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Volumn 29, Issue 3, 2009, Pages 178-195

The Physiology of Urinary Concentration: An Update

Author keywords

aquaporin; mathematical modelling; sodium transport; urea transport; urine concentrating mechanism; Vasopressin

Indexed keywords

AQUAPORIN; CARRIER PROTEIN; SODIUM; UREA; VASOPRESSIN;

EID: 66749192123     PISSN: 02709295     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semnephrol.2009.03.008     Document Type: Article
Times cited : (169)

References (118)
  • 1
    • 84882890312 scopus 로고    scopus 로고
    • The urine concentrating mechanism and urea transporters
    • Alpern R.J., and Hebert S.C. (Eds), Academic Press, San Diego
    • Sands J.M., and Layton H.E. The urine concentrating mechanism and urea transporters. In: Alpern R.J., and Hebert S.C. (Eds). The kidney: physiology and pathophysiology (2008), Academic Press, San Diego 1143-1178
    • (2008) The kidney: physiology and pathophysiology , pp. 1143-1178
    • Sands, J.M.1    Layton, H.E.2
  • 2
    • 0013338801 scopus 로고
    • Urinary concentrating and diluting processes
    • Andreoli T.E., Hoffman J.F., Fanestil D.D., and Schultz S.G. (Eds), Plenum, New York
    • Knepper M.A., and Stephenson J.L. Urinary concentrating and diluting processes. In: Andreoli T.E., Hoffman J.F., Fanestil D.D., and Schultz S.G. (Eds). Physiology of membrane disorders (1986), Plenum, New York 713-726
    • (1986) Physiology of membrane disorders , pp. 713-726
    • Knepper, M.A.1    Stephenson, J.L.2
  • 3
    • 0014458406 scopus 로고
    • The time-course of changes in renal tissue composition during lysine vasopressin infusion in the rat
    • Hai M.A., and Thomas S. The time-course of changes in renal tissue composition during lysine vasopressin infusion in the rat. Pflugers Arch 310 (1969) 297-319
    • (1969) Pflugers Arch , vol.310 , pp. 297-319
    • Hai, M.A.1    Thomas, S.2
  • 4
    • 0020051845 scopus 로고
    • Measurement of osmolality in kidney slices using vapor pressure osmometry
    • Knepper M.A. Measurement of osmolality in kidney slices using vapor pressure osmometry. Kidney Int 21 (1982) 653-655
    • (1982) Kidney Int , vol.21 , pp. 653-655
    • Knepper, M.A.1
  • 5
    • 57349191140 scopus 로고    scopus 로고
    • Role of three-dimensional architecture in the urine concentrating mechanism of the rat renal inner medulla
    • Pannabecker T.L., Dantzler W.H., Layton H.E., and Layton A.T. Role of three-dimensional architecture in the urine concentrating mechanism of the rat renal inner medulla. Am J Physiol Renal Physiol 295 (2008) F1271-F1285
    • (2008) Am J Physiol Renal Physiol , vol.295
    • Pannabecker, T.L.1    Dantzler, W.H.2    Layton, H.E.3    Layton, A.T.4
  • 6
    • 0014159349 scopus 로고
    • Der architektonische und funktionelle Aufbau der Rattenniere
    • Kriz W. Der architektonische und funktionelle Aufbau der Rattenniere. Z Zellforsch 82 (1967) 495-535
    • (1967) Z Zellforsch , vol.82 , pp. 495-535
    • Kriz, W.1
  • 7
    • 0015406331 scopus 로고
    • Countercurrent multiplication system without active transport in inner medulla
    • Kokko J.P., and Rector F.C. Countercurrent multiplication system without active transport in inner medulla. Kidney Int 2 (1972) 214-223
    • (1972) Kidney Int , vol.2 , pp. 214-223
    • Kokko, J.P.1    Rector, F.C.2
  • 8
    • 0015385254 scopus 로고
    • Concentration of urine in a central core model of the renal counterflow system
    • Stephenson J.L. Concentration of urine in a central core model of the renal counterflow system. Kidney Int 2 (1972) 85-94
    • (1972) Kidney Int , vol.2 , pp. 85-94
    • Stephenson, J.L.1
  • 11
    • 84914913501 scopus 로고
    • Herstellung Konzentrierrter Lösungen aus Verdünnten Durch Blosse Membranwirkung: Ein Modellversuch zur Funktion der Niere
    • Kuhn W., and Ryffel K. Herstellung Konzentrierrter Lösungen aus Verdünnten Durch Blosse Membranwirkung: Ein Modellversuch zur Funktion der Niere. Hoppe-Seylers Z Physiol Chem 276 (1942) 145-178
    • (1942) Hoppe-Seylers Z Physiol Chem , vol.276 , pp. 145-178
    • Kuhn, W.1    Ryffel, K.2
  • 12
    • 0000117105 scopus 로고
    • Micropuncture study of the mammalian urinary concentrating mechanism: evidence for the countercurrent hypothesis
    • Gottschalk C.W., and Mylle M. Micropuncture study of the mammalian urinary concentrating mechanism: evidence for the countercurrent hypothesis. Am J Physiol 196 (1959) 927-936
    • (1959) Am J Physiol , vol.196 , pp. 927-936
    • Gottschalk, C.W.1    Mylle, M.2
  • 13
    • 0015589991 scopus 로고
    • Sodium chloride and water transport in the medullary thick ascending limb of Henle. Evidence for active chloride transport
    • Rocha A.S., and Kokko J.P. Sodium chloride and water transport in the medullary thick ascending limb of Henle. Evidence for active chloride transport. J Clin Invest 52 (1973) 612-623
    • (1973) J Clin Invest , vol.52 , pp. 612-623
    • Rocha, A.S.1    Kokko, J.P.2
  • 16
    • 0027469925 scopus 로고
    • Urinary concentrating mechanism: the role of the inner medulla
    • Chou C.-L., Knepper M.A., and Layton H.E. Urinary concentrating mechanism: the role of the inner medulla. Semin Nephrol 13 (1993) 168-181
    • (1993) Semin Nephrol , vol.13 , pp. 168-181
    • Chou, C.-L.1    Knepper, M.A.2    Layton, H.E.3
  • 17
    • 2442555092 scopus 로고    scopus 로고
    • Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct
    • Fenton R.A., Chou C.-L., Stewart G.S., Smith C.P., and Knepper M.A. Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct. Proc Natl Acad Sci U S A 101 (2004) 7469-7474
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 7469-7474
    • Fenton, R.A.1    Chou, C.-L.2    Stewart, G.S.3    Smith, C.P.4    Knepper, M.A.5
  • 18
    • 0030020602 scopus 로고    scopus 로고
    • Permeability criteria for effective function of passive countercurrent multiplier
    • Layton H.E., Knepper M.A., and Chou C.-L. Permeability criteria for effective function of passive countercurrent multiplier. Am J Physiol Renal Physiol 270 (1996) F9-F20
    • (1996) Am J Physiol Renal Physiol , vol.270
    • Layton, H.E.1    Knepper, M.A.2    Chou, C.-L.3
  • 19
    • 0018941574 scopus 로고
    • How descending limb of Henle's loop permeability affects hypertonic urine formation
    • Moore L.C., and Marsh D.J. How descending limb of Henle's loop permeability affects hypertonic urine formation. Am J Physiol Renal Physiol 239 (1980) F57-F71
    • (1980) Am J Physiol Renal Physiol , vol.239
    • Moore, L.C.1    Marsh, D.J.2
  • 20
    • 0023492615 scopus 로고
    • Passive, one-dimensional countercurrent models do not simulate hypertonic urine formation
    • Wexler A.S., Kalaba R.E., and Marsh D.J. Passive, one-dimensional countercurrent models do not simulate hypertonic urine formation. Am J Physiol Renal Physiol 253 (1987) F1020-F1030
    • (1987) Am J Physiol Renal Physiol , vol.253
    • Wexler, A.S.1    Kalaba, R.E.2    Marsh, D.J.3
  • 21
    • 0025825310 scopus 로고
    • Three-dimensional anatomy and renal concentrating mechanism. I. Modelling results
    • Wexler A.S., Kalaba R.E., and Marsh D.J. Three-dimensional anatomy and renal concentrating mechanism. I. Modelling results. Am J Physiol Renal Physiol 260 (1991) F368-F383
    • (1991) Am J Physiol Renal Physiol , vol.260
    • Wexler, A.S.1    Kalaba, R.E.2    Marsh, D.J.3
  • 22
    • 0027355911 scopus 로고
    • How is urine concentrated by the renal inner medulla?
    • Knepper M.A., Chou C.-L., and Layton H.E. How is urine concentrated by the renal inner medulla?. Contrib Nephrol 102 (1993) 144-160
    • (1993) Contrib Nephrol , vol.102 , pp. 144-160
    • Knepper, M.A.1    Chou, C.-L.2    Layton, H.E.3
  • 23
    • 0028436302 scopus 로고
    • Externally driven countercurrent multiplication in a mathematical model of the urinary concentrating mechanism of the renal inner medulla
    • Jen J.F., and Stephenson J.L. Externally driven countercurrent multiplication in a mathematical model of the urinary concentrating mechanism of the renal inner medulla. Bull Math Biol 56 (1994) 491-514
    • (1994) Bull Math Biol , vol.56 , pp. 491-514
    • Jen, J.F.1    Stephenson, J.L.2
  • 24
    • 0027511902 scopus 로고
    • In vitro perfusion of chinchilla thin limb segments: urea and NaCl permeabilities
    • Chou C.-L., and Knepper M.A. In vitro perfusion of chinchilla thin limb segments: urea and NaCl permeabilities. Am J Physiol Renal Physiol 264 (1993) F337-F343
    • (1993) Am J Physiol Renal Physiol , vol.264
    • Chou, C.-L.1    Knepper, M.A.2
  • 25
    • 0033825826 scopus 로고    scopus 로고
    • Inner medullary lactate production and accumulation: a vasa recta model
    • Thomas S.R. Inner medullary lactate production and accumulation: a vasa recta model. Am J Physiol Renal Physiol 279 (2000) F468-F481
    • (2000) Am J Physiol Renal Physiol , vol.279
    • Thomas, S.R.1
  • 26
    • 0037216444 scopus 로고    scopus 로고
    • Inner medullary lactate production and urine-concentrating mechanism: a flat medullary model
    • Hervy S., and Thomas S.R. Inner medullary lactate production and urine-concentrating mechanism: a flat medullary model. Am J Physiol Renal Physiol 284 (2003) F65-F81
    • (2003) Am J Physiol Renal Physiol , vol.284
    • Hervy, S.1    Thomas, S.R.2
  • 27
    • 0037369415 scopus 로고    scopus 로고
    • Concentration of solutes in the renal inner medulla: interstitial hyaluronan as a mechano-osmotic transducer
    • Knepper M.A., Saidel G.M., Hascall V.C., and Dwyer T. Concentration of solutes in the renal inner medulla: interstitial hyaluronan as a mechano-osmotic transducer. Am J Physiol Renal Physiol 284 (2003) F433-F446
    • (2003) Am J Physiol Renal Physiol , vol.284
    • Knepper, M.A.1    Saidel, G.M.2    Hascall, V.C.3    Dwyer, T.4
  • 29
    • 0001079340 scopus 로고
    • Das Multiplikationsprinzip als Grundlage der Harnkonzentrierung in der Niere
    • Hargitay B., and Kuhn W. Das Multiplikationsprinzip als Grundlage der Harnkonzentrierung in der Niere. Z Elektrochem 55 (1951) 539-558
    • (1951) Z Elektrochem , vol.55 , pp. 539-558
    • Hargitay, B.1    Kuhn, W.2
  • 30
    • 84984087398 scopus 로고
    • Aktiver Salztransport als moglicher (und wahrscheinlicher) Einzeleffekt bei der Harnkonzentrierung in der Niere
    • Kuhn W., and Ramel A. Aktiver Salztransport als moglicher (und wahrscheinlicher) Einzeleffekt bei der Harnkonzentrierung in der Niere. Helv Chim Acta 42 (1959) 628-660
    • (1959) Helv Chim Acta , vol.42 , pp. 628-660
    • Kuhn, W.1    Ramel, A.2
  • 31
    • 27944459721 scopus 로고    scopus 로고
    • A region-based mathematical model of the urine concentrating mechanism in the rat outer medulla. I. Formulation and base-case results
    • Layton A.T., and Layton H.E. A region-based mathematical model of the urine concentrating mechanism in the rat outer medulla. I. Formulation and base-case results. Am J Physiol Renal Physiol 289 (2005) F1346-F1366
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Layton, A.T.1    Layton, H.E.2
  • 32
    • 27944510246 scopus 로고    scopus 로고
    • A region-based mathematical model of the urine concentrating mechanism in the rat outer medulla. II. Parameter sensitivity and tubular inhomogeneity
    • Layton A.T., and Layton H.E. A region-based mathematical model of the urine concentrating mechanism in the rat outer medulla. II. Parameter sensitivity and tubular inhomogeneity. Am J Physiol Renal Physiol 289 (2005) F1367-F1381
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Layton, A.T.1    Layton, H.E.2
  • 35
    • 0014314374 scopus 로고
    • Permeability of the loop of Henle, vasa recta, and collecting duct to water, urea, and sodium
    • Morgan T., and Berliner R.W. Permeability of the loop of Henle, vasa recta, and collecting duct to water, urea, and sodium. Am J Physiol 215 (1968) 108-115
    • (1968) Am J Physiol , vol.215 , pp. 108-115
    • Morgan, T.1    Berliner, R.W.2
  • 36
    • 0015987508 scopus 로고
    • Sodium, chloride, urea, and water transport in the thin ascending limb of Henle
    • Imai M., and Kokko J.P. Sodium, chloride, urea, and water transport in the thin ascending limb of Henle. J Clin Invest 53 (1974) 393-402
    • (1974) J Clin Invest , vol.53 , pp. 393-402
    • Imai, M.1    Kokko, J.P.2
  • 37
    • 0014864781 scopus 로고
    • Sodium chloride and water transport in the descending limb of Henle
    • Kokko J.P. Sodium chloride and water transport in the descending limb of Henle. J Clin Invest 49 (1970) 1838-1846
    • (1970) J Clin Invest , vol.49 , pp. 1838-1846
    • Kokko, J.P.1
  • 38
    • 0015384086 scopus 로고
    • Urea transport in the proximal tubule and the descending limb of Henle
    • Kokko J.P. Urea transport in the proximal tubule and the descending limb of Henle. J Clin Invest 51 (1972) 1999-2008
    • (1972) J Clin Invest , vol.51 , pp. 1999-2008
    • Kokko, J.P.1
  • 39
    • 0001524618 scopus 로고
    • An economy of water in renal function referable to urea
    • Gamble J.L., McKhann C.F., Butler A.M., and Tuthill E. An economy of water in renal function referable to urea. Am J Physiol 109 (1934) 139-154
    • (1934) Am J Physiol , vol.109 , pp. 139-154
    • Gamble, J.L.1    McKhann, C.F.2    Butler, A.M.3    Tuthill, E.4
  • 40
    • 34347163191 scopus 로고
    • Konzentrierung von Lösungen unterschiedlicher Zusammensetzung durch alleinige Gegenstromdiffusion und Geggenstromosmose als möglicher Mechanismus der Harnkonzentrierung
    • Niesel W., and Röskenbleck H. Konzentrierung von Lösungen unterschiedlicher Zusammensetzung durch alleinige Gegenstromdiffusion und Geggenstromosmose als möglicher Mechanismus der Harnkonzentrierung. Pflugers Arch 283 (1965) 230-241
    • (1965) Pflugers Arch , vol.283 , pp. 230-241
    • Niesel, W.1    Röskenbleck, H.2
  • 41
    • 0027234747 scopus 로고
    • Distributed solute and water reabsorption in a central core model of the renal medulla
    • Layton H.E., and Davies J.M. Distributed solute and water reabsorption in a central core model of the renal medulla. Math Biosci 116 (1993) 169-196
    • (1993) Math Biosci , vol.116 , pp. 169-196
    • Layton, H.E.1    Davies, J.M.2
  • 42
    • 0028435903 scopus 로고
    • The effect of solution non-ideality on membrane transport in three-dimensional models of the renal concentrating mechanism
    • Wang X., Wexler A.S., and Marsh D.J. The effect of solution non-ideality on membrane transport in three-dimensional models of the renal concentrating mechanism. Bull Math Biol 56 (1994) 515-546
    • (1994) Bull Math Biol , vol.56 , pp. 515-546
    • Wang, X.1    Wexler, A.S.2    Marsh, D.J.3
  • 43
    • 0031731240 scopus 로고    scopus 로고
    • Cycles and separations in a model of the renal medulla
    • Thomas S.R. Cycles and separations in a model of the renal medulla. Am J Physiol Renal Physiol 275 (1998) F671-F690
    • (1998) Am J Physiol Renal Physiol , vol.275
    • Thomas, S.R.1
  • 45
    • 0024396698 scopus 로고
    • Electrolyte, urea, and water transport in a two-nephron central core model of the renal medulla
    • Stephenson J.L., Zhang Y., and Tewarson R.P. Electrolyte, urea, and water transport in a two-nephron central core model of the renal medulla. Am J Physiol Renal Physiol 257 (1989) F388-F413
    • (1989) Am J Physiol Renal Physiol , vol.257
    • Stephenson, J.L.1    Zhang, Y.2    Tewarson, R.P.3
  • 46
    • 0029162283 scopus 로고
    • Inner medullary external osmotic driving force in a 3D model of the renal concentrating mechanism
    • Thomas S.R., and Wexler A.S. Inner medullary external osmotic driving force in a 3D model of the renal concentrating mechanism. Am J Physiol Renal Physiol 269 (1995) F159-F171
    • (1995) Am J Physiol Renal Physiol , vol.269
    • Thomas, S.R.1    Wexler, A.S.2
  • 47
    • 4644320202 scopus 로고    scopus 로고
    • Three-dimensional lateral and vertical relationships of inner medullary loops of Henle and collecting ducts
    • Pannabecker T.L., and Dantzler W.H. Three-dimensional lateral and vertical relationships of inner medullary loops of Henle and collecting ducts. Am J Physiol Renal Physiol 287 (2004) F767-F774
    • (2004) Am J Physiol Renal Physiol , vol.287
    • Pannabecker, T.L.1    Dantzler, W.H.2
  • 48
    • 0347990544 scopus 로고    scopus 로고
    • Three-dimensional functional reconstruction of inner medullary thin limbs of Henle's loop
    • Pannabecker T.L., Abbott D.E., and Dantzler W.H. Three-dimensional functional reconstruction of inner medullary thin limbs of Henle's loop. Am J Physiol Renal Physiol 286 (2004) F38-F45
    • (2004) Am J Physiol Renal Physiol , vol.286
    • Pannabecker, T.L.1    Abbott, D.E.2    Dantzler, W.H.3
  • 49
    • 0029035477 scopus 로고
    • The renal concentrating mechanism in insects and mammals: a new hypothesis involving hydrostatic pressures
    • Schmidt-Nielsen B. The renal concentrating mechanism in insects and mammals: a new hypothesis involving hydrostatic pressures. Am J Physiol Regul Integr Comp Physiol 268 (1995) R1087-R1100
    • (1995) Am J Physiol Regul Integr Comp Physiol , vol.268
    • Schmidt-Nielsen, B.1
  • 50
    • 0022415872 scopus 로고
    • Control of sodium and potassium transport in the cortical collecting duct of the rat. Effects of bradykinin, vasopressin, and deoxycorticosterone
    • Tomita K., Pisano J.J., and Knepper M.A. Control of sodium and potassium transport in the cortical collecting duct of the rat. Effects of bradykinin, vasopressin, and deoxycorticosterone. J Clin Invest 76 (1985) 132-136
    • (1985) J Clin Invest , vol.76 , pp. 132-136
    • Tomita, K.1    Pisano, J.J.2    Knepper, M.A.3
  • 51
    • 0023119952 scopus 로고
    • Urea permeability of mammalian inner medullary collecting duct system and papillary surface epithelium
    • Sands J.M., and Knepper M.A. Urea permeability of mammalian inner medullary collecting duct system and papillary surface epithelium. J Clin Invest 79 (1987) 138-147
    • (1987) J Clin Invest , vol.79 , pp. 138-147
    • Sands, J.M.1    Knepper, M.A.2
  • 53
    • 54049130491 scopus 로고    scopus 로고
    • Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2
    • Hoffert J.D., Fenton R.A., Moeller H.B., Simons B., Tchapyjnikov D., McDill B.W., et al. Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2. J Biol Chem 283 (2008) 24617-24627
    • (2008) J Biol Chem , vol.283 , pp. 24617-24627
    • Hoffert, J.D.1    Fenton, R.A.2    Moeller, H.B.3    Simons, B.4    Tchapyjnikov, D.5    McDill, B.W.6
  • 54
    • 33846890894 scopus 로고    scopus 로고
    • Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct
    • Hoffert J.D., Pisitkun T., Wang G.H., Shen R.F., and Knepper M.A. Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct. Am J Physiol Renal Physiol 292 (2007) F691-F700
    • (2007) Am J Physiol Renal Physiol , vol.292
    • Hoffert, J.D.1    Pisitkun, T.2    Wang, G.H.3    Shen, R.F.4    Knepper, M.A.5
  • 55
    • 33646485094 scopus 로고    scopus 로고
    • Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites
    • Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., and Knepper M.A. Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Proc Natl Acad Sci U S A 103 (2006) 7159-7164
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7159-7164
    • Hoffert, J.D.1    Pisitkun, T.2    Wang, G.3    Shen, R.-F.4    Knepper, M.A.5
  • 58
    • 0019732284 scopus 로고
    • ADH action: evidence for a membrane shuttle mechanism
    • Wade J.B., Stetson D.L., and Lewis S.A. ADH action: evidence for a membrane shuttle mechanism. Ann N Y Acad Sci 372 (1981) 106-117
    • (1981) Ann N Y Acad Sci , vol.372 , pp. 106-117
    • Wade, J.B.1    Stetson, D.L.2    Lewis, S.A.3
  • 59
    • 0015158590 scopus 로고
    • A micropuncture study of collecting tubule function in rats with hereditary diabetes insipidus
    • Jamison R.L., Buerkert J., and Lacy F.B. A micropuncture study of collecting tubule function in rats with hereditary diabetes insipidus. J Clin Invest 50 (1971) 2444-2452
    • (1971) J Clin Invest , vol.50 , pp. 2444-2452
    • Jamison, R.L.1    Buerkert, J.2    Lacy, F.B.3
  • 60
    • 23344432987 scopus 로고    scopus 로고
    • Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2
    • Uchida S., Sohara E., Rai T., Ikawa M., Okabe M., and Sasaki S. Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2. Mol Cell Biol 25 (2005) 7357-7363
    • (2005) Mol Cell Biol , vol.25 , pp. 7357-7363
    • Uchida, S.1    Sohara, E.2    Rai, T.3    Ikawa, M.4    Okabe, M.5    Sasaki, S.6
  • 61
    • 0037155920 scopus 로고    scopus 로고
    • Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B
    • Yang B., Bankir L., Gillespie A., Epstein C.J., and Verkman A.S. Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B. J Biol Chem 277 (2002) 10633-10637
    • (2002) J Biol Chem , vol.277 , pp. 10633-10637
    • Yang, B.1    Bankir, L.2    Gillespie, A.3    Epstein, C.J.4    Verkman, A.S.5
  • 62
    • 0037184066 scopus 로고    scopus 로고
    • Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B
    • Yang B., and Verkman A.S. Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. J Biol Chem 277 (2002) 36782-36786
    • (2002) J Biol Chem , vol.277 , pp. 36782-36786
    • Yang, B.1    Verkman, A.S.2
  • 63
    • 1942506723 scopus 로고    scopus 로고
    • Upregulation of urea transporter UT-A2 and water channels AQP2 and AQP3 in mice lacking urea transporter UT-B
    • Klein J.D., Sands J.M., Qian L., Wang X., and Yang B. Upregulation of urea transporter UT-A2 and water channels AQP2 and AQP3 in mice lacking urea transporter UT-B. J Am Soc Nephrol 15 (2004) 1161-1167
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1161-1167
    • Klein, J.D.1    Sands, J.M.2    Qian, L.3    Wang, X.4    Yang, B.5
  • 64
    • 0020383518 scopus 로고
    • Water, urea, sodium, chloride, and potassium transport in the in vitro perfused papillary collecting duct
    • Rocha A.S., and Kudo L.H. Water, urea, sodium, chloride, and potassium transport in the in vitro perfused papillary collecting duct. Kidney Int 22 (1982) 485-491
    • (1982) Kidney Int , vol.22 , pp. 485-491
    • Rocha, A.S.1    Kudo, L.H.2
  • 65
    • 0023250416 scopus 로고
    • Effects of glutaraldehyde fixation on renal tubular function. I. Preservation of vasopressin-stimulated water and urea pathways in rat papillary collecting duct
    • Kondo Y., and Imai M. Effects of glutaraldehyde fixation on renal tubular function. I. Preservation of vasopressin-stimulated water and urea pathways in rat papillary collecting duct. Pflugers Arch 408 (1987) 479-483
    • (1987) Pflugers Arch , vol.408 , pp. 479-483
    • Kondo, Y.1    Imai, M.2
  • 67
    • 0034833034 scopus 로고    scopus 로고
    • Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene
    • Bagnasco S.M., Peng T., Janech M.G., Karakashian A., and Sands J.M. Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene. Am J Physiol Renal Physiol 281 (2001) F400-F406
    • (2001) Am J Physiol Renal Physiol , vol.281
    • Bagnasco, S.M.1    Peng, T.2    Janech, M.G.3    Karakashian, A.4    Sands, J.M.5
  • 71
    • 0029825786 scopus 로고    scopus 로고
    • Molecular cloning and characterization of the vasopressin-regulated urea transporter of rat kidney collecting ducts
    • Shayakul C., Steel A., and Hediger M.A. Molecular cloning and characterization of the vasopressin-regulated urea transporter of rat kidney collecting ducts. J Clin Invest 98 (1996) 2580-2587
    • (1996) J Clin Invest , vol.98 , pp. 2580-2587
    • Shayakul, C.1    Steel, A.2    Hediger, M.A.3
  • 74
    • 33748749047 scopus 로고    scopus 로고
    • Loss of N-linked glycosylation reduces urea transporter UT-A1 response to vasopressin
    • Chen G., Froehlich O., Yang Y., Klein J.D., and Sands J.M. Loss of N-linked glycosylation reduces urea transporter UT-A1 response to vasopressin. J Biol Chem 281 (2006) 27436-27442
    • (2006) J Biol Chem , vol.281 , pp. 27436-27442
    • Chen, G.1    Froehlich, O.2    Yang, Y.3    Klein, J.D.4    Sands, J.M.5
  • 75
    • 35648970630 scopus 로고    scopus 로고
    • The UT-A1 urea transporter interacts with snapin, a snare-associated protein
    • Mistry A.C., Mallick R., Froehlich O., Klein J.D., Rehm A., Chen G., et al. The UT-A1 urea transporter interacts with snapin, a snare-associated protein. J Biol Chem 282 (2007) 30097-30106
    • (2007) J Biol Chem , vol.282 , pp. 30097-30106
    • Mistry, A.C.1    Mallick, R.2    Froehlich, O.3    Klein, J.D.4    Rehm, A.5    Chen, G.6
  • 76
    • 0035001773 scopus 로고    scopus 로고
    • UT-A3: localization and characterization of an additional urea transporter isoform in the IMCD
    • Terris J.M., Knepper M.A., and Wade J.B. UT-A3: localization and characterization of an additional urea transporter isoform in the IMCD. Am J Physiol Renal Physiol 280 (2001) F325-F332
    • (2001) Am J Physiol Renal Physiol , vol.280
    • Terris, J.M.1    Knepper, M.A.2    Wade, J.B.3
  • 79
    • 0032926594 scopus 로고    scopus 로고
    • Cloning and characterization of two new mRNA isoforms of the rat renal urea transporter: UT-A3 and UT-A4
    • Karakashian A., Timmer R.T., Klein J.D., Gunn R.B., Sands J.M., and Bagnasco S.M. Cloning and characterization of two new mRNA isoforms of the rat renal urea transporter: UT-A3 and UT-A4. J Am Soc Nephrol 10 (1999) 230-237
    • (1999) J Am Soc Nephrol , vol.10 , pp. 230-237
    • Karakashian, A.1    Timmer, R.T.2    Klein, J.D.3    Gunn, R.B.4    Sands, J.M.5    Bagnasco, S.M.6
  • 80
    • 4544247884 scopus 로고    scopus 로고
    • Characterization of a human colonic cDNA encoding a structurally novel urea transporter, UT-A6
    • Smith C.P., Potter E.A., Fenton R.A., and Stewart G.S. Characterization of a human colonic cDNA encoding a structurally novel urea transporter, UT-A6. Am J Physiol Cell Physiol 287 (2004) C1087-C1093
    • (2004) Am J Physiol Cell Physiol , vol.287
    • Smith, C.P.1    Potter, E.A.2    Fenton, R.A.3    Stewart, G.S.4
  • 81
    • 34147144719 scopus 로고    scopus 로고
    • Acute regulation of the urea transporter mUT-A3 expressed in a MDCK cell line
    • Stewart G.S., King S.L., Potter E.A., and Smith C.P. Acute regulation of the urea transporter mUT-A3 expressed in a MDCK cell line. Am J Physiol Renal Physiol 292 (2007) F1157-F1163
    • (2007) Am J Physiol Renal Physiol , vol.292
    • Stewart, G.S.1    King, S.L.2    Potter, E.A.3    Smith, C.P.4
  • 82
    • 0034985716 scopus 로고    scopus 로고
    • Molecular characterization of a novel urea transporter from kidney inner medullary collecting ducts
    • Shayakul C., Tsukaguchi H., Berger U.V., and Hediger M.A. Molecular characterization of a novel urea transporter from kidney inner medullary collecting ducts. Am J Physiol Renal Physiol 280 (2001) F487-F494
    • (2001) Am J Physiol Renal Physiol , vol.280
    • Shayakul, C.1    Tsukaguchi, H.2    Berger, U.V.3    Hediger, M.A.4
  • 83
    • 0027372483 scopus 로고
    • Cloning and characterization of the vasopressin-regulated urea transporter
    • You G., Smith C.P., Kanai Y., Lee W.-S., Stelzner M., and Hediger M.A. Cloning and characterization of the vasopressin-regulated urea transporter. Nature 365 (1993) 844-847
    • (1993) Nature , vol.365 , pp. 844-847
    • You, G.1    Smith, C.P.2    Kanai, Y.3    Lee, W.-S.4    Stelzner, M.5    Hediger, M.A.6
  • 84
    • 0033956332 scopus 로고    scopus 로고
    • UT-A2: a 55 kDa urea transporter protein in thin descending limb of Henle's loop whose abundance is regulated by vasopressin
    • Wade J.B., Lee A.J., Liu J., Ecelbarger C.A., Mitchell C., Bradford A.D., et al. UT-A2: a 55 kDa urea transporter protein in thin descending limb of Henle's loop whose abundance is regulated by vasopressin. Am J Physiol Renal Physiol 278 (2000) F52-F62
    • (2000) Am J Physiol Renal Physiol , vol.278
    • Wade, J.B.1    Lee, A.J.2    Liu, J.3    Ecelbarger, C.A.4    Mitchell, C.5    Bradford, A.D.6
  • 85
    • 0028151415 scopus 로고
    • Cloning and functional expression of a urea transporter from human bone marrow cells
    • Olives B., Neau P., Bailly P., Hediger M.A., Rousselet G., Cartron J.P., et al. Cloning and functional expression of a urea transporter from human bone marrow cells. J Biol Chem 269 (1994) 31649-31652
    • (1994) J Biol Chem , vol.269 , pp. 31649-31652
    • Olives, B.1    Neau, P.2    Bailly, P.3    Hediger, M.A.4    Rousselet, G.5    Cartron, J.P.6
  • 86
    • 0032540009 scopus 로고    scopus 로고
    • Urea transporter UT3 functions as an efficient water channel-direct evidence for a common water/urea pathway
    • Yang B.X., and Verkman A.S. Urea transporter UT3 functions as an efficient water channel-direct evidence for a common water/urea pathway. J Biol Chem 273 (1998) 9369-9372
    • (1998) J Biol Chem , vol.273 , pp. 9369-9372
    • Yang, B.X.1    Verkman, A.S.2
  • 87
    • 0033569732 scopus 로고    scopus 로고
    • At physiological expression levels the Kidd blood group/urea transporter protein is not a water channel
    • Sidoux-Walter F., Lucien N., Olivès B., Gobin R., Rousselet G., Kamsteeg E.J., et al. At physiological expression levels the Kidd blood group/urea transporter protein is not a water channel. J Biol Chem 274 (1999) 30228-30235
    • (1999) J Biol Chem , vol.274 , pp. 30228-30235
    • Sidoux-Walter, F.1    Lucien, N.2    Olivès, B.3    Gobin, R.4    Rousselet, G.5    Kamsteeg, E.J.6
  • 88
    • 0036079910 scopus 로고    scopus 로고
    • Vasopressin rapidly increases the phosphorylation of the UT-A1 urea transporter activity in rat IMCDs through PKA
    • Zhang C., Sands J.M., and Klein J.D. Vasopressin rapidly increases the phosphorylation of the UT-A1 urea transporter activity in rat IMCDs through PKA. Am J Physiol Renal Physiol 282 (2002) F85-F90
    • (2002) Am J Physiol Renal Physiol , vol.282
    • Zhang, C.1    Sands, J.M.2    Klein, J.D.3
  • 89
    • 49949101889 scopus 로고    scopus 로고
    • Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation
    • Blount M.A., Mistry A.C., Froehlich O., Price S.R., Chen G., Sands J.M., et al. Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation. Am J Physiol Renal Physiol 295 (2008) F295-F299
    • (2008) Am J Physiol Renal Physiol , vol.295
    • Blount, M.A.1    Mistry, A.C.2    Froehlich, O.3    Price, S.R.4    Chen, G.5    Sands, J.M.6
  • 90
    • 0025767832 scopus 로고
    • An independent effect of osmolality on urea transport in rat terminal IMCDs
    • Sands J.M., and Schrader D.C. An independent effect of osmolality on urea transport in rat terminal IMCDs. J Clin Invest 88 (1991) 137-142
    • (1991) J Clin Invest , vol.88 , pp. 137-142
    • Sands, J.M.1    Schrader, D.C.2
  • 91
    • 0026647725 scopus 로고
    • Characteristics of osmolarity-stimulated urea transport in rat IMCD
    • Gillin A.G., and Sands J.M. Characteristics of osmolarity-stimulated urea transport in rat IMCD. Am J Physiol Renal Physiol 262 (1992) F1061-F1067
    • (1992) Am J Physiol Renal Physiol , vol.262
    • Gillin, A.G.1    Sands, J.M.2
  • 92
    • 0026561140 scopus 로고
    • Effect of peritubular hypertonicity on water and urea transport of inner medullary collecting duct
    • Kudo L.H., César K.R., Ping W.C., and Rocha A.S. Effect of peritubular hypertonicity on water and urea transport of inner medullary collecting duct. Am J Physiol Renal Physiol 262 (1992) F338-F347
    • (1992) Am J Physiol Renal Physiol , vol.262
    • Kudo, L.H.1    César, K.R.2    Ping, W.C.3    Rocha, A.S.4
  • 93
    • 0025274143 scopus 로고
    • Concentration dependence of urea and thiourea transport pathway in rat inner medullary collecting duct
    • Chou C.-L., Sands J.M., Nonoguchi H., and Knepper M.A. Concentration dependence of urea and thiourea transport pathway in rat inner medullary collecting duct. Am J Physiol Renal Physiol 258 (1990) F486-F494
    • (1990) Am J Physiol Renal Physiol , vol.258
    • Chou, C.-L.1    Sands, J.M.2    Nonoguchi, H.3    Knepper, M.A.4
  • 94
    • 0027282151 scopus 로고
    • Osmolarity-stimulated urea transport in rat terminal IMCD: role of intracellular calcium
    • Gillin A.G., Star R.A., and Sands J.M. Osmolarity-stimulated urea transport in rat terminal IMCD: role of intracellular calcium. Am J Physiol Renal Physiol 265 (1993) F272-F277
    • (1993) Am J Physiol Renal Physiol , vol.265
    • Gillin, A.G.1    Star, R.A.2    Sands, J.M.3
  • 95
    • 0033711929 scopus 로고    scopus 로고
    • Angiotensin II increases vasopressin-stimulated facilitated urea permeability in rat terminal IMCDs
    • Kato A., Klein J.D., Zhang C., and Sands J.M. Angiotensin II increases vasopressin-stimulated facilitated urea permeability in rat terminal IMCDs. Am J Physiol Renal Physiol 279 (2000) F835-F840
    • (2000) Am J Physiol Renal Physiol , vol.279
    • Kato, A.1    Klein, J.D.2    Zhang, C.3    Sands, J.M.4
  • 96
    • 0023933365 scopus 로고
    • Calcium and cyclic adenosine monophosphate as second messengers for vasopressin in the rat inner medullary collecting duct
    • Star R.A., Nonoguchi H., Balaban R., and Knepper M.A. Calcium and cyclic adenosine monophosphate as second messengers for vasopressin in the rat inner medullary collecting duct. J Clin Invest 81 (1988) 1879-1888
    • (1988) J Clin Invest , vol.81 , pp. 1879-1888
    • Star, R.A.1    Nonoguchi, H.2    Balaban, R.3    Knepper, M.A.4
  • 97
    • 57349177906 scopus 로고    scopus 로고
    • Urea transporters UT-A1 and UT-A3 accumulate in the plasma membrane in response to increased hypertonicity
    • Blessing N.W., Blount M.A., Sands J.M., Martin C.F., and Klein J.D. Urea transporters UT-A1 and UT-A3 accumulate in the plasma membrane in response to increased hypertonicity. Am J Physiol Renal Physiol 295 (2008) F1336-F1341
    • (2008) Am J Physiol Renal Physiol , vol.295
    • Blessing, N.W.1    Blount, M.A.2    Sands, J.M.3    Martin, C.F.4    Klein, J.D.5
  • 98
    • 33749239657 scopus 로고    scopus 로고
    • Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts
    • Klein J.D., Froehlich O., Blount M.A., Martin C.F., Smith T.D., and Sands J.M. Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts. J Am Soc Nephrol 17 (2006) 2680-2686
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2680-2686
    • Klein, J.D.1    Froehlich, O.2    Blount, M.A.3    Martin, C.F.4    Smith, T.D.5    Sands, J.M.6
  • 99
    • 0031970773 scopus 로고    scopus 로고
    • Long-term regulation of collecting duct urea transporter proteins in rat
    • Terris J., Ecelbarger C.A., Sands J.M., and Knepper M.A. Long-term regulation of collecting duct urea transporter proteins in rat. J Am Soc Nephrol 9 (1998) 729-736
    • (1998) J Am Soc Nephrol , vol.9 , pp. 729-736
    • Terris, J.1    Ecelbarger, C.A.2    Sands, J.M.3    Knepper, M.A.4
  • 100
    • 1642314628 scopus 로고    scopus 로고
    • Role of vasopressin in diabetes mellitus-induced changes in medullary transport proteins involved in urine concentration in Brattleboro rats
    • Kim D.-U., Sands J.M., and Klein J.D. Role of vasopressin in diabetes mellitus-induced changes in medullary transport proteins involved in urine concentration in Brattleboro rats. Am J Physiol Renal Physiol 286 (2004) F760-F766
    • (2004) Am J Physiol Renal Physiol , vol.286
    • Kim, D.-U.1    Sands, J.M.2    Klein, J.D.3
  • 101
    • 0014261893 scopus 로고
    • Impaired urinary concentration after vasopressin and its gradual correction in hypothalamic diabetes insipidus
    • Harrington A.R., and Valtin H. Impaired urinary concentration after vasopressin and its gradual correction in hypothalamic diabetes insipidus. J Clin Invest 47 (1968) 502-510
    • (1968) J Clin Invest , vol.47 , pp. 502-510
    • Harrington, A.R.1    Valtin, H.2
  • 103
    • 0034623952 scopus 로고    scopus 로고
    • The TonE/TonEBP pathway mediates tonicity-responsive regulation of UT-A urea transporter expression
    • Nakayama Y., Peng T., Sands J.M., and Bagnasco S.M. The TonE/TonEBP pathway mediates tonicity-responsive regulation of UT-A urea transporter expression. J Biol Chem 275 (2000) 38275-38280
    • (2000) J Biol Chem , vol.275 , pp. 38275-38280
    • Nakayama, Y.1    Peng, T.2    Sands, J.M.3    Bagnasco, S.M.4
  • 104
    • 7144227386 scopus 로고    scopus 로고
    • Adenylate cyclase-coupled vasopressin receptor activates AQP2 promoter via a dual effect on CRE and AP1 elements
    • Yasui M., Zelenin S.M., Celsi G., and Aperia A. Adenylate cyclase-coupled vasopressin receptor activates AQP2 promoter via a dual effect on CRE and AP1 elements. Am J Physiol Renal Physiol 272 (1997) F443-F450
    • (1997) Am J Physiol Renal Physiol , vol.272
    • Yasui, M.1    Zelenin, S.M.2    Celsi, G.3    Aperia, A.4
  • 105
    • 0029919180 scopus 로고    scopus 로고
    • Cloning and kidney cell-specific activity of the promoter of the murine renal Na-K-Cl cotransporter gene
    • Igarashi P., Whyte D.A., and Nagami G.T. Cloning and kidney cell-specific activity of the promoter of the murine renal Na-K-Cl cotransporter gene. J Biol Chem 271 (1996) 9666-9674
    • (1996) J Biol Chem , vol.271 , pp. 9666-9674
    • Igarashi, P.1    Whyte, D.A.2    Nagami, G.T.3
  • 106
    • 0026871953 scopus 로고
    • Urinary concentrating ability in patients with Jk(a-b-) blood type who lack carrier-mediated urea transport
    • Sands J.M., Gargus J.J., Fröhlich O., Gunn R.B., and Kokko J.P. Urinary concentrating ability in patients with Jk(a-b-) blood type who lack carrier-mediated urea transport. J Am Soc Nephrol 2 (1992) 1689-1696
    • (1992) J Am Soc Nephrol , vol.2 , pp. 1689-1696
    • Sands, J.M.1    Gargus, J.J.2    Fröhlich, O.3    Gunn, R.B.4    Kokko, J.P.5
  • 107
    • 0346099295 scopus 로고    scopus 로고
    • Lack of UT-B in vasa recta and red blood cells prevents urea-induced improvement of urinary concentrating ability
    • Bankir L., Chen K., and Yang B. Lack of UT-B in vasa recta and red blood cells prevents urea-induced improvement of urinary concentrating ability. Am J Physiol Renal Physiol 286 (2004) F144-F151
    • (2004) Am J Physiol Renal Physiol , vol.286
    • Bankir, L.1    Chen, K.2    Yang, B.3
  • 108
    • 33947509228 scopus 로고    scopus 로고
    • Role of UTB urea transporters in the urine concentrating mechanism of the rat kidney
    • Layton A.T. Role of UTB urea transporters in the urine concentrating mechanism of the rat kidney. Bull Math Biol 69 (2007) 887-929
    • (2007) Bull Math Biol , vol.69 , pp. 887-929
    • Layton, A.T.1
  • 109
    • 33745331159 scopus 로고    scopus 로고
    • Facilitated transport in vasa recta: theoretical effects on solute exchange in the medullary microcirculation
    • Edwards A., and Pallone T.L. Facilitated transport in vasa recta: theoretical effects on solute exchange in the medullary microcirculation. Am J Physiol Renal Physiol 272 (1997) F505-F514
    • (1997) Am J Physiol Renal Physiol , vol.272
    • Edwards, A.1    Pallone, T.L.2
  • 110
    • 0031922662 scopus 로고    scopus 로고
    • A multiunit model of solute and water removal by inner medullary vasa recta
    • Edwards A., and Pallone T.L. A multiunit model of solute and water removal by inner medullary vasa recta. Am J Physiol Heart Circ Physiol 274 (1998) H1202-H1210
    • (1998) Am J Physiol Heart Circ Physiol , vol.274
    • Edwards, A.1    Pallone, T.L.2
  • 111
    • 0000849880 scopus 로고
    • Dilution and concentration of the urine and the action of antidiuretic hormone
    • Berliner R.W., Levinsky N.G., Davidson D.G., and Eden M. Dilution and concentration of the urine and the action of antidiuretic hormone. Am J Med 24 (1958) 730-744
    • (1958) Am J Med , vol.24 , pp. 730-744
    • Berliner, R.W.1    Levinsky, N.G.2    Davidson, D.G.3    Eden, M.4
  • 112
    • 33947268484 scopus 로고    scopus 로고
    • Urea and renal function in the 21st century: insights from knockout mice
    • Fenton R.A., and Knepper M.A. Urea and renal function in the 21st century: insights from knockout mice. J Am Soc Nephrol 18 (2007) 679-688
    • (2007) J Am Soc Nephrol , vol.18 , pp. 679-688
    • Fenton, R.A.1    Knepper, M.A.2
  • 113
    • 33947228754 scopus 로고    scopus 로고
    • Critical role of urea in the urine-concentrating mechanism
    • Sands J.M. Critical role of urea in the urine-concentrating mechanism. J Am Soc Nephrol 18 (2007) 670-671
    • (2007) J Am Soc Nephrol , vol.18 , pp. 670-671
    • Sands, J.M.1
  • 114
    • 0001418454 scopus 로고
    • Micropuncture study of net transtubular movement of water and urea in nondiuretic mammalian kidney
    • Lassiter W.E., Gottschalk C.W., and Mylle M. Micropuncture study of net transtubular movement of water and urea in nondiuretic mammalian kidney. Am J Physiol 200 (1961) 1139-1146
    • (1961) Am J Physiol , vol.200 , pp. 1139-1146
    • Lassiter, W.E.1    Gottschalk, C.W.2    Mylle, M.3
  • 115
    • 0023128178 scopus 로고
    • Pathways of urea transport in the mammalian kidney
    • Knepper M.A., and Roch-Ramel F. Pathways of urea transport in the mammalian kidney. Kidney Int 31 (1987) 629-633
    • (1987) Kidney Int , vol.31 , pp. 629-633
    • Knepper, M.A.1    Roch-Ramel, F.2
  • 116
    • 0023115785 scopus 로고
    • Cycles and separations: the histotopography of the urinary concentrating process
    • Lemley K.V., and Kriz W. Cycles and separations: the histotopography of the urinary concentrating process. Kidney Int 31 (1987) 538-548
    • (1987) Kidney Int , vol.31 , pp. 538-548
    • Lemley, K.V.1    Kriz, W.2
  • 117
    • 33744814622 scopus 로고    scopus 로고
    • Three-dimensional architecture of inner medullary vasa recta
    • Pannabecker T.L., and Dantzler W.H. Three-dimensional architecture of inner medullary vasa recta. Am J Physiol Renal Physiol 290 (2006) F1355-F1366
    • (2006) Am J Physiol Renal Physiol , vol.290
    • Pannabecker, T.L.1    Dantzler, W.H.2
  • 118
    • 0017637993 scopus 로고
    • Structural and functional heterogeneity of mammalian nephrons
    • Valtin H. Structural and functional heterogeneity of mammalian nephrons. Am J Physiol Renal Physiol 233 (1977) F491-F501
    • (1977) Am J Physiol Renal Physiol , vol.233
    • Valtin, H.1


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