, 2002
12. Sands JM: Renal urea transporters. Curr Opin Nephrol Hypertens 13: 525-532, 2004
13. Fenton RA, Knepper MA: Urea and renal function in the 21st century: Insights from knockout mice. J Am Soc Nephrol 18: 679-688, 2007
14. Fenton RA, Chou C-L, Stewart GS, Smith CP, Knepper MA: Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct. Proc Natl Acad Sci USA 101: 7469-7474, 2004
15. Fenton RA, Flynn A, Shodeinde A, Smith CP, Schnermann J, Knepper MA: Renal phenotype of UT-A urea transporter knockout mice. J Am Soc Nephrol 16: 1583-1592, 2005
16. Uchida S, Sohara E, Rai T, Ikawa M, Okabe M, Sasaki S: Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2. Mol Cell Biol 25: 7357-7363, 2005
17. Yang B, Bankir L, Gillespie A, Epstein CJ, Verkman AS: Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B. J Biol Chem 277: 10633-10637, 2002
18. Yang B, Verkman AS: Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. J Biol Chem 277: 36782-36786, 2002
19. Klein JD, Sands JM, Qian L, Wang X, Yang B: Upregulation of urea transporter UT-A2 and water channels AQP2 and AQP3 in mice lacking urea transporter UT-B. J Am Soc Nephrol 15: 1161-1167, 2004
20. Berliner RW, Levinsky NG, Davidson DG, Eden M: Dilution and concentration of the urine and the action of antidiuretic hormone. Am J Med 24: 730-744, 1958
21. Fenton RA, Chou CL, Sowersby H, Smith CP, Knepper MA: Gamble's "economy of water" revisited: Studies in urea transporter knockout mice. Am J Physiol Renal Physiol 291: F148-F154, 2006
22. Layton AT, Pannabecker TL, Dantzler WH, Layton HE: Two modes for concentrating urine in rat inner medulla. Am J Physiol Renal Physiol 287: F816-F839, 2004
23. Pannabecker TL, Dantzler WH: Three-dimensional lateral and vertical relationships of inner medullary loops of Henle and collecting ducts. Am J Physiol Renal Physiol 287: F767-F774, 2004
24. Pannabecker TL, Abbott DE, Dantzler WH: Three-dimensional functional reconstruction of inner medullary thin limbs of Henle's loop. Am J Physiol Renal Physiol 286: F38-F45, 2004